DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kz and Dhx38

DIOPT Version :9

Sequence 1:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	XP_006255639.1	Gene:	Dhx38 / 292007	RGDID:	1310345	Length:	1227	Species:	Rattus norvegicus

Alignment Length:	1078	Identity:	291/1078 - (26%)
Similarity:	470/1078 - (43%)	Gaps:	256/1078 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 GYDE-ANALVLPSEKRATKIKVDKVQHVKILSKKQRKHL-----QAIVDKKKKKEGRAQLLGDLA 98
            |||| .|.|...||....:    :.||   |.|:::|.:     |...|.::.:..|....|.:.
  Rat   332 GYDEFHNPLAYSSEDYVRR----REQH---LHKQKQKRISAQRRQINEDNERWETNRMLTSGVVH 389

  Fly    99 AVQIPEEELQQYTSISQVQTVGLKRLPTLDEYLAKKKERQAQVLAEKSSASGLRVNAIKGSK--R 161
            .:::.|:..:...:...:....|.. |.||..:...|:.: .|:..|.:.|.|.:.|.|||:  |
  Rat   390 RLEVDEDFEEDNAAKVHLMVHNLVP-PFLDGRIVFTKQPE-PVIPVKDATSDLAIIARKGSQTVR 452

  Fly   162 KLLVEEEEELQAKRKNPNVISVEEDDEDSSSSDEDDEEAPAQSAPIAIPTPVSIAPPQIAVKPPI 226
            |.. |::|..:|:.|:..:...:..|......:|:.::|..:...:...|....|...
  Rat   453 KHR-EQKERRKAQHKHWELAGTKLGDIMGVKKEEEPDKAMTEDGKVDYRTEQKFADHM------- 509

  Fly   227 KKLKPEPNPPACIHQTVYVPVHRTTEVQNARLRLPILAEEQQVMETINENPIVIVAGETGSGKTT 291
             |.|.|.:....          :...:...|..|||.|.:|:::..|.:|.||||.|||||||||
  Rat   510 -KEKSEASSEFA----------KKKSILEQRQYLPIFAVQQELLTIIRDNSIVIVVGETGSGKTT 563

  Fly   292 QLPQFLYEAGYAQHKMIGVTEPRRVAAIAMSKRVAHEM--NLPESEVSYLIRFEGNVTPATRIKF 354
            ||.|:|::.||..:.|||.|:||||||::::|||:.||  ||.| ||.|.||||...:..|.||:
  Rat   564 QLTQYLHQDGYTDYGMIGCTQPRRVAAMSVAKRVSEEMGGNLGE-EVGYAIRFEDCTSENTLIKY 627

  Fly   355 MTDGVLLKEIETDFLLSKYSVIILDEAHERSVYTDILVGLLSRIVPLRHKRGQPLKLIIMSATL- 418
            ||||:||:|...:..|..||.||:|||||||:.||:|.|||..:|    .|...||||:.|||:
  Rat   628 MTDGILLRESLREADLDHYSAIIMDEAHERSLNTDVLFGLLREVV----ARRSDLKLIVTSATMD 688

  Fly   419 --RVSDFTENTRLFKIPPPLLKVEARQFPVTIHFQKRTPDDYVAEAYRKTLKIHNKLPEGGILIF 481
              :.:.|..|..:|.||       .|.|||.|.|.|...:|||..|.:::|::|.....|.||||
  Rat   689 ADKFAAFFGNVPIFHIP-------GRTFPVDILFSKTPQEDYVEAAVKQSLQVHLSGAPGDILIF 746

  Fly   482 VTGQQEVNQLVRKLRRTFPYHHAPTKDVAKNGKVSEEEKEETIDDAASTVEDPKELEFDMKRVIR 546
            :.||:::                                |.|.|   ..||..:|||
  Rat   747 MPGQEDI--------------------------------EVTSD---QIVEHLEELE-------- 768

