DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pcx and Pcnx

DIOPT Version :9

Sequence 1:NP_001259183.2 Gene:pcx / 31204 FlyBaseID:FBgn0003048 Length:3417 Species:Drosophila melanogaster
Sequence 2:NP_061284.2 Gene:Pcnx / 54604 MGIID:1891924 Length:2344 Species:Mus musculus


Alignment Length:3310 Identity:1006/3310 - (30%)
Similarity:1373/3310 - (41%) Gaps:1122/3310 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGSQTLEILRQGVWASLTGGYFYDPHQGVFCNVVHLYLWLYLLCSPFVAYLIFLQYFPSTWLTWC 65
            ||||||:||||||||:|:||::|||||..|.|.:||||||:||..||..|:.    .||:.:...
Mouse     1 MGSQTLQILRQGVWAALSGGWYYDPHQATFVNALHLYLWLFLLGLPFTLYMA----LPSSMIIVA 61

  Fly    66 LYCVITSLTILMVKLANLALHRLYDRAQTMSEGNLKGQFVKVTKE-TEPRHDDEGGIEMKVIRPG 129
            :||.:.:...:::|:.|..|||..|..:.:.         :..|| |:.|...|.|         
Mouse    62 VYCPVVAAVFIILKMVNYRLHRALDAGEIVD---------RSAKEFTDQRAKAEQG--------- 108

  Fly   130 GSRISGEQAINEASEENSIMSIDNVNSIIDLKVDVHRKNSSESIELMFYAPSMLSGGSQQDQQSL 194
                                           .....||:|:        .||...||.:      
Mouse   109 -------------------------------NCSTRRKDSN--------GPSDPGGGIE------ 128

  Fly   195 AGSASVSKSIR-STGPGGNSSTSAAAQADMFNKYLTVYPEVVEAAGSSAGSADGGSSGGDSRSGA 258
                 :|:.|| :|.|.|.||.::.|..|..|:.                    ||  |.||.|.
Mouse   129 -----MSEFIREATPPVGCSSRNSYAGLDPSNQI--------------------GS--GSSRLGT 166

  Fly   259 AVSTLGHTG-AGTAPAQHVRTGHLSRKCSEVFSRRHRRRLERQSSLDTAAAAANSNAENKLMRNQ 322
            |.:..|.|. |.|:....:..|..|..|.|.         ..:..|.|         :.||.|..
Mouse   167 AATIKGDTDTAKTSDDISLSLGQSSSLCKEG---------SEEQDLAT---------DRKLFRLV 213

  Fly   323 SDTIATAAPSFLHSQPTNKARGQTNPRQHFITSAPSTGIGGGDAPTSSTAVVVIAPASNSLVNPG 387
            |:      .||:..||:..:.||..||..                            |:.:..|.
Mouse   214 SN------DSFISIQPSLSSCGQDLPRDF----------------------------SDKVSLPS 244

  Fly   388 RSSRLQRHRSSE-----------------THDERLKHQSRGGLFQPILQLPHHSAASSIGALAVL 435
            .|   |.||..:                 :|..|.:|:.||                        
Mouse   245 HS---QHHRVDQSLCSACDTEVASLVPLHSHSYRKEHRPRG------------------------ 282

  Fly   436 GGGGNVAANDVEDMELGLVRNAGSGGVADACSRALQSWILDPFPDGYLEDDSYTKSDLGIEQPHQ 500
                              |....|..||              |||..|.         |:     
Mouse   283 ------------------VPRTSSSAVA--------------FPDASLS---------GL----- 301

  Fly   501 PTFRTQHRHHHHHHHLHHHLGGAIIRKDPTSTMSALQLAAVTQPGTGGSVTGGGGAAGGGGSAAG 565
            |.::.|.|.                ..||.:.:.:      ::|.:|...:..|.:.....|...
Mouse   302 PLYQQQQRR----------------GLDPVTELDS------SKPHSGTRESSAGKSCPPAQSQPA 344

  Fly   566 MKRRRHSNATSYKHGSSQS-NKSSLVGGGGSRGPSGEAGTSGGAGGTGGVRRIKSAALEVLCPQP 629
            ..||:.|:....|.|.|:: |....|....|........|.....||.  |...|........|.
Mouse   345 ADRRKSSSQPPTKCGKSRALNAEKSVDSLRSLSTRSSGSTESYCSGTD--RDTNSTLSSYKSEQT 407

