Protein Alignment pcx and PCNX2

DIOPT Version :10

• Sequence 1: NP_001259183.2
• Gene: pcx / 31204
• FlyBaseID: FBgn0003048
• Length: 3417
• Species: Drosophila melanogaster
• Sequence 2: NP_055616.3
• Gene: PCNX2 / 80003
• HGNCID: 8736
• Length: 2137
• Species: Homo sapiens
• Alignment Length: 3125
• Identity: 881/3125 - (28%)
• Similarity: 1226/3125 - (39%)
• Gaps: 1127/3125 - (36%)

  Fly     1 MGSQTLEILRQGVWASLTGGYFYDPHQGVFCNVVHLYLWLYLLCSPFVAYLIFLQYFPSTWLTWC 65
            |.||.|::|||||||:||||:::||.|..|.|..||||||:||..|...:|.    ||...:...
Human     1 MVSQVLQLLRQGVWAALTGGWYHDPEQSKFTNSCHLYLWLFLLLLPLALHLA----FPPNAIIVF 61

  Fly    66 LYCVITSLTILMVKLANLALHRLYDRAQTMSEGNLKGQFVKVTKETEPRHDDEGGIEMKVIRPGG 130
            .||...::...::||.:..||.::|:.:.:.:...:       ||.:|..|.|.
Human    62 FYCSAVTIFFTIIKLVSYRLHLMFDKGEVIQQKPSR-------KEEKPNKDKEA----------- 108

  Fly   131 SRISGEQAINEASEENSIMSIDNVNSIIDLKVDVHRKNSSESIELMFYAPSMLSGGS-------- 187
               .||...|..:..|: ..|.|     ..|.:..|..|:..:.......|:.|..|
Human   109 ---KGEHITNHRNPSNN-RQIHN-----GKKEEASRNLSTPPLRCSSRGQSITSHHSSGPLELSA 164

  Fly   188 QQDQQSLAGSASVS----KSIRSTGPGGNSSTSAAAQADMF----NKYLTVYPEVVEAAGSSAGS 244
            |:..:.|.|...:.    ..:.||.||....:..|:||.|.    ...:.|.|...|...:..|.
Human   165 QETVEDLKGVILLEDHPIAPVSSTSPGIKVESLPASQAHMLETTTKSVIPVKPVATETLINGKGK 229

  Fly   245 ADGGSSGGDSRSGAAVSTLGHTGAGTAPAQHVRTG------------HLSRKCSEVFSRRHRRRL 297
            ..||.                   |..|.:|...|            |||              |
Human   230 ERGGK-------------------GQPPLRHRSEGGLVDKGPLKKLPHLS--------------L 261

  Fly   298 ERQSSLDTAAAAANSNAENKLMRNQSDTIATAAPSFLHSQPTNKARGQTNPRQHFITSAPSTGIG 362
            .:...|:|..:.....:||               |.|..:|.:..||..  |:...:.:|...:
Human   262 SQYDLLETDVSFQPWGSEN---------------SVLIPEPVSCPRGSI--RERVQSKSPQDSL- 308

  Fly   363 GGDAPTSSTAVV--VIAPASNSL-VNPGRSSRLQRHRSSETHDER----LKHQSRGG----LFQP 416
            ....|...|.|.  |..||..|. |:......|..|:..::.|..    |...|:.|    |.:|
Human   309 SSSCPQCDTIVAKPVEEPADTSCQVDTSCQGDLPLHQEVDSSDSEVAVTLIDTSQPGDPLSLHEP 373

  Fly   417 ILQLPHHSAASSIGALAVLGGGGNVAANDVEDMELGL-VRNAGSGGVADACSRALQSWILDPFPD 480
            |..:...|:                ..|.:.|:|..| :|..|:
Human   374 IKIVITMSS----------------TPNSMTDLESSLHLRVVGT--------------------- 401

  Fly   481 GYLEDDSYTKSDLGIEQPHQPTFRTQHRHHHHHHHLHHHLGGAIIRKDPTSTMSALQLAAVTQPG 545
                :.:..|||   .:|..|                   |.|   ..|.:...::.:..:..|.
Human   402 ----EKTSVKSD---AEPTNP-------------------GAA---GSPNAEQISIPVITLDLPE 437

