Protein Alignment kz and DQX1

DIOPT Version :10

• Sequence 1: NP_476591.1
• Gene: kz / 31205
• FlyBaseID: FBgn0001330
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: NP_598376.2
• Gene: DQX1 / 165545
• HGNCID: 20410
• Length: 717
• Species: Homo sapiens
• Alignment Length: 870
• Identity: 204/870 - (23%)
• Similarity: 328/870 - (37%)
• Gaps: 260/870 - (29%)

  Fly   249 RTTEVQNARLRLPILAEEQQVMETINENP--IVIVAGETGSGKTTQLPQFLYEAGYA---QHKMI 308
            |..|:...|..|||.|.....:|.:..||  :|:|:||.||||:||:||:..|...|   |...:
Human    34 RYYELLKQRQALPIWAARFTFLEQLESNPTGVVLVSGEPGSGKSTQIPQWCAEFALARGFQKGQV 98

  Fly   309 GVTEPRRVAAIAMSKRVAHEMNLP-ESEVSYLIRFEGNVTPATRIKFMTDGVLLKEIETDFLLSK 372
            .||:|..:||.:::.|||.||:|. ..||.|.|..|....|.|.::|..|.:||:|:.:......
Human    99 TVTQPYPLAARSLALRVADEMDLTLGHEVGYSIPQEDCTGPNTLLRFCWDRLLLQEVASTRGTGA 163

  Fly   373 YSVIILDEAHERSVYTDILVGLLSRIVPLRHKRGQPLKLIIMSATLRVSDFTE-----NTRLFKI 432
            :.|::||||.||||.:|.|.|||           |..:|..:...|||...|:     ..|.|..
Human   164 WGVLVLDEAQERSVASDSLQGLL-----------QDARLEKLPGDLRVVVVTDPALEPKLRAFWG 217

  Fly   433 PPPLLKV--EARQFPVTIHFQKRTPDDYVAEAYRKTLKIHNKLPEGGILIFVTGQQEVNQLVRKL 495
            .||::.:  |..:.|..|::. ..|.|.|..|.:..|::..|...|.:|:|:..::|::.....|
Human   218 NPPIVHIPREPGERPSPIYWD-TIPPDRVEAACQAVLELCRKELPGDVLVFLPSEEEISLCCESL 281

  Fly   496 RRTFPYHHAPTKDVAKNGKVSEEEKEETIDDAASTVEDPKELEFDMKRVIRNIRKSKKKFLAQMA 560
            .|                                      |:|               ..|.|..
Human   282 SR--------------------------------------EVE---------------SLLLQGL 293

  Fly   561 LPKINLDDYKLPGDDTEADMHEQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQPLWVLPLYSL 625
            .|::      ||       :|  ||.....:.:.||.|
Human   294 PPRV------LP-------LH--PDCGRAVQAVYEDMD--------------------------- 316

  Fly   626 LSSEKQNRIFLPVPDGCRLCVVSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFVVTYTS 690
                            .|..||:..:|:.|.::|.|::|:|.|.:...:|:........|:...|
Human   317 ----------------ARKVVVTHWLADFSFSLPSIQHVIDSGLELRSVYNPRIRAEFQVLRPIS 365

  Fly   691 KASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDI-QKKPVED------LMLQMRCMGID 748
            |..|:.|..||.....|.|..||..:     |.:...|.: |.:..|:      |:|:.|.:...
Human   366 KCQAEARRLRARGFPPGSCLCLYPKS-----FLELEAPPLPQPRVCEENLSSLVLLLKRRQIAEP 425

  Fly   749 RVVHFPFPSPPDQVQLQAAERRLIVLGALEVAKTENTDLPPAVTRLGHVISRFPVAPRFGKMLAL 813
            ...|| ...|..:..:||.| .|..|.||:    ::.||    :.||.::|.||:||...|.|..
Human   426 GECHF-LDQPAPEALMQALE-DLDYLAALD----DDGDL----SDLGVILSEFPLAPELAKALLA 480

  Fly   814 SHQ----QNLLPYTVCLVAA-------LSVQEVLIETGVQRDEDVAPGANRFHRKRQSWAASGNY 867
            |.:    ..:|.....|.||       ||.:|..:...::..:
Human   481 SCEFDCVDEMLTLAAMLTAAPGFTRPPLSAEEAALRRALEHTD---------------------- 523

  Fly   868 QLLGDPMVLLRAVGAAEYAGSQGRLPEFCAANGLRQKAMSEVRKLR---VQLTNEINLNVSDVEL 929
               ||...|::...|...:|:.   ..:|.|.||...|:.:..|||   ::|...|.|.:|....
Human   524 ---GDHSSLIQVYEAFIQSGAD---EAWCQARGLNWAALCQAHKLRGELLELMQRIELPLSLPAF 582

  Fly   930 GVDPELKPPTDAQARFLRQILLAGMGDRVARKVP------------LADIADKEERRRLKYAYNC 982
            |        ::...|.|::.|::|...:|||...            :|.::          :|.|
Human   583 G--------SEQNRRDLQKALVSGYFLKVARDTDGTGNYLLLTHKHVAQLS----------SYCC 629

  Fly   983 -ADMEEPAFLHVSSVLRQKAPEWVIYQEAYELQNGDSTKMFIRGITAIEPEWLLLYVP--LLCN- 1043
             .....||          :.|.||:|.. :.:...:...:    ::.|:|:.|:...|  .|.|
Human   630 YRSRRAPA----------RPPPWVLYHN-FTISKDNCLSI----VSEIQPQMLVELAPPYFLSNL 679

  Fly  1044 --------IREVREDPAPRFDKTSG 1060
                    :.::||..|   |.|:|
Human   680 PPSESRDLLNQLREGMA---DSTAG 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_476591.1	HrpA	260..>1071	CDD:441249	201/859 (23%)
		DEXHc_DHX37	260..439	CDD:350740	69/189 (37%)
DQX1	NP_598376.2	HrpA	44..>615	CDD:441249	180/744 (24%)
		DEXQc_DQX1	45..224	CDD:350744	69/189 (37%)
		DEAQ box. /evidence=ECO:0000305|PubMed:11353393	170..173		2/2 (100%)
		OB_NTP_bind	591..674	CDD:400182	19/107 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	694..717		4/11 (36%)