DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kz and rha-2

DIOPT Version :9

Sequence 1:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_498895.1	Gene:	rha-2 / 176207	WormBaseID:	WBGene00015525	Length:	1148	Species:	Caenorhabditis elegans

Alignment Length:	1200	Identity:	471/1200 - (39%)
Similarity:	675/1200 - (56%)	Gaps:	129/1200 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 YDEANALVLPSEKR----------ATKIKVD----KVQHVKILSKKQRKHLQAIVDKKKKKEGRA 91
            ||....:::|.|||          ||..|.:    |.:.|..|:|:.::.|.|:..:|..|:.:.
Worm    15 YDANELMIVPGEKRKKLEKSGEKSATGGKKNRNFAKEKEVAKLTKQAKRKLAAVQSRKALKQTQE 79

  Fly    92 QLLGDLAAVQIPEEELQQYTSISQVQTVGLKRLPTLDEYLAKKKERQAQVLAEKSSASGLRVNAI 156
            :|...||..|:...:|.|.:|.::               |:|:.|: |.|..||     |:|.:.
Worm    80 ELFAGLAEFQLDPSKLCQLSSSTK---------------LSKEPEK-APVFPEK-----LKVFSG 123

  Fly   157 KGSKRKLLVEEEEELQAKRKNPNVISVEEDDEDSSSSDEDDEEAPAQSAPIAIPTPVSIAPPQIA 221
            |           .:.:|||...:....  |||.||..:|::||.............|.|.|..:.
Worm   124 K-----------TKTEAKRTQQDYYPT--DDESSSEEEEEEEEGDNDIEDAGNTVEVKIEPIDLD 175

  Fly   222 VKPPIKKLKPEPN----------------------PPACIHQTVYVPVHRTTEVQNARLRLPILA 264
            .........||.|                      |...:.....|.|.|:.|:|.:|..|||.|
Worm   176 DVDEAIDGNPETNLDQIVVKREDDEESDNEDILALPTTTVINRKKVIVERSKEIQKSRAELPIFA 240

  Fly   265 EEQQVMETINENPIVIVAGETGSGKTTQLPQFLYEAGYA-QHKMIGVTEPRRVAAIAMSKRVAHE 328
            ||.:::|.||||.:.:|.||||||||||:|||||||||| :.::||:|||||||||||::||..|
Worm   241 EEMRIVEAINENLVTVVCGETGSGKTTQIPQFLYEAGYASEGELIGITEPRRVAAIAMAQRVGVE 305

  Fly   329 MNLPESEVSYLIRFEGNVTPATRIKFMTDGVLLKEIETDFLLSKYSVIILDEAHERSVYTDILVG 393
            :..|: ||||.||:||..:..|.|.|||||||:||:|.|.:|.|||||::|||||||:|:|:|:|
Worm   306 LAKPD-EVSYQIRYEGTRSETTNILFMTDGVLMKEMEQDVMLKKYSVILIDEAHERSMYSDVLIG 369

  Fly   394 LLSRIVPLRHKRGQPLKLIIMSATLRVSDFTENTRLFKIPPPLLKVEARQFPVTIHFQKRTPDDY 458
            :||||||||.|..:||:|:|||||||:.|||.......:.|.::||:||||||::||:|||||||
Worm   370 MLSRIVPLRSKTARPLRLVIMSATLRLDDFTHKKLFPLLTPKVIKVDARQFPVSVHFEKRTPDDY 434

  Fly   459 VAEAYRKTLKIHNKLPEGGILIFVTGQQEVNQLVRKLRRTFPYHHAPTKDVAKNGKV----SEEE 519
            :|.|:|||.:||..||.|.||:|||||.||.||:.||::.:|..:    :..|||:|    ::|.
Worm   435 IASAFRKTCRIHETLPPGAILVFVTGQHEVKQLITKLKKRYPVVY----ETDKNGEVLVKGTKEW 495

  Fly   520 KEETIDDAAS-TVED-----PKELEFDMKRVIRNIRKSKKKFLAQMALPKINLDDYKLPGDD-TE 577
            ||:.::.|.| .:||     |:..:|:                        ::||..:.||| .|
Worm   496 KEKKVEAAKSIKLEDFKEETPETEDFE------------------------DVDDGLMDGDDMNE 536

  Fly   578 ADMHEQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQPLWVLPLYSLLSSEKQNRIFLPVPDGC 642
            ....|..|:.:|.|..:.|..|. .:|:..|......:||:.||||||||..||.|:|...|.|.
Worm   537 RGAAEAFDDYEEFENGDGDLSDG-KVENSIGAPPADCEPLYCLPLYSLLSMGKQRRVFDETPAGM 600

  Fly   643 RLCVVSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAG 707
            ||||:||||||||||||.:|||:|.|.:|.||||.:||||.|.|...|:||.|||||||||||||
Worm   601 RLCVISTNVAETSLTIPGVKYVIDGGFEKRRLYDSITGVSRFAVCRISQASGDQRAGRAGRISAG 665

