DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kz and Dhx37

DIOPT Version :9

Sequence 1:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_001099396.2	Gene:	Dhx37 / 288647	RGDID:	1306837	Length:	1150	Species:	Rattus norvegicus

Alignment Length:	1230	Identity:	560/1230 - (45%)
Similarity:	758/1230 - (61%)	Gaps:	131/1230 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGK--KVHNAKAR----QNPQTIVDNSAVKKIQIDVDAVAGGNQVGYDEANALVLPS-EKRATKI 58
            |||  :.:|.|.|    ..|....:...|:....|.|.:.     |.|.:||||||. :|:.||.
  Rat     1 MGKLRRRYNVKGRLQAESRPAKGPEAPPVRLELEDKDVLK-----GVDASNALVLPGRKKKKTKA 60

  Fly    59 KVDKVQHVKILSKKQRKHLQAIVDKKKKKEGRAQLLGDLAAVQIPEEELQQYTSISQVQTVGLKR 123
            .....:..|.|:||:||.||.::::|:||..||:||..|:.||:.|.|:..:.:.:::.|
  Rat    61 PPPSKKERKPLTKKERKVLQKVLEQKEKKSQRAELLQKLSEVQVSEAEMSLFYTTAKLGT----- 120

  Fly   124 LPTLDEYLAKKKERQAQVLAEKSSASGL-RVNAIKGSKRKLLVEEEEELQAKRKNPNVISVEEDD 187
                .:.:...|||:    .::.:|.|. :|:::.|              |.||.....|.|||.
  Rat   121 ----GDRMYHIKERK----PDQPAAQGQEKVSSLSG--------------AHRKRHRSSSTEEDS 163

  Fly   188 EDSSSSDEDDEEA--------------PAQSAPIAIPTPVSIAPPQIAVKPPIKKLKPEPNPPAC 238
            |.|..|:.::..|              |..::.|..|.|....||.....||  :......|||.
  Rat   164 EASEDSEPEEVTADQPRTSTGADLVHPPPATSEIKSPVPTPQPPPPGTSAPP--ETPASAPPPAL 226

  Fly   239 IHQTVYVPVHRTTEVQNARLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLYEAGY- 302
            ....|::||:||.|:|..||:||||||||.:||.:.|:|||||.||||||||||:|||||||||
  Rat   227 AKPAVFIPVNRTPEMQEERLKLPILAEEQAIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGYS 291

  Fly   303 AQHKMIGVTEPRRVAAIAMSKRVAHEMNLPESEVSYLIRFEGNVTPATRIKFMTDGVLLKEIETD 367
            ::..:|||||||||||:|||:|||.||||....|||.||:|||||..|||||||||||||||:.|
  Rat   292 SEDSIIGVTEPRRVAAVAMSQRVAKEMNLSHRVVSYQIRYEGNVTEETRIKFMTDGVLLKEIQKD 356

  Fly   368 FLLSKYSVIILDEAHERSVYTDILVGLLSRIVPLRHKRGQPLKLIIMSATLRVSDFTENTRLFKI 432
            |||.||.|:|:|||||||||||||:|||||||.||.||..||||:||||||||.|||:|.|||..
  Rat   357 FLLLKYKVVIIDEAHERSVYTDILLGLLSRIVALRAKRHLPLKLLIMSATLRVEDFTQNQRLFTT 421

  Fly   433 PPPLLKVEARQFPVTIHFQKRTP-DDYVAEAYRKTLKIHNKLPEGGILIFVTGQQEVNQLVRKLR 496
            |||::|||:||||||:||.|||| |||..|.:||..|||..||.||||:|:|||.||:.|.|:||
  Rat   422 PPPVIKVESRQFPVTVHFNKRTPLDDYSGECFRKVCKIHRMLPAGGILVFLTGQAEVHALCRRLR 486

  Fly   497 RTFPYHHAPTKDVAKNGKVSEEEKEETIDDAASTVEDPKELEFDMKRVIRNIRKSKKKF-LAQ-M 559
            :.||..                            ...|:|:|.|....:|..:||:.:. .|| |
  Rat   487 KAFPIR----------------------------CSQPQEMEEDSAEGMRRFKKSRTRARKAQAM 523

  Fly   560 ALPKINLDDYK-LP---GD-DTEADMHEQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQ---- 615
            |||:||||:|. ||   || |.||:|      |||:|.|..|.|.:||   :|....|::.
  Rat   524 ALPQINLDNYSVLPAGEGDEDREAEM------DDEEEALGSDLDLDLG---DSEANEGEQPDASL 579

  Fly   616 PLWVLPLYSLLSSEKQNRIFLPVPDGCRLCVVSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTG 680
            ||.||||||||:.|||.::|.|.|:|.||||::|||||||||||.||||||||:.|.|.||::||
  Rat   580 PLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVIATNVAETSLTIPGIKYVVDCGKVKKRYYDRVTG 644

