DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kz and Ythdc2

DIOPT Version :9

Sequence 1:NP_001284815.1 Gene:kz / 31205 FlyBaseID:FBgn0001330 Length:1192 Species:Drosophila melanogaster
Sequence 2:NP_001156485.1 Gene:Ythdc2 / 240255 MGIID:2448561 Length:1445 Species:Mus musculus


Alignment Length:1275 Identity:304/1275 - (23%)
Similarity:485/1275 - (38%) Gaps:362/1275 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 GRAQLLGDL-------AAVQI--------PEEELQQYTSISQVQTVGLKRLPT------------ 126
            |||:.|.|:       .||.|        .:.|::..:|::..:...:.||..            
Mouse    46 GRAKGLKDIRIDEEVKIAVNIALERFRYGDQREMEFPSSLTSTERAFIHRLSQSLGLVSKSKGKG 110

  Fly   127 LDEYLAKKKERQAQVLAEKSSASGLRVNAIKGSKRKLLV------EEEEELQAKRKNPNVISVE- 184
            .:.||..||:..::. |.......|..|. |.:.|.|:.      :|..||..|.:..||.:|| 
Mouse   111 ANRYLTVKKKDGSET-AHAMMTCNLTHNT-KHAVRSLIQRFPVTNKERTELLPKTERGNVFAVEA 173

  Fly   185 EDDEDSSSSDEDDEEAPAQSAPIAIPTPVSIAPPQIAVKPPIKKLKPEPNPPACIHQTVYVPVHR 249
            |:.|.|.:|...:...|                                          .|||.|
Mouse   174 ENREMSKTSGRLNNGIP------------------------------------------QVPVKR 196

  Fly   250 -TTEVQNARLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLYEAGYAQHKMIGV--- 310
             .:|..:.|..||:..:::::::.|.||.:|::.||||||||||:||||.:..:..    |:   
Mouse   197 GESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKN----GIPCR 257

  Fly   311 ---TEPRRVAAIAMSKRVAHEMNLPESE-VSYLIRFEGNVTPATRIKFMTDGVLLKEIET-DFLL 370
               |:|||:||||:::|||.|......: :.|.||.|..|:|.|.:.|.|:||||:.:.. |..|
Mouse   258 IFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMAGDSTL 322

  Fly   371 SKYSVIILDEAHERSVYTDILVGLLSRIVPLRHKRGQPLKLIIMSATLRVSDFTENTRLFKIPPP 435
            |..:.:|:||.|||..::|.   ||:::..|..|. ..||||:.||.|.|:.|   .|.|. ..|
Mouse   323 STVTHVIVDEVHERDRFSDF---LLTKLRDLLQKH-PTLKLILSSAALDVNLF---IRYFG-SCP 379

  Fly   436 LLKVEARQFPVTIHF--------------------------------------QKRT--PDDYVA 460
            ::.::.|.|.|...|                                      |:.|  |:....
Mouse   380 VIYIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQREEKQQTTLTEWYSAQENTFKPESQRQ 444

  Fly   461 EAYRKTLKIHNKLPEGGILIF-------------------------------VTGQQEVNQLVRK 494
            .|.....:.::.|.:||..:|                               |....:|..|:..
Mouse   445 RAVASVSEEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHKDVDAFAQVFHLILT 509

  Fly   495 LRRTFPYHHAPTKDVA---KNGKVSEEEKEETIDDAASTVEDPKE--------LEFDMKRVIRNI 548
            ...:..|.|:.|...|   ..|:....:.|:.|...|:.......        ..|....::..:
Mouse   510 ENVSVDYRHSETSATALMVAAGRGFTSQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLL 574

  Fly   549 RKSKKKFLAQMALPKINLDDYKL---PGDDTEADMHE-----QPDEDDEQEGLE----------- 594
                :.:.|.:...  |||:..|   .|:|..|:..|     ....|||:..|:           
Mouse   575 ----ESYSASLEFG--NLDESSLVQTNGNDLSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICH 633

  Fly   595 -----------EDNDDELGLED----ESGMGSGQRQPLWVLPLYSLLSSEKQNRIFLPVPDGCRL 644
                       ...|:.:||.|    :....:.......|..|:|.:.:..|.::....|.|.|.
Mouse   634 SCDAGAILIFLPGYDEIVGLRDRILFDDKRFADNTHRYQVFMLHSNMQTSDQKKVLKNPPAGVRK 698

  Fly   645 CVVSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGHC 709
            .::|||:||||:|:..:.:|:|.|:.|.:.:|.|..|:...:.:.|||||.||.|||||...|.|
Mouse   699 IILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGIC 763

