|
Fly 1 MGSQTLEILRQGVWASLTGGYFYDPHQGVFCNVVHLYLWLYLLCSPFVAYLIFLQYFPSTWLTWC 65
||||.|:|||||||||||||:|:||||..|.|..|||:|::||..||:.|:: .|.:.:...
Human 1 MGSQVLQILRQGVWASLTGGWFFDPHQSTFSNCFHLYVWIFLLIFPFLLYMV----LPPSLMVAG 61
Fly 66 LYCVITSLTILMVKLANLALHRLYD-------RAQTMSEGNLKGQFVKVTKETEPRHDD-----E 118
:||::.::....:|..|..||.::| |:.||.| .|.||...| :
Human 62 VYCLVVAVIFATIKTVNYRLHAMFDQGEIVEKRSSTMGE-----------LEEEPAQGDSNPPRD 115
Fly 119 GGIEMKVIRPGGSRISGEQAINEASEENSIMSIDNVNSII----------DLKVDVHRKNSSESI 173
.|:||.|.| ::|....: ..|.::|:...:.|:.:: |:| ::.|:..|.::
Human 116 PGVEMTVFR----KVSSTPPV-RCSSQHSVFGFNQVSELLPRMEDSGPLRDIK-ELVREQGSNNV 174
Fly 174 ELMFYAPSMLSGGSQQDQQSLAGSASVSKSIRSTGPGGNSSTSAAAQADMFNKYLTVYPEVVEAA 238
.:......||...| |:.|.| .:..|.||.....|.|: .:::
Human 175 IVTSADREMLKLSS---QEKLIG------DLPQTPPGAVPDPSLAS---------------TDSS 215
Fly 239 GSSAGSADGGSSGGDSRSGAAVSTLGHTGAGTAPAQHVRTGHLSRKCSEVF-------------- 289
..|..:.||....|.|.:...:|.| ..|.||::.|:.|
Human 216 EPSPLAGDGAPWSGSSMADTPMSPL-------------LKGSLSQELSKSFLTLTQPDRALVRTS 267
Fly 290 SRRHRRR-------LERQSSLDTAAAAANSNAENKLMRNQSDTIAT-----------------AA 330
|||.:|| |:|:.|.:.....|.| :::.......:|::: .|
Human 268 SRREQRRGAGGYQPLDRRGSGEPTPQKAGS-SDSCFSGTDRETLSSFKSEKTNSTHLDSPPGGPA 331
Fly 331 PSFLHSQPTNKARGQTNPRQHFITSAPS--------TGIGGGDAPTSSTAVVVIAPASNSLVNPG 387
|....:.|.::|....:|. ...|| |.||.|..|..:..::|:.|...:|:.|.
Human 332 PEGSDTDPPSEAELPASPD----AGVPSDDTLRSFDTVIGAGTPPGLAEPLLVVRPKDLALLRPS 392
Fly 388 -RSSRLQRHRSSETHDERLKHQSRGGLFQPILQLPHHSAASSIGALAVLGGGGNVAANDVEDMEL 451
|...|:||........| |:|:
Human 393 KRQPPLRRHSPPGRAPRR-----------PLLE-------------------------------- 414
Fly 452 GLVRNAGSGGVADACSRALQSWILDPFPDGYLEDDSYTKSDLGIEQPHQPTFRTQHRHHHHHHHL 516
|| |:.||:..:: |.|.....:.|:|.|:
Human 415 --------GG-------------------GFFEDEDTSE---GSELSPASSLRSQRRY------- 442
Fly 517 HHHLGGAIIRKDPTSTMSALQLAAVTQPGTGGSVTGGGGAAGGGGSAAGMKRRRHSNATSYKHGS 581
..|.:|:.|.. |.....||||| .|:|
Human 443 ---------STDSSSSTSCY------------SPESSRGAAGG-------PRKR----------- 468
Fly 582 SQSNKSSLVGGGGSRGPSG-EAGTSGGAGGTGGVRRIKSAALEVLCPQPSVSNLSPHPNSVEAIS 645
|.|.| |.||:
Human 469 --------------RAPHGAEEGTA---------------------------------------- 479
Fly 646 GQQQMRNPLPPPSKSLVRNQHLNLYPTQGYGDGTPSAGGGGPGNSSTCSSLFFGSSSACGSTTAL 710
.||.:. |.|| .||| ::||
Human 480 ---------VPPKRP---------YGTQ----RTPS------------------TASA------- 497
Fly 711 IEPPVYPIVEHSDEKTAHEEHGDDCLGIGQGNADDDDEVDDVPIRRRTRALGCSQTHYSVESDVG 775
Human 498 ----------------------------------------------------------------- 497
Fly 776 GFLADEVGADEDVFKDFDDNLEHILSELQQTHNQLDDVLKTHDLHHHSHLHHHKAASVEGAGPSG 840
|| |.:..|::|| |
Human 498 ---------------------------------------KT----------HARVLSMDGA---G 510
Fly 841 GSVAVGVSAGNDDEDEETEDNNTGSRSPLLNDRNRQPATLREIQADKQLRQELSHQSGAVIPAPN 905
|.|. |.||.. .:.||..|.| |..|.:
Human 511 GDVL---------------------RPPLAG-----------------CKAELEAQVG-VEQAAS 536
Fly 906 PPVPIRSEADSGCPSSDCEQVSASSKDQLLSGIELELQQYQILQRCQLDEEQPCTSKMAAKSLGA 970
.||.:.:||..| |::: |...|.:|.||..... ||:..|.