  Fly   546 TGGSVTGGGGAAGGGGSAAGMKRRRHSNATSYKHGSSQSNKSSLVGGGGSRGPSGEAGTSGGAGG 610
            .||   ||.....|.||....:|.:...:|         |:.|..|       |||.|.:
Human   438 GGG---GGVPCPEGNGSERTPERLKTRVST---------NQCSGYG-------SGEGGNA----- 478

  Fly   611 TGGVRRIKSAALEVLCPQPSVSNLSPHPNSVEAISGQQQMRNPLPPPSKSLVRNQHLNLYPTQGY 675
               ::...|::.|   |..|||.|:|...| |:..|::...|..|...||....:|..:.
Human   479 ---IKDHSSSSRE---PWESVSRLTPDTGS-ESKVGKEGQTNLDPSSCKSSHEKRHARVL----- 531

  Fly   676 GDGTPSAGGGGPGNSSTCSSLFFGSSSACGSTTALIEPPVYPIVEHSDEKTAHEEHGDDCLGIGQ 740
                 |...|        :.:|...|||              .:.:..|||......|
Human   532 -----SVDSG--------TDVFLSKSSA--------------EIVNDTEKTMPTSKSD------- 562

  Fly   741 GNADDDDEVDDVPIRRRTRALGCSQTHYSVESDVGGFLADEVGADEDVFKDFDDNLEHILSELQQ 805
                                         :|:..|..      .:|..|.:|...||.|.:....
Human   563 -----------------------------LEAKEGQM------PNESNFLEFVSLLESINTSKMT 592

  Fly   806 THNQLDDVLKTHD---LHHHSHLHHHKAASVEGAGPSGGSVAVGVSAGNDDEDEETEDNNTGSRS 867
            ..:||:...:.::   |...:.....|...:|...|||.|...|      ..|.:::|:.  |..
Human   593 ASSQLNGSAEQNEESGLLRDNCSQEKKEEILENEKPSGHSSKQG------KPDLQSQDHT--STG 649

  Fly   868 PLLNDRNRQPA-TLREIQADKQLRQEL----SHQSGAVIPAPNPPVPIRSEADSGCPSSDCEQVS 927
            |...    ||| |....|.::| ||.:    |.|..:|:           :..||..:|..|::|
Human   650 PACT----QPAKTTAFFQGNRQ-RQIIYRVTSQQDSSVL-----------QVISGPETSVQEEIS 698

  Fly   928 ASSKDQLLSGIELELQQYQILQRCQLDEEQPCTSKMAAKSLGAIPKVVKYREVDELRRRRRGGSP 992
                   :..:.:.:.::..::.|.|            ||                ..::.|  |
Human   699 -------VDAMHVFIDEHGEIRSCYL------------KS----------------GNQKEG--P 726

  Fly   993 ADAAEAGNEFALVKQTKQASRNSSSSNSTHSISLTDSLTADIHKMLWLMHGGAVDDRGRPITGTS 1057
            .....:.|:  .:.|.::...:|||:.::.|
Human   727 LQPLPSNND--CLSQAREMQVSSSSTTTSES---------------------------------- 755

  Fly  1058 ADGTPIPASSSLVPPNMSNAHFQFYQDAIQALQGTHPTSG----SSVEHMTNIELARDKLRLDAK 1118
                                     ||         |:||    |:::....:.:||
Human   756 -------------------------QD---------PSSGDPAVSALQQQLLLMVAR-------- 778

  Fly  1119 LMCEQLVAAAEANSGVRGNTLATQQMTQQQVGMLMRGGSSSRHPSSAPFSVQGLINVIRSERPAA 1183
                                 .||..|.:.|...:...|.|        |.||..|
Human   779 ---------------------RTQSETPRHVSQDLEASSCS--------STQGKFN--------- 805

