DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kz and mog-5

DIOPT Version :9

Sequence 1:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_495019.1	Gene:	mog-5 / 173920	WormBaseID:	WBGene00003393	Length:	1200	Species:	Caenorhabditis elegans

Alignment Length:	1158	Identity:	301/1158 - (25%)
Similarity:	476/1158 - (41%)	Gaps:	317/1158 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RQNPQTIVDNSAVK--KIQIDVDAVAGGNQVGYDEANALVLPSEKRATKIKVDKVQHVKI-LSKK 72
            ||..:.:|..|.::  ::|...|.:..|..|                 |:||:|:::.|| ||.|
Worm   257 RQKQEGLVHISQIRNERVQTVADVLKRGENV-----------------KVKVNKIENGKISLSMK 304

  Fly    73 QRKHLQAIVDKKKKKE---------------------------------------------GRAQ 92
            :       ||:...::                                             |:|:
Worm   305 E-------VDQNSGEDLNPRETDLNPDAIGVRPRTPPASTSSWMNPEASGVGQGPSTSIGGGKAR 362

  Fly    93 L---------------LGDLAAVQIP--EEE---LQQYTSISQVQTVGLKRLPTLDEYLAKKKER 137
            :               .|.|.|..:|  :||   |:.|...|..:.:.::.:....::|....:.
Worm   363 VRISTPERWELRQMQGAGVLTATDMPDFDEEMGVLRNYDDESDGEDIEIELVEDEPDFLRGYGKG 427

  Fly   138 QAQV----LAEKSSASGLRVNAIKGSKRKLLVEEEEELQAKRKNPNVISVEEDDEDSSSSDEDDE 198
            .|::    :.:....|..:...::|:..|  ..:|.::||:|:.                |.|.:
Worm   428 GAEIEPVKVVKNPDGSLAQAALMQGALSK--ERKETKIQAQRER----------------DMDTQ 474

  Fly   199 EAPAQSAPIAIPTPVSIAPPQIAVKPPIKKLKPEPNPPACIHQTV--YVPVHRTTEVQNARLR-- 259
            :..:.:|.|..|...:.:....|.:...:..|.:..|....|.|.  .....|.|.:.....|
Worm   475 KGFSSNARILDPMSGNQSTAWSADESKDRNNKMKEMPEWLKHVTAGGKATYGRRTNLSMVEQRES 539

  Fly   260 LPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLYEAGYAQHKMIGVTEPRRVAAIAMSKR 324
            |||.|.::.:||.:.:|.|::|.||||||||||:.|:..|||..:...||.|:||||||::::||
Worm   540 LPIFALKKNLMEAMIDNQILVVVGETGSGKTTQMTQYAIEAGLGRRGKIGCTQPRRVAAMSVAKR 604

  Fly   325 VAHEMNLP-ESEVSYLIRFEGNVTPATRIKFMTDGVLLKEIETDFLLSKYSVIILDEAHERSVYT 388
            ||.|.... .::|.|.||||...:..|.||:||||:||:|...|..||.||:|:|||||||:::|
Worm   605 VAEEYGCKLGTDVGYTIRFEDCTSQDTIIKYMTDGMLLRECLIDPDLSGYSLIMLDEAHERTIHT 669

  Fly   389 DILVGLLSRIVPLRHKRGQP-LKLIIMSATLRVSDFTENTRLFKIPPPLLKVEARQFPVTIHFQK 452
            |:|.|||....     |.:| |||||.||||....|:|    :.:..|:..:..|.|||.|.:.:
Worm   670 DVLFGLLKAAA-----RKRPELKLIITSATLDSVKFSE----YFLEAPIFTIPGRTFPVEILYTR 725

  Fly   453 RTPDDYVAEAYRKTLKIHNKLPEGGILIFVTGQQEVNQLVRKLRRTFPYHHAPTKDVAKNGKVSE 517
            ....||:..|:...::||...|.|.:|:|:|||:|:
Worm   726 EPESDYLEAAHITVMQIHLTEPPGDVLVFLTGQEEI----------------------------- 761

