DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kz and Dhx29

DIOPT Version :9

Sequence 1:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_766182.2	Gene:	Dhx29 / 218629	MGIID:	2145374	Length:	1365	Species:	Mus musculus

Alignment Length:	1100	Identity:	270/1100 - (24%)
Similarity:	447/1100 - (40%)	Gaps:	293/1100 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 EYLAKKKERQAQVLAEKSSASGLRVNAIKGSKRKLL--VEEEEELQAKRKNPNVISVEEDDEDSS 191
            |:..::|:|:.....|.:....|.:       .|||  ::::::.|.:::..:.....||.|:|.
Mouse   466 EWSDEEKKREELNKMETNKPRDLFI-------AKLLNKLKQQQQQQQQQRPESEKGGSEDPEESW 523

  Fly   192 SSDEDDEEAPAQSAPIAIPTPV-SIAPPQIAVKPPIKKLKPEPNPPACIHQTVYVPVHRTTEVQN 255
            .:...||:..|.|..   ||.. .:||    |:...::|:..|               :...:..
Mouse   524 ENLVSDEDLAALSLE---PTSAEDLAP----VRSLFRRLQSTP---------------KYQRLLK 566

  Fly   256 ARLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLY------EAGYAQHKMIGVTEPR 314
            .|.:||:......::||:..:.:|:|||||||||:||:|.||.      |.| |:...|..|:||
Mouse   567 ERQQLPVFKHRDSIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLDECG-ARKCNIVCTQPR 630

  Fly   315 RVAAIAMSKRVAHEMNLP------ESEVSYLIRFEGNVTPATRIKFMTDGVLLKEIETDFLLSKY 373
            |::|::::.||..|:...      .|...|.||.|...:.:||:.:.|.||||::::.|.||:..
Mouse   631 RISAVSLATRVCEELGCESGPGGRNSLCGYQIRMESRASESTRLLYCTTGVLLRKLQEDGLLADV 695

  Fly   374 SVIILDEAHERSVYTDILVGLLSRIVPLRHKRGQPLKLIIMSATLRVSDFTENTRLFKIPPPLLK 438
            |.:|:||.|||||.:|.|:.:|..|:..|    ..|.||:||||:....|:    .:....|:|:
Mouse   696 SHVIVDEVHERSVQSDFLLVILKEILQKR----SDLHLILMSATVDSDKFS----TYFTHCPILR 752

  Fly   439 VEARQFPVTI-HFQKRTPDDYVAEAYRKTLKIHNKLPEGGILIFVTGQQEVNQLVRKLRRTFPYH 502
            :..|.:||.: |.     :|.|.|.             |.:|
Mouse   753 ISGRSYPVEVFHL-----EDIVEET-------------GFVL----------------------- 776

  Fly   503 HAPTKDVAKNGKVSEEEKEETIDDAASTVEDPKELEF---------DMKRVIRNIRKSKKKFLAQ 558
               .||.....|..|||:|.||:..:......|..|:         ::....:......:..:..
Mouse   777 ---EKDSEYCQKFLEEEEEITINVTSKAGGVKKYQEYIPVQSGASPELNPFYQKYSSRTQHAILY 838

  Fly   559 MALPKINLD-------------DYK---------LPGDDTEADMHEQPDEDDEQEGLEEDNDDEL 601
            |...|||||             .::         |||......:::.
Mouse   839 MNPHKINLDLILELLVYLDKSPQFRNIEGAVLIFLPGLAHIQQLYDL------------------ 885

  Fly   602 GLEDESGMGSGQRQPLWVLPLYSLLSSEKQNRIFLPVPDGCRLCVVSTNVAETSLTIPHIKYVVD 666
             |..:....|.:.|   |:.|:|:||::.|...|:..|.|.|..|::||:|||.:|||.:.:|:|
Mouse   886 -LSSDRRFYSERYQ---VIALHSVLSTQDQAAAFMFPPPGVRKIVLATNIAETGITIPDVVFVID 946

