DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pcx and pcnx2

DIOPT Version :9

Sequence 1:	NP_001259183.2	Gene:	pcx / 31204	FlyBaseID:	FBgn0003048	Length:	3417	Species:	Drosophila melanogaster
Sequence 2:	XP_690089.4	Gene:	pcnx2 / 561583	ZFINID:	ZDB-GENE-090312-150	Length:	2005	Species:	Danio rerio

Alignment Length:	3039	Identity:	850/3039 - (27%)
Similarity:	1190/3039 - (39%)	Gaps:	1169/3039 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSQTLEILRQGVWASLTGGYFYDPHQGVFCNVVHLYLWLYLLCSPFVAYLIFLQYFPSTWLTWC 65
            ||||.::.||||||||||||:::||.|..|.|..|||||::||..|...:|.    .|.|..|..
Zfish     1 MGSQVVQTLRQGVWASLTGGWYHDPDQNKFNNSCHLYLWMFLLMLPLSLHLA----LPPTTTTLS 61

  Fly    66 LYCVITSLTILMVKLANLALHRLYDRAQTMSEGNLKGQFVKVTKETEPRHDDEGGIEMKVIRPGG 130
            :||...:|..:::|:.|..||.::|:...:::
Zfish    62 IYCTSVTLFFIVIKMINYRLHVMFDKGDIVAQ--------------------------------- 93

  Fly   131 SRISGEQAINEASEENSIMSIDNVNSIIDLKVDVHRK-NSSESIELMFYAPSMLSGGSQQDQQSL 194
                                    ||:.|:...|.:| |:|:|.                 ..||
Zfish    94 ------------------------NSVPDISKGVDKKSNASDSC-----------------LPSL 117

  Fly   195 AGSASVSKSIRSTGPGGNSSTSAAAQADMFNKYLTVYPEVVEAAGSSAGSADGGSSGGDSRSGAA 259
            ..|::|..|:         :||...:    |:     |..|..........|.|..|...:|...
Zfish   118 RKSSTVPDSV---------ATSVLTK----NR-----PSPVIQVTVKQTETDPGLIGECPKSEEL 164

  Fly   260 VSTLGHTGAGTAPAQHVRTGHLSRKCSEVFSRRHRRRLERQSSLDTAAAAANSNAENKLMRNQSD 324
            .:|.|.:..                   :.:.|.|...|.|.:.|....:.|::....|:  |.:
Zfish   165 KNTEGQSDV-------------------ICNDRSRPEAEEQLTPDDDVFSPNTDQSAPLL--QGE 208

  Fly   325 TIATA----APSFLHSQPTNKARGQTNPRQHFITSAPSTGIGGGDAPTSSTAVVVIAPASNSLVN 385
            .|.:|    |...|...|||:            ...|.|     |...::|::.:   |.|
Zfish   209 QIPSAHRDKAEEDLPPTPTNE------------DDKPPT-----DPNNNNTSLEI---AEN---- 249

  Fly   386 PGRSSRLQRHRSSETHDERLKHQSRGGLFQPILQLPHHSAASSIGALAVLGGGGNVAANDVEDME 450
                    |.|..|.:                       .:..|..:.|.....:|..::.:.::
Zfish   250 --------RERPEENY-----------------------CSDEIAVVLVDNSSPSVNLDESDTVK 283

  Fly   451 LGLVRNAGSGGVADACSRALQSWILDPFPDGYLEDDSYTKSDLGIEQPHQPTFRTQHRHHHHHHH 515
            :.:..:.                  ||.....|| :|..:|.|...|.||
Zfish   284 IIITMSC------------------DPQTAAELE-ESVKQSILQSAQSHQ--------------- 314

  Fly   516 LHHHLGGAIIRKDPTSTMSALQLAAVTQPGTGGSVTGGGGAAGGGGSAAGMKRRRHSNATSYKHG 580
                                                                            |
Zfish   315 ----------------------------------------------------------------G 315