  Fly   710 YRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQ------MRCMGIDRVVHFPFPSPPDQVQLQAAE 768
            :||:|...:.:..| |..|::.:.|:::|.|.      :.|...|.::..|.|.|          
Mouse   764 FRLFSRLRFQNMLE-FQTPELLRMPLQELCLHTKLLAPVNCTIADFLMKAPEPPP---------- 817

  Fly   769 RRLIVLGALEVAKT-ENTDLPPAVTRLGHVISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSV 832
             .|||..|:::.|| :..|....:|.||:.::..||.|..|||:            :|.|....:
Mouse   818 -ALIVRNAVQMLKTIDAMDAWEDLTELGYHLADLPVEPHLGKMV------------LCAVVLKCL 869

  Fly   833 QEVLIE--TGVQRDEDVAP------GANRFHRKRQSWAASGNYQLLGDPMVLLRAVGAAEYAGSQ 889
            ..:|..  |...||..|.|      .|....|||   ..:|.:   .|.|.||||..|.:.|.|.
Mouse   870 DPILTIACTLAYRDPFVLPTQASQKRAAMLCRKR---FTAGTF---SDHMALLRAFQAWQKARSD 928

  Fly   890 GRLPEFCAANGLRQKAMSEVRKLRVQLTNEINL----------NVSDVELGVDPELKPPTDAQA- 943
            |....||..|.|.|..|..:..:|.||..::..          ::.||.          |:::. 
Mouse   929 GWERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGGDIRDVN----------TNSENW 983

  Fly   944 RFLRQILLAGMGDRVARKVPLADIADKEERRRLKYAYNCADMEEPAFLHVSSVLRQ----KAP-- 1002
            ..::..|:|||...:..       .|:|.      .......|:....|.:|||.|    |.|  
Mouse   984 AVVKAALVAGMYPNLVH-------VDREN------VILTGPKEKKVRFHPTSVLSQPQYKKIPPA 1035

  Fly  1003 ------------EWVIYQE---AYELQNGDSTKMFIRGITAIEPEWLLLY---VPLLCNIRE--- 1046
                        :|:||.|   |:.:.|       ||..:|:.|..:|::   ..|..|..:   
Mouse  1036 NGQAAAIQALPTDWLIYDEMTRAHRIAN-------IRCCSAVTPVTVLVFCGPARLASNALQEPS 1093

  Fly  1047 -VREDPAPRFDKTSGKIFCHVDATFGKSGWELPLGEVEMPLSEKACCYFGMFLLDGEVCSRLADF 1110
             .|.|..|. |.:..::.....|...    .|.|.|            :..|.|:.|..|.|...
Mouse  1094 SFRADGIPN-DSSDSEMEDRTTANLA----ALKLDE------------WLNFKLEPEAASLLLQL 1141

  Fly  1111 RSKLKS-------TPASVIKSWSSMNNKVLRFKRALITKQ 1143
            |.|..|       .|:   |.||.::...:|...|:::.:
Mouse  1142 RQKWHSLFLRRMRAPS---KPWSQVDEATIRAIIAVLSTE 1178

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kzNP_001284815.1 HrpA 237..1058 CDD:224557 251/999 (25%)
DEXDc 279..418 CDD:238005 61/146 (42%)
P-loop_NTPase 369..>500 CDD:304359 40/201 (20%)
HELICc 619..704 CDD:197757 33/84 (39%)
HA2 774..859 CDD:214852 24/93 (26%)
OB_NTP_bind 915..1039 CDD:285018 30/158 (19%)
Ythdc2NP_001156485.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..50 3/3 (100%)
R3H_DEXH_helicase 61..119 CDD:100077 9/57 (16%)
DEXDc 225..364 CDD:238005 59/146 (40%)
DEAH box 331..334 2/2 (100%)
ANK 502..587 CDD:238125 13/90 (14%)
ANK repeat 520..552 CDD:293786 6/31 (19%)
ANK 1 521..553 6/31 (19%)
Ank_4 524..574 CDD:290365 6/49 (12%)
ANK 2 554..586 2/37 (5%)
ANK repeat 554..582 CDD:293786 2/31 (6%)
Helicase_C 625..757 CDD:278689 36/131 (27%)
HA2 831..916 CDD:214852 25/102 (25%)
OB_NTP_bind 954..1081 CDD:285018 30/156 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1179..1303 304/1275 (24%)
YTH 1304..1434 CDD:282058
N6-methyladenosine binding. /evidence=ECO:0000250|UniProtKB:Q9Y5A9 1309..1311
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1643
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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