DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kz and dhx37

DIOPT Version :9

Sequence 1:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	XP_005172500.1	Gene:	dhx37 / 100009635	ZFINID:	ZDB-GENE-030131-4505	Length:	1153	Species:	Danio rerio

Alignment Length:	1225	Identity:	546/1225 - (44%)
Similarity:	760/1225 - (62%)	Gaps:	107/1225 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MG--KKVHNAKARQNPQTIVDNSAVKKIQIDVDAVAGGNQVGYDEANALVLPSEKRATKIKVDKV 63
            ||  :|.||.|.||...::...:|.::..:.|:...|....|.|:.||||||    |||.|..||
Zfish     1 MGRLRKKHNWKGRQQSTSVQTAAADRQTNVQVEIQDGAVLKGVDDCNALVLP----ATKTKKQKV 61

  Fly    64 QH----VKILSKKQRKHLQAIVDKKKKKEGRAQLLGDLAAVQIPEEELQQYTSISQVQTVGLKRL 124
            :.    .|.|:|||||:|:.::::|.||..||::|..||.||:||.||:...:.:::.|.|  :|
Zfish    62 ERPVTKKKALTKKQRKNLEKVLEQKDKKAHRAEVLSKLAEVQLPEAELKLLYTTAKLGTGG--KL 124

  Fly   125 PTLDEYLAKKKERQAQVLAEKSSASGLRVNAIKGSKRKLLVEEEEELQAKRKNPNVISVEEDDED 189
                 |..|:...:.|    ...:|.::::::.|:.||...|.:||.:......:..|.::||.:
Zfish   125 -----YHIKESVNEGQ----DGGSSSVKISSLSGANRKRRREADEEEEENESEMSESSEDDDDSE 180

  Fly   190 SSSSDEDDEEAPAQSAPIAIPTPVSIAPPQIAVKPPIKKLKPEPNPPACIHQ----TVYVPVHRT 250
            .|.|.|:::|..::...........:...:  .||....:|.|........:    .|::||.|.
Zfish   181 ESDSSEEEKEKISEEKHTEEQQQQQVLKEE--TKPKEADMKEEKKAETWTKEDCKPAVFIPVERL 243

  Fly   251 TEVQNARLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQFLYEAGYAQH-KMIGVTEPR 314
            .|:|.||||||:|||||.:||.:.::..|::.||||||||||:||||||||:|.. .:|||||||
Zfish   244 PEIQEARLRLPVLAEEQIIMEAVKDHECVVLCGETGSGKTTQVPQFLYEAGFASSGGIIGVTEPR 308

  Fly   315 RVAAIAMSKRVAHEMNLPESEVSYLIRFEGNVTPATRIKFMTDGVLLKEIETDFLLSKYSVIILD 379
            |||||:||.|||.||||....|||.||:|||||..|:||.||||||||||:.||||.||||||:|
Zfish   309 RVAAISMSHRVATEMNLSSGVVSYQIRYEGNVTENTKIKVMTDGVLLKEIQRDFLLQKYSVIIID 373

  Fly   380 EAHERSVYTDILVGLLSRIVPLRHKRGQPLKLIIMSATLRVSDFTENTRLFKIPPPLLKVEARQF 444
            ||||||||||||:||||||||||:|:|.|:|||||||||||.|||||.|||..|||::|||||||
Zfish   374 EAHERSVYTDILIGLLSRIVPLRNKKGLPMKLIIMSATLRVEDFTENKRLFSSPPPVIKVEARQF 438

  Fly   445 PVTIHFQKRTP-DDYVAEAYRKTLKIHNKLPEGGILIFVTGQQEVNQLVRKLRRTFPYHHAPTKD 508
            .||:||.|||| |||..|.:||..|||..||.||||:|:|||.||:.:.|:||:.|||
Zfish   439 AVTVHFNKRTPMDDYTGETFRKICKIHRMLPPGGILVFLTGQAEVHSVCRRLRKAFPY------- 496

  Fly   509 VAKNGKVSEEEKEETIDDAASTVEDPKELEFDMKRVIRNIRKSKKKFLAQMALPKINLDDYK-LP 572
                    :..:|.|         |..|.|.|:|:    .:::|||   .::||:||||:|. ||
Zfish   497 --------KPNREHT---------DMMETEEDLKK----SKRAKKK---NVSLPRINLDNYSALP 537

  Fly   573 GDDTEADMHEQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQ----PLWVLPLYSLLSSEKQNR 633
            .|:.:.|.....||||     .|.:|.||.|.|.......::.    ||:||||||||:.|:|.:
Zfish   538 VDEGDEDRQAGIDEDD-----GEGSDLELELGDHPDTDHEEKADPSIPLYVLPLYSLLAPEQQAK 597

  Fly   634 IFLPVPDGCRLCVVSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFVVTYTSKASADQRA 698
            :|.|.|.|.|||||:|||||||||||.|||||||||.|.|.||::||||:|.||:.|:|||:|||
Zfish   598 VFRPPPAGSRLCVVATNVAETSLTIPGIKYVVDCGRVKKRFYDRVTGVSSFKVTWISQASANQRA 662