  Fly   581 SSQSNKSSLVGGGGSRGPSGEAGTSGGAGGTGGVRRIKSAALEVLCPQ--PSVSNLSPHPNSVEA 643
            .|.                                          ||.  |.::..|||
Zfish   316 DSD------------------------------------------CPVKIPVITFDSPH------ 332

  Fly   644 ISGQQQMRNPLPPPSKSLVRNQHLNLYPTQGYGDGTPSAGGGGPGNSSTCSSLFFGSSSACGSTT 708

Zfish   333 ----------------------------------------------------------------- 332

  Fly   709 ALIEPPVYPIVEHSDEKTAHEEHGDDCLGIGQGNADDDDEVDDVPIRRRTRALGCSQTHYSVESD 773
                        .::|.||                 :|||.||.||
Zfish   333 ------------EAEEPTA-----------------EDDEKDDTPI------------------- 349

  Fly   774 VGGFLADEVGADEDVFKDFDDNLEHILSELQQTHNQLDDVLKTHDLHHHSHLHHHKAASVEGAGP 838
                     |.|..|               |:...:.|.:|....
Zfish   350 ---------GGDNSV---------------QEKSERQDSLLAKEP-------------------- 370

  Fly   839 SGGSVAVGVSAGNDDEDEETEDN--NTGSRSPLLNDRNRQPATLREIQADKQLRQELSHQSGAVI 901
                    :|:.:..|.:|.|.|  ...:.|||:.:.:.....:.            ||
Zfish   371 --------ISSDSAQECKEIESNEQEMPNMSPLMTNNSSSGIDVN------------SH------ 409

  Fly   902 PAPNPPVPIRSEADS---------GCPSSDCEQVSASSKDQLLSGIELELQQYQILQRCQLDEEQ 957
            |..:.|..::.:||.         .|..|........|.|   ||.:..|..|:  .:.:|....
Zfish   410 PDESDPPELKLDADGFLQIPSAYMRCTQSGRTHARGLSID---SGRDAVLISYK--AKDKLGTMT 469

  Fly   958 PCTSKMAAKSLGAIPKVVKYREVDELRR-----RRRGGSPA-DAAEAGNEFALVKQTKQASRNSS 1016
            ...|.:.||. |.||....:.|...|..     |..||:.| :..|..||.:::  |::.|..|.
Zfish   470 SSKSDLEAKE-GQIPNESNFVEFVSLLESINSIRFGGGNEAEEEIEERNEQSMM--TEKDSDVSE 531

  Fly  1017 SSNSTHSISLTDSLTADIHKMLWLMHGGAVDDRGRPITG-----TSADGTP----IPASSSLVPP 1072
            |:......:..:||..|..|        .:.:...||..     |..|..|    :|:.:|
Zfish   532 STGQHERPNPPNSLATDTMK--------TIPETLIPIVSPESPQTDKDRDPDYDSLPSQTS---- 584

  Fly  1073 NMSNAHFQFYQDAIQALQGTHPTSGSSVEHMTNIELARDKLRLDAKLMCEQ---LVAAAEANSGV 1134
                   |.....:|.:  ..|.:.|..|..|...:.|::.|   ||..|:   |...||..:|.
Zfish   585 -------QSESSMLQVI--CRPEATSKEEAYTFHTVHRERPR---KLYNERALNLPLGAELITGN 637

  Fly  1135 RGNTLATQQMTQQQVGMLMRGGSSSRHPSSAPFSVQGLINVIRSERPAARSQLDALQQ---LSDA 1196
            ..:.|:|...::.|.|  :.||     ||..||  |..|...|..|| .|:..:..|:   |.|:
Zfish   638 ICDLLSTSSNSECQDG--LAGG-----PSECPF--QRRILPTRRLRP-RRTHPEIFQEEDSLDDS 692

  Fly  1197 AAALAANASEAASVSASGAGGGASSGGGGVLSALGLANHPSNQISQISQLSQMSQPMLNVDGHFA 1261
            :..
Zfish   693 SET-------------------------------------------------------------- 695