  Fly  1184 RSQLDALQQLSDAAAALAANASEAASVSASGAGGGASSGGGGVLSALGLANHPSNQISQISQLSQ 1248
            |.|
Human   806 REQ-------------------------------------------------------------- 808

  Fly  1249 MSQPMLNVDGHFAPYCDYWRPACLLSATEKPAAPKSFYKYRF---KWCGQEHEFKIAMDRLELLA 1310
                                                |||:..   ||      .|:..|||.|||
Human   809 ------------------------------------FYKFIIFPGKW------IKVWYDRLTLLA 831

  Fly  1311 LFDRDLHWMHVLLASLLCTLVACLGAAILQHDHYKDLCALLFCAVIAGAQYSLVKSVQPDAASPV 1375
            |.||.......:||.||..||:.||...|.....||:..||||.|:|..||||:||||||.|||:
Human   832 LLDRTEDIKENVLAILLIVLVSLLGFLTLSQGFCKDMWVLLFCLVMASCQYSLLKSVQPDPASPI 896

  Fly  1376 HGFNKTVAYSRAIYFCLAGGMLLLLKRLDTDYGERTPDPVVFFGMR-YSPADVVALLLQA----L 1435
            ||.|:.:.|||.||||:..|::||   |||....|.|...|.:|:: :||     :.||:    |
Human   897 HGHNQIITYSRPIYFCVLCGLILL---LDTGAKARHPPSYVVYGLKLFSP-----VFLQSARDYL 953

  Fly  1436 YILLLCFPIIFSVGLCPQINTFLMYLLEQIDMHVFGGNAASSLLGSFLCVVRSVLAVMLLYGPLY 1500
            .:.|.|||.|..:||.||||||..||||||||..|||:|.|.:..:...|.|||||..||:...:
Human   954 IVFLYCFPAISLLGLFPQINTFCTYLLEQIDMLFFGGSAVSGITSAVYSVARSVLAAALLHAVCF 1018

  Fly  1501 GALDEQRGTQYI--LFSIFCAMLVPLGYHLSRCASDFSHLWRLIKTCIVSTYRDDEDEDLSQMQH 1563
            .|:.|....|:|  |||.||.:||.|.|||||.:||.|.|...|:..:..
Human  1019 SAVKEPWSMQHIPALFSAFCGLLVALSYHLSRQSSDPSVLMSFIQCRLFP--------------- 1068

  Fly  1564 IATGTVTGSGTANSTALQLTTSTPKQHRQTDVKTEHEQIELSSLEKLTVNEEHHEKDHGADDQLE 1628
                                            |..|:.:
Human  1069 --------------------------------KFLHQNL-------------------------- 1075

  Fly  1629 TDQDLPLQQKHSKSKTSSLGSSQQTLGKTISSSKRAITASSSCTSIGTGEPAVEAGALTEEAVEG 1693
                                                                             
Human  1076 ----------------------------------------------------------------- 1075

  Fly  1694 EEQRRNTLAGEVGSKHELAENYDQAAKIDECEDKISSSSATNPGDMSTLTAGAGTATTDATPACL 1758
                                                                             
Human  1076 ----------------------------------------------------------------- 1075

  Fly  1759 EADPDAEAEAPADEKQHQGILGTGTGTGTGTTEASENGSGGGANGNTNSNGTGNDLPDPLPRKLQ 1823
                   ||:.|                                             ||||:|::
Human  1076 -------AESAA---------------------------------------------DPLPKKMK 1088

  Fly  1824 ATVTTRLKNDLVVMTLLAVSVLGLHCSTVFTALQPDLNVVLYSFIGVLGLLLHYIVPQMRKHMPW 1888
            .:||..||.||:|..::||....:..||||.:|:|.|::||::..|.:|.:.||::||:|||.||
Human  1089 DSVTDVLKWDLIVCAVVAVLSFAVSASTVFLSLRPFLSIVLFALAGAVGFVTHYVLPQLRKHHPW 1153

