DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kz and Dhx15

DIOPT Version :9

Sequence 1:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_001178526.1	Gene:	Dhx15 / 289693	RGDID:	1308072	Length:	795	Species:	Rattus norvegicus

Alignment Length:	850	Identity:	251/850 - (29%)
Similarity:	386/850 - (45%)	Gaps:	197/850 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 PACIHQTVYVP-VHRTTEVQNARLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLYE 299
            |.||:....:| ..|..::...||:||:...:.:..:.:..:...::.||||||||||:||:..|
  Rat   112 PQCINPFTNLPHTPRYYDILKKRLQLPVWEYKDRFTDILVRHQSFVLVGETGSGKTTQIPQWCVE 176

  Fly   300 AGYAQ-----HKMIGVTEPRRVAAIAMSKRVAHEMN-LPESEVSYLIRFEGNVTPATRIKFMTDG 358
              |.:     .:.:..|:||||||:::::|||.||: :...||.|.||||...:..|.:|:||||
  Rat   177 --YMRSLPGPKRGVACTQPRRVAAMSVAQRVADEMDVMLGQEVGYSIRFEDCSSAKTILKYMTDG 239

  Fly   359 VLLKEIETDFLLSKYSVIILDEAHERSVYTDILVGLLSRIVPLRHKRGQPLKLIIMSATLRVSDF 423
            :||:|...|.||.:|.||||||||||::.||||:|:|..:|    ::...||:|:|||||....|
  Rat   240 MLLREAMNDPLLERYGVIILDEAHERTLATDILMGVLKEVV----RQRSDLKVIVMSATLDAGKF 300

  Fly   424 TENTRLFKIPPPLLKVEARQFPVTIHFQKRTPDDYVAEAYRKTLKIHN-KLPEGGILIFVTGQQE 487
                :::....|||.:..|..||.|.:......||:..|.|..::||. :..||.:|:|:|||:|
  Rat   301 ----QIYFDNCPLLTIPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEEEGDLLLFLTGQEE 361

  Fly   488 VNQLVRKLRRTFPYHHAPTKDVAKNGKVSEEEKEETIDDAASTVEDPKELEFDMKRVIRNIRKSK 552
            :::..::::|                         .:||....|.|.|
  Rat   362 IDEACKRIKR-------------------------EVDDLGPEVGDIK----------------- 384

  Fly   553 KKFLAQMALPKINLDDYKLPGDDTEADMHEQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQPL 617

  Rat   385 ----------------------------------------------------------------- 384

  Fly   618 WVLPLYSLLSSEKQNRIFLPVP----DGC--RLCVVSTNVAETSLTIPHIKYVVDCGRQKTRLYD 676
             ::||||.|..::|.|||.|.|    :|.  |..|||||:|||||||..:.:|:|.|..|.::|:
  Rat   385 -IIPLYSTLPPQQQQRIFEPPPPKKQNGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYN 448

  Fly   677 KLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQ 741
            ....|.:.:||..|||||.||||||||...|.|:|||:...|....:|.:.|:|.:..:..::||
  Rat   449 PRIRVESLLVTAISKASAQQRAGRAGRTRPGKCFRLYTEKAYKTEMQDNTYPEILRSNLGSVVLQ 513

  Fly   742 MRCMGIDRVVHFPFPSPPDQVQLQAAERRLIVLGALEVAKTENTDLPPAVTRLGHVISRFPVAPR 806
            ::.:|||.:|||.|..||....|..|...|..|.||    .::.||    |.||.:::.||:.|:
  Rat   514 LKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAAL----NDDGDL----TELGSMMAEFPLDPQ 570

  Fly   807 FGKMLALSHQQNLLPYTVCLVAALSVQEVLIE-TGVQRDEDVAPGANRFHRKRQSWAASGNYQLL 870
            ..||:..|...|.....:.:.|.|||.:..:. |..::..|.|  ..||            ..:.
  Rat   571 LAKMVIASCDYNCSNEVLSITAMLSVPQCFVRPTEAKKAADEA--KMRF------------AHID 621

  Fly   871 GDPMVLLRAVGAAEYAGSQGRLPEFCAANGLRQKAMSEVRKLRVQLT---NEINLNVSDVELGVD 932
            ||.:.||....|.:   ......::|..|.:..:::.....:|.||:   :..||.
  Rat   622 GDHLTLLNVYHAFK---QNHESVQWCYDNFINYRSLMSADNVRQQLSRIMDRFNLP--------- 674

  Fly   933 PELKPPTDAQAR----FLRQILLAGMGDRVARKVPLADIADKEERRRLKYAYNCADMEEPAFLHV 993
               :..||..:|    .:|:.|:.|...:||            ...|..:.....| .:...||.
  Rat   675 ---RRSTDFTSRDYYINIRKALVTGYFMQVA------------HLERTGHYLTVKD-NQVVQLHP 723

  Fly   994 SSVLRQKAPEWVIYQEAYELQNGDSTKMFIRGITAIEPEWLLLYVPLLCNIREVREDPAPR-FDK 1057
            |:||..| ||||:|.| :.|    :||.:||..|.|:||||:...|...::....:..|.| .|:
  Rat   724 STVLDHK-PEWVLYNE-FVL----TTKNYIRTCTDIKPEWLVKIAPQYYDMSNFPQCEAKRQLDR 782

  Fly  1058 TSGKI 1062
            ...|:
  Rat   783 IIAKL 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	249/843 (30%)
		DEXDc	279..418	CDD:238005	69/144 (48%)
		P-loop_NTPase	369..>500	CDD:304359	51/131 (39%)
		HELICc	619..704	CDD:197757	45/90 (50%)
		HA2	774..859	CDD:214852	24/85 (28%)
		OB_NTP_bind	915..1039	CDD:285018	37/130 (28%)
Dhx15	NP_001178526.1	HrpA	124..763	CDD:224557	242/812 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820