  Fly  1262 PYCDYWRPACLLSATEKPAAPKSFYKYRF---KWCGQEHEFKIAMDRLELLALFDRDLHWMHVLL 1323
                        |..|||:. |.:||.:.   ||      ..|..|||.|:||.||::.....::
Zfish   696 ------------STQEKPSR-KLYYKLKVFPGKW------VNILYDRLTLMALLDRNMDMTENMV 741

  Fly  1324 ASLLCTLVACLGAAILQHDHYKDLCALLFCAVIAGAQYSLVKSVQPDAASPVHGFNKTVAYSRAI 1388
            |..|..|||.||..:|....:||:....||.|||..||||:|||||||||||||.|:.|.||||.
Zfish   742 AVFLAFLVAFLGFVLLNEGCFKDIWVFQFCLVIASCQYSLLKSVQPDAASPVHGHNQIVIYSRAA 806

  Fly  1389 YFCLAGGMLLLLKRLDTDYGERTPD-PV-VFFGMRYSPADVVALLLQALYILLLCFPIIFSVGLC 1451
            |||:..|::.:|:.:     .|||| || .|:|:....:||:......|.....|||:.|.:||.
Zfish   807 YFCIFCGLIWILEIV-----LRTPDLPVSTFYGITIVTSDVLQYTQDILVGFTYCFPVTFLLGLF 866

  Fly  1452 PQINTFLMYLLEQIDMHVFGGNAASSLLGSFLCVVRSVLAVMLLYGPLYGALDEQRGTQYI--LF 1514
            ||||||::|.|||||||.|||.||:.|..:..|:|||:.|:.||||...|||.|....|:|  ||
Zfish   867 PQINTFVIYFLEQIDMHFFGGTAATGLPSAVYCIVRSLTALSLLYGFCLGALKEPWDEQHIPALF 931

  Fly  1515 SIFCAMLVPLGYHLSRCASDFSHLWRLIKTCIVSTYRDDEDEDLSQMQHIATGTVTGSGTANSTA 1579
            |.|||:||.:.|||||.:||.|.|:.|||
Zfish   932 SGFCALLVVVSYHLSRQSSDPSVLFSLIK------------------------------------ 960

  Fly  1580 LQLTTSTPKQHRQTDVKTEHEQIELSSLEKLTVNEEHHEKDHGADDQLETDQDLPLQQKHSKSKT 1644

Zfish   961 ----------------------------------------------------------------- 960

  Fly  1645 SSLGSSQQTLGKTISSSKRAITASSSCTSIGTGEPAVEAGALTEEAVEGEEQRRNTLAGEVGSKH 1709
                                   |....|:|.||.            |.||...||
Zfish   961 -----------------------SKLMPSLGHGEE------------EEEESAENT--------- 981

  Fly  1710 ELAENYDQAAKIDECEDKISSSSATNPGDMSTLTAGAGTATTDATPACLEADPDAEAEAPADEKQ 1774

Zfish   982 ----------------------------------------------------------------- 981

  Fly  1775 HQGILGTGTGTGTGTTEASENGSGGGANGNTNSNGTGNDLPDPLPRKLQATVTTRLKNDLVVMTL 1839
                                                     ||||.||:.:|...|.:||||.:|
Zfish   982 -----------------------------------------DPLPEKLRGSVKEILLSDLVVCSL 1005

  Fly  1840 LAVSVLGLHCSTVFTALQPDLNVVLYSFIGVLGLLLHYIVPQMRKHMPWLCFSRPLLRQREFGQF 1904
            .:|....:..||||.:|:|.:::|||:....:|.:.||::||:|||.|||..|.|:|:.:|:.||
Zfish  1006 ASVLTFAITASTVFLSLRPFVSIVLYAVAATVGFVTHYLIPQLRKHHPWLWISHPVLKSKEYSQF 1070