  Fly  1889 LCFSRPLLRQREFGQFEVLNAPKIMWFEKLYIYLSVLERNVLFPLLAISSLTADSQLIV--AKFG 1951
            :..|.|:|:.:|:.|.||.:...:||||:||::|...|:.:|:|.|.:::||.|:.||.  .:.|
Human  1154 MWISHPILKNKEYHQREVRDVAHLMWFERLYVWLQCFEKYILYPALILNALTIDAFLISNHRRLG 1218

  Fly  1952 LPWGTLIVAICALKFVRNAYSDPTNQYLIIIFTVLLFRIDFAMATETFIIDYFFVSLAFRKCCDF 2016
            ..|...::.|..:|.:|.::.:|..|::.:.|||:.|..|:...:|:|::|:|.||:.|.|..|.
Human  1219 THWDIFLMIIAGMKLLRTSFCNPVYQFINLSFTVIFFHFDYKDISESFLLDFFMVSILFSKLGDL 1283

  Fly  2017 LLKLQFIVTYIAPWQITWGSAFHAFAQPFSVPHSAMLFLQAAISAVLSTPLNPFLGSAIFLTSYV 2081
            |.||||::||:||||:.|||:||.|||.|::|||||||.|...:::.||||:|||||.||:||||
Human  1284 LHKLQFVLTYVAPWQMAWGSSFHVFAQLFAIPHSAMLFFQTIATSIFSTPLSPFLGSVIFITSYV 1348

  Fly  2082 RPIKFWERDYNTRRIDHSNTRLSSQLERDLGADDNNLNSIFYEHLTRSLQHSLCGDLLMGRWGNV 2146
            ||:||||::|||||:|:|||||:.|:|||.|.|||||||||||||||:||.||||||::|||||.
Human  1349 RPVKFWEKNYNTRRVDNSNTRLAVQIERDPGNDDNNLNSIFYEHLTRTLQESLCGDLVLGRWGNY 1413

  Fly  2147 NQGDCFVLASDDLNCLVHIIELGNGLCTFQMRGLEFRGTYCQQREVEAITEDVEDNDGCCCCDPG 2211
            :.||||:|||||||..||:||:||||.|||:||||||||||||||||||.|..|::.|||||.||
Human  1414 SSGDCFILASDDLNAFVHLIEIGNGLVTFQLRGLEFRGTYCQQREVEAIMEGDEEDRGCCCCKPG 1478

  Fly  2212 HLPQLLSANAMFSTRWLAWQVVAAQYVIEGYSISDNLASATLQVFEYRKVLITYYIKSIIYYVVK 2276
            |||.|||.||.|..|||.|::...||::|||||.||.|:..||||:.|::||.|||||||||:|.
Human  1479 HLPHLLSCNAAFHLRWLTWEITQTQYILEGYSILDNNAATMLQVFDLRRILIRYYIKSIIYYMVT 1543

  Fly  2277 NPKLEQWLASGPIQDALQHTLSRQFVDLD-PIFNFNLDEDFDFRAVGITRSSFCYVYLKWINYCV 2340
            :|||..|:.:..:..:||......:::.| .:||.|:|:|:.....||||:|||.|||:||.:|.
Human  1544 SPKLLSWIKNESLLKSLQPFAKWHYIERDLAMFNINIDDDYVPCLQGITRASFCNVYLEWIQHCA 1608

  Fly  2341 DMRRDANSMGGAPPAQAPAAAGGASSAPATAGVAPPAPVTPAHNDSKSTPNLSAHGGQAGPSSGQ 2405
            ..|::
Human  1609 RKRQE------------------------------------------------------------ 1613

  Fly  2406 SKSQSQQQLRRPQKSVAQETSVGGGGVVVGGTTVPGTGGVTGGGGDPQLSSSHSFANISRQTSES 2470
                                                                             
Human  1614 ----------------------------------------------------------------- 1613

  Fly  2471 APGLGGYVAYMDQNVFVKLAKSSTTTGAGAGAPTSRKESQEKPALRLKLASVGKDAPLVSLCLAL 2535
                                            |::..:|.|             |:|||:|..||
Human  1614 --------------------------------PSTTLDSDE-------------DSPLVTLSFAL 1633