  Fly   630 SVSN----LSPH-----------------PNSVEAISGQQQMR------------NPLPPP---- 657
            |.::    ||.|                 .:|||..|.:...|            .|..||    
Mouse   408 SSTHIESILSEHEESPKVGDKSARKRECGADSVEERSHRADDRRTSSDKTAPEGNTPAGPPEAPD 472

  Fly   658 -----------------SKSLVRNQHLNLYPTQGYGDGTPSAGGGGPGNSSTCSSLFFGSSSACG 705
                             |:...:|.|.|.:...  ||..|..........|...|| ...|..|.
Mouse   473 AQASEEMADQAAPSSSASEDANKNPHANEFTVP--GDRPPEQSAESKEEQSEKPSL-ATDSRVCK 534

  Fly   706 STTAL-----IEPPVYPIVEHSDEKTAHEEHGDDCLGIGQGNADDDDEVDDVPIRRRTRALGCSQ 765
            .....     :.|....::..:  .:||:                       |.||||.....|.
Mouse   535 DDGGKQKEGDVRPKSSSLIHRT--TSAHK-----------------------PGRRRTGKKRASS 574

  Fly   766 THYSVESDVGGFL--------ADEVGADEDVFKDFDDNLEHILSELQQTHNQLDDVLKTHDLHHH 822
            ...|...|...|.        :...|.|||                ....:.|......|..|..
Mouse   575 FDSSRHRDYVSFRGVSGTKPHSAVFGHDED----------------SSDQSDLSRAPSIHSAHQF 623

  Fly   823 SHLHHHKAASVEGAGPSGGSVAVGVSAGNDDEDEETEDNNTGSRSPLLNDRNRQPATLREIQADK 887
            |......|.|.....|.|...|:....|:.|...:::..:.....|....:.|.........:.|
Mouse   624 SSDSSSSATSHSCQSPEGKYGALKTKHGHRDRGTDSDHTHRAHPGPEGTTKKRASRRTSSTSSAK 688

  Fly   888 QLRQELSHQSGAV--------IPAPNPPVPIRSEADSGCPSSDCEQVSASSKDQLLSGIELELQQ 944
            ...:.||..||.|        :.||:...|:.:.      .||.|.......|:|          
Mouse   689 TRARVLSLDSGTVACLNDSNRLLAPDSMKPLTTS------KSDLEAKEGEVLDEL---------- 737

  Fly   945 YQILQRC-QLDEEQPCTSKMAAKSLGAIPKVVKYREVDELRRRRRGGSPADAAEAGNEFALVKQT 1008
             .:|.|. ||:        ...:|..::|..|.:.|.:|   :......|.|:|....|...:.|
Mouse   738 -SLLGRASQLE--------TVTRSRNSLPSQVAFPEGEE---QDAATGAAQASEEAVAFRRERST 790

  Fly  1009 --KQASRNSSSSNSTHSISLTDSLTADIHKMLWLMHGGAVDDRGRPITGTSADGTPIPASSSLVP 1071
              :||.|...::.|                              .|...|...|:|:    ||  
Mouse   791 FRRQAVRRRHNAGS------------------------------NPTPPTLLIGSPL----SL-- 819

  Fly  1072 PNMSNAHFQFYQDAIQALQGTHPTSGSSVEHMTNIELARDKLRLDAKLMCEQLVAAAEANSGVRG 1136
                       ||..|..|.|                  .::::.::...:..|.:|.|:..||.
Mouse   820 -----------QDGQQGQQST------------------AQVKVQSRPPSQAAVLSASASLLVRK 855

  Fly  1137 NTLATQQMTQQQVGMLMRGGSSSRHPSSAPFSV---------QGLINVIRSERPAARSQLDALQQ 1192
            .::..:........:    |.||.|.....||.         ..|:|.    .||||.       
Mouse   856 GSVHLEASHDHASAV----GGSSLHDELGKFSSTLYETGGCDMSLVNF----EPAARR------- 905

  Fly  1193 LSDAAAALAANASEAASVSASGAGGGASSGGGGVLSALGLANHPSNQIS----QISQLSQMSQPM 1253
                    |:|..:..|               .|.|:..:..:|.:.:|    ::::|..:...:
Mouse   906 --------ASNICDTDS---------------HVSSSTSVRFYPHDMLSLPQIRLNRLLTIDTDL 947

  Fly  1254 L-NVDGHFAPYCDYWRPACLLSATEKP---AAPKSFYKYRF-----KWCGQEHEFKIAMDRLELL 1309
            | ..|...:|.         |:||..|   ||.|..:.|||     .|.|      |..|||.||
Mouse   948 LEQQDIDLSPD---------LAATYGPTEEAAQKVKHYYRFWVLPQLWIG------INFDRLTLL 997

