DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kz and ddx-15

DIOPT Version :9

Sequence 1:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_741147.1	Gene:	ddx-15 / 175771	WormBaseID:	WBGene00018967	Length:	739	Species:	Caenorhabditis elegans

Alignment Length:	838	Identity:	254/838 - (30%)
Similarity:	370/838 - (44%)	Gaps:	209/838 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 KLKPEPNPPACIHQTVYVPVHRTTEVQNARLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQ 292
            ::.|..|.|..         :|...:...|.:||:...:::.||.:..|..:.:.||||||||||
Worm    53 QINPYNNQPFS---------NRYWAIWEKRSQLPVWEYKEKFMELLRNNQCITLVGETGSGKTTQ 108

  Fly   293 LPQFLYE------AGY--AQHKMIGVTEPRRVAAIAMSKRVAHEMNLP-ESEVSYLIRFEGNVTP 348
            :||:..|      .|.  .|.:::..|:||||||::::.|||.||::. ..||.|.||||..::.
Worm   109 IPQWAVEFMKQQQQGQPPGQARLVACTQPRRVAAMSVATRVAEEMDVVLGQEVGYSIRFEDCISE 173

  Fly   349 ATRIKFMTDGVLLKEIETDFLLSKYSVIILDEAHERSVYTDILVGLLSRIVPLRHKRGQPLKLII 413
            .|.:|:.|||:||:|.....||.||.|:||||||||::.||||:||:..||    :....:|::|
Worm   174 RTVLKYCTDGMLLREAMNSPLLDKYKVLILDEAHERTLATDILMGLIKEIV----RNRADIKVVI 234

  Fly   414 MSATLRVSDFTENTRLFKIPPPLLKVEARQFPVTIHFQKRTPDDYVAEAYRKTLKIHN-KLPEGG 477
            |||||....|   .|.|: ..|||.|..|.|||.|.|......||:..|.|..::||. :..||.
Worm   235 MSATLDAGKF---QRYFE-DCPLLSVPGRTFPVEIFFTPNAEKDYLEAAIRTVIQIHMVEEVEGD 295

  Fly   478 ILIFVTGQQEVNQLVRKLRRTFPYHHAPTKDVAKNGKVSEEEKEETIDDAASTVEDPKELEFDMK 542
            ||:|:|||:|:.:.                                                 .|
Worm   296 ILLFLTGQEEIEEA-------------------------------------------------CK 311

  Fly   543 RVIRNIRKSKKKFLAQMALPKINLDDYKLPGDDTEADMHEQPDEDDEQEGLEEDNDDELGLEDES 607
            |:.|.|:          ||           |.|..|
Worm   312 RIDREIQ----------AL-----------GADAGA----------------------------- 326

  Fly   608 GMGSGQRQPLWVLPLYSLLSSEKQNRIFLPVPDG------CRLCVVSTNVAETSLTIPHIKYVVD 666
                     |..:||||.|....|.|||.|.|..      .|.||:|||:|||||||..:.:|:|
Worm   327 ---------LSCIPLYSTLPPAAQQRIFEPAPPNRPNGAISRKCVISTNIAETSLTIDGVVFVID 382

  Fly   667 CGRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQ 731
            .|..|.::|:....|.:.:|...|||||.||||||||...|.|:|||:...|....:|.:.|:|.
Worm   383 PGFSKQKVYNPRIRVESLLVCPISKASAMQRAGRAGRTKPGKCFRLYTETAYGSEMQDQTYPEIL 447

  Fly   732 KKPVEDLMLQMRCMGIDRVVHFPFPSPPDQVQLQAAERRLIVLGALEVAKTENTDLPPAVTRLGH 796
            :..:..::||::.:|.:.:|||.|..||      |.|..:..|..|...:..|.|  ..:|.||.
Worm   448 RSNLGSVVLQLKKLGTEDLVHFDFMDPP------APETLMRALELLNYLQAINDD--GELTELGS 504

  Fly   797 VISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVLIETGVQRDEDVAPGANRFHRKRQSW 861
            :::.||:.|:..|||..|.:.|.....:.:.|.|||.:..:.....|.|.....|...|
Worm   505 LMAEFPLDPQLAKMLITSTELNCSNEILSITAMLSVPQCWVRPNEMRTEADEAKARFAH------ 563

  Fly   862 AASGNYQLLGDPMVLLRAVGAAEYAGSQGRLPEFCAANGLRQKAMSEVRKLRVQLT---NEINLN 923
                   :.||.:.||....:.:.....   |::|..|.:..:.|.....:|.||:   ::.||.
Worm   564 -------IDGDHLTLLNVYHSFKQNQED---PQWCYDNFINYRTMKTADTVRTQLSRVMDKYNLR 618

  Fly   924 VSDVELGVDPELKPPTDAQAR----FLRQILLAGMGDRVA---RKVPLADIADKEERRRLKYAYN 981
                        :..||.::|    .:|:.|:||...:||   |......:.|.:       ..|
Worm   619 ------------RVSTDFKSRDYYLNIRKALVAGFFMQVAHLERSGHYVTVKDNQ-------LVN 664

  Fly   982 CADMEEPAFLHVSSVLRQKAPEWVIYQEAYELQNGDSTKMFIRGITAIEPEWLLLYVP 1039
                     ||.|:||..| |||.:|.| :.|    :||.|||.:|.:.|||||...|
Worm   665 ---------LHPSTVLDHK-PEWALYNE-FVL----TTKNFIRTVTDVRPEWLLQIAP 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	251/829 (30%)
		DEXDc	279..418	CDD:238005	68/147 (46%)
		P-loop_NTPase	369..>500	CDD:304359	56/131 (43%)
		HELICc	619..704	CDD:197757	43/90 (48%)
		HA2	774..859	CDD:214852	23/84 (27%)
		OB_NTP_bind	915..1039	CDD:285018	39/133 (29%)
ddx-15	NP_741147.1	Motor_domain	41..>106	CDD:277568	16/61 (26%)
		DEXDc	70..266	CDD:214692	87/203 (43%)
		DEXDc	95..239	CDD:238005	68/147 (46%)
		HELICc	327..419	CDD:197757	43/91 (47%)
		HA2	489..572	CDD:214852	23/97 (24%)
		OB_NTP_bind	607..709	CDD:285018	40/135 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920