DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kz and dhx15

DIOPT Version :9

Sequence 1:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_001135571.1	Gene:	dhx15 / 100216120	XenbaseID:	XB-GENE-1008945	Length:	761	Species:	Xenopus tropicalis

Alignment Length:	943	Identity:	273/943 - (28%)
Similarity:	416/943 - (44%)	Gaps:	253/943 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 RLPTLDEYLAKKKERQAQVLAEKSSASGLRVNAIKGSKRKLLVEEEEELQAKRKNPNVISVEEDD 187
            ||...|:|:|.||         :||         .|..|    :.|.:.::|.::      .:.|
Frog     6 RLDLGDDYVANKK---------RSS---------DGKDR----DRERDDRSKDRD------RDRD 42

  Fly   188 EDSSSSDEDDEEAPAQSAPIAIPTPVSIAPPQIAVKPPIKKLKPEPNPPACIHQTV-------YV 245
            .|.....:.|:::...|....|..         :..||:|        ||.:.|.:       :.
Frog    43 RDRERDRDKDKDSRGSSNSTYITA---------SGMPPLK--------PAAVAQGINPFTNLPHT 90

  Fly   246 PVHRTTEVQNARLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLYEAGYAQ-----H 305
            |  |..::...||.||:...:::..|.:.:|...::.||||||||||:||:..:  |.:     .
Frog    91 P--RYYDILKKRLLLPVWEYKERFTEILMKNQSFVLVGETGSGKTTQIPQWCVD--YMRLLPGPK 151

  Fly   306 KMIGVTEPRRVAAIAMSKRVAHEMN-LPESEVSYLIRFEGNVTPATRIKFMTDGVLLKEIETDFL 369
            :.:..|:||||||:::::|||.||: :...||.|.||||...:..|.:|:||||:||:|...|.|
Frog   152 RGVACTQPRRVAAMSVAQRVADEMDVMLGQEVGYSIRFEDCSSAKTILKYMTDGMLLREAMNDPL 216

  Fly   370 LSKYSVIILDEAHERSVYTDILVGLLSRIVPLRHKRGQPLKLIIMSATLRVSDFTENTRLFKIPP 434
            |.:|.|:||||||||::.||||:|:|..:|..|:    .||:|:|||||....|    :::....
Frog   217 LERYGVVILDEAHERTLATDILMGVLKEVVRQRN----DLKVIVMSATLDAGKF----QVYFDSC 273

  Fly   435 PLLKVEARQFPVTIHFQKRTPDDYVAEAYRKTLKIHN-KLPEGGILIFVTGQQEVNQLVRKLRRT 498
            |||.:..|..||.|.:......||:..|.|..::||. :..||.:|:|:|||:|:::..::::|
Frog   274 PLLTIPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEEEGDLLLFLTGQEEIDEACKRIKR- 337

  Fly   499 FPYHHAPTKDVAKNGKVSEEEKEETIDDAASTVEDPKELEFDMKRVIRNIRKSKKKFLAQMALPK 563
                                    .|||....|.|.|
Frog   338 ------------------------EIDDLGPDVGDIK---------------------------- 350

  Fly   564 INLDDYKLPGDDTEADMHEQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQPLWVLPLYSLLSS 628
                                                                   ::||||.|..
Frog   351 -------------------------------------------------------IIPLYSTLPP 360

  Fly   629 EKQNRIFLP----VPDGC--RLCVVSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFVVT 687
            ::|.|||.|    .|.|.  |..|||||:|||||||..:.:|:|.|..|.::|:....|.:.:||
Frog   361 QQQQRIFEPPPPKKPSGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVT 425

  Fly   688 YTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQMRCMGIDRVVH 752
            ..|||||.||||||||...|.|:|||:...|....:|.:.|:|.:..:..::||::.:|||.:||
Frog   426 AISKASAQQRAGRAGRTRPGKCFRLYTEKAYKTEMQDNTYPEILRSNLGSVVLQLKKLGIDDLVH 490

  Fly   753 FPFPSPPDQVQLQAAERRLIVLGALEVAKTENTDLPPAVTRLGHVISRFPVAPRFGKMLALSHQQ 817
            |.|..||....|..|...|..|.||    .::.||    |.||.:::.||:.|:..||:..|...
Frog   491 FDFMDPPAPETLMRALELLNYLAAL----NDDGDL----TELGSMMAEFPLDPQLAKMVIASCDY 547

  Fly   818 NLLPYTVCLVAALSVQEVLIE-TGVQRDEDVAPGANRFHRKRQSWAASGNYQLLGDPMVLLRAVG 881
            |.....:.:.|.|||.:..|. |.|::..|.|  ..||            ..:.||.:.||....
Frog   548 NCSNEILSITAMLSVPQCFIRPTEVKKAADEA--KMRF------------AHIDGDHLTLLNVYH 598

  Fly   882 A--AEYAGSQGRLPEFCAANGLRQKAMSEVRKLRVQLT---NEINLNVSDVELGVDPELKPPTDA 941
            |  ..:..||     :|..|.:..:::.....:|.||:   :..||.            :..||.
Frog   599 AFKQNHESSQ-----WCYDNFINYRSLMSADNVRQQLSRIMDRFNLP------------RRSTDF 646

  Fly   942 QAR----FLRQILLAGMGDRVARKVPLADIADKEERRRLKYAYNCADMEEPAFLHVSSVLRQKAP 1002
            .:|    .:|:.|:.|...:||            ...|..:.....| .:...||.|:||..| |
Frog   647 TSRDYYINIRKALVTGYFMQVA------------HLERTGHYLTVKD-NQVVQLHPSTVLDHK-P 697

  Fly  1003 EWVIYQEAYELQNGDSTKMFIRGITAIEPEWLL 1035
            |||:|.| :.|    :||.:||..|.|:||||:
Frog   698 EWVLYNE-FVL----TTKNYIRTCTDIKPEWLV 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	251/829 (30%)
		DEXDc	279..418	CDD:238005	68/144 (47%)
		P-loop_NTPase	369..>500	CDD:304359	51/131 (39%)
		HELICc	619..704	CDD:197757	45/90 (50%)
		HA2	774..859	CDD:214852	26/85 (31%)
		OB_NTP_bind	915..1039	CDD:285018	37/128 (29%)
dhx15	NP_001135571.1	Motor_domain	81..>133	CDD:277568	14/53 (26%)
		DEXDc	97..288	CDD:214692	83/200 (42%)
		DEXDc	120..261	CDD:238005	68/146 (47%)
		HELICc	348..441	CDD:197757	46/175 (26%)
		HA2	511..594	CDD:214852	28/104 (27%)
		OB_NTP_bind	628..731	CDD:285018	37/129 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010