  Fly  1310 ALFDRDLHWMHVLLASLLCTLVACLGAAILQHDHYKDLCALLFCAVIAGAQYSLVKSVQPDAASP 1374
            |||||:...:..:||.:|..|||.||:.:|....::|:....||.|||..||||:||||||::||
Mouse   998 ALFDRNREILENILAVVLAILVAFLGSILLIQGFFRDIWVFQFCLVIASCQYSLLKSVQPDSSSP 1062

  Fly  1375 VHGFNKTVAYSRAIYFCLAGGMLLLLKRLDTDYGER--TPDPVVFFGMRYSPADVVALLLQALYI 1437
            .||.|:.:||||.:||||..|::.||     |||.|  |......:|:.::...|:......:.:
Mouse  1063 RHGHNRIIAYSRPVYFCLCCGLIWLL-----DYGSRNLTTSKFKLYGVTFTNPLVLLSARDLVIV 1122

  Fly  1438 LLLCFPIIFSVGLCPQINTFLMYLLEQIDMHVFGGNAASSLLG---SFLCVVRSVLAVMLLYGPL 1499
            ..|||||:|.:||.||:|||:|||.||:|:|:|||||.:|||.   ||||   |::||.||||..
Mouse  1123 FTLCFPIVFFIGLLPQVNTFVMYLCEQLDIHIFGGNATTSLLAALYSFLC---SIVAVALLYGLC 1184

  Fly  1500 YGALDEQRGTQY--ILFSIFCAMLVPLGYHLSRCASDFSHLWRLIKTCIVSTYRDDEDEDLSQMQ 1562
            ||||.:....|:  :|||:||.:||.:.|||||.:||.|.|:.|:::.|.               
Mouse  1185 YGALRDSWDGQHVPVLFSVFCGLLVAVSYHLSRQSSDPSVLFSLMQSKIF--------------- 1234

  Fly  1563 HIATGTVTGSGTANSTALQLTTSTPKQHRQTDVKTEHEQIELSSLEKLTVNEEHHEKDHGADDQL 1627
                                    ||                                       
Mouse  1235 ------------------------PK--------------------------------------- 1236

  Fly  1628 ETDQDLPLQQKHSKSKTSSLGSSQQTLGKTISSSKRAITASSSCTSIGTGEPAVEAGALTEEAVE 1692
                                                                             
Mouse  1237 ----------------------------------------------------------------- 1236

  Fly  1693 GEEQRRNTLAGEVGSKHELAENYDQAAKIDECEDKISSSSATNPGDMSTLTAGAGTATTDATPAC 1757
                                                                             
Mouse  1237 ----------------------------------------------------------------- 1236

  Fly  1758 LEADPDAEAEAPADEKQHQGILGTGTGTGTGTTEASENGSGGGANGNTNSNGTGNDLPDPLPRKL 1822
                        ||||..:..|                                :::.||||.||
Mouse  1237 ------------ADEKNPEDPL--------------------------------SEVKDPLPEKL 1257

  Fly  1823 QATVTTRLKNDLVVMTLLAVSVLGLHCSTVFTALQPDLNVVLYSFIGVLGLLLHYIVPQMRKHMP 1887
            ..:|:.||::||||..::.|....:|.|||||||||.|..|||:.:||:||:.||::||:||.:|
Mouse  1258 SNSVSERLQSDLVVCVIIGVLYFAIHVSTVFTALQPALKYVLYALVGVVGLVTHYVLPQVRKQLP 1322

  Fly  1888 WLCFSRPLLRQREFGQFEVLNAPKIMWFEKLYIYLSVLERNVLFPLLAISSLTADSQLIVA--KF 1950
            |.||||||||..|..|:||.||..:||||||:::|..:|:|:::||:.::.|::.::.|.:  |.
Mouse  1323 WHCFSRPLLRTAEHSQYEVRNAATMMWFEKLHVWLLFVEKNIIYPLIVLNELSSSAETIASPKKL 1387

  Fly  1951 GLPWGTLIVAICALKFVRNAYSDPTNQYLIIIFTVLLFRIDFAMATETFIIDYFFVSLAFRKCCD 2015
            ....|.|::.|..||.:|:::|.||.||:.:|||||.|:.|:...:||.::|.||:|:.|.|..:
Mouse  1388 DTELGALMITIAGLKLLRSSFSSPTYQYITVIFTVLFFKFDYEAFSETMLLDLFFMSILFSKLWE 1452