  Fly   518 EEKEETIDDAASTVEDPKELEFDMKRVIRNIRKSKKKFLAQMALPKINLDDYKLPGDDTEADMHE 582

Worm   762 ----------------------------------------------------------------- 761

  Fly   583 QPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQPLWVLPLYSLLSSEKQNRIFLPVPDGCRLCVV 647
                         |...|:..|....||....: |.:||:|..|.||.|.|||.|.|.|.|..|:
Worm   762 -------------DTSCEVLYERMKSMGPDVPE-LIILPVYGALPSEMQTRIFDPAPAGKRKVVI 812

  Fly   648 STNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYRL 712
            :||:|||||||..|.||||.|..|.::|:..:|:.:.|||..|:|:|.||:|||||...|.||||
Worm   813 ATNIAETSLTIDGIFYVVDPGFVKQKIYNPKSGMDSLVVTPISQAAAKQRSGRAGRTGPGKCYRL 877

  Fly   713 YSSAVYNDCFEDFSQPDIQKKPVEDLMLQMRCMGIDRVVHFPFPSPPDQVQLQAAERRLIVLGAL 777
            |:...:.|.......|:||:..:...:||::.|||:.::.|.|...|....:..|...|..|.||
Worm   878 YTERAFRDEMLPTPVPEIQRTNLASTLLQLKAMGINNLIDFDFMDAPPLDSMITALNTLHTLSAL 942

  Fly   778 EVAKTENTDLPPAVTRLGHVISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVLIETGVQ 842
                    |....:|:||..::.||:.|...|:|.:|.........:.:||.|:||.:......:
Worm   943 --------DGDGLLTKLGRRMAEFPLEPSLSKLLIMSVDLGCSEEVLTIVAMLNVQNIFYRPKEK 999

  Fly   843 RDEDVAPGANRFHRKRQSWAASGNYQLLGDPMVLLRAVGA-AEYAGSQGRLPEFCAANGLRQKAM 906
            :|......| :||:..            ||.:.||....: ..:..||    .:|..|.::.::|
Worm  1000 QDHADQKKA-KFHQPE------------GDHLTLLAVYNSWKNHHFSQ----PWCFENFIQVRSM 1047

  Fly   907 SEVRKLRVQLTNEINLNVSDVELGVDPELKPPTDAQARFLRQILLAGMGDRVAR--KVPLADIAD 969
            ...:.:|.||     |.:.|                   ..::|:...|..|:|  |...:....
Worm  1048 KRAQDIRKQL-----LGIMD-------------------RHKLLMVSCGRDVSRVQKAICSGFFR 1088

  Fly   970 KEERRRLKYAYNCADMEEPAFLHVSSVLRQKAPEWVIYQEAYELQNGDSTKMFIRGITAIEPEWL 1034
            ...:|..:..|......:..::|.||...|:.||||:|.|...     :||.::|.:|||:|:||
Worm  1089 NAAKRDPQEGYRTLTDGQNVYIHPSSACFQQQPEWVVYHELVM-----TTKEYMREVTAIDPKWL 1148

  Fly  1035 LLYVPLLCNI----------REVREDPAPRFDKTSGKIFCHVDATFGKSGWEL 1077
            :.:.|....|          |..:.||.  |||       :.||    :.|.:
Worm  1149 VEFAPSFFKIGDSTKLSTFKRNQKIDPL--FDK-------YADA----NAWRI 1188

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	250/839 (30%)
		DEXDc	279..418	CDD:238005	73/140 (52%)
		P-loop_NTPase	369..>500	CDD:304359	50/131 (38%)
		HELICc	619..704	CDD:197757	45/84 (54%)
		HA2	774..859	CDD:214852	22/84 (26%)
		OB_NTP_bind	915..1039	CDD:285018	30/125 (24%)
mog-5	NP_495019.1	S1_DHX8_helicase	234..311	CDD:240189	19/77 (25%)
		DEXDc	534..721	CDD:214692	91/195 (47%)
		DEXDc	557..695	CDD:238005	74/142 (52%)
		HELICc	766..870	CDD:197757	51/104 (49%)
		HA2	939..1021	CDD:214852	24/102 (24%)
		OB_NTP_bind	1055..1154	CDD:285018	30/127 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820