Protein Alignment pcx and PCNX3

DIOPT Version :9

• Sequence 1: NP_001259183.2
• Gene: pcx / 31204
• FlyBaseID: FBgn0003048
• Length: 3417
• Species: Drosophila melanogaster
• Sequence 2: XP_011543326.1
• Gene: PCNX3 / 399909
• HGNCID: 18760
• Length: 2047
• Species: Homo sapiens
• Alignment Length: 3154
• Identity: 914/3154 - (28%)
• Similarity: 1235/3154 - (39%)
• Gaps: 1232/3154 - (39%)

  Fly     1 MGSQTLEILRQGVWASLTGGYFYDPHQGVFCNVVHLYLWLYLLCSPFVAYLIFLQYFPSTWLTWC 65
            ||||.|:|||||||||||||:|:||||..|.|..|||:|::||..||:.|::    .|.:.:...
Human     1 MGSQVLQILRQGVWASLTGGWFFDPHQSTFSNCFHLYVWIFLLIFPFLLYMV----LPPSLMVAG 61

  Fly    66 LYCVITSLTILMVKLANLALHRLYD-------RAQTMSEGNLKGQFVKVTKETEPRHDD-----E 118
            :||::.::....:|..|..||.::|       |:.||.|           .|.||...|     :
Human    62 VYCLVVAVIFATIKTVNYRLHAMFDQGEIVEKRSSTMGE-----------LEEEPAQGDSNPPRD 115

  Fly   119 GGIEMKVIRPGGSRISGEQAINEASEENSIMSIDNVNSII----------DLKVDVHRKNSSESI 173
            .|:||.|.|    ::|....: ..|.::|:...:.|:.::          |:| ::.|:..|.::
Human   116 PGVEMTVFR----KVSSTPPV-RCSSQHSVFGFNQVSELLPRMEDSGPLRDIK-ELVREQGSNNV 174

  Fly   174 ELMFYAPSMLSGGSQQDQQSLAGSASVSKSIRSTGPGGNSSTSAAAQADMFNKYLTVYPEVVEAA 238
            .:......||...|   |:.|.|      .:..|.||.....|.|:               .:::
Human   175 IVTSADREMLKLSS---QEKLIG------DLPQTPPGAVPDPSLAS---------------TDSS 215

  Fly   239 GSSAGSADGGSSGGDSRSGAAVSTLGHTGAGTAPAQHVRTGHLSRKCSEVF-------------- 289
            ..|..:.||....|.|.:...:|.|             ..|.||::.|:.|
Human   216 EPSPLAGDGAPWSGSSMADTPMSPL-------------LKGSLSQELSKSFLTLTQPDRALVRTS 267

  Fly   290 SRRHRRR-------LERQSSLDTAAAAANSNAENKLMRNQSDTIAT-----------------AA 330
            |||.:||       |:|:.|.:.....|.| :::.......:|:::                 .|
Human   268 SRREQRRGAGGYQPLDRRGSGEPTPQKAGS-SDSCFSGTDRETLSSFKSEKTNSTHLDSPPGGPA 331

  Fly   331 PSFLHSQPTNKARGQTNPRQHFITSAPS--------TGIGGGDAPTSSTAVVVIAPASNSLVNPG 387
            |....:.|.::|....:|.    ...||        |.||.|..|..:..::|:.|...:|:.|.
Human   332 PEGSDTDPPSEAELPASPD----AGVPSDDTLRSFDTVIGAGTPPGLAEPLLVVRPKDLALLRPS 392

  Fly   388 -RSSRLQRHRSSETHDERLKHQSRGGLFQPILQLPHHSAASSIGALAVLGGGGNVAANDVEDMEL 451
             |...|:||........|           |:|:
Human   393 KRQPPLRRHSPPGRAPRR-----------PLLE-------------------------------- 414

  Fly   452 GLVRNAGSGGVADACSRALQSWILDPFPDGYLEDDSYTKSDLGIEQPHQPTFRTQHRHHHHHHHL 516
                    ||                   |:.||:..::   |.|.....:.|:|.|:
Human   415 --------GG-------------------GFFEDEDTSE---GSELSPASSLRSQRRY------- 442