  Fly  2016 FLLKLQFIVTYIAPWQITWGSAFHAFAQPFSVPHSAMLFLQAAISAVLSTPLNPFLGSAIFLTSY 2080
            .|.||||:.||:||||||||||||||||||:||||||||:||.:||..|||||||||||||:|||
Mouse  1453 LLYKLQFVYTYVAPWQITWGSAFHAFAQPFAVPHSAMLFVQAIVSAFFSTPLNPFLGSAIFITSY 1517

  Fly  2081 VRPIKFWERDYNTRRIDHSNTRLSSQLERDLGADDNNLNSIFYEHLTRSLQHSLCGDLLMGRWGN 2145
            |||:|||||||||:|:|||||||:|||:|:.|:||||||||||||||||||||||||||:|||||
Mouse  1518 VRPVKFWERDYNTKRVDHSNTRLASQLDRNPGSDDNNLNSIFYEHLTRSLQHSLCGDLLLGRWGN 1582

  Fly  2146 VNQGDCFVLASDDLNCLVHIIELGNGLCTFQMRGLEFRGTYCQQREVEAITEDVEDNDGCCCCDP 2210
            .:.||||:||||.||.|||:||:||||.|||:||||||||||||||||||||.||:::|.|||:|
Mouse  1583 YSTGDCFILASDYLNALVHLIEIGNGLVTFQLRGLEFRGTYCQQREVEAITEGVEEDEGFCCCEP 1647

  Fly  2211 GHLPQLLSANAMFSTRWLAWQVVAAQYVIEGYSISDNLASATLQVFEYRKVLITYYIKSIIYYVV 2275
            ||:|.:||.||.|..|||||:||..:|::|||||:||.|::.||||:.|:||.|||:|.|||||.
Mouse  1648 GHVPHVLSFNAAFGQRWLAWEVVVTKYILEGYSITDNSAASMLQVFDLRRVLTTYYVKGIIYYVT 1712

  Fly  2276 KNPKLEQWLASGPIQDALQHTLSRQFVDLDPIFNFNLDEDFDFRAVGITRSSFCYVYLKWINYCV 2340
            .:.|||:|||:..:|:.|:....|.:||:||.||.|:|||:|.|..||:|.|||.:||.||.|| 
Mouse  1713 TSSKLEEWLANETMQEGLRLCADRNYVDVDPTFNPNIDEDYDHRLAGISRESFCVIYLSWIEYC- 1776

  Fly  2341 DMRRDANSMGGAPPAQAPAAAGGASSAPATAGVAPPAPVTPAHNDSKSTPNLSAHGGQAGPSSGQ 2405
                                                                             
Mouse  1777 ----------------------------------------------------------------- 1776

  Fly  2406 SKSQSQQQLRRPQKSVAQETSVGGGGVVVGGTTVPGTGGVTGGGGDPQLSSSHSFANISRQTSES 2470
                                                                             
Mouse  1777 ----------------------------------------------------------------- 1776

  Fly  2471 APGLGGYVAYMDQNVFVKLAKSSTTTGAGAGAPTSRKESQEKPALRLKLASVGKDAPLVSLCLAL 2535
                                             :||         |.|...|.||:.||:||..|
Mouse  1777 ---------------------------------SSR---------RAKPLDVDKDSSLVTLCYGL 1799

  Fly  2536 GLLARRSLATASHSALTGVEFFLHGLHALFKGDFRITSPRDEWVFADMELLHSVVAPAVKMALKL 2600
            .:|.||:|.||||...:.:|.||:||||||||||||:|.||||:|||||||..||.|.::|::||
Mouse  1800 CVLGRRALGTASHHMSSNLESFLYGLHALFKGDFRISSVRDEWIFADMELLRKVVVPGIRMSIKL 1864

  Fly  2601 QQDHITNPDEFLDPHALYDAIDNCSNELVISHEADPVWRSAVLRGAPNLLALRHVMEDGSDEYRI 2665
            .|||.|:|||:.||..||:||.:....|||:||.||.||||||..:|:||||||||:||::||:|
Mouse  1865 HQDHFTSPDEYDDPTVLYEAIVSHEKNLVIAHEGDPAWRSAVLANSPSLLALRHVMDDGTNEYKI 1929

