Protein Alignment kz and DHX30

DIOPT Version :10

• Sequence 1: NP_476591.1
• Gene: kz / 31205
• FlyBaseID: FBgn0001330
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: XP_047303683.1
• Gene: DHX30 / 22907
• HGNCID: 16716
• Length: 1265
• Species: Homo sapiens
• Alignment Length: 1056
• Identity: 243/1056 - (23%)
• Similarity: 400/1056 - (37%)
• Gaps: 329/1056 - (31%)

  Fly   112 SISQVQTVGLK-RLPTLD-------EYLAKKKERQAQVLAEKSSASGLRVNAIKGSKRKLLVEEE 168
            ::.|..|||.| :|.||.       .::||.: |:|:  ||..:|:    .|.|..|...||:..
Human   335 NLMQFHTVGTKTKLSTLTLLWPCPMTFVAKGR-RKAE--AENKAAA----LACKKLKSLGLVDRN 392

  Fly   169 EELQAKRKNP------NVISVEEDDEDSSSSDEDDEEAPAQSAP--IAIPTPV------------ 213
            .|       |      |:.|:.|..|             .|..|  |.:|.|:
Human   393 NE-------PLTHAMYNLASLRELGE-------------TQRRPCTIQVPEPILRKIETFLNHYP 437

  Fly   214 ---SIAPPQIAVK-----PPIKKLKPEPNPPACIHQTVYVPVHRTTEVQNA-------RLRLPIL 263
               |...|::.::     |..|...|..:|   |....|||:....||:.:       |.|.|:.
Human   438 VESSWIAPELRLQSDDILPLGKDSGPLSDP---ITGKPYVPLLEAEEVRLSQSLLELWRRRGPVW 499

  Fly   264 AEEQQ---------VMETINENPIVIVAGETGSGKTTQLPQFLYE----AGYAQHKMIGVTEPRR 315
            .|..|         ::..|.::|:|:::|:||.||||::||.|.|    .|......:.:|:|||
Human   500 QEAPQLPVDPHRDTILNAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRR 564

  Fly   316 VAAIAMSKRVAHEMNLP--ESEVSYLIRFEGNVTPATR---IKFMTDGVLLKEIETDFLLSKYSV 375
            ::|:::::||:||:. |  ...|.:.:|.|..  |.:|   :.|.|.|:||::::::..|...|.
Human   565 ISAVSVAQRVSHELG-PSLRRNVGFQVRLESK--PPSRGGALLFCTVGILLRKLQSNPSLEGVSH 626

  Fly   376 IILDEAHERSVYTDILVGLLSRIVPLRHKRGQP-LKLIIMSATLRVSDFTENTRLFKIPPPLLKV 439
            :|:||.|||.|.||.|:.||..:     :|..| |:|::||||   .|....:|.|. ..|::||
Human   627 VIVDEVHERDVNTDFLLILLKGL-----QRLNPALRLVLMSAT---GDNERFSRYFG-GCPVIKV 682

  Fly   440 EARQFPVTIHFQKRTPDDYVAE----AYRKTLKIHNKLPE---------------------GGIL 479
            ....:||..|:.    :|.:|:    .|....:.|....|                     ||||
Human   683 PGFMYPVKEHYL----EDILAKLGKHQYLHRHRHHESEDECALDLDLVTDLVLHIDARGEPGGIL 743

  Fly   480 IFVTGQQEVNQLVRKLRRTFPYHHAPTKDVAKNGKVSEEEKEETIDDAASTVEDPKELEFDMKRV 544
            .|:.|.||:..:.::|:.....|
Human   744 CFLPGWQEIKGVQQRLQEALGMH------------------------------------------ 766

  Fly   545 IRNIRKSKKKFLAQMALPKINLDDYKLPGDDTEADMHEQPDEDDEQEGLEEDNDDELGLEDESGM 609
                   :.|:|
Human   767 -------ESKYL----------------------------------------------------- 771

  Fly   610 GSGQRQPLWVLPLYSLLSSEKQNRIFLPVPDGCRLCVVSTNVAETSLTIPHIKYVVDCGRQKTRL 674
                     :||::|.:....|..||...|.|.|..|::||:||||:||..|.:|||.|..|...
Human   772 ---------ILPVHSNIPMMDQKAIFQQPPVGVRKIVLATNIAETSITINDIVHVVDSGLHKEER 827

  Fly   675 YDKLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQKKPVEDLM 739
            ||..|.||.....:.|:|:..||.|||||..:|..|.|:..:.. :....|..|:|.:.|:|:|:
Human   828 YDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRL-EKMVPFQVPEILRTPLENLV 891

  Fly   740 LQMRCMGIDRVVHFP-------FPSPPDQVQLQAAERRLIVLGALEVAKTENTDLPPAVTRLGHV 797
            ||.:       :|.|       .....|...::|.:..:|:|..:.|     .|....:|.||..
Human   892 LQAK-------IHMPEKTAVEFLSKAVDSPNIKAVDEAVILLQEIGV-----LDQREYLTTLGQR 944

  Fly   798 ISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVLIETGVQRDEDVAPGANRFHRKRQSWA 862
            ::.....||..|.:.|:.....|...:.:|:.|:           ||.        |....|:.|
Human   945 LAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLT-----------RDP--------FSSSLQNRA 990

  Fly   863 ASGNYQLL------GDPMVLLRAV-GAAEYAGSQGR--LPEFCAANGLRQKAMSEVRKLRVQLTN 918
            .....:.|      .|.:..:||| |..|....|.|  ...:...|.|...::..:..|..|.:.
Human   991 EVDKVKALLSHDSGSDHLAFVRAVAGWEEVLRWQDRSSRENYLEENLLYAPSLRFIHGLIKQFSE 1055

  Fly   919 EINLNVSDVELGVDPELKPPTDA------------QARFLRQILLAGMGDRVARKVPLADIADKE 971
                |:.:..|     :..|:|.            :...::.:|:||:...      |..:...:
Human  1056 ----NIYEAFL-----VGKPSDCTLASAQCNEYSEEEELVKGVLMAGLYPN------LIQVRQGK 1105

  Fly   972 ERRRLKYAYNCADMEEPA---FLHVSSVLRQKA---PEWVIYQEAYELQNGDSTKMFIRGITAIE 1030
            ..|:.|:..|.......:   .||.|::.|:..   ..|:.|..|.: .||   .:|:|..:.:.
Human  1106 VTRQGKFKPNSVTYRTKSGNILLHKSTINREATRLRSRWLTYFMAVK-SNG---SVFVRDSSQVH 1166

  Fly  1031 PEWLLLYVPLLCNIRE 1046
            |..:||......:||:
Human  1167 PLAVLLLTDGDVHIRD 1182

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_476591.1	HrpA	260..>1071	CDD:441249	198/865 (23%)
		DEXHc_DHX37	260..439	CDD:350740	64/197 (32%)
DHX30	XP_047303683.1	HrpA	497..>1029	CDD:441249	167/690 (24%)
		OB_NTP_bind	1086..1173	CDD:400182	20/96 (21%)