DRSC/TRiP Functional Genomics Resources

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Protein Alignment kz and DHX36

DIOPT Version :9

Sequence 1:NP_001284815.1 Gene:kz / 31205 FlyBaseID:FBgn0001330 Length:1192 Species:Drosophila melanogaster
Sequence 2:NP_065916.2 Gene:DHX36 / 170506 HGNCID:14410 Length:1008 Species:Homo sapiens


Alignment Length:1019 Identity:244/1019 - (23%)
Similarity:428/1019 - (42%) Gaps:242/1019 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    84 KKKKEGRAQLLGDLAAVQIPEEELQQYTSISQVQTVGLKRLPTLDEYLAKK-KERQAQV--LAEK 145
            :|.||...|   :.|.|.:.|...:|...:             |:...||. ||.:||:  .|.:
Human    72 QKNKEAERQ---ERAVVHMDERREEQIVQL-------------LNSVQAKNDKESEAQISWFAPE 120

  Fly   146 SSASGLRVNA--IKGSKRKLLVEEEEELQAKRKNPNVISVEEDDEDSSSSDEDDEEAPAQSAPIA 208
            ....|..|:.  ...|:.||.::|::.:..::|...:.:....|.||....:::|          
Human   121 DHGYGTEVSTKNTPCSENKLDIQEKKLINQEKKMFRIRNRSYIDRDSEYLLQENE---------- 175

  Fly   209 IPTPVSIAPPQIAVKPPIKKLKPEPNPPACIHQTVYVPVHRTTEVQNARLRLPILAEEQQVMETI 273
                    |.....:..::.|:.:.|.            .|..|:|:.|.:||....:::::..|
Human   176 --------PDGTLDQKLLEDLQKKKND------------LRYIEMQHFREKLPSYGMQKELVNLI 220

  Fly   274 NENPIVIVAGETGSGKTTQLPQFL----YEAGYAQHKMIGVTEPRRVAAIAMSKRVAHEMNLPES 334
            :.:.:.:::||||.|||||:.||:    .|.|......|..|:|||::||::::|||.|.  .||
Human   221 DNHQVTVISGETGCGKTTQVTQFILDNYIERGKGSACRIVCTQPRRISAISVAERVAAER--AES 283

  Fly   335 -----EVSYLIRFEGNVTPATR--IKFMTDGVLLKEIETDFLLSKYSVIILDEAHERSVYTDILV 392
                 ...|.||.:..: |..:  |.:.|.|::|:.:::|..||..|.|:|||.|||::.:|:|:
Human   284 CGSGNSTGYQIRLQSRL-PRKQGSILYCTTGIILQWLQSDPYLSSVSHIVLDEIHERNLQSDVLM 347

  Fly   393 GLLSRIVPLRHKRGQPLKLIIMSATLRVSDFTE---NTRLFKIPPPLLKVEARQFPVTIHFQKRT 454
            .::..::..|    ..||:|:|||||....|:|   |.       |::.:....|||.       
Human   348 TVVKDLLNFR----SDLKVILMSATLNAEKFSEYFGNC-------PMIHIPGFTFPVV------- 394

  Fly   455 PDDYVAEAYRKTLKIHNKLPEGGILIFVTGQQEVNQLVRKLRRTFPYHHAPTKDVAKNGKVSEEE 519
              :|:.|...:.::            :|..|:|              |.:..|.....|.|:.:|
Human   395 --EYLLEDVIEKIR------------YVPEQKE--------------HRSQFKRGFMQGHVNRQE 431

  Fly   520 KEE-----------------------TIDDAASTVEDPKELEFDMKRVIRNIRKSKKKFLAQMAL 561
            |||                       |: |....:||.|   .|:..::..||            
Human   432 KEEKEAIYKERWPDYVRELRRRYSASTV-DVIEMMEDDK---VDLNLIVALIR------------ 480

  Fly   562 PKINLDDYK------LPGDDTEADMHEQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQPLWVL 620
             .|.|::..      |||.|..:.:|   |....|...:.|.                   ..::
Human   481 -YIVLEEEDGAILVFLPGWDNISTLH---DLLMSQVMFKSDK-------------------FLII 522

  Fly   621 PLYSLLSSEKQNRIFLPVPDGCRLCVVSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFV 685
            ||:||:.:..|.::|...|.|.|..|::||:||||:||..:.||:|.|:.|...:|....:|...
Human   523 PLHSLMPTVNQTQVFKRTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMS 587