  Fly   517 HHHLGGAIIRKDPTSTMSALQLAAVTQPGTGGSVTGGGGAAGGGGSAAGMKRRRHSNATSYKHGS 581
                     ..|.:|:.|..            |.....|||||       .|:|
Human   443 ---------STDSSSSTSCY------------SPESSRGAAGG-------PRKR----------- 468

  Fly   582 SQSNKSSLVGGGGSRGPSG-EAGTSGGAGGTGGVRRIKSAALEVLCPQPSVSNLSPHPNSVEAIS 645
                          |.|.| |.||:
Human   469 --------------RAPHGAEEGTA---------------------------------------- 479

  Fly   646 GQQQMRNPLPPPSKSLVRNQHLNLYPTQGYGDGTPSAGGGGPGNSSTCSSLFFGSSSACGSTTAL 710
                     .||.:.         |.||    .|||                  ::||
Human   480 ---------VPPKRP---------YGTQ----RTPS------------------TASA------- 497

  Fly   711 IEPPVYPIVEHSDEKTAHEEHGDDCLGIGQGNADDDDEVDDVPIRRRTRALGCSQTHYSVESDVG 775
                                                                             
Human   498 ----------------------------------------------------------------- 497

  Fly   776 GFLADEVGADEDVFKDFDDNLEHILSELQQTHNQLDDVLKTHDLHHHSHLHHHKAASVEGAGPSG 840
                                                   ||          |.:..|::||   |
Human   498 ---------------------------------------KT----------HARVLSMDGA---G 510

  Fly   841 GSVAVGVSAGNDDEDEETEDNNTGSRSPLLNDRNRQPATLREIQADKQLRQELSHQSGAVIPAPN 905
            |.|.                     |.||..                 .:.||..|.| |..|.:
Human   511 GDVL---------------------RPPLAG-----------------CKAELEAQVG-VEQAAS 536

  Fly   906 PPVPIRSEADSGCPSSDCEQVSASSKDQLLSGIELELQQYQILQRCQLDEEQPCTSKMAAKSLGA 970
            .||.:.:||..| |:::                       |...|.:|.||.....  ||:..|.
Human   537 EPVVLPAEARRG-PAAN-----------------------QPGWRGELQEEGAVGG--AAEETGR 575

  Fly   971 IPKVVKYREVDELRRRRRGGS-PADAAEAGNEFALVKQTKQASRNSSSSNSTHSISLTDSLTADI 1034
            ..:....|....:|||...|| |...|..........|..|..|.:|     ||.:||  |.:.:
Human   576 RDRSSSVRRTQAIRRRHNAGSNPTPPASVMGSPPSSLQEAQRGRAAS-----HSRALT--LPSAL 633

  Fly  1035 H--KMLWLMHGGA-------VDDRGRPITGTSADGTPIPASSSLVPPNMSNAHFQFYQDAIQALQ 1090
            |  ..|.|...||       .||        :::|.               .|: ||.::.....
Human   634 HFASSLLLTRAGANVHEACTFDD--------TSEGA---------------VHY-FYDESGVRRS 674

  Fly  1091 GTHPTSGSSVEHMTNIELARDKLRLDAKLMCEQLVAAAEANSGVRGNTLATQQMTQQQVGMLMR- 1154
            .|...:|...|:...                                    ||..|...|...|
Human   675 YTFGLAGGGYENPVG------------------------------------QQGEQTANGAWDRH 703

  Fly  1155 GGSSSRHPSSAPFSVQGLINVIRSERPAARSQLDALQQLSDAAAALAANASEAASVSASGAGGGA 1219
            ..|||.|.:..|.:..|| |::: .||.
Human   704 SHSSSFHSADVPEATGGL-NLLQ-PRPV------------------------------------- 729

  Fly  1220 SSGGGGVLSALGLANHPSNQISQISQLSQMSQPMLNVDGHFAPYCDYWRPACLLSATEKPAAPKS 1284
                  ||..:.:...|    .:|.:...:.|..|:....              ....:.|.|::
Human   730 ------VLQGMQVRRVP----LEIPEFDLLDQDSLHESQE--------------QTLMEEAPPRA 770