  Fly   667 CGRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQ 731
            .||.|...|.:.:.:|:.|.|:.|||||.||.|||||:..|.|:|||:...: :.|.|:|.|:|.
Mouse   947 TGRTKENKYHESSQMSSLVETFVSKASALQRQGRAGRVRDGFCFRLYTRERF-EGFLDYSVPEIL 1010

  Fly   732 KKPVEDLMLQ-MRC-MGIDRVVHFPFPSPPDQV-------QLQAAERRLIVL---GALEVAKTEN 784
            :.|:|:|.|. |:| :|          ||.|.:       |||.....:.:|   ||.|..:
Mouse  1011 RVPLEELCLHIMKCDLG----------SPEDFLSKALDPPQLQVISNAMNLLRKIGACEPNE--- 1062

  Fly   785 TDLPPAVTRLGHVISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVLIETGVQRDE-DVA 848
                |.:|.||..::..||..:.||||........|.....|.|.::.:...|....::|| |:|
Mouse  1063 ----PKLTPLGQHLAALPVNVKIGKMLIFGAIFGCLEPVATLAAVMTEKSPFITPIGRKDEADLA 1123

  Fly   849 PGANRFHRKRQSWAASGNYQLLGDPMVLLRAVGAAEYAGSQGRLP---EFCAANGLRQKAMSEVR 910
                     :.|.|.:.:     |.:.:..|....:.|..:|...   .:|..|.|.:.::..:.
Mouse  1124 ---------KSSLAVADS-----DHLTIYNAYLGWKKAQQEGGFRSEISYCQRNFLNRTSLLTLE 1174

  Fly   911 KLRVQLTNEI------------------NLNVSDVELGVDPELKPPTDAQARFLRQILLAGMGDR 957
            .::.:|...:                  .|:..|:.|                |:.:|.||:.|.
Mouse  1175 DVKQELMKLVKAAGFSSSPSWEGRKGPQTLSFQDIAL----------------LKAVLAAGLYDS 1223

  Fly   958 VARKVPLADIADKEERRRLKYAYNCADMEEPAFLHVSSVLRQ-KAPEWVIYQEAYELQNGDSTKM 1021
            |. |:......|..|    |.|......:..|.:|.|||.|. :...|::|||....     |::
Mouse  1224 VG-KIMCTKSVDVTE----KLACMVETAQGKAQVHPSSVNRDLQTYGWLLYQEKVRY-----TRV 1278

  Fly  1022 FIRGITAIEPEWLLLYVPLLCNIREVREDPAPRFDKTSGKIFCHVDATFGKSGWELPLGEVEMPL 1086
            ::|..|.|.|..:||                                 ||        |::|:..
Mouse  1279 YLRETTLITPFPVLL---------------------------------FG--------GDIEVQH 1302

  Fly  1087 SEKACCYFGMFLLDGEVCSRLADFRSKLKSTPASVIK------SWSSMNNKVLRFKRALI 1140
            .|:.....|.......|  ::|....:|:....||::      ..|..|:|:|:....||
Mouse  1303 RERLLSVDGWIYFQAPV--KIAVIFKQLRVLIDSVLRKKLENPKMSLENDKILQIITELI 1360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	229/899 (25%)
		DEXDc	279..418	CDD:238005	62/150 (41%)
		P-loop_NTPase	369..>500	CDD:304359	35/131 (27%)
		HELICc	619..704	CDD:197757	39/84 (46%)
		HA2	774..859	CDD:214852	22/88 (25%)
		OB_NTP_bind	915..1039	CDD:285018	32/142 (23%)
Dhx29	NP_766182.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..74
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..222
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	235..257
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..524		5/23 (22%)
		DEXDc	577..763	CDD:214692	71/194 (37%)
		DEXDc	588..735	CDD:238005	61/151 (40%)
		DEAH box. /evidence=ECO:0000255\|HAMAP-Rule:MF_03068	701..704		2/2 (100%)
		Helicase_C	863..984	CDD:278689	45/142 (32%)
		HA2	1055..1136	CDD:214852	24/101 (24%)
		OB_NTP_bind	1178..1298	CDD:285018	35/186 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810