  Fly   686 VTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQMRCMGIDRV 750
            ..:.|||:|.||.|||||:..||||.|| :.:.....:|:..|:|.:.|:|:|.||::.:.:..:
Human   588 AEWVSKANAKQRKGRAGRVQPGHCYHLY-NGLRASLLDDYQLPEILRTPLEELCLQIKILRLGGI 651

  Fly   751 VHF--PFPSPPDQVQLQAAERRLIVLGALEVAKTENTDLPPAVTRLGHVISRFPVAPRFGKMLAL 813
            .:|  ....||....:..:.|.|:.|.||:  |.|.      :|.||..::|.||.|..|||:..
Human   652 AYFLSRLMDPPSNEAVLLSIRHLMELNALD--KQEE------LTPLGVHLARLPVEPHIGKMILF 708

  Fly   814 SHQQNLLPYTVCLVAALSVQE-VLIETGVQRDEDVAPGANRFHRKRQSWAASGNYQLLGDPMVLL 877
            ......|...:.:.|:||.:: .:|..|.::..|.         :|:..|....    .|.:.::
Human   709 GALFCCLDPVLTIAASLSFKDPFVIPLGKEKIADA---------RRKELAKDTR----SDHLTVV 760

  Fly   878 RAVGAAEYAGSQGRLPE--FCAANGLRQKAMSEVRKLRVQLTNEINLNVSDVELGV--------- 931
            .|....|.|..:|...|  :|....|....:..:..::.|....:        ||.         
Human   761 NAFEGWEEARRRGFRYEKDYCWEYFLSSNTLQMLHNMKGQFAEHL--------LGAGFVSSRNPK 817

  Fly   932 DPELKPPTDAQARFLRQILLAGMGDRVARKVPLADIADKEERRRLKYAYNCADMEEPAFLHVSSV 996
            |||....:|.: :.::.::.||:..:|| |:.|    :..::|::...|...|  ....:|..||
Human   818 DPESNINSDNE-KIIKAVICAGLYPKVA-KIRL----NLGKKRKMVKVYTKTD--GLVAVHPKSV 874

  Fly   997 LRQKAP---EWVIYQEAYELQNGDSTKMFIRGITAIEPEWLLLY 1037
            ..::..   .|:||.....     ::.:::...|.:.|..||.:
Human   875 NVEQTDFHYNWLIYHLKMR-----TSSIYLYDCTEVSPYCLLFF 913

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kzNP_001284815.1 HrpA 237..1058 CDD:224557 214/861 (25%)
DEXDc 279..418 CDD:238005 54/149 (36%)
P-loop_NTPase 369..>500 CDD:304359 33/133 (25%)
HELICc 619..704 CDD:197757 35/84 (42%)
HA2 774..859 CDD:214852 22/85 (26%)
OB_NTP_bind 915..1039 CDD:285018 26/135 (19%)
DHX36NP_065916.2 Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000269|PubMed:18279852 1..200 31/173 (18%)
Required for the pre-miR-134 transport. /evidence=ECO:0000250|UniProtKB:D4A2Z8 1..104 9/47 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..58
Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000269|PubMed:18854321 1..51
Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000269|PubMed:21149580, ECO:0000269|PubMed:21846770, ECO:0000269|PubMed:24151078 53..105 9/48 (19%)
DSM (DHX36-specific motif). /evidence=ECO:0000269|PubMed:20472641, ECO:0000269|PubMed:22238380, ECO:0000269|PubMed:24369427, ECO:0000269|PubMed:26195789, ECO:0000269|PubMed:26649896 53..75 1/2 (50%)
RecA-like domain 1. /evidence=ECO:0000250|UniProtKB:Q05B79 106..386 86/323 (27%)
DEXDc 210..392 CDD:214692 61/195 (31%)
DEXDc 224..369 CDD:238005 54/151 (36%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 265..317 17/54 (31%)
DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541 334..337 2/2 (100%)
RecA-like domain 2. /evidence=ECO:0000250|UniProtKB:Q05B79 387..628 77/315 (24%)
Helicase_C 476..606 CDD:278689 47/164 (29%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 498..557 19/80 (24%)
Nuclear localization signal. /evidence=ECO:0000303|PubMed:14731398 517..528 4/29 (14%)
WH domain. /evidence=ECO:0000250|UniProtKB:Q05B79 629..698 21/76 (28%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 638..697 17/66 (26%)
HA2 676..760 CDD:214852 25/104 (24%)
OB_NTP_bind 800..917 CDD:285018 26/135 (19%)
OB-fold-like subdomains. /evidence=ECO:0000250|UniProtKB:Q05B79 841..905 14/75 (19%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 849..860 1/10 (10%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 870..900 6/34 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1643
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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