Protein Alignment kz and Dhx33

DIOPT Version :10

• Sequence 1: NP_476591.1
• Gene: kz / 31205
• FlyBaseID: FBgn0001330
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: NP_848144.3
• Gene: Dhx33 / 216877
• MGIID: 2445102
• Length: 698
• Species: Mus musculus
• Alignment Length: 849
• Identity: 249/849 - (29%)
• Similarity: 375/849 - (44%)
• Gaps: 191/849 - (22%)

  Fly   218 PQIAVKPPIKKLKPEPNPPA-----------------------CIHQTVYVPVHRTTEVQNARLR 259
            |:.|..||.|:.:|...||.                       .:.|....|.....|:|  |..
Mouse     2 PEEASLPPAKRFRPGSCPPGRRVVMLLTAGGGGGAGGGRRQTPPLAQPSASPYREALELQ--RRS 64

  Fly   260 LPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLYEAGYAQHKMIGVTEPRRVAAIAMSKR 324
            |||.....|::..:......::.||||||||||:||:|||.|.::..:|.||:|||||||:::.|
Mouse    65 LPIFRARGQLLAQLRNLDNAVLIGETGSGKTTQIPQYLYEGGISRQGIIAVTQPRRVAAISLATR 129

  Fly   325 VAHEMNLPESE-VSYLIRFEGNVTPATRIKFMTDGVLLKEIETDFLLSKYSVIILDEAHERSVYT 388
            |:.|......: |.|.:|||...:..|||||:|||:||:|..:|.||.|||.:||||||||:::|
Mouse   130 VSDEKRTELGKLVGYTVRFEDVTSEDTRIKFLTDGMLLREAISDSLLRKYSCVILDEAHERTIHT 194

  Fly   389 DILVGLLSRIVPLRHKRGQ-PLKLIIMSATLRVSDFTENTRLFKIPPPLLKVEARQFPVTIHFQK 452
            |:|.|::......|.:.|: |||:|:||||:.|..|::    :....|:|.:|.||.|:.|.:.|
Mouse   195 DVLFGVVKTAQKRRKELGKLPLKVIVMSATMDVDLFSQ----YFNRAPVLYLEGRQHPIQIFYTK 255

  Fly   453 RTPDDYVAEAYRKTLKIHNKLPEG-GILIFVTGQQEVNQLVRKLRRTFPYHHAPTKDVAKNGKVS 516
            :...||:..|.....:||.:.|.. .||:|:|||:|:..:.:..|           |:|::
Mouse   256 QPQQDYLHAALVSVFQIHQEAPASQDILVFLTGQEEIEAMSKTCR-----------DIARH---- 305

  Fly   517 EEEKEETIDDAASTVEDPKELEFDMKRVIRNIRKSKKKFLAQMALPKINLDDYKLPGDDTEADMH 581
                                                                  ||
Mouse   306 ------------------------------------------------------LP--------- 307

  Fly   582 EQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQPLWVLPLYSLLSSEKQNRIFLPVPDGCRLCV 646
                                     .|..|     :.|||||:.|...:|.|:|...|.|.|..:
Mouse   308 -------------------------DGCPS-----MLVLPLYASLPYSQQLRVFQGAPKGYRKVI 342

  Fly   647 VSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYR 711
            :|||:||||:||..||||||.|..|.:.|:..:|:....|...||..|.||.|||||..:|.|||
Mouse   343 ISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTGRAGREDSGICYR 407

  Fly   712 LYSSAVYNDCFEDFSQPDIQKKPVEDLMLQMRCMGIDRVVHFPFPSPPDQVQLQAAERRLIVLGA 776
            ||:...: :.||..:.|:||:..:..::||:..|.:..|:.|.|.|.|....::||..:|.:|||
Mouse   408 LYTEDEF-EKFEKMTVPEIQRCNLASVILQLLAMKVPNVLTFDFMSKPSPDHIEAAIAQLDLLGA 471

  Fly   777 LEVAKTENTDLPPAVTRLGHVISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVLIETGV 841
            || .|.:...|.|    :|..::.||:.|||.|.:.||.:.:.....:.:|:.|||..||.....
Mouse   472 LE-HKDDQLTLTP----IGRKMAAFPLEPRFAKTILLSSKFHCTEEILTIVSLLSVDSVLYNPPA 531

  Fly   842 QRDEDVAPGANRFHRKRQSWAASGNYQLLGDPMVLLRAVGAAEYAGSQGRLPEFCAANGLRQKAM 906
            :|||        ....|:.:.:|.     ||.:.||......:..|..   .::|..|.:..|.|
Mouse   532 RRDE--------VQSVRKKFISSE-----GDHITLLNIYRTFKNIGGN---KDWCKENFVNSKNM 580

  Fly   907 SEVRKLRVQLTNEINLNVSDVELGVDPELKPPTDAQARFLRQILLAGMGD-RVARKVPLADIADK 970
            ..|.::|.|| .||.|.:|                      ..:::..|| ...|:.....:...
Mouse   581 LLVAEVRAQL-REICLKMS----------------------MPIMSSRGDMESVRRCMAHSLFMN 622

  Fly   971 EERRRLKYAYNCADMEEPAFLHVSSVLRQKAPEWVIYQEAYELQNGDSTKMFIRGITAIEPEWLL 1035
            ....:....|...|..:|..:|.||||....|..|:|.....     :.|.::|.:..::.|||.
Mouse   623 TAELQTDGTYATTDTHQPVAIHPSSVLFHCKPACVVYTSLLY-----TNKCYMRDLCVVDAEWLY 682

  Fly  1036 LYVP 1039
            ...|
Mouse   683 EAAP 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_476591.1	HrpA	260..>1071	CDD:441249	236/784 (30%)
		DEXHc_DHX37	260..439	CDD:350740	81/180 (45%)
Dhx33	NP_848144.3	Required for nucleolar location. /evidence=ECO:0000250|UniProtKB:Q9H6R0	1..71		16/70 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		6/17 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..50		1/20 (5%)
		HrpA	64..>534	CDD:441249	194/587 (33%)
		DEAH box	185..188		2/2 (100%)
		HA2, required for interaction with EIF3G and RPL26. /evidence=ECO:0000250|UniProtKB:Q9H6R0	462..553		32/108 (30%)
		Critical for rDNA-binding	536..550		3/18 (17%)
		OB_NTP_bind	611..688	CDD:400182	18/81 (22%)