  Fly  1285 FYKYRF-----KWCGQEHEFKIAMDRLELLALFDRDLHWMHVLLASLLCTLVACLGAAILQHDHY 1344
            .:.|::     :|....:|      ||.||||.||....:..:....|.:|||.||..:|....:
Human   771 QHSYKYWLLPGRWTSVRYE------RLALLALLDRTRGVLENIFGVGLSSLVAFLGYLLLLKGFF 829

  Fly  1345 KDLCALLFCAVIAGAQYSLVKSVQPDAASPVHGFNKTVAYSRAIYFCLAGGMLLLLKRLDTDYGE 1409
            .|:....||.|||..||||:||||||||||:||.|..:||||.:|||:...::.||..|    |.
Human   830 TDIWVFQFCLVIASCQYSLLKSVQPDAASPMHGHNWVIAYSRPVYFCICCLLIWLLDAL----GS 890

  Fly  1410 RTP-DPVVFFGMRYSPADVVALLLQALYILLLCFPIIFSVGLCPQINTFLMYLLEQIDMHVFGGN 1473
            ..| .||..:|:....|...........:..||||.:|.:||.||:||.|||||||||||.|||.
Human   891 AQPFPPVSLYGLTLFSASFFFCARDVATVFTLCFPFVFLLGLLPQVNTCLMYLLEQIDMHGFGGT 955

  Fly  1474 AASSLLGSFLCVVRSVLAVMLLYGPLYGALDEQRGTQY--ILFSIFCAMLVPLGYHLSRCASDFS 1536
            ||:|.|.:...:.||:||..||||...||:......|:  :|||:||.:||.|.|||||.:||.:
Human   956 AATSPLTAVFSLSRSLLAAALLYGFCLGAIKTPWPEQHVPVLFSVFCGLLVALSYHLSRQSSDPT 1020

  Fly  1537 HLWRLIKTCIVSTYRDDEDEDLSQMQHIATGTVTGSGTANSTALQLTTSTPKQHRQTDVKTEHEQ 1601
            .||.||::.:                                                    ..:
Human  1021 VLWSLIRSKL----------------------------------------------------FPE 1033

  Fly  1602 IELSSLEKLTVNEEHHEKDHGADDQLETDQDLPLQQKHSKSKTSSLGSSQQTLGKTISSSKRAIT 1666
            :|..|||
Human  1034 LEERSLE---------------------------------------------------------- 1040

  Fly  1667 ASSSCTSIGTGEPAVEAGALTEEAVEGEEQRRNTLAGEVGSKHELAENYDQAAKIDECEDKISSS 1731
                                                                             
Human  1041 ----------------------------------------------------------------- 1040

  Fly  1732 SATNPGDMSTLTAGAGTATTDATPACLEADPDAEAEAPADEKQHQGILGTGTGTGTGTTEASENG 1796
                              |..|.|
Human  1041 ------------------TARAEP----------------------------------------- 1046

  Fly  1797 SGGGANGNTNSNGTGNDLPDPLPRKLQATVTTRLKNDLVVMTLLAVSVLGLHCSTVFTALQPDLN 1861
                              |||||.|::.:|...|.:|||:..::||....:..||||.||:..|.
Human  1047 ------------------PDPLPDKMRQSVREVLHSDLVMCVVIAVLTFAISASTVFIALKSVLG 1093

  Fly  1862 VVLYSFIGVLGLLLHYIVPQMRKHMPWLCFSRPLLRQREFGQFEVLNAPKIMWFEKLYIYLSVLE 1926
            .|||:..|.:|...||::||:||.:||.|.|:|:|:..|:.|:||..|.::|||||||..|..:|
Human  1094 FVLYALAGAVGFFTHYLLPQLRKQLPWFCLSQPVLKPLEYSQYEVRGAAQVMWFEKLYAGLQCVE 1158

