Protein Alignment kz and rha-1

DIOPT Version :10

• Sequence 1: NP_476591.1
• Gene: kz / 31205
• FlyBaseID: FBgn0001330
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: NP_495890.2
• Gene: rha-1 / 174417
• WormBaseID: WBGene00004355
• Length: 1301
• Species: Caenorhabditis elegans
• Alignment Length: 1234
• Identity: 274/1234 - (22%)
• Similarity: 482/1234 - (39%)
• Gaps: 332/1234 - (26%)

  Fly    68 ILSKKQRKHLQAIVDKKKKKEG-------RAQLLGDLAAVQIPE----EELQQYTSISQVQTVGL 121
            |..|.:.......||.|.:..|       :..|...|..:::|:    .::::..::..::|...
 Worm   144 ITQKAEEIAASETVDLKSEIHGGWTMENSKKALNEFLQKMRLPQVNYGTKIRESNTVKTMETTAQ 208

  Fly   122 KRLPTLDEYLAKKKERQAQVLAEKSSASGL-----RVNAIK---GSKRKLLVEEEEELQAKRKNP 178
            ..:|.:::.|..|.....:.::|.:.|..:     .:|.::   |..:|..|....|:
 Worm   209 IFVPQINKNLVGKGTGSNKKVSEAACAMNIVRQMFHLNIMQSYSGPIKKSKVSTLPEI------- 266

  Fly   179 NVISVEEDDEDSSSS---------DEDDEEAPAQSAPIAIPTPVSIA---------PPQIAVKPP 225
             .||:.||.....:.         .|.:|.:....||.::.|.|.:|         ...|:..||
 Worm   267 -AISIPEDLSTRVTEYVRSCGLELPEINETSATPEAPTSLLTDVKLAQFPVSEICSASNISWAPP 330

  Fly   226 IKKLKP------EPNPPAC-----IHQTV-----YVPVHRTTEVQNARLRLPILAEEQQVMETIN 274
            ::...|      :..|.|.     |.|.:     :.......::...|..||:....:.:::|:.
 Worm   331 LQNWNPWRASNIDEEPLAFMSMEQISQRIMEKEDFKRGEALDKITAQRGELPVAQYRENIVQTVA 395

  Fly   275 ENPIVIVAGETGSGKTTQLPQFLYE-----AGYAQHKMIGVTEPRRVAAIAMSKRVAHEMNLPES 334
            ||.:.::.||||.||:||:.|||.|     :..|....: |::|||::||::::|||:|......
 Worm   396 ENRVTLIKGETGCGKSTQVAQFLLESFLENSNGASFNAV-VSQPRRISAISLAERVANERGEEVG 459

  Fly   335 EV-SYLIRFEGNVTPAT--RIKFMTDGVLLKEIETDFLLSKYSVIILDEAHERSVYTDILVGLLS 396
            |. .|.:||: :.||..  .|.|.|.||||:.:|..  |...|.:|:||.|||.|.||.::.:|.
 Worm   460 ETCGYNVRFD-SATPRPYGSIMFCTVGVLLRMMENG--LRGISHVIIDEIHERDVDTDFVLIVLR 521

  Fly   397 RIVPLRHKRGQPLKLIIMSATLRVSDFTENTRLFKI-----PPPLLKVEARQFPVTIHFQKRTPD 456
            .::    ...:.|::::||||:....|   |..|..     |.|::.:..|.|||...:.:..
 Worm   522 EMI----STYRDLRVVLMSATIDTDLF---TNFFSSIPDVGPTPVITMHGRTFPVQSFYLEDI-- 577

  Fly   457 DYVAEAYRKTLKIHN--KLPEGGILIFVTGQQEVNQLVRKLRRTFPYHHAPTKDVAKNGKVSEEE 519
                        :||  .:||           |.:|  :|.::..|    |..|        ::|
 Worm   578 ------------LHNLQHMPE-----------EPDQ--KKRKKGGP----PPPD--------DDE 605

  Fly   520 KEETIDDAA---STVEDPKELEFDMKRVIRNIRKSKKKFLAQMALPKINLDDYKLPGDDTEADMH 581
            .:|.:||..   :.:.||            :|.:|.|     .|:.:|:..|  :|....||.::
 Worm   606 GDEEVDDKGRNMNILTDP------------SINESLK-----TAMSRISEKD--IPFGVIEAILN 651