  Fly   681 VSAFVVTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQMRCM 745
            ||:|.||:.|:||||||||||||...|||||||||||:.| ||.|..|:|.::|||||:|||:.:
  Rat   645 VSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFGD-FEQFPPPEITRRPVEDLILQMKAL 708

  Fly   746 GIDRVVHFPFPSPPDQVQLQAAERRLIVLGALE-------VAKTENTDLPPAVTRLGHVISRFPV 803
            .|::|::||||:||....|.|||..||.||||:       :.|.:.:.|...:|.||..:|.|||
  Rat   709 NIEKVINFPFPTPPSVEALIAAEELLIALGALQAPPKQERMKKLQMSQLSCPITALGRTMSTFPV 773

  Fly   804 APRFGKMLALSHQQNLLPYTVCLVAALSVQEVL--IETGVQRDEDVAP---GANRFHRKRQSWAA 863
            |||:.||||||.|...||||:.:|||::|:|:.  ::.....:|::|.   ...|..:.:::||.
  Rat   774 APRYAKMLALSQQHGCLPYTIAIVAAMTVRELFEELDRPAASEEELAELKGRRTRVAQMKRTWAG 838

  Fly   864 SGNYQLLGDPMVLLRAVGAAEYAGSQGRLPEFCAANGLRQKAMSEVRKLRVQLTNEINLNVSDVE 928
            .|....|||.||||.||||.||||..   |:||.|||||.|||.|:|:||.|||..:|....:..
  Rat   839 QGASLKLGDLMVLLGAVGACEYAGCS---PQFCQANGLRYKAMLEIRRLRGQLTTAVNAVCPEAG 900

  Fly   929 LGVDPELKPPTDAQARFLRQILLAGMGDRVARKVPLADIADKEERRRLKYAYNCADMEEPAFLHV 993
            |.:||:::|||::|..:||||:.||:||.:||:|...|:.|.    :.|.||....:::|.|:|.
  Rat   901 LFLDPKMQPPTESQVTYLRQIMAAGLGDHLARRVQSEDLLDP----KWKNAYKTPLLDDPVFIHP 961

  Fly   994 SSVLRQKAPEWVIYQEAYELQNGDSTKMFIRGITAIEPEWLLLYVPLLCNIREVREDPAPRFDKT 1058
            ||||.::.||:|:|||..|     :|||:::|::.:|.:|:...:|..|......|:|||.:...
  Rat   962 SSVLFRELPEFVVYQEIVE-----TTKMYMKGVSTVEIQWIPSLLPSYCQFDAPLEEPAPTYCPE 1021

  Fly  1059 SGKIFCHVDATFGKSGWELPLGEVEMPLSEKACCYFGMFLLDGEVCSRLADFRSKLKSTPASVIK 1123
            ||::.||..:.|.:.||.||..:|:.|.......||..|||:|:|..:||.|:|.|.|:|.:::|
  Rat  1022 SGRVLCHRASVFYRVGWPLPAVQVDFPEGIDRYKYFARFLLEGQVFRKLASFKSCLLSSPNTMLK 1086

  Fly  1124 SWSSMNNKVLRFKRALITKQIHNRQALIDQWNSDPHFLLEEYQNLLYDVALSELTPLWPP 1183
            :|:.:..:.....|||:.::..:|.:|:..|..:|.:||.||...|......::...|||
  Rat  1087 TWARLQPRTETLLRALVAQKADSRDSLLAAWKKNPKYLLAEYCEWLPKAMHGDVEKNWPP 1146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	448/845 (53%)
		DEXDc	279..418	CDD:238005	108/139 (78%)
		P-loop_NTPase	369..>500	CDD:304359	92/131 (70%)
		HELICc	619..704	CDD:197757	61/84 (73%)
		HA2	774..859	CDD:214852	35/96 (36%)
		OB_NTP_bind	915..1039	CDD:285018	47/123 (38%)
Dhx37	NP_001099396.2	HrpA	236..1009	CDD:224557	440/822 (54%)
		DEXDc	267..407	CDD:238005	108/139 (78%)
		HELICc	578..667	CDD:197757	62/88 (70%)
		HA2	730..781	CDD:282288	21/50 (42%)
		HA2	761..852	CDD:214852	37/90 (41%)
		OB_NTP_bind	887..1004	CDD:285018	48/125 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341548
Domainoid	1	1.000	227	1.000	Domainoid score	I2419
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6641
Inparanoid	1	1.050	949	1.000	Inparanoid score	I321
OMA	1	1.010	-	-		QHG54789
OrthoDB	1	1.010	-	-		D203698at33208
OrthoFinder	1	1.000	-	-		FOG0005033
OrthoInspector	1	1.000	-	-		oto97807
orthoMCL	1	0.900	-	-		OOG6_102322
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3558
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770