DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pcx and Pcnx4

DIOPT Version :9

Sequence 1:	NP_001259183.2	Gene:	pcx / 31204	FlyBaseID:	FBgn0003048	Length:	3417	Species:	Drosophila melanogaster
Sequence 2:	NP_080603.2	Gene:	Pcnx4 / 67708	MGIID:	1914958	Length:	1177	Species:	Mus musculus

Alignment Length:	996	Identity:	208/996 - (20%)
Similarity:	328/996 - (32%)	Gaps:	315/996 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1865 YSFIGVL-------GLLLHYI-VPQMRKHMPWLCFSRPLLRQREFGQFEVLNAPKIMWF--EKLY 1919
            :.||.||       |||.||: |||:.:..          .|...| :.::....|:|.  |...
Mouse   369 FLFIAVLGMALLEAGLLHHYVSVPQVSRSG----------AQAVVG-YVLMVLLSIVWILRETQS 422

  Fly  1920 IYLSVLERNVLFP--LLAISSLTADSQLIVAKFGLPWGTLIVAICALKFVRNAYSDPTNQYLIII 1982
            ||:..:.||..:|  :.|: |:..|.|..:.|.|.....|:..:..|..|.....|.:...|..:
Mouse   423 IYIFGIFRNPFYPKDIHAV-SVFYDKQNKLLKIGAVRWILLTLVSPLAMVAFLALDSSLHGLHSV 486

  Fly  1983 FTVLLFRIDFAMA---TETFIIDYFFVSLAFR--------------------------KCCDFLL 2018
            ...:.|...|.|.   |||.:::...||....                          :...|:.
Mouse   487 SVSIGFTRAFRMVWQNTETALLETVVVSAVHMVSSTDCWWNRSLDTGIRLLLIGIMRDRLIQFIT 551

  Fly  2019 KLQFIVT-YIAPWQ------------ITWGSAFHAFAQPFSVPHSAMLFLQAAISAVLSTPLNPF 2070
            ||||.|| .:|.|.            ....:.|..|.....|           :|.:||:||.|.
Mouse   552 KLQFAVTVLLALWTEKKQHRKTTTTLCVLNTVFAPFVLGIIV-----------LSTLLSSPLLPL 605

  Fly  2071 LGSAIFLTSYVRPIKFWERDYNTRRIDHSNTRLSSQLERDLGADDNNLNSIFYEHLTRSLQHSLC 2135
            ....:||..:.||::.|.....|                   |.....:|:||..:...|..:|.
Mouse   606 FTLPVFLVGFPRPVQSWPGAVGT-------------------AACVCTDSVFYHQMVPRLTAALQ 651

  Fly  2136 GDLLMGRWGNVNQGDCFVLASDDLNCLVHIIELGNGLCTFQMRGLEFRGTYCQQREVEAITEDVE 2200
            ..:..|..|.:..|..::...:|....:.|:|.|...|...::|||.:.|.|...|.:.:.|..|
Mouse   652 TAMAAGSLGLLLPGSHYLGRFEDRLIWIMILECGYTYCCINVKGLELQETSCHTAEAQRVDEVFE 716

  Fly  2201 -----DNDGCCCCDPGHLPQLLSANAMFSTRWLAWQVVAAQYVIEGYSIS-DNLASATLQVFEYR 2259
                 ::...|..:. ||..:|:...:...:..:    .|:.|:.|...| |||.       |::
Mouse   717 SAFQREHPQVCSLNE-HLENVLTPCTVLPVKLYS----DARNVLTGIIDSPDNLK-------EFK 769

  Fly  2260 KVLITYYIKSIIYYVVKNPKLEQWLASGPIQDALQHTLSRQFVDLDPIFNFNLDEDFDFRAVGIT 2324
            ..||...:..:|.:..|.|..::
Mouse   770 DDLIKVLVWVLIQHCSKRPSTQE------------------------------------------ 792

  Fly  2325 RSSFCYVYLKWINYCVDMRRDANSMGGAPPAQAPAAAGGASSAPATAGVAPPAPVTPAHNDSKST 2389
                               ....:.|.|.||..||    |:|:|....:          .||:|
Mouse   793 -------------------NKTENTGEASPALPPA----ANSSPCPESL----------EDSES- 823

  Fly  2390 PNLSAHGGQAGPSSGQSKSQSQQQLRRPQKSVAQETSVGGGGVVVGGTTVPGTGGVTGGGGDPQL 2454
                   ..:..|.|...........|.:|..:::...         |.:|..|.|.....|...
Mouse   824 -------ANSDWSDGSIFDDEPAIKNRKEKLQSKDLPC---------TKLPIPGSVDSQNPDDHS 872

  Fly  2455 SSSHSFANISRQTSESAP----GLGGYVAYM-------DQNVFVKLA---KSSTTTGAGAGAPTS 2505
            :.:....::.|......|    |....|||:       .|:..:.|.   :|::|       |.|
Mouse   873 AGTGPKNDLYRTVILGLPAVDKGQREDVAYIPLVEFSCSQSRLLSLPEEWRSNST-------PRS 930

  Fly  2506 R----------------------KESQEKPALRLKLASVGKDAPLVSLCLALGLLARRSLATASH 2548
            :                      ..|:||..:   |..:.||..|..|
Mouse   931 KILEMSALFPEDWYQFVLRQLECFHSEEKSRV---LEEIAKDKALKDL----------------- 975

  Fly  2549 SALTGVEFFLHGLHALFKG----DFRITSPRD---------------EWVFADMELLHSVVAPAV 2594
                    ::|.:.|.:.|    |..:.||..               :|:....||.| :|..|.
Mouse   976 --------YVHTVMACYIGLFGIDNGVPSPGQLVRVYNGGLPWAGTLDWLSEKPELFH-LVRKAF 1031

  Fly  2595 KMALKLQQDHITNPDEFLDPHALYDAIDNCSNEL-------VISHEADPVWRSAVLRGAPNLLAL 2652
            :..|||..|..:     |.|...:..:.||..|.       ::|.|.   |:.|:|...|.|..|
Mouse  1032 RYTLKLMVDKAS-----LGPIEDFKELTNCLREYERDWYIGLVSEEQ---WKRAILEEKPCLFCL 1088

  Fly  2653 RHVMEDGSDEYRIIRLTKRCLSFRVIKLNRECVRGLWAGQQQELIYLRNRNPERGSIQNAKQALR 2717
            .:....|....|::.|.:  :|..:.|||.|.|||.||....||:|..|.:.||.|||.....||
Mouse  1089 GYESSMGVYTSRVLMLQE--MSVHIGKLNAEAVRGQWANLSWELLYATNDDEERYSIQAHPLLLR 1151

  Fly  2718 NIINSSCDQPIGYPIYVS-PL 2737
            |:...:.|.|:||||:.| ||
Mouse  1152 NLTVQAADPPLGYPIFSSKPL 1172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pcx	NP_001259183.2	Pecanex_C	2523..2746	CDD:282845	67/242 (28%)
pcx	NP_001259183.2	Loricrin	<2779..>2842	CDD:292475
Pcnx4	NP_080603.2	Pecanex_C	<1059..1174	CDD:282845	43/119 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000