  Fly   582 EQPDEDDEQEGLEEDNDDELG-------------------LEDESGMGSGQRQPLWVLPLYSLLS 627
                 |....|::       |                   ||.:.   .||.....:|||:|.|:
 Worm   652 -----DIASRGVD-------GAVLVFLPGWAEIMTLCNRLLEHQE---FGQANKYEILPLHSQLT 701

  Fly   628 SEKQNRIFLPVPDGCRLCVVSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFVVTYTSKA 692
            |::|.::|...| |.|..:||||:||||:||..:.||:|..:.|.|:|.....:..|...:.||.
 Worm   702 SQEQRKVFNHYP-GKRKIIVSTNIAETSITIDDVVYVIDSCKAKERMYTSNNNMVHFATVWASKT 765

  Fly   693 SADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQMRCMGIDRVVHF--PF 755
            :..||.|||||:.||:.:.|.|...: :..:|....::.:.|:..:.|.::.:.:..|..|  ..
 Worm   766 NVIQRRGRAGRVRAGYAFHLCSKMRF-EALDDHGTAEMLRIPLHQIALTIKLLRLGSVGEFLGKA 829

  Fly   756 PSPPDQVQLQAAERRLIVLGALEVAKTENTDLPPAVTRLGHVISRFPVAPRFGKMLALSHQQNLL 820
            ..||....:..:|..|..:|||:    .|.:|    |.||.:::|.|:.|...|:|.|.
 Worm   830 LQPPPYDMVVESEAVLQAMGALD----RNLEL----TSLGKMLARMPIEPVIAKVLILG------ 880

  Fly   821 PYTVCLVAALSVQEVLIETG---------VQRDEDVAPGANRFHRKRQSWAA---SGNYQLLGDP 873
                   .||....|:.:..         |.|::         |..|.|...   :||  ...|.
 Worm   881 -------TALGAGSVMCDVASAMSFPTPFVPREK---------HHSRLSGTQRKFAGN--KFSDH 927

  Fly   874 MVLLRAVGA---AEYAGSQGRLPEFCAANGLRQKAMSEVRKLRVQLTNEINLNVS---DVELGVD 932
            :.::..:..   |...|:.....|||....|....:......|.||.:.:....|   |:...:.
 Worm   928 VAIVSVIQGYREAVQMGASAAEREFCERYSLSNPVLKMTDGARRQLIDVLRNQCSFPEDILFDIS 992

  Fly   933 PELKPPTDAQARFLRQILLAGMGDRVARKVPLADIADKEERRRL--KYAY-----NCADMEEPAF 990
            ..:..| |.:...:|.:|:..:...||..|....:...|:...|  ||:.     |..:|:.|:.
 Worm   993 VNVNGP-DRELNLMRSLLVMALYPNVAYYVGKRKVLTIEQSSALINKYSMLVPMNNRQEMDFPSP 1056

  Fly   991 LHVSSVLRQKAPEWVIYQEAYELQNGDSTKMFIRGITAIEPEWLLLYVPLLCNIREVREDPAPRF 1055
            |             :::.|....:.....:|.:  |:||:   ||::
 Worm  1057 L-------------LVFTEKVRTRCISCKQMSV--ISAIQ---LLVF------------------ 1085

  Fly  1056 DKTSGKIFCHVDATFGKSGWELPLGEVEMPLSEKACCYFGMFLLDGEVCSRLADFRSKLKSTPAS 1120
              .|.|:.|              :||             |:..:|..:..|:.      .||.|:
 Worm  1086 --GSRKVEC--------------VGE-------------GLVRIDETITIRMN------VSTAAA 1115

  Fly  1121 VIKSWSSMNNKVLRFKRALITKQIHNRQALIDQWNSDPHFLLEEYQNLLYDVA----LSELTPL 1180
            :|.....:        .||:.|...|.::|.....||     .|.:.||.|::    :||..|:
 Worm  1116 LIGLRPCI--------EALLVKSCENPESLAGLNPSD-----AELRQLLRDISSEEFMSEAGPI 1166

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_476591.1	HrpA	260..>1071	CDD:441249	211/874 (24%)
		DEXHc_DHX37	260..439	CDD:350740	64/191 (34%)
rha-1	NP_495890.2	DSRM_DHX9_rpt1	4..73	CDD:380683
		DSRM_DHX9_rpt2	169..244	CDD:380684	9/74 (12%)
		DEAD-like_helicase_N	325..562	CDD:475120	73/247 (30%)
		HrpA	380..>897	CDD:441249	167/623 (27%)
		OB_NTP_bind	1005..1087	CDD:400182	20/119 (17%)