  Fly  1905 EVLNAPKIMWFEKLYIYLSVLERNVLFPLLAISSLTADSQLIV--AKFGLPWGTLIVAICALKFV 1967
            |......:||||:||:.|...|:.:::|.:.:|:||.|...:.  .|.|:....|::.:..:|.:
Zfish  1071 EPREDAHLMWFERLYVGLLTFEKYIVYPAIILSALTNDGFTLSHRKKLGIHCDVLLMTVAGMKLL 1135

  Fly  1968 RNAYSDPTNQYLIIIFTVLLFRIDFAMATETFIIDYFFVSLAFRKCCDFLLKLQFIVTYIAPWQI 2032
            |.::.||:.|:|.:|||::.|..|.:.|:|||::::|.:|:.|.|..|.|.||.||:.|||||||
Zfish  1136 RASFCDPSYQFLTLIFTIVFFEFDCSSASETFLLNFFLMSIIFNKLWDLLHKLHFILVYIAPWQI 1200

  Fly  2033 TWGSAFHAFAQPFSVPHSAMLFLQAAISAVLSTPLNPFLGSAIFLTSYVRPIKFWERDYNTRRID 2097
            .||||||||||||:|||||||.||..|:.:..|||:||||||||:|||.||:|:|||:|||:|||
Zfish  1201 AWGSAFHAFAQPFAVPHSAMLLLQTFITTLFYTPLSPFLGSAIFITSYPRPVKYWERNYNTKRID 1265

  Fly  2098 HSNTRLSSQLERDLGADDNNLNSIFYEHLTRSLQHSLCGDLLMGRWGNVNQGDCFVLASDDLNCL 2162
            :||:||.||::::.|.|||||||||||:|||||||||||||::|||||...||||:||||.||.|
Zfish  1266 NSNSRLVSQVDKETGCDDNNLNSIFYEYLTRSLQHSLCGDLMLGRWGNYCAGDCFILASDYLNAL 1330

  Fly  2163 VHIIELGNGLCTFQMRGLEFRGTYCQQREVEAITEDVEDNDGCCCCDPGHLPQLLSANAMFSTRW 2227
            ||:||:||||.|||:||||||||||||||||||||.||::|.||||:|||||.:||.||.|:.||
Zfish  1331 VHLIEVGNGLVTFQLRGLEFRGTYCQQREVEAITEGVEEDDYCCCCEPGHLPHVLSCNAAFNLRW 1395

  Fly  2228 LAWQVVAAQYVIEGYSISDNLASATLQVFEYRKVLITYYIKSIIYYVVKNPKLEQWLASGPIQDA 2292
            |||:|...:|::||||||:|.|:..|||::.||:|||||:||||||:|.:|||:.|:....:|:|
Zfish  1396 LAWEVTTTKYLLEGYSISENNAATMLQVYDLRKLLITYYLKSIIYYLVISPKLQMWIKDQTMQEA 1460

  Fly  2293 LQHTLSRQFVDLDP-IFNFNLDEDFDFRAVGITRSSFCYVYLKWINYCVDMRRDANSMGGAPPAQ 2356
            |........::.|| :|:..:|||:.....|:||:|||.|||:||.||.:
Zfish  1461 LVFYTKWHHIEKDPAVFSMKIDEDYVHCLQGVTRASFCNVYLEWIQYCAN--------------- 1510

  Fly  2357 APAAAGGASSAPATAGVAPPAPVTPAHNDSKSTPNLSAHGGQAGPSSGQSKSQSQQQLRRPQKSV 2421
                                                                    :|..|..|
Zfish  1511 --------------------------------------------------------KLEEPVDS- 1518

  Fly  2422 AQETSVGGGGVVVGGTTVPGTGGVTGGGGDPQLSSSHSFANISRQTSESAPGLGGYVAYMDQNVF 2486

Zfish  1519 ----------------------------------------------------------------- 1518

