Protein Alignment kz and smgl-2

DIOPT Version :10

• Sequence 1: NP_476591.1
• Gene: kz / 31205
• FlyBaseID: FBgn0001330
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: NP_001294374.1
• Gene: smgl-2 / 177135
• WormBaseID: WBGene00021365
• Length: 1089
• Species: Caenorhabditis elegans
• Alignment Length: 962
• Identity: 248/962 - (25%)
• Similarity: 403/962 - (41%)
• Gaps: 269/962 - (27%)

  Fly   128 DEYLAKKKERQA---QVLAEKSSASGLRVNAIKGSKRKLLVEEEEELQA-------KRKNPNVIS 182
            :||   :|.|.|   ..|.::...||.| ...|.::::|:..:.:.:|:       :||...
 Worm     7 EEY---EKHRGALFRHFLPDEPGTSGNR-RGEKSTEQELIDTQRKSIQSYFNRFFRERKGET--- 64

  Fly   183 VEEDDEDSSSSDEDDEEAPAQSAPIAIPTP-------------VSIAPPQIAVKPPIKKLKPEPN 234
              .|..|.:....||         :.||..             :.|.|.|:....|......|..
 Worm    65 --NDHFDVNRVKFDD---------LGIPQDTGGLNRIRFKGENLGIMPTQLGHITPWLYRHFEYA 118

  Fly   235 PPACIHQTVYVPVHRTTEVQNARLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLYE 299
            ....:....:....:..:::..:..|||.....:::|.:..|.::||||:||.||:||:||:|.:
 Worm   119 YHVALQFNQHQKFQKLQKLRKLQKELPIAERAGEIVELLKTNQVLIVAGDTGCGKSTQVPQYLLK 183

  Fly   300 AGYAQHKMIGVTEPRRVAAIAMSKRVAHE-MNLPESEVSYLIRFEGNVTPATRIKFMTDGVLLKE 363
            ||:..   :..|:|||:|..|:::|||:| :|...|||::.||||...:..|::.|:|:|:||::
 Worm   184 AGFTG---VACTQPRRIACTALARRVAYETLNQYGSEVAFQIRFETTKSQKTKLLFLTEGLLLRQ 245

  Fly   364 IETDFLLSKYSVIILDEAHERSVYTDILVGLLSRIVPLRHKRGQPLKLIIMSATLRVSDFTENTR 428
            :|.|.||.||:||||||.|||.:.:|:|:|||..:...|    ..||||:||||:       |..
 Worm   246 MEKDSLLEKYNVIILDEVHERHLTSDLLIGLLRDLCTKR----DDLKLILMSATI-------NLD 299

  Fly   429 LFK---IPPPLLKVEARQFPVTIHF----------QKRT----PDDYVAEAYRKTLKIHNK---- 472
            |||   ...|:::|..|.||:.:.:          .|:|    |     |.|.|.|::.:|
 Worm   300 LFKGYFEGAPVVQVPGRLFPIDVRWHPIKQFIDQSDKKTHKIDP-----EPYLKILELIDKQFPS 359

  Fly   473 LPEGGILIFVTGQQEVNQLVRKLRRTFPYHHAPTKDVAK--NGKVSEEEKEETIDDAASTVEDPK 535
            ...|..|||:.|..|::.:...|           |:.|:  ||
 Worm   360 TQRGDALIFLNGVAEISMVAEHL-----------KNYAELTNG---------------------- 391

  Fly   536 ELEFDMKRVIRNIRKSKKKFLAQMALPKINLDDYKLPGDDTEADMHEQPDEDDEQEGLEEDNDDE 600
                                                                             
 Worm   392 ----------------------------------------------------------------- 391

  Fly   601 LGLEDESGMGSGQRQPLW-VLPLYSLLSSEKQNRIFLPVPDGCRLCVVSTNVAETSLTIPHIKYV 664
                             | :|.|:|.||.|:|:::|...|.|.|.|::||||||||:||..|::|
 Worm   392 -----------------WIILMLHSTLSVEEQDKVFDQAPVGIRKCILSTNVAETSVTIDGIRFV 439

  Fly   665 VDCGRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPD 729
            :|.|:.....::..||.......:.|||||:||.|||||...|.||||||...: :..:||:..:
 Worm   440 IDSGKVNLIKHEPGTGTQKLTEFWVSKASANQRKGRAGRTGPGICYRLYSQEQF-EKMDDFTVSE 503

  Fly   730 IQKKPVEDLMLQMRC--MGIDRVVHFPFPSPPDQVQLQAAERRLIVLGALEVAKTENTDLPPAVT 792
            |.:..::::.|:|..  :|:|... |||...|.:..|...   |.||....|.:::..|: ..:|
 Worm   504 INRVSLQEMALKMISLNLGLDPRT-FPFIEKPSEDVLNEG---LEVLKFQRVLRSDRGDI-LTLT 563

  Fly   793 RLGHVISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVLIETGVQRDEDVAPGANRFHR- 856
            .||:::|:.||.....|||......:.|...:.:.|.||||              :|..||.:|
 Worm   564 ALGNMVSKLPVEVPIAKMLVYGCVVDELEVMLTVAAGLSVQ--------------SPFTNRSYRE 614

  Fly   857 -----KRQSWAASGNYQLLGDPMVLLRAVGAAEYA---GSQGRLPEFCAANGLRQKAMSEVRKLR 913
                 :|.|..:.     ||||..|:...  .|:.   ..:|....:...||:.:..:.|:.|||
 Worm   615 LEIVERRASLTSP-----LGDPFTLISIF--REWVLQKAFEGTARRWTMENGIDEHRLYEISKLR 672

  Fly   914 V---QLTNEINL--NVSDVELGVDPELKPPTD-AQARFLRQILLAGMGDRVARKVPLAD------ 966
            .   |:..:..|  ..|..|.|.|...:...| .:.|.|..:..:...:...:||..|:
 Worm   673 AQYRQILEDAGLVEKASAAETGEDDSRQRRIDQGEKRKLFDLKKSQRNNDRRQKVLNANKHFDKI 737

  Fly   967 IADKEERRRLKYAYNCADME---EPAFLHVSSVLRQKAPEWVIYQEAYELQN 1015
            :.||||.          |:|   :|....|.:|      |:::..:..:::|
 Worm   738 LEDKEEE----------DLEAEKDPLKADVKTV------EFLLSHKQRDVEN 773

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_476591.1	HrpA	260..>1071	CDD:441249	223/807 (28%)
		DEXHc_DHX37	260..439	CDD:350740	78/182 (43%)
smgl-2	NP_001294374.1	HrpA	143..>694	CDD:441249	204/711 (29%)
		OB_NTP_bind	788..888	CDD:400182