  Fly  2536 GLLARRSLATASHSALTGVEFFLHGLHALFKGDFRITSPRDEWVFADMELLHSVVAPAVKMALKL 2600
            ..|.||:|.||:|:....::.||:|||.|||||||||: |||||||||:|||.|||||::|:|||
Human  1634 CTLGRRALGTAAHNMAISLDSFLYGLHVLFKGDFRITA-RDEWVFADMDLLHKVVAPAIRMSLKL 1697

  Fly  2601 QQDHITNPDEFLDPHALYDAIDNCSNELVISHEADPVWRSAVLRGAPNLLALRHVMEDGSDEYRI 2665
            .||..|.|||:.||..||:||.:...::||.||.||.||.|||.....||.||||:::|:|||::
Human  1698 HQDQFTCPDEYEDPAVLYEAIQSFEKKVVICHEGDPAWRGAVLSNKEELLTLRHVVDEGADEYKV 1762

  Fly  2666 IRLTKRCLSFRVIKLNRECVRGLWAGQQQELIYLRNRNPERGSIQNAKQALRNIINSSCDQPIGY 2730
            |.|.:..|||:|||:|:|||||||||||||||:|||||||||||||.||.|||:||||||||:||
Human  1763 IMLHRSFLSFKVIKVNKECVRGLWAGQQQELIFLRNRNPERGSIQNNKQVLRNLINSSCDQPLGY 1827

  Fly  2731 PIYVSPLTTSYADTNAQLCEVIGGAITLDTIRHTVLGWWHRIRERCRQGCSSGSALEPHPGSGPV 2795
            |:|||||||||..|:.||..:.||.||||.||......|.|:|:.|.....||..:|...|.|..
Human  1828 PMYVSPLTTSYLGTHRQLKNIWGGPITLDRIRTWFWTKWVRMRKDCNARQHSGGNIEDVDGGGAP 1892

  Fly  2796 QLGACNFGSGGSVVGAASTATGVGASTGSGLGVAAPGT--AGSTGGESGDLAPVFISAPLYNTLT 2858
            ..|..|..||||...:|......||..|..   :..||  .|...|.|             .::.
Human  1893 TTGGNNAPSGGSQESSAEQPRKGGAQHGVS---SCEGTQRTGRRKGRS-------------QSVQ 1941

  Fly  2859 VNSYYSVRPGNV-PGGPI-----------------PGNLGGNYVS-----DSL------------ 2888
            .:|..|.||..: ..|||                 ...|.|:.:|     .||
Human  1942 AHSALSQRPPMLSSSGPILESRQTFLQTSTSVHELAQRLSGSRLSLHASATSLHSQPPPVTTTGH 2006

  Fly  2889 --------AVVRGGLAVMPVKPTSTTL--------------IAGLLNRERDETSGSG-------I 2924
                    |::|..|.    ..||:||              |:||...|...||.:.       :
Human  2007 LSVRERAEALIRSSLG----SSTSSTLSFLFGKRSFSSALVISGLSAAEGGNTSDTQSSSSVNIV 2067

  Fly  2925 MGAGASGPTRATSSGGVRSRRPEVGSSRGRDHER------RATLPIASGGAGGEP-GKDLTAPQT 2982
            ||..|...::||.........|: .:.:|:.|:|      ..||.:....|..|. |.|.||.|.
Human  2068 MGPSARAASQATRHLSEPCEPPD-ATEQGQLHDRCLAEAVADTLGVVCRRASQEDMGLDDTASQQ 2131

  Fly  2983 QVEHE 2987
            .|..|
Human  2132 SVSDE 2136

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pcx	NP_001259183.2	Pecanex_C	2523..2747	CDD:461533	145/223 (65%)
PCNX2	NP_055616.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	92..163		17/97 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	225..251		7/44 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	402..530		41/183 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	545..572		8/82 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	593..612		3/18 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	621..655		10/45 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	740..763		9/90 (10%)
		Pecanex_C	1619..1844	CDD:461533	147/238 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1876..1958		24/97 (25%)