  Fly   699 GRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQKKPVEDLMLQMRCMGIDRVVHFPFPSPPDQVQ 763
            |||||...|||||||||||:.| |..||:.:|.::|||||:|||:.:.|::||:||||:||....
Zfish   663 GRAGRTEPGHCYRLYSSAVFGD-FSLFSEAEITRRPVEDLVLQMKDLNIEKVVNFPFPTPPSSEA 726

  Fly   764 LQAAERRLIVLGALE-------VAKTENTDLPPAVTRLGHVISRFPVAPRFGKMLALSHQQNLLP 821
            |.|||..||.|||||       :::.|...|...::.||..::.||||||:.|||||..||..:.
Zfish   727 LIAAEELLISLGALEKPARHGRLSEMEKARLSCPISPLGRAMAAFPVAPRYAKMLALGRQQGCMQ 791

  Fly   822 YTVCLVAALSVQEVLIETGVQRDEDVAPGAN-----------RFHRKRQSWAASGNYQLLGDPMV 875
            |.:.:|:|::|:|:.      .|.|...|:.           |..:.|:.||..|...||||.||
Zfish   792 YIITIVSAMTVREIF------EDYDRPAGSEEENVKMSGKKARSVQMRRLWAGQGASLLLGDLMV 850

  Fly   876 LLRAVGAAEYAGSQGRLPEFCAANGLRQKAMSEVRKLRVQLTNEINLNVSDVELGVDPELKPPTD 940
            ||.||||.|:|   |..|:||..||||.|||.|:|:||.||||.:|...:|.::.||.::.|||:
Zfish   851 LLGAVGACEFA---GLTPQFCEENGLRFKAMLEIRRLRGQLTNAVNAVCADADVYVDNKMAPPTE 912

  Fly   941 AQARFLRQILLAGMGDRVARKVPLADIADKEERRRLKYAYNCADMEEPAFLHVSSVLRQKAPEWV 1005
            ||...||||:|||:||.:||:|...::.|.:.|.    ||....:::|.|:|.||.|.:..||:|
Zfish   913 AQVLCLRQIVLAGLGDHIARRVQAEELLDPKWRN----AYKTPLLDDPVFIHPSSALHKTLPEFV 973

  Fly  1006 IYQEAYELQNGDSTKMFIRGITAIEPEWLLLYVPLLCNIREVREDPAPRFDKTSGKIFCHVDATF 1070
            :|||..|     :|||::||:.|::.:|:...:|..|:.....|.|||||....|::.||..:||
Zfish   974 VYQEIME-----TTKMYMRGVCAVQDDWIPKLLPQYCHFSAPEESPAPRFCPLIGRVKCHQQSTF 1033

  Fly  1071 GKSGWELPLGEVEMPLSEKACCYFGMFLLDGEVCSRLADFRSKLKSTPASVIKSWSSMNNKVLRF 1135
            .:..|:||..|::.|...:....|..|.|:|:||.::..|.|.|.|:|::::|:|:.:..:....
Zfish  1034 FRVSWKLPAIEMDYPEGLERYKLFAKFFLEGQVCPKIQKFSSCLLSSPSTMLKTWAKLQPRTEVL 1098

  Fly  1136 KRALITKQIHNRQALIDQWNSDPHFLLEEYQNLLYDVALSELTPLWPPVDKKEPQ 1190
            ..||::::..||.:|...|..:..:||..|...:.:....|::.:|||:.:.:|:
Zfish  1099 LTALVSEKADNRTSLEAAWRKNEKYLLSAYCQWIPESLHEEVSKIWPPIGQADPR 1153

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	438/849 (52%)
		DEXDc	279..418	CDD:238005	107/139 (77%)
		P-loop_NTPase	369..>500	CDD:304359	95/131 (73%)
		HELICc	619..704	CDD:197757	61/84 (73%)
		HA2	774..859	CDD:214852	31/102 (30%)
		OB_NTP_bind	915..1039	CDD:285018	49/123 (40%)
dhx37	XP_005172500.1	HrpA	200..1007	CDD:224557	436/863 (51%)
		DEXDc	272..412	CDD:238005	107/139 (77%)
		HELICc	583..667	CDD:197757	60/83 (72%)
		HA2	730..781	CDD:282288	20/50 (40%)
		HA2	761..>813	CDD:214852	22/57 (39%)
		OB_NTP_bind	<918..1004	CDD:285018	37/94 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581553
Domainoid	1	1.000	222	1.000	Domainoid score	I2536
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6641
Inparanoid	1	1.050	940	1.000	Inparanoid score	I336
OMA	1	1.010	-	-		QHG54789
OrthoDB	1	1.010	-	-		D203698at33208
OrthoFinder	1	1.000	-	-		FOG0005033
OrthoInspector	1	1.000	-	-		oto39282
orthoMCL	1	0.900	-	-		OOG6_102322
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1918
SonicParanoid	1	1.000	-	-		X3558
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800