DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kz and Dhx33

DIOPT Version :9

Sequence 1:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_001099272.1	Gene:	Dhx33 / 287464	RGDID:	1307239	Length:	698	Species:	Rattus norvegicus

Alignment Length:	848	Identity:	253/848 - (29%)
Similarity:	379/848 - (44%)	Gaps:	189/848 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 PQIAVKPPIKKLKPEPNPPA-----------------------CIHQTVYVPVHRTTEVQNARLR 259
            |:.|..||.|:.:|...||.                       .:.|....|.....|:|  |..
  Rat     2 PEEAGLPPAKRFRPGSCPPGRRVVMLLTAGSGGGAGGGRRQTPPLAQPSASPYREALELQ--RRS 64

  Fly   260 LPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLYEAGYAQHKMIGVTEPRRVAAIAMSKR 324
            |||.....|::..:......::.||||||||||:||:|||.|.::..:|.||:|||||||:::.|
  Rat    65 LPIFRARGQLLAQLRNLDNAVLIGETGSGKTTQIPQYLYEGGISRQGIIAVTQPRRVAAISLATR 129

  Fly   325 VAHEMNLPESE-VSYLIRFEGNVTPATRIKFMTDGVLLKEIETDFLLSKYSVIILDEAHERSVYT 388
            |:.|......: |.|.:|||...:..|||||:|||:||:|..:|.||.|||.:||||||||:::|
  Rat   130 VSDEKRTELGKLVGYTVRFEDVTSEDTRIKFLTDGMLLREAISDSLLRKYSCVILDEAHERTIHT 194

  Fly   389 DILVGLLSRIVPLRHKRGQ-PLKLIIMSATLRVSDFTENTRLFKIPPPLLKVEARQFPVTIHFQK 452
            |:|.|::......|.:.|: |||:|:||||:.|..|::    :....|:|.:|.||.|:.|.:.|
  Rat   195 DVLFGVVKTAQKRRKELGKLPLKVIVMSATMDVDLFSQ----YFNGAPVLYLEGRQHPIQIFYTK 255

  Fly   453 RTPDDYVAEAYRKTLKIHNKLPEG-GILIFVTGQQEVNQLVRKLRRTFPYHHAPTKDVAKNGKVS 516
            :...||:..|.....:||.:.|.. .||:|:|||:|:..:.:..|           |:||:
  Rat   256 QPQQDYLHAALVSVFQIHQEAPSSQDILVFLTGQEEIEAMSKTCR-----------DIAKH---- 305

  Fly   517 EEEKEETIDDAASTVEDPKELEFDMKRVIRNIRKSKKKFLAQMALPKINLDDYKLPGDDTEADMH 581
                                                                  ||
  Rat   306 ------------------------------------------------------LP--------- 307

  Fly   582 EQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQPLWVLPLYSLLSSEKQNRIFLPVPDGCRLCV 646
                                     .|..|     :.|||||:.|...:|.|:|...|.|.|..:
  Rat   308 -------------------------DGCPS-----MLVLPLYASLPYSQQLRVFQGAPKGYRKVI 342

  Fly   647 VSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYR 711
            :|||:||||:||..||||||.|..|.:.|:..:|:....|...||..|.||.|||||..:|.|||
  Rat   343 ISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTGRAGREDSGICYR 407

  Fly   712 LYSSAVYNDCFEDFSQPDIQKKPVEDLMLQMRCMGIDRVVHFPFPSPPDQVQLQAAERRLIVLGA 776
            ||:...: |.||..:.|:||:..:..:|||:..|.:..|:.|.|.|.|....::||..:|.:|||
  Rat   408 LYTEDEF-DKFEKMAAPEIQRCNLASVMLQLLAMKVPNVLTFDFMSRPSPDHIEAAIAQLDLLGA 471

  Fly   777 LEVAKTENTDLPPAVTRLGHVISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVLIETGV 841
            |     |:.|...|:|.:|..::.||:.|:|.|.:.||.:.:.....:.:|:.|||..||.....
  Rat   472 L-----EHKDDQLALTPIGRKMAAFPLEPKFAKTILLSSKFHCTEEILTIVSLLSVDSVLYNPPA 531

  Fly   842 QRDEDVAPGANRFHRKRQSWAASGNYQLLGDPMVLLRAVGAAEYAGSQGRLPEFCAANGLRQKAM 906
            :|||        ....|:.:.:|.     ||.:.||......:..|..   .::|..|.:..|.|
  Rat   532 RRDE--------VQSVRKKFISSE-----GDHITLLNIYRTFKNIGGN---KDWCKENFVNSKNM 580

  Fly   907 SEVRKLRVQLTNEINLNVSDVELGVDPELKPPTDAQARFLRQILLAGMGDRVARKVPLADIADKE 971
            ..|.::|.|| .:|.|.:|      .|.:....|.::  :|:.|...:....|...|
  Rat   581 LLVAEVRAQL-RDICLKMS------MPIMSSRGDMES--VRRCLAHSLFMSTAELQP-------- 628

  Fly   972 ERRRLKYAYNCADMEEPAFLHVSSVLRQKAPEWVIYQEAYELQNGDSTKMFIRGITAIEPEWLLL 1036
                 ...|...|..:|..:|.||||....|..|:|.....     :.|.::|.:..::.|||..
  Rat   629 -----DGTYATTDTHQPVAIHPSSVLFHCKPACVVYTSLLY-----TNKCYMRDLCVVDAEWLYE 683

  Fly  1037 YVP 1039
            ..|
  Rat   684 AAP 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	245/829 (30%)
		DEXDc	279..418	CDD:238005	72/140 (51%)
		P-loop_NTPase	369..>500	CDD:304359	51/132 (39%)
		HELICc	619..704	CDD:197757	41/84 (49%)
		HA2	774..859	CDD:214852	25/84 (30%)
		OB_NTP_bind	915..1039	CDD:285018	27/123 (22%)
Dhx33	NP_001099272.1	DEXDc	49..252	CDD:214692	89/208 (43%)
		DEXDc	83..225	CDD:238005	72/141 (51%)
		Helicase_C	282..399	CDD:278689	55/224 (25%)
		HA2	469..554	CDD:214852	29/102 (28%)
		OB_NTP_bind	588..688	CDD:285018	28/126 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820