DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kz and dhx32a

DIOPT Version :9

Sequence 1:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_001189401.3	Gene:	dhx32a / 100006246	ZFINID:	ZDB-GENE-130613-6	Length:	728	Species:	Danio rerio

Alignment Length:	854	Identity:	195/854 - (22%)
Similarity:	319/854 - (37%)	Gaps:	253/854 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 RLRLPILAEEQQVMETINENPIVIVAGETGSGKTTQLPQ----FLYEAGYAQHKMIGVTEPRRVA 317
            |..||:.....:.|..:..|.|:||:|.|.:||:||:||    |...|.| ||.::..::.:|..
Zfish    49 RKTLPVWKYRHEFMTLLENNQILIVSGTTKTGKSTQIPQWCAEFCLSAQY-QHGVVVCSQIQRRQ 112

  Fly   318 AIAMSKRVAHEMNLP-ESEVSYLIRFEGNVTPATRIKFMTDGVLLKEIETDFLLSKYSVIILDEA 381
            |:.::.|||.||::. ..|:.|.|..|...:..|.:::.||.:||:|:.:|.||.:|.|:::|:|
Zfish   113 AVDLALRVADEMDVNIGHEIGYSIPLETCCSNDTILRYCTDDILLREMMSDPLLEQYGVVLVDQA 177

  Fly   382 HERSVYTDILVGLLSRIVPLRHKRGQPLKLIIMSATLRVSDFTENTRLFKIPP------------ 434
            |||:|.||:|:|||..::..|.:    |:|:::||                ||
Zfish   178 HERTVSTDVLLGLLREVLLQRPE----LRLVVLSA----------------PPTPETLLTHYGSV 222

  Fly   435 PLLKVEARQFPVTIHFQKRTPDDYVAEAYRKTLKIHNKLPEGGILIFVTGQQEVNQLVRKLRRTF 499
            |.|.:||......||....:.:.:.: |.|..|::|.....|.:.:|:..:|||
Zfish   223 PRLHLEAPSAGEVIHSSSSSSESFYS-ALRLALEVHRSREPGDVAVFLATEQEV----------- 275

  Fly   500 PYHHAPTKDVAKNGKVSEEEKEETIDDAASTVEDPKELEFDMKRVIRNIRKSKKKFLAQ-MALPK 563
                     |.....:::|....::.                              |.: :|:|
Zfish   276 ---------VCACNIITKEASRMSVS------------------------------LGELLAVP- 300

  Fly   564 INLDDYKLPGDDTEADMHEQPDEDDEQEGLEEDNDDELGLEDESGMGSGQRQPLWVLPLYSLLSS 628
                                                         |.||.   ..:.|  .:..|
Zfish   301 ---------------------------------------------MCSGH---AGICP--PVTES 315

  Fly   629 EKQNRIFLPVPDGCRLCVVSTNVAETSLTIPHIKYVVDCGRQKTRLYDKLTGVSAFVVTYTSKAS 693
            .:.:|         |:.|..:.:.:...::..|.:|:|.|.:|..:|:.....|:.|:...||..
Zfish   316 PQMSR---------RIFVSCSQLEDLFWSVDSIAFVIDTGVEKRLVYNPRLRASSEVIRPISKCQ 371

  Fly   694 ADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFS-----QPDIQKKPVEDLMLQMRCMGIDRVVHF 753
            |:.|....|  |.|.|:.||.        ||..     .|.|.:..:....|.::.|....|.|.
Zfish   372 AEMRKQLTG--STGKCFCLYP--------EDVQLPAEIHPRILESNITSTALFLKRMEAAGVTHC 426

  Fly   754 PFPSPPDQVQLQAAERRLIVLGALEVAKTENTDLPPAVTRLGHVISRFPVAPRFGKMLALSHQQN 818
            .|.:.||...|..|...|..|.||        |....::.:|.::|..|:.|:..|.|..|.:.:
Zfish   427 HFINRPDPEGLMQALEELDYLAAL--------DNDGNLSEMGIIMSELPLEPQMAKALLASCEFD 483

  Fly   819 LLPYTVCLVAALSVQEVLIETGVQRDEDVAPGANRFHRKRQSWAASGNYQLLGDPMVLLRAVGAA 883
            .....:.:.|.|:.....||..|....:|.    |.|.|.|        ...||...|:.....
Zfish   484 CASEMLTIAAMLTAPSCFIEPPVGMLTEVM----RCHMKFQ--------HPEGDHFTLINIYNT- 535

  Fly   884 EYAGSQGRLPEF-----CAANGLRQKAMSEVRKLRVQLTN---EINLNVSDVELGVDPELKPPTD 940
             :..|| |.|.|     |....|...|:.....:|.||::   .|.|.:|:...|        |.
Zfish   536 -FKRSQ-REPYFSQEQWCEQYYLCCAALQTADAIRSQLSDVLKRIELPISEPAFG--------TK 590

  Fly   941 AQARFLRQILLAGMGDRVARKVPLADIADKEERRRLKYAYNCADMEEPAFL----HVSSVLRQKA 1001
            ..|..:::.||||...::||.|                     |.....|:    ||:...|..|
Zfish   591 TNALNIKRALLAGYFMQMARDV---------------------DGSGNYFMLLNKHVAQAHRLSA 634

  Fly  1002 ----------PEWVIYQEAYELQNGDSTKMFIRGITAIEPEWLLLYVP--LLCNI-----REVRE 1049
                      |||:::.| |.|     |...||.:|.|.|...:...|  ..||:     :|:.:
Zfish   635 YGAKAQKLGLPEWLLFHE-YSL-----TDNSIRTLTHISPHAFVQMAPQYFFCNLPPSESKEILQ 693

  Fly  1050 DPAPRFDKT 1058
            :...| |:|
Zfish   694 NILDR-DRT 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	194/852 (23%)
		DEXDc	279..418	CDD:238005	54/143 (38%)
		P-loop_NTPase	369..>500	CDD:304359	38/142 (27%)
		HELICc	619..704	CDD:197757	18/84 (21%)
		HA2	774..859	CDD:214852	20/84 (24%)
		OB_NTP_bind	915..1039	CDD:285018	33/140 (24%)
dhx32a	NP_001189401.3	HrpA	14..>610	CDD:224557	167/733 (23%)
dhx32a	NP_001189401.3	OB_NTP_bind	569..678	CDD:311586	34/143 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910