DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kz and let-355

DIOPT Version :9

Sequence 1:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_491604.3	Gene:	let-355 / 172199	WormBaseID:	WBGene00020263	Length:	856	Species:	Caenorhabditis elegans

Alignment Length:	1017	Identity:	264/1017 - (25%)
Similarity:	422/1017 - (41%)	Gaps:	240/1017 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 KKQRKHLQAIVDKKK-KKEGRAQLLGDLAAVQIPEEELQQYTSISQVQTVGLKRLPTLDEYLAKK 134
            ||:::..|...|.|| |....||:...|...::.....|......:.|.:...:..|:   |.||
Worm    11 KKKKRKFQIDKDGKKIKPNPGAQISKILQNGKVNGNSRQTGGQEQKFQNLEALKKKTM---LLKK 72

  Fly   135 KERQAQVLAEKSSASGLRVNAIKGSKRKLLVEEEEELQAK--RKNPNVISVEEDDEDSSSSDEDD 197
            |::|....                       ::||||.:.  |....::..|:..|.::.|.:..
Worm    73 KKKQMNNF-----------------------QKEEELLSSTFRITNGILKKEKKIEVTTISTQTP 114

  Fly   198 EEAPAQSAPIAIPTPVSIAPPQIAVKPPIKKLKPEPNPPACIHQTVYVPVHRTTEVQNARLRLPI 262
            ::.|  ..||:.|:....|.|....|....:..|              |.......:.:|.:|||
Worm   115 KKLP--KTPISTPSNSKNATPMSTRKHSSSQQSP--------------PHFEANYEKFSRPQLPI 163

  Fly   263 LAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLYEAGYAQHKMIGVTEPRRVAAIAMSKRVAH 327
            .|.|||:|..:.....:||.|||||||:||:||....||.|....|.||:|||||||:::.|||.
Worm   164 DAVEQQLMYELASQETLIVIGETGSGKSTQVPQLCVRAGIANSGSIAVTQPRRVAAISLASRVAT 228

  Fly   328 EM--NLPESEVSYLIRFEGNVTPATRIKFMTDGVLLKEIETDFLLSKYSVIILDEAHERSVYTDI 390
            ||  |: ...|.|.:|||......|:|::||||::|::.....||.|||.:|:|||||||:::|:
Worm   229 EMGTNI-GGIVGYHVRFENATCHKTKIEYMTDGIVLRKALVSPLLDKYSCVIIDEAHERSLHSDV 292

  Fly   391 LVGLLSRIVPLRHKRGQPLKLIIMSATLRVSDFTENTRLFKIPPPLLKVEARQFPVTI-HFQKR- 453
            |:.:|.:....|.:...||:||||||||:...|.......|:    :.|..|.||:.: |...:
Worm   293 LMCILRQCQDQRRETNNPLRLIIMSATLQAEKFQSYFNNAKV----VLVAGRTFPIEVFHVNPKI 353

  Fly   454 ----TPDDYVAEAYRKTLKIHNKLPEG-GILIFVTGQQEVNQLVRKLRRTFPYHHAPTKDVAKNG 513
                :..|||..|......:|...|:| .||:|:||.:|:..:..:|...             ||
Worm   354 NKSFSSTDYVYNAVICVKYVHLTEPKGRDILVFLTGSEEIEAVASQLAEL-------------NG 405

  Fly   514 KVSEEEKEETIDDAASTVEDPKELEFDMKRVIRNIRKSKKKFLAQMALPKINLDDYKLPGDDTEA 578
                                                          :||             ..|
Worm   406 ----------------------------------------------SLP-------------ASA 411

  Fly   579 DMHEQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQPLWVLPLYSLLSSEKQNRIFLPVPDGCR 643
            |:                                    |..:|||:.|..|||...|...|.|.|
Worm   412 DV------------------------------------LMPVPLYAALRPEKQKEAFRKTPQGAR 440

  Fly   644 LCVVSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGH 708
            ..::|||:||||:|||.|:.|:|.|:.||:.::....:....|...|||.|.||||||||.:.|.
Worm   441 KVIISTNIAETSVTIPGIRVVIDSGKVKTKRFEAFNRIDVLKVHNVSKAQAKQRAGRAGRDAPGK 505

  Fly   709 CYRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQMRCMGIDRVVHFPFPSPPDQVQLQAAERRLIV 773
            ||||||...::. ||..:.|:|.:..:....|::..:|:..........||:...:.||...|..
Worm   506 CYRLYSREDFHK-FEAENMPEILRCNLSATFLELMKLGMKNPHRLKLIDPPETDNINAALLELTS 569

  Fly   774 LGALEVAKTENTDLPPAVTRLGHVISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVLIE 838
            |||:....::.:..  |:|.:|.....:|:.|...::|..:.::..:...:.:|||:....:...
Worm   570 LGAIRPVNSDRSKF--ALTEMGDAFCMYPLPPDHARILFQAQKEGCIMEAIKIVAAMQTDALFSG 632

  Fly   839 TGVQR-DEDVAPGANRFHRKRQSWAASGNYQLLGDPMVLLRAVGAA-EYAGSQGRLPEFCAANGL 901
            .|..: |.||.....||..:.            ||.:.||:.|... ::.....:..|..|..|.
Worm   633 AGDSKSDADVDRIRRRFETRE------------GDHITLLKLVLVTNQFFDQLNKKTESDARYGK 685

  Fly   902 RQKAMSE-----VRKL-RVQLTNEINLNVSDVELGVDPELKPPTDAQ--------ARF--LRQIL 950
            ..|::..     :||. ...:.||.:|..:.:   ::.:||.....|        |.|  :|:.|
Worm   686 ANKSLEREYNQTIRKFCNDNMINEQHLKTASM---IEEQLKQIAIEQKVTFSTCGADFMKMRKAL 747

  Fly   951 LAGM------GDRVARKVPLADIADKEERRRLKYAYNCADMEEPAF---LHVSSVLRQKAPEWVI 1006
            ..||      .||            :|:|.||        |..||.   :|.||.|.:..|.:::
Worm   748 ALGMFLNSCEYDR------------QEDRYRL--------MINPAITLKIHPSSCLSRSKPAYIV 792

  Fly  1007 YQEAYELQNGDSTKMFIRGITAIEPEWLLLYVPLLCNIREVR 1048
            :.|..:     :..:|...:|.|:.:|:.   ||:.:.:::|
Worm   793 FSELMK-----TNDLFALQVTLIDGDWVR---PLISDHKKMR 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	230/848 (27%)
		DEXDc	279..418	CDD:238005	69/140 (49%)
		P-loop_NTPase	369..>500	CDD:304359	48/137 (35%)
		HELICc	619..704	CDD:197757	39/84 (46%)
		HA2	774..859	CDD:214852	18/85 (21%)
		OB_NTP_bind	915..1039	CDD:285018	31/142 (22%)
let-355	NP_491604.3	HrpA	149..>800	CDD:224557	222/806 (28%)
		DEXDc	180..320	CDD:238005	69/140 (49%)
		Helicase_C	383..500	CDD:278689	52/224 (23%)
		HA2	569..660	CDD:214852	20/104 (19%)
		OB_NTP_bind	712..822	CDD:285018	31/140 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820