Protein Alignment kz and dhx37

DIOPT Version :10

• Sequence 1: NP_476591.1
• Gene: kz / 31205
• FlyBaseID: FBgn0001330
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: NP_593520.1
• Gene: dhx37 / 2543371
• PomBaseID: SPAPB1A10.06C
• Length: 1183
• Species: Schizosaccharomyces pombe
• Alignment Length: 1279
• Identity: 423/1279 - (33%)
• Similarity: 620/1279 - (48%)
• Gaps: 305/1279 - (23%)

  Fly     1 MG--KKVHNAKARQNPQTIVDNSAVKKI--------------QIDVDAVAGGNQVGYDEANALVL 49
            ||  :|..|.|.||        |.::|:              |.....|....:....::||.:|
pombe     1 MGRLRKRFNEKGRQ--------SGIQKMLNLKRARLHRSVREQESSSEVHANPEPDNQDSNAEIL 57

  Fly    50 ---PSEKRATKIKVDKVQHVK----ILSKKQRKHLQAIVDKKKKKEGRAQLLGDLAAVQIPEEEL 107
               |.|:|..:.:..|.|.:|    .:|.|::|.|...::.|.|||..|.|:..||..:|....|
pombe    58 IDVPKEERQKRKQELKDQLLKENEGSISSKKKKRLDKYIENKLKKEEVASLIAKLAEERIDTSLL 122

  Fly   108 QQYTSISQVQTV--GLKR--------LP----------TLDEYLAKKKERQAQVLA-EK-SSASG 150
            ....::.:..|.  .||:        ||          .:|......|...|:..| || |:.||
pombe   123 SSSKNLGKQATAKEKLKKSLLEEKLGLPLSDADSRLYKVVDVETTTTKSSTAETNAPEKYSTRSG 187

  Fly   151 LRVNAIKGSKRKLLVEEEEELQAKRK-----------NPNVISVEED-----------DEDSSSS 193
            .......|:....:....:.|..|:|           :|...|.|||           |.|:||.
pombe   188 FGFGFSTGTNESEITPNIKVLPPKKKKNASWGKMLNEDPEYDSAEEDYLSTDSEEFSEDSDNSSE 252

  Fly   194 DEDDEEAPA-QSAPIAIPTPV-------------------------------------------- 213
            :..|...|: :.|...:|..|
pombe   253 ENKDTNEPSTKDAEKTVPEDVVNLRSEQKLQPSFGHPEFENEDFDLETSEDDSSDDATERASRFK 317

  Fly   214 SIAPPQI---------------------------AVKPPIK-KLKPEPNPPACI------HQTVY 244
            |.|..||                           |.:.|.| |::.|...|...      .:|.|
pombe   318 SWANKQILGADVGEKSHDVAPDNKIDNPDADMVRAQRMPRKLKMREEDVEPTADDIEIKGRKTTY 382

  Fly   245 VPVHRTTEVQNARLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLYEAGYAQHK--- 306
            ..::|..|:|.:||.|||:||||::||.|..|.:||:.|.|||||||||||||:|||::..:
pombe   383 TIINRPPEIQESRLALPIVAEEQRIMEQIFANDVVIICGATGSGKTTQLPQFLFEAGFSSPESEN 447

  Fly   307 --MIGVTEPRRVAAIAMSKRVAHEMNLPESEVSYLIRFEGNVTPATRIKFMTDGVLLKEIETDFL 369
              ||.:|:||||||::::|||:.|:....|:|||.|||:..:.|.|.|||||||:||:|:.:|||
pombe   448 PGMIAITQPRRVAAVSIAKRVSEELTGFSSKVSYQIRFDSTINPDTAIKFMTDGILLRELSSDFL 512

  Fly   370 LSKYSVIILDEAHERSVYTDILVGLLSRIVPLRH------KRGQPLKLIIMSATLRVSDFTENTR 428
            |:.||.:|:||||||||.||||:|||||||.||.      ::.:|||||||||||||:||:||..
pombe   513 LTAYSAVIVDEAHERSVNTDILLGLLSRIVRLRREMSKSDQKVKPLKLIIMSATLRVTDFSENKL 577

  Fly   429 LFKIPPPLLKVEARQFPVTIHFQKRTPDDYVAEAYRKTLKIHNKLPEGGILIFVTGQQEVNQLVR 493
            ||.:|||::|::|||:||:|||.:.|..||:.:|:.|...||.:||.|.||:|:||||||.||.:
pombe   578 LFSVPPPIIKIDARQYPVSIHFNRTTKPDYLQDAFDKVCLIHKRLPAGSILVFLTGQQEVEQLCQ 642

