DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kz and TDRD9

DIOPT Version :9

Sequence 1:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_694591.2	Gene:	TDRD9 / 122402	HGNCID:	20122	Length:	1382	Species:	Homo sapiens

Alignment Length:	1021	Identity:	245/1021 - (23%)
Similarity:	414/1021 - (40%)	Gaps:	274/1021 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 EDSSSSDEDDEEAPAQSAPIAIPTPVSIAPPQIAVKPPIKKLKPEPNPPACIHQTVYVPVHRTTE 252
            |:....|......||..||.....|   |.|..|.:..:.:...|         ..|:..:|..|
Human    39 EEVQRQDVAPGAGPAAQAPALAQAP---ARPAAAFERSLSQRSSE---------VEYINKYRQLE 91

  Fly   253 VQN-------------------ARLR--------------LPILAEEQQVMETINENPIVIVAGE 284
            .|.                   |:|.              |||...:::|:..|..|.:||:.|.
Human    92 AQELDVCRSVQPTSGPGPRPSLAKLSSVTCIPGTTYKYPDLPISRYKEEVVSLIESNSVVIIHGA 156

  Fly   285 TGSGKTTQLPQFLYEAGYAQHK---MIGVTEPRRVAAIAMSKRVAHEMNLP-ESEVSYLIRFEGN 345
            |||||:|||||::.: .|.|..   .|.||:||::.|.::::.::.|.... ...|.|.:..|..
Human   157 TGSGKSTQLPQYILD-HYVQRSAYCSIVVTQPRKIGASSIARWISKERAWTLGGVVGYQVGLEKI 220

  Fly   346 VTPATRIKFMTDGVLLKEIETDFLLSKYSVIILDEAHERSVYTDILVGLLSRIVPLRHKRGQPLK 410
            .|..||:.:||.||||::|.:...|.:::.||:||.|||:...|.|:.::.:::   ....:.:|
Human   221 ATEDTRLIYMTTGVLLQKIVSAKSLMEFTHIIIDEVHERTEEMDFLLLVVRKLL---RTNSRFVK 282

  Fly   411 LIIMSATLRVSDFTENTRLFKIPPPLLKVEARQFPVTIHFQKRTPDDYVAEAYRKTLKIHNKLPE 475
            :::||||:...:|.:   .|.:|     |:.:..|..| |:.......|.|.|...|: |
Human   283 VVLMSATISCKEFAD---YFAVP-----VQNKMNPAYI-FEVEGKPHSVEEYYLNDLE-H----- 332

  Fly   476 GGILIFVTGQQEVNQLVRKLRRTFPYHHAPTKDVAKNGKVSEEEKEETI------DDAASTVEDP 534
                                     .||:         |:|....||.:      :.|.|.::..
Human   333 -------------------------IHHS---------KLSPHLLEEPVITKDIYEVAVSLIQMF 363

  Fly   535 KELEFDMKRVIRNIRKSKKKFLAQMALPKINLDDYKLPGDDTEADMHEQPDEDDEQEGLEEDNDD 599
            .:|  |||.     ..:|....||..|.:.::..: |||......|||.
Human   364 DDL--DMKE-----SGNKAWSGAQFVLERSSVLVF-LPGLGEINYMHEL---------------- 404

  Fly   600 ELGLEDESGMGSGQRQPLWVLPLYSLLSSEKQNRIFL-PVPDGCRLCVVSTNVAETSLTIPHIKY 663
                     :.|...:.|.|.||:|.::.|:||.:|| ||| |.|..::|||:||:|:|:|.:||
Human   405 ---------LTSLVHKRLQVYPLHSSVALEEQNNVFLSPVP-GYRKIILSTNIAESSVTVPDVKY 459

  Fly   664 VVDCGRQKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQP 728
            |:|....:|.:.|:.|...:..:::.||.|.:||.|||||:|.|:||||.....:::...|...|
Human   460 VIDFCLTRTLVCDEDTNYQSLRLSWASKTSCNQRKGRAGRVSRGYCYRLVHKDFWDNSIPDHVVP 524

  Fly   729 DIQKKPVEDLMLQMRC--MGIDRVVHFPFPSPPDQVQLQAAERRLIVL---GALEVAKTENTDLP 788
            ::.:.|:...:|:::.  ||..|.:.....|||.   |...||.:::|   |||.|:.....:.|
Human   525 EMLRCPLGSTILKVKLLDMGEPRALLATALSPPG---LSDIERTILLLKEVGALAVSGQREDENP 586

  Fly   789 --PAVTRLGHVISRFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVLIETGVQRDEDVAPGA 851
              ..:|.||.|:::.||..:.||::.|.|....|...:.:.||||::........|..:.
Human   587 HDGELTFLGRVLAQLPVNQQLGKLIVLGHVFGCLDECLIIAAALSLKNFFAMPFRQHLDG----- 646

  Fly   852 NRFHRKRQSWAASGNYQLLGDPMVLL---------RAVGAAEYAGSQ---GRLPEFCAANGLRQK 904
               :|.:.:::.|..    .|.:.|:         |..|...|...:   |||      |.::.|
Human   647 ---YRNKVNFSGSSK----SDCIALVEAFKTWKACRQTGELRYPKDELNWGRL------NYIQIK 698

  Fly   905 AMSEVRKLRVQLTNEINLNVSDVELGVDPELKPPTDAQ----ARFLRQILLAG--------MGDR 957
            .:.||    .:|..|:...:|...:.||.. :|..|.:    .||:.|::|||        .| :
Human   699 RIREV----AELYEELKTRISQFNMHVDSR-RPVMDQEYIYKQRFILQVVLAGAFYPNYFTFG-Q 757

  Fly   958 VARKVPLADIADKEERRRLKYAYNCADMEEPAFLHVSSVLRQKAPEWVIYQEAYELQN------- 1015
            ...::.:.::|.|:.:                   .:.||:...|...:|.:  :||:
Human   758 PDEEMAVRELAGKDPK-------------------TTVVLKHIPPYGFLYYK--QLQSLFRQCGQ 801

  Fly  1016 -----GDSTKMFIRGITAIEPEWLLLYVPLLCNIREVREDPAPRFDKTSGKIFCHVDATFGKSGW 1075
                 .|..|.|:                      |...:|..|| ||...::..:..:..|...
Human   802 VKSIVFDGAKAFV----------------------EFSRNPTERF-KTLPAVYMAIKMSQLKVSL 843

  Fly  1076 ELPLGEVEMPLSEKACCYFGMFLLDGEVCSRLADFRSKLKSTPASV 1121
            ||.:...|.              ::|:|.....   |||::|..:|
Human   844 ELSVHSAEE--------------IEGKVQGMNV---SKLRNTRVNV 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	221/907 (24%)
		DEXDc	279..418	CDD:238005	49/142 (35%)
		P-loop_NTPase	369..>500	CDD:304359	27/130 (21%)
		HELICc	619..704	CDD:197757	38/85 (45%)
		HA2	774..859	CDD:214852	23/89 (26%)
		OB_NTP_bind	915..1039	CDD:285018	25/147 (17%)
TDRD9	NP_694591.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..62		6/22 (27%)
		HrpA	132..>716	CDD:224557	188/695 (27%)
		DEXDc	149..290	CDD:238005	49/144 (34%)
		DEAH box. /evidence=ECO:0000250\|UniProtKB:Q14BI7	254..257		2/2 (100%)
		Helicase_C	383..500	CDD:278689	47/143 (33%)
		HA2	588..665	CDD:214852	19/88 (22%)
		TUDOR	904..1013	CDD:278965
		TUDOR	949..996	CDD:119391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810