  Fly   708 HCYRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQMRCMGIDRVVHFPFPSPPDQVQLQAAERRLI 772
            |.|||||||||.| |..|:.|:|..||.:.|:|.::.|.|.:||:|||||.||:..|::||:||.
Worm   666 HAYRLYSSAVYQD-FVKFADPEILSKPADQLVLHLKSMNIVKVVNFPFPSAPDEQMLESAEKRLC 729

  Fly   773 VLGALEVAKTENTDLPPAVTRLGHVISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVLI 837
            .||||. ..|:|......:|:||..::.||:||.:.|.:|::.|.||:.:.:.|::.|||:|.||
Worm   730 RLGALS-ESTKNGKTEARITKLGKTLAVFPLAPSYAKFIAMADQHNLMSHAILLISLLSVREPLI 793

  Fly   838 ETGVQR---DEDVAPGANRFHRKRQSWAASGNYQLLGDPMVLLRAVGAAEYAGSQGRLPEFCAAN 899
            .....|   .|:.........::|:.|.:....:.|||..||:.|...||......|   .|...
Worm   794 PVSSLRGDTPEETKELMKNVLKERRRWCSHTGARRLGDLKVLMHAASVAEQIKYNAR---ECEKV 855

  Fly   900 GLRQKAMSEVRKLRVQLTNEINLNV-SDVELGVDPELKPPTDAQARFLRQILLAGMGDRVARKVP 963
            |||.||:.|.||||.||||.:|.:. .:....:|.:|.||||.||:.|||:::|...||:||:|.
Worm   856 GLRVKALVEARKLRQQLTNIVNASCKKEHAAALDSDLPPPTDQQAQLLRQMVVASFSDRLARRVD 920

  Fly   964 LADIADKEERRRLKYAYNCADMEEPAFLHVSSVLRQKAPEWVIYQEAYELQNGDSTKMFIRGITA 1028
            .:  ..:||.:  |.||....::...|:...||:..:.||:|||||..::    :.|..:..:.|
Worm   921 RS--VGQEEVQ--KGAYETTLIKGHVFIDPCSVVFTEEPEFVIYQELVQV----NEKKLMTSVCA 977

  Fly  1029 IEPEWLLLYVPLLCNIREVREDPAPRFDKTSGKIFCHVDATFGKSGWELPLGEVEMPLSEKACCY 1093
            ::.|||.......||..|..::..|.:|.....:...|..|||...||||.....:|.......|
Worm   978 VDKEWLSRLAESYCNYGEQDKNQEPIYDPVKDMVVKTVKVTFGPLNWELPNENRSVPHDIMMYRY 1042

  Fly  1094 FGMFLLDGEVCSRLADFRSKLKSTPASVIKSWSSMNNKVLRFKRALITKQIHNRQALIDQWNSDP 1158
            |.:|||||.|..:|.::..||.:.|::::|||:.:..:.......||.|::..|.:|.:||..:.
Worm  1043 FALFLLDGLVFEKLKEYTPKLLAPPSTMVKSWAKLQKRTEMLLNKLIEKEVTTRSSLKEQWLKNE 1107

  Fly  1159 HFLLEEYQNLLYDVALSELTPLWPPVDKKE 1188
            ::|||||...:.:....:::.:|||::..|
Worm  1108 NWLLEEYLEWVPESVHQQISLMWPPLEDHE 1137

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	379/836 (45%)
		DEXDc	279..418	CDD:238005	92/139 (66%)
		P-loop_NTPase	369..>500	CDD:304359	80/130 (62%)
		HELICc	619..704	CDD:197757	57/84 (68%)
		HA2	774..859	CDD:214852	27/87 (31%)
		OB_NTP_bind	915..1039	CDD:285018	42/124 (34%)
rha-2	NP_498895.1	HrpA	218..989	CDD:224557	374/813 (46%)
		DEXDc	254..394	CDD:238005	92/140 (66%)
		P-loop_NTPase	<350..>477	CDD:304359	77/126 (61%)
		HELICc	577..662	CDD:197757	57/84 (68%)
		HA2	730..822	CDD:214852	29/92 (32%)
		OB_NTP_bind	870..990	CDD:285018	42/127 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159701
Domainoid	1	1.000	202	1.000	Domainoid score	I1749
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6641
Inparanoid	1	1.050	744	1.000	Inparanoid score	I298
Isobase	1	0.950	-	0	Normalized mean entropy	S2229
OMA	1	1.010	-	-		QHG54789
OrthoDB	1	1.010	-	-		D203698at33208
OrthoFinder	1	1.000	-	-		FOG0005033
OrthoInspector	1	1.000	-	-		oto18805
orthoMCL	1	0.900	-	-		OOG6_102322
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1918
SonicParanoid	1	1.000	-	-		X3558
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750