  Fly  2666 IRLTKRCLSFRVIKLNRECVRGLWAGQQQELIYLRNRNPERGSIQNAKQALRNIINSSCDQPIGY 2730
            |.|.:|.|||||||:|:||||||||||||||::||||||||||||||||||||:|||||||||||
Mouse  1930 IMLNRRYLSFRVIKVNKECVRGLWAGQQQELVFLRNRNPERGSIQNAKQALRNMINSSCDQPIGY 1994

  Fly  2731 PIYVSPLTTSYADTNAQLCEVIGGAITLDTIRHTVLGWWHRIRERCRQGCSSGSALEPHPGSGPV 2795
            ||:||||||||:|::.||.|::||.|:|..||:.::..|||:|:.|..||:||..:|.....|..
Mouse  1995 PIFVSPLTTSYSDSHDQLKEILGGPISLGNIRNFIVSTWHRLRKGCGAGCNSGGNIEDSDTGGGT 2059

  Fly  2796 QLGACNFGSGGSVVGAASTATGVG-ASTGSGLGVAAPGTAGSTGGESGDLAPVFISAPLYNTL-T 2858
               :|   .|.|.|.|:.....|. .|||.      ||....:|     |.|...|.|  .|| |
Mouse  2060 ---SC---PGNSAVTASDPHNNVSQGSTGH------PGQGAGSG-----LHPPTTSYP--PTLGT 2105

  Fly  2859 VNSYYSVRPGNVPGGPIPGNLGGN----YVSDSLAVVRGGLAVMPVKPTSTTLIA---------- 2909
            .:|.:||:...|...|...::...    |.|...::.......:|.:.:||:.|:          
Mouse  2106 SHSAHSVQSSLVRQSPARASMASQSSYCYSSRHSSLRMSTTGFVPCRRSSTSQISLRNLPSSIQS 2170

  Fly  2910 --GLLNRERDETSGSGIMGAGASG-PTRATSSGGVRSRRPEVGSSRGRDHERRATLPIASGGAGG 2971
              .::|:.  |.:..|.||....| |:.::||..:.:.:          |.   ||....|..||
Mouse  2171 RLSMVNQM--EAASQGGMGCVQHGLPSSSSSSQSIPACK----------HH---TLVAFLGAEGG 2220

  Fly  2972 EPGKDLTAPQTQVEHEPSPRSTKLSSSSGSLGLGMGVGLGNIITTPGDYPRKTKGPICLTAVDTG 3036
            :                           ||                            .|....|
Mouse  2221 Q---------------------------GS----------------------------ATEAQPG 2230

  Fly  3037 TSSSAAEGKPAGSGTVAGTGVGGVIRKPRIEIFKKVIIVDDTGIYDCLDII--DAVVWPTERMRN 3099
            .:||.|....|..|                |:..:|.|||.:.|.:.:::.  ..:.||.|.:|.
Mouse  2231 NTSSPANISHARKG----------------EVIYRVQIVDLSQILEGINVSKRKELHWPDEGIRL 2279

  Fly  3100 NGGRLSWKDWEPSAGMVGHVVHCWTPNHKDIRFRSHVNRYVYLVEIGDHYVPVEELGLRE 3159
            ..||.|||||.|..||.|||||.|.|..:|...|||:::.|.||:|.|.||.:.|.|:.|
Mouse  2280 KAGRNSWKDWSPQEGMEGHVVHRWVPCSRDPSTRSHIDKTVLLVQIDDKYVTIIETGVLE 2339

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pcxNP_001259183.2 Pecanex_C 2523..2746 CDD:282845 155/222 (70%)
Loricrin <2779..>2842 CDD:292475 18/63 (29%)
PcnxNP_061284.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 101..163 24/142 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 271..290 7/60 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 306..692 77/453 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 749..837 25/155 (16%)
YdiL 993..1229 CDD:224185 117/243 (48%)
ABC2_membrane_4 1035..1282 CDD:289500 121/506 (24%)
EcsB <1402..>1527 CDD:299768 82/124 (66%)
Pecanex_C 1785..2009 CDD:282845 156/223 (70%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2051..2123 26/90 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167833486
Domainoid 1 1.000 1031 1.000 Domainoid score I25
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1504 1.000 Inparanoid score I102
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D41206at33208
OrthoFinder 1 1.000 - - FOG0002108
OrthoInspector 1 1.000 - - otm42385
orthoMCL 1 0.900 - - OOG6_104101
Panther 1 1.100 - - O PTHR12372
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3574
SonicParanoid 1 1.000 - - X1397
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1111.020

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