  Fly   547 NIRKSKKKFLAQMALPKINLDDYKLPGDDTEADMHEQPDEDDEQEGLEEDNDDELGLEDESGMGS 611

  Rat   769 ----------------------------------------------------------------- 768

  Fly   612 GQRQPLWVLPLYSLLSSEKQNRIFLPVPDGCRLCVVSTNVAETSLTIPHIKYVVDCGRQKTRLYD 676
             ....|.|||:||.|.|:.|.:||...|||.|.|:|:||:||||||:..|.:|:|.|..|.::::
  Rat   769 -NAPALAVLPIYSQLPSDLQAKIFQKAPDGVRKCIVATNIAETSLTVDGIMFVIDSGYCKLKVFN 832

  Fly   677 KLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQ 741
            ...|:.|..:...|:|:|:||:|||||...|.|:|||:.:.|.:.....:.|:||:..:.:::|.
  Rat   833 PRIGMDALQIYPISQANANQRSGRAGRTGPGQCFRLYTQSAYKNELLTTTVPEIQRTNLANVVLL 897

  Fly   742 MRCMGIDRVVHFPFPSPPDQVQLQAAERRLIVLGALEVAKTENTDLPPAVTRLGHVISRFPVAPR 806
            ::.:|:..::.|.|..||.:..:..:..:|.:||||     :||.   .:|..|.::..||:.|.
  Rat   898 LKSLGVQDLLQFHFMDPPPEDNMLNSMYQLWILGAL-----DNTG---GLTSTGRLMVEFPLDPA 954

  Fly   807 FGKMLALSHQQNLLPYTVCLVAALSVQEVLI-------ETGVQRDEDVAPGANR--FHRKRQSWA 862
            ..|||.:|.........:.:|:.|||..:..       |:...|::...|.::.  :......|
  Rat   955 LSKMLIVSCDMGCSSEILLIVSMLSVPAIFYRPKGREEESDQIREKFAVPESDHLTYLNVYLQW- 1018

  Fly   863 ASGNYQLLGDPMVLLRAVGAAEYAGSQGRLPEFCAANGLRQKAMSEVRKLRVQLTN-EINLNVSD 926
            .:.||..:                        :|..:.:..|||.:||::|.||.: .:...:|.
  Rat  1019 KNNNYSTI------------------------WCNDHFIHAKAMRKVREVRAQLKDIMVQQRMSL 1059

  Fly   927 VELGVDPELKPPTDAQARFLRQILLAGMGDRVARKVPLADIADKEERRRLKYAYNCADMEEPAFL 991
            ...|.|.::.......|.|.:...|.|:|:.|..:..:                       |..|
  Rat  1060 ASCGTDWDIVRKCICAAYFHQAAKLKGIGEYVNIRTGM-----------------------PCHL 1101

  Fly   992 HVSSVL--RQKAPEWVIYQEAYELQNGDSTKMFIRGITAIEPEWLLLYVPLLCNIREV---REDP 1051
            |.:|.|  ....|::::|.|...     :||.:::.:||::.|||....|:..::::.   |::.
  Rat  1102 HPTSSLFGMGYTPDYIVYHELVM-----TTKEYMQCVTAVDGEWLAELGPMFYSVKQAGKSRQEN 1161

  Fly  1052 APRFDKTSGKIFCHVDATFGKSGWELPLGEVEMPLSEK 1089
            ..|..:.:..:                  |.||.|:|:
  Rat  1162 RRRAKEEASAM------------------EEEMALAEE 1181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	241/840 (29%)
		DEXDc	279..418	CDD:238005	79/140 (56%)
		P-loop_NTPase	369..>500	CDD:304359	52/133 (39%)
		HELICc	619..704	CDD:197757	40/84 (48%)
		HA2	774..859	CDD:214852	22/93 (24%)
		OB_NTP_bind	915..1039	CDD:285018	26/126 (21%)
Dhx38	XP_006255639.1	DUF3984	<190..>299	CDD:289881
		DEXDc	526..713	CDD:214692	98/198 (49%)
		DEXDc	551..687	CDD:238005	79/140 (56%)
		HELICc	758..861	CDD:197757	48/179 (27%)
		HA2	930..1012	CDD:214852	22/89 (25%)
		OB_NTP_bind	<1063..1146	CDD:285018	23/110 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820