  Fly  1927 RNVLFPLLAISSLTADSQLIVA---KFGLPWGTLIVAICALKFVRNAYSDPTNQYLIIIFTVLLF 1988
            :.:::|.:.:::||.|:..:|:   |:......|::.:..||.:|:|:..|..|||.:.||||||
Human  1159 KYLIYPAVVLNALTVDAHTVVSHPDKYCFYCRALLMTVAGLKLLRSAFCCPPQQYLTLAFTVLLF 1223

  Fly  1989 RIDFAMATETFIIDYFFVSLAFRKCCDFLLKLQFIVTYIAPWQITWGSAFHAFAQPFSVPHSAML 2053
            ..|:...::.|::|||.:||...|..|.|.||:|::|||||||||||||||||||||:|||||||
Human  1224 HFDYPRLSQGFLLDYFLMSLLCSKLWDLLYKLRFVLTYIAPWQITWGSAFHAFAQPFAVPHSAML 1288

  Fly  2054 FLQAAISAVLSTPLNPFLGSAIFLTSYVRPIKFWERDYNTRRIDHSNTRLSSQLERDLGADDNNL 2118
            |:||.:|.:.||||||.||||:|:.||.||:|||||||||:|:|||||||.:||:|:.|||||||
Human  1289 FVQALLSGLFSTPLNPLLGSAVFIMSYARPLKFWERDYNTKRVDHSNTRLVTQLDRNPGADDNNL 1353

  Fly  2119 NSIFYEHLTRSLQHSLCGDLLMGRWGNVNQGDCFVLASDDLNCLVHIIELGNGLCTFQMRGLEFR 2183
            ||||||||||||||:|||||::|||||...|||||||||.||.|||:||:||||.|||:||||||
Human  1354 NSIFYEHLTRSLQHTLCGDLVLGRWGNYGPGDCFVLASDYLNALVHLIEVGNGLVTFQLRGLEFR 1418

  Fly  2184 GTYCQQREVEAITEDVEDNDGCCCCDPGHLPQLLSANAMFSTRWLAWQVVAAQYVIEGYSISDNL 2248
            ||||||||||||||.||:::|||||:|||||::||.||.|..|||||:|.|::||:||||||||.
Human  1419 GTYCQQREVEAITEGVEEDEGCCCCEPGHLPRVLSFNAAFGQRWLAWEVTASKYVLEGYSISDNN 1483

  Fly  2249 ASATLQVFEYRKVLITYYIKSIIYYVVKNPKLEQWLASGPIQDALQHTLSRQFVDLDPIFNFNLD 2313
            |::.||||:.||:|||||:|||||||.::||||.||:...|..||:......:.|.||.|:.::|
Human  1484 AASMLQVFDLRKILITYYVKSIIYYVSRSPKLEVWLSHEGITAALRPVRVPGYADSDPTFSLSVD 1548

  Fly  2314 EDFDFRAVGITRSSFCYVYLKWINYCVDMRRDANSMGGAPPAQAPAAAGGASSAPATAGVAPPAP 2378
            ||:|.|..|::..|||.|:|:||.||...|
Human  1549 EDYDLRLSGLSLPSFCAVHLEWIQYCASRR----------------------------------- 1578

  Fly  2379 VTPAHNDSKSTPNLSAHGGQAGPSSGQSKSQSQQQLRRPQKSVAQETSVGGGGVVVGGTTVPGTG 2443
                                                                             
Human  1579 ----------------------------------------------------------------- 1578

  Fly  2444 GVTGGGGDPQLSSSHSFANISRQTSESAPGLGGYVAYMDQNVFVKLAKSSTTTGAGAGAPTSRKE 2508
                                      |.|        :||:
Human  1579 --------------------------SQP--------VDQD------------------------ 1585

  Fly  2509 SQEKPALRLKLASVGKDAPLVSLCLALGLLARRSLATASHSALTGVEFFLHGLHALFKGDFRITS 2573
                           .::|||:||..|.:|.||:|.|||||....:|.||:||||||||||||||
Human  1586 ---------------WNSPLVTLCFGLCVLGRRALGTASHSMSASLEPFLYGLHALFKGDFRITS 1635

