DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kz and Dhx29

DIOPT Version :9

Sequence 1:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	XP_002729053.2	Gene:	Dhx29 / 100362324	RGDID:	2318361	Length:	1366	Species:	Rattus norvegicus

Alignment Length:	1085	Identity:	265/1085 - (24%)
Similarity:	447/1085 - (41%)	Gaps:	272/1085 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 KKKERQAQVLAEKSSASGLRVNAIKGSK------RKLL--VEEEEELQAKRKNP-NVISVEEDDE 188
            ||||               .:|.::.:|      .|||  ::::::||.:|::| |.....||.|
  Rat   472 KKKE---------------ELNKMETNKPRDLFIAKLLSKLKQQQQLQQQRQHPENKTETAEDPE 521

  Fly   189 DSSSSDEDDEEAPAQSAPIAIPTPVSIAPPQIAVKPPIKKLKPEPNPPACIHQTVYVPVHRTTEV 253
            :|..:...||:..|.|..   ||......|   |:...::|:..|               :...:
  Rat   522 ESWENLVSDEDLSALSLE---PTGAEDLEP---VRNLFRRLQSTP---------------KYQRL 565

  Fly   254 QNARLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLYE------AGYAQHKMIGVTE 312
            ...|.:||:......::||:..:.:|:|||||||||:||:|.||.|      .| |:...|..|:
  Rat   566 LKERQQLPVFKHRASIVETLKRHRVVVVAGETGSGKSTQVPHFLLEDLLLNDCG-ARKCNIVCTQ 629

  Fly   313 PRRVAAIAMSKRVAHEMNLP------ESEVSYLIRFEGNVTPATRIKFMTDGVLLKEIETDFLLS 371
            |||::|::::.||..|:...      .|...|.||.|...:.:||:.:.|.||||::::.|.||:
  Rat   630 PRRISAVSLATRVCEELGCEGGPGGRNSLCGYQIRMESRASESTRLLYCTTGVLLRKLQEDGLLA 694

  Fly   372 KYSVIILDEAHERSVYTDILVGLLSRIVPLRHKRGQPLKLIIMSATLRVSDFTENTRLFKIPPPL 436
            ..|.:|:||.|||||.:|.|:.:|..|:..|    ..|.||:||||:....|:    .:....|:
  Rat   695 DVSHVIVDEVHERSVQSDFLLVILKEILQKR----SDLHLILMSATVDSDKFS----TYFTHCPI 751

  Fly   437 LKVEARQFPVTI-HFQKRTPD-------------DYVAEAYRKTLKIHNKLPEGGILIFVTGQQE 487
            |::..|.:||.: |.:....:             .::.|....|:.:.:|  .|||
  Rat   752 LRISGRSYPVEVFHLEDIVEETGFILEKDSEYCQKFLEEEEEITINVTSK--AGGI--------- 805

  Fly   488 VNQLVRKLRRTFPYHHAPTKDVAKNGKVSEEEKEETIDDAASTVEDPKELEFDM----------K 542
                 :|.:...|.....:.:::     ...:|..:....|....:|.::..|:          .
  Rat   806 -----KKYQECIPVQSGASPELS-----PFYQKYSSRTQYAVLYMNPHKINLDLILELLVYLDKS 860

  Fly   543 RVIRNIRKSKKKFLAQMALPKINLDDYKLPGDDTEADMHEQPDEDDEQEGLEEDNDDELGLEDES 607
            ...|||..:...||..:|                    |.|...|              .|.::.
  Rat   861 PQFRNIEGAVLIFLPGLA--------------------HIQQLYD--------------LLSNDR 891

  Fly   608 GMGSGQRQPLWVLPLYSLLSSEKQNRIFLPVPDGCRLCVVSTNVAETSLTIPHIKYVVDCGRQKT 672
            ...|.:.|   ::.|:|:||::.|...|:..|.|.|..|::||:|||.:|||.:.:|:|.||.|.
  Rat   892 RFYSERYQ---LIALHSVLSTQDQAAAFMLPPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKE 953

  Fly   673 RLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQKKPVED 737
            ..|.:.:.:|:.|.|:.|||||.||.|||||:..|.|:|||:...: :.|.::|.|:|.:.|:|:
  Rat   954 NKYHESSQMSSLVETFVSKASALQRQGRAGRVRDGFCFRLYTRERF-EGFLEYSVPEILRVPLEE 1017

  Fly   738 LMLQ-MRC-MGIDRVVHFPFPSPPDQVQLQAAERRLIVLGALEVAKTENTDLPPAVTRLGHVISR 800
            |.|. |:| :|...........||....:..|...|..:||.|.::       |.:|.||..::.
  Rat  1018 LCLHIMKCDLGSPEDFLSKALDPPQPQVISNAMNLLRKIGACEPSE-------PKLTPLGQHLAA 1075

  Fly   801 FPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVLIETGVQRDE-DVAPGANRFHRKRQSWAAS 864
            .||..:.||||........|.....|.|.::.:...|....::|| |:|         :.|.|.:
  Rat  1076 LPVNVKIGKMLIFGAIFGCLEPVATLAAVMTEKSPFITPIGRKDEADLA---------KSSLAVA 1131

  Fly   865 GNYQLLGDPMVLLRA-VG---AAEYAGSQGRLPEFCAANGLRQKAMSEVRKLRVQLTNEIN---- 921
            .:     |.:.:..| :|   |.:..|.:..: .:|..|.|.:.::..:..::.:|...:.
  Rat  1132 DS-----DHLTIYNAYLGWKKAQQEGGFRSEI-SYCQRNFLNRTSLLTLEDVKQELMKLVRAAGF 1190

  Fly   922 --------------LNVSDVELGVDPELKPPTDAQARFLRQILLAGMGDRVARKVPLADIADKEE 972
                          |:..|:.|                |:.:|.||:.|.|. |:......|..|
  Rat  1191 SSSTSWEGKKGPQALSFQDIAL----------------LKAVLAAGLYDSVG-KIMCTKSVDVTE 1238

  Fly   973 RRRLKYAYNCADMEEPAFLHVSSVLRQ-KAPEWVIYQEAYELQNGDSTKMFIRGITAIEPEWLLL 1036
                |.|......:..|.:|.|||.|. :...|::|||....     .::::|..|.|.|..:||
  Rat  1239 ----KLACMVETAQGKAQVHPSSVNRDLQTYGWLLYQEKVRY-----ARVYLRETTLITPFPVLL 1294

  Fly  1037 YVPLLCNIREVREDPAPRFDKTSGKIFCHVDATFGKSGWELPLGEVEMPLSEKACCYFGMFLLDG 1101
                                             ||        |::|:...|:.....|......
  Rat  1295 ---------------------------------FG--------GDIEVQHRERLLSVDGWIYFQA 1318

  Fly  1102 EVCSRLADFRSKLKSTPASVIK------SWSSMNNKVLRFKRALI 1140
            .|  ::|....:|:....||::      ..|..|:|:|:....||
  Rat  1319 PV--KIAVIFKQLRVLIDSVLRKKLENPKMSLENDKILQIITELI 1361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	220/882 (25%)
		DEXDc	279..418	CDD:238005	62/150 (41%)
		P-loop_NTPase	369..>500	CDD:304359	37/144 (26%)
		HELICc	619..704	CDD:197757	38/84 (45%)
		HA2	774..859	CDD:214852	21/85 (25%)
		OB_NTP_bind	915..1039	CDD:285018	31/142 (22%)
Dhx29	XP_002729053.2	HrpA	531..1314	CDD:224557	235/960 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810