  Fly  2487 VKLAKSSTTTGAGAGAPTSRKESQEKPALRLKLASVGKDAPLVSLCLALGLLARRSLATASHSAL 2551
                                                .:|:|||:||.||.:|.||||:||:|:..
Zfish  1519 ------------------------------------DEDSPLVTLCFALSVLGRRSLSTAAHNRS 1547

  Fly  2552 TGVEFFLHGLHALFKGDFRITSPRDEWVFADMELLHSVVAPAVKMALKLQQDHITNPDEFLDPHA 2616
            ..:|.||:|.:.||||||||.: :||||||||:||..||||||:|:|||.|||.|:.:|..:|..
Zfish  1548 NSLESFLYGFNTLFKGDFRIAA-KDEWVFADMDLLQMVVAPAVRMSLKLHQDHFTSLEETEEPAV 1611

  Fly  2617 LYDAIDNCSNELVISHEADPVWRSAVLRGAPNLLALRHVMEDGSDEYRIIRLTKRCLSFRVIKLN 2681
            |::||.:..:.|||.||:||.||.|||.....||.|||::::|:|||:||.|.||.|||:|||||
Zfish  1612 LHEAISSYRSSLVICHESDPAWRRAVLSSRDTLLTLRHMVDEGADEYKIIMLYKRHLSFKVIKLN 1676

  Fly  2682 RECVRGLWAGQQQELIYLRNRNPERGSIQNAKQALRNIINSSCDQPIGYPIYVSPLTTSYADTNA 2746
            :||||||||||||||::|||||||||||||:||||||:||||||||:|||::||||||||..::.
Zfish  1677 KECVRGLWAGQQQELVFLRNRNPERGSIQNSKQALRNMINSSCDQPLGYPMFVSPLTTSYMGSHK 1741

  Fly  2747 QLCEVIGGAITLDTIRHTVLGWWHRIRERCRQGCSSGSALEPHPGSGPVQLGACNFGSGGSVVGA 2811
            |...:.||..:||:||..:|..|.|:|:.....|:||..:|...         |   :|.|:...
Zfish  1742 QTRNIWGGPFSLDSIRLWLLSRWFRVRKDNLTSCNSGMNMEDVD---------C---AGSSMSQN 1794

  Fly  2812 ASTATGVGASTGSG---------------------------------LGVAAPGTAGSTGGESGD 2843
            .::||....|...|                                 .|.......||..|..|.
Zfish  1795 HNSATSQSLSLYHGRPRSSQSRHHAAHREYRSRSVQPQAQRPPVTSRSGPILDSQHGSASGGPGL 1859

  Fly  2844 LAPVFISAPLYNTLTVNSYYSVRPGNVPGGPIPGNLGGNYVSDSLAVVRGGLAVMPVKPTSTTLI 2908
            :..:..|...:||.::.|.:|..|.....||:....|.:         |.|    .|..:|:||
Zfish  1860 VQRLSNSQLSFNTSSIASVFSQVPRLSTTGPLVSAAGPH---------RSG----QVSSSSSTL- 1910

  Fly  2909 AGLLNRERDETSG---SGIMGA--GASGPTRATSSGGVRSRRPEVGSSR 2952
             .||..:|..:||   ||:..|  |.:..|:::||..: :..|...|||
Zfish  1911 -SLLFGKRSFSSGLVISGLSAADGGNTSDTQSSSSVNI-ALGPSCRSSR 1957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pcx	NP_001259183.2	Pecanex_C	2523..2746	CDD:282845	143/222 (64%)
pcx	NP_001259183.2	Loricrin	<2779..>2842	CDD:292475	15/95 (16%)
pcnx2	XP_690089.4	Pecanex_C	1517..1740	CDD:282845	144/325 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576174
Domainoid	1	1.000	1047	1.000	Domainoid score	I25
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41206at33208
OrthoFinder	1	1.000	-	-		FOG0002108
OrthoInspector	1	1.000	-	-		otm24557
orthoMCL	1	0.900	-	-		OOG6_104101
Panther	1	1.100	-	-	O	PTHR12372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1397
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.850