  Fly  2574 PRDEWVFADMELLHSVVAPAVKMALKLQQDHITNPDEFLDPHALYDAIDNCSNELVISHEADPVW 2638
            ||||||||||:|||.||||.|:|||||.|||.|:|||:.:|.||||||......||||||.||.|
Human  1636 PRDEWVFADMDLLHRVVAPGVRMALKLHQDHFTSPDEYEEPAALYDAIAANEERLVISHEGDPAW 1700

  Fly  2639 RSAVLRGAPNLLALRHVMEDGSDEYRIIRLTKRCLSFRVIKLNRECVRGLWAGQQQELIYLRNRN 2703
            |||:|...|:|||||||::|.||||:||.|.:|.|||||||:||||||||||||||||::|||||
Human  1701 RSAILSNTPSLLALRHVLDDASDEYKIIMLNRRHLSFRVIKVNRECVRGLWAGQQQELVFLRNRN 1765

  Fly  2704 PERGSIQNAKQALRNIINSSCDQPIGYPIYVSPLTTSYADTNAQLCEVIGGAITLDTIRHTVLGW 2768
            |||||||||||||||:||||||||:||||||||||||.|.::.||..:.||.|:|..|.|.:|..
Human  1766 PERGSIQNAKQALRNMINSSCDQPLGYPIYVSPLTTSLAGSHPQLRALWGGPISLGAIAHWLLRT 1830

  Fly  2769 WHRIRERCRQGCSSGSALEPHPGSGPVQLGACNFGSGGSVVGAASTATGVGAST-----GSGLGV 2828
            |.|:.:.|..||:||         |.|....|   |||..:.:.|....|...|     |:|...
Human  1831 WERLHKGCGAGCNSG---------GNVDDSDC---SGGGGLTSLSNNPPVAHPTPENTAGNGDQP 1883

  Fly  2829 AAPGTA----GSTGGESGDLAPVFISAPLYNTLTVNSYYSVRPGNVPGGPIPGNLGGNYVSDSLA 2889
            ..||..    .|..|......|..:..|              |..:||.|
Human  1884 LPPGPGWGPRSSLSGSGDGRPPPLLQWP--------------PPRLPGPP--------------- 1919

  Fly  2890 VVRGGLAVMPVKPTSTTLIAGLLNRERDETS---GSGIMGAGASGPTRATSSGGVRSRRPEVGSS 2951
                     |..|..|         |...||   |.|::  .:.||:...|.||.:
Human  1920 ---------PASPIPT---------EGPRTSRPPGPGLL--SSEGPSGKWSLGGRK--------- 1955

  Fly  2952 RGRDHERRATLPIASGGAGGEPGKDLTAPQTQVEHEPSPR-STKLSSSSGSLGLGMGVGLGNIIT 3015
                         ..||:.|||...            ||: .|..|.:...|.|.:.:.|...::
Human  1956 -------------GLGGSDGEPASG------------SPKGGTPKSQAPLDLSLSLSLSLSPDVS 1995

  Fly  3016 TPGDYPRKTKGPICL--TAVDTGTSSSAAEGKPA 3047
            |....||.::...||  :|.::||...|....||
Human  1996 TEASPPRASQDIPCLDSSAPESGTPMGALGDWPA 2029

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pcx	NP_001259183.2	Pecanex_C	2523..2746	CDD:282845	163/222 (73%)
		Loricrin	<2779..>2842	CDD:292475	19/71 (27%)
PCNX3	XP_011543326.1	Pecanex_C	1583..1808	CDD:282845	165/263 (63%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143310
Domainoid	1	1.000	1059	1.000	Domainoid score	I25
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1473	1.000	Inparanoid score	I107
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41206at33208
OrthoFinder	1	1.000	-	-		FOG0002108
OrthoInspector	1	1.000	-	-		otm40320
orthoMCL	1	0.900	-	-		OOG6_104101
Panther	1	1.100	-	-	LDO	PTHR12372
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3574
SonicParanoid	1	1.000	-	-		X1397
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.930