  Fly   494 KLRRTFPYHHAPTKDVAKNGKVSEEEKEETIDDAASTVEDPKELEFDMKRVIRNIR--KSKKKFL 556
            .||                                             ||.:|:.|  ||:.:.:
pombe   643 MLR---------------------------------------------KRFVRSFRPLKSRARIV 662

  Fly   557 AQMALPKINLDDYKLPGDDTEADMHEQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQPLWVLP 621
            .......:..:|.:   .:|| |:.:.|          ..:...:..:|||       :|::|||
pombe   663 VSRKTMSVENEDLQ---SETE-DIDQVP----------TSSSSSVTYDDES-------EPMYVLP 706

  Fly   622 LYSLLSSEKQNRIFLPVPDGCRLCVVSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFVV 686
            |||||::|.|.::|...|:|.|:|:|:|||||||:|||:|:||||||:.|.|:|::.|.|..|.|
pombe   707 LYSLLTTEDQMKVFDSSPEGHRMCIVATNVAETSITIPNIRYVVDCGKAKERVYNEKTSVQKFEV 771

  Fly   687 TYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQMRCMGIDRVV 751
            .:.|||:||||||||||...|||||||||||::..|...|.|:|.:.|||.::|||:.|.||.:.
pombe   772 RWISKANADQRAGRAGRTGPGHCYRLYSSAVFDSSFPLHSLPEILRTPVESIVLQMKNMNIDNIA 836

  Fly   752 HFPFPSPPDQVQLQAAERRLIVLGALEVAKTENTDLPPAVTRLGHVISRFPVAPRFGKMLALSHQ 816
            :||||:.|.:.:|:.:.:.|..|||:        |....:|:||..:|.||::|||.|||.:..|
pombe   837 NFPFPTSPGRSRLEKSLKLLSNLGAI--------DSEGVLTKLGEQMSLFPLSPRFSKMLIIGQQ 893

  Fly   817 QNLLPYTVCLVAALSVQEVLI-----------------ETGVQRDEDVAPGANRFHRKRQSWAAS 864
            ...|||.:.||:|||:.::.:                 ||.:..|:::.......:|.|..:.|.
pombe   894 HGCLPYVIALVSALSINQLFVSKQSLLYDAHDKNSRSEETDLIDDDEIKQKEEYKNRMRGYFNAI 958

  Fly   865 GNYQLLGDP----MVLLRAVGAAEYAGSQGRLPEFCAANGLRQKAMSEVRKLRVQLTNEINLNVS 925
            ..:|.: ||    :.||.||.|.:||..:.:   ||..|.||:||:.||..||.|:...:...:.
pombe   959 SRFQAI-DPDAPALSLLSAVCAYDYASDKRK---FCKENYLREKALEEVTNLRKQIIGLLKRYMV 1019

  Fly   926 DVELG-VDPELKPPTDAQARFLRQILLAGMGDRVARKVPLADIADKEERRRLKYAYNCADMEEPA 989
            .||.. ...:|||||..|.:.|||.:.:...|:||       :.|||:|..:           ..
pombe  1020 RVEKEFFKLQLKPPTSVQIKALRQFIASAYIDQVA-------LYDKEKRGYV-----------TL 1066

  Fly   990 FLHVSSVLRQKAP--------EWVIYQEAYELQNGDSTKMFIRGITAIEPEWL--LLYVPLLCNI 1044
            |...|.|: |..|        |:|:|...:|.::|   ::::..:|.|.||.|  |.....|.:.
pombe  1067 FPSGSEVV-QFVPDRTYNIDSEYVVYLSLHESRSG---RVYMSPLTEISPEHLARLAKNTTLLSY 1127

  Fly  1045 REVREDPAPRFDKTSGKIFCHV------DATFGKSGWELPLGEV 1082
            .:....|..|:...:.|..|.|      :...|...|.||..::
pombe  1128 SKPLSYPPIRYLDNATKRECWVIPILSANIGTGSPSWNLPAVQI 1171

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_476591.1	HrpA	260..>1071	CDD:441249	336/861 (39%)
		DEXHc_DHX37	260..439	CDD:350740	112/189 (59%)
dhx37	NP_593520.1	PTZ00108	<69..314	CDD:240271	49/244 (20%)
		HrpA	397..>909	CDD:441249	267/585 (46%)
		OB_NTP_bind	1041..1121	CDD:400182	26/101 (26%)