DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kz and mog-1

DIOPT Version :9

Sequence 1:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_499212.1	Gene:	mog-1 / 176409	WormBaseID:	WBGene00003389	Length:	1131	Species:	Caenorhabditis elegans

Alignment Length:	1037	Identity:	280/1037 - (27%)
Similarity:	452/1037 - (43%)	Gaps:	265/1037 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 EKRATKIKVDKVQHVKILSKKQ--RKHLQAIVDKKKKKEGRAQLLGDLAAVQIPEEELQQYTSIS 114
            |||..:.: :|.|..::..|:|  ::..:...:.:..:.|...:..:|:::...|.:..:.|.:
Worm   256 EKREKQWQ-EKTQKPRLTVKQQAIKRENELWENNRLHRSGVVAMADELSSIFEDETDENRVTIL- 318

  Fly   115 QVQTVGLKRLPTLDEYLAKKKERQAQVLAEKSSASGLRVNAIKGS---KRKLLVEEEEELQAKR- 175
             ||.:   ..|.||..:...|:.| .::....:...:.|:|.:||   :::..||:.::.|.|.
Worm   319 -VQNI---VPPFLDGRIVFTKQAQ-PIIPVVDTTCDMAVSAARGSVAVRKRREVEDRKKAQDKHW 378

  Fly   176 -----KNPNVISVEEDDEDSSSSDEDDEEAPAQSAPIAIPTPVSIAPPQIAVKPPIKKLKPEPNP 235
                 |..|::.|:|..::::..::||.....:|...|.....:.|....|::..||:
Worm   379 ELAGSKLGNLMGVKEKKDETADPEDDDSGNYKESHQFASHMKDNEAVSDFAMEKSIKQ------- 436

  Fly   236 PACIHQTVYVPVHRTTEVQNARLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLYEA 300
                 |..|               ||:.|..|::|..|.||.:||:.|||||||||||.|:|.|.
Worm   437 -----QREY---------------LPVFACRQKMMNVIRENNVVIIVGETGSGKTTQLAQYLLED 481

  Fly   301 GYAQHKMIGVTEPRRVAAIAMSKRVAHEMNLP-ESEVSYLIRFEGNVTPATRIKFMTDGVLLKEI 364
            |:....:||.|:||||||:::::|||.||.:. ..:|.|.||||...:..|.||:||||:||:|.
Worm   482 GFGDSGLIGCTQPRRVAAMSVARRVADEMGVDLGQDVGYAIRFEDCTSEKTIIKYMTDGILLREC 546

  Fly   365 ETDFLLSKYSVIILDEAHERSVYTDILVGLLSRIVPLRHKRGQPLKLIIMSATLRVSDFTE---- 425
            ..|..|.:||.||:|||||||:.||:|.|||..::..|    ..||||:.|||:....|.:
Worm   547 LGDGSLDQYSAIIMDEAHERSLNTDVLFGLLREVIAKR----ADLKLIVTSATMDADKFADFFGG 607

  Fly   426 NTRLFKIPPPLLKVEARQFPVTIHFQKRTP-DDYVAEAYRKTLKIHNKLPEGGILIFVTGQQEVN 489
            |...|.||       .|.|||.: |..||| :|||..|.::.:.||....:|.||||:.||:::.
Worm   608 NCPTFTIP-------GRTFPVEL-FHARTPVEDYVDAAVKQAVTIHLGGMDGDILIFMPGQEDIE 664

  Fly   490 QLVRKLRRTFPYHHAPTKDVAKNGKVSEEEKEETIDDAASTVEDPKELEFDMKRVIRNIRKSKKK 554
                                                   .|.|..||
Worm   665 ---------------------------------------CTCEMIKE------------------ 672

  Fly   555 FLAQMALPKINLDDYKLPGDDTEADMHEQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQPLWV 619
                                                         :||..||:       .||.|
Worm   673 ---------------------------------------------KLGELDEA-------PPLAV 685

  Fly   620 LPLYSLLSSEKQNRIFLPVPDGCRLCVVSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAF 684
            ||:||.|.|:.|.:||...|.|.|..:|:||:||||||:..|.:|:|.|..|.::|:...|:.|.
Worm   686 LPIYSQLPSDLQAKIFQRAPGGMRKAIVATNIAETSLTVDGILFVIDPGFCKMKVYNPRIGMDAL 750

  Fly   685 VVTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQMRCMGIDR 749
            .:...|:|||:||.|||||...|.|||||:...:.|.....:.|:||:..:.:::|.::.:|:|.
Worm   751 SIFPVSQASANQRTGRAGRTGPGQCYRLYTERQFKDELLKSTVPEIQRTNLANVVLLLKSLGVDD 815

  Fly   750 VVHFPFPSPPDQVQLQAAERRLIVLGALEVAKTENTDLPPAVTRLGHVISRFPVAPRFGKMLALS 814
            ::.|.|...|.|..:..:..:|..||||     :||.   .:|.:|..:..||:.|...|||.:|
Worm   816 LLKFHFMDAPPQDNMLNSMYQLWTLGAL-----DNTG---QLTPMGRKMVEFPLDPTLSKMLIMS 872

  Fly   815 HQQNLLPYTVCLVAALSVQEVLI-------ETGVQRDEDVAPGAN-----------RFHRKRQSW 861
            .:.......:.:|:.|||..:..       |...::::...|.::           |.|:....|
Worm   873 AEMGCSDEVLTIVSMLSVPAIFFRPKGREEEADAKKEKFQVPESDHLTFLNVYIQWRTHKYSAKW 937

  Fly   862 AASGNYQLLGDPMVLLRAVGAAEYAGSQGRLPEFCAANGLRQKAMSEVRKLRVQLTNEI--NLNV 924
                                              ||.|.|..||:.:||::|.|| .||  :|.:
Worm   938 ----------------------------------CADNYLHVKALKKVREVRAQL-KEIMQDLKL 967

  Fly   925 SDVELGVDPELKPPTDAQARFLRQILLAGMGDRVARKVPLADIADKEERRRLKYAYNCADMEEPA 989
            ..:..|.:.::.......|.|.....|.|:|:.|..:..:                       |.
Worm   968 PLISNGSEWDIVRKCICSAYFHNAARLKGIGEYVNVRTGI-----------------------PC 1009

  Fly   990 FLHVSSVLRQKA--PEWVIYQEAYELQNGDSTKMFIRGITAIEPEWLLLYVPLLCNIREVRE 1049
            |||.:|.|....  |::|:|.|...     :.|.:::.:||::..||....|:..:|:|.::
Worm  1010 FLHPTSALFGMGFMPDYVVYHELIM-----TAKEYMQCVTAVDAIWLAELGPMFYSIKESKQ 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	242/841 (29%)
		DEXDc	279..418	CDD:238005	73/139 (53%)
		P-loop_NTPase	369..>500	CDD:304359	52/135 (39%)
		HELICc	619..704	CDD:197757	40/84 (48%)
		HA2	774..859	CDD:214852	23/102 (23%)
		OB_NTP_bind	915..1039	CDD:285018	27/127 (21%)
mog-1	NP_499212.1	DUF1777	114..>239	CDD:285811
		DEXDc	437..620	CDD:214692	90/208 (43%)
		DEXDc	458..596	CDD:238005	73/141 (52%)
		HELICc	622..778	CDD:238034	71/265 (27%)
		HA2	840..922	CDD:214852	21/89 (24%)
		OB_NTP_bind	956..1056	CDD:285018	27/128 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820