Human 537 EPVVLPAEARRG-PAAN-----------------------QPGWRGELQEEGAVGG--AAEETGR 575
Fly 971 IPKVVKYREVDELRRRRRGGS-PADAAEAGNEFALVKQTKQASRNSSSSNSTHSISLTDSLTADI 1034
..:....|....:|||...|| |...|..........|..|..|.:| ||.:|| |.:.:
Human 576 RDRSSSVRRTQAIRRRHNAGSNPTPPASVMGSPPSSLQEAQRGRAAS-----HSRALT--LPSAL 633
Fly 1035 H--KMLWLMHGGA-------VDDRGRPITGTSADGTPIPASSSLVPPNMSNAHFQFYQDAIQALQ 1090
| ..|.|...|| .|| :::|. .|: ||.::.....
Human 634 HFASSLLLTRAGANVHEACTFDD--------TSEGA---------------VHY-FYDESGVRRS 674
Fly 1091 GTHPTSGSSVEHMTNIELARDKLRLDAKLMCEQLVAAAEANSGVRGNTLATQQMTQQQVGMLMR- 1154
.|...:|...|:... ||..|...|...|
Human 675 YTFGLAGGGYENPVG------------------------------------QQGEQTANGAWDRH 703
Fly 1155 GGSSSRHPSSAPFSVQGLINVIRSERPAARSQLDALQQLSDAAAALAANASEAASVSASGAGGGA 1219
..|||.|.:..|.:..|| |::: .||.
Human 704 SHSSSFHSADVPEATGGL-NLLQ-PRPV------------------------------------- 729
Fly 1220 SSGGGGVLSALGLANHPSNQISQISQLSQMSQPMLNVDGHFAPYCDYWRPACLLSATEKPAAPKS 1284
||..:.:...| .:|.:...:.|..|:.... ....:.|.|::
Human 730 ------VLQGMQVRRVP----LEIPEFDLLDQDSLHESQE--------------QTLMEEAPPRA 770
Fly 1285 FYKYRF-----KWCGQEHEFKIAMDRLELLALFDRDLHWMHVLLASLLCTLVACLGAAILQHDHY 1344
.:.|:: :|....:| ||.||||.||....:..:....|.:|||.||..:|....:
Human 771 QHSYKYWLLPGRWTSVRYE------RLALLALLDRTRGVLENIFGVGLSSLVAFLGYLLLLKGFF 829
Fly 1345 KDLCALLFCAVIAGAQYSLVKSVQPDAASPVHGFNKTVAYSRAIYFCLAGGMLLLLKRLDTDYGE 1409
.|:....||.|||..||||:||||||||||:||.|..:||||.:|||:...::.||..| |.
Human 830 TDIWVFQFCLVIASCQYSLLKSVQPDAASPMHGHNWVIAYSRPVYFCICCLLIWLLDAL----GS 890
Fly 1410 RTP-DPVVFFGMRYSPADVVALLLQALYILLLCFPIIFSVGLCPQINTFLMYLLEQIDMHVFGGN 1473
..| .||..:|:....|...........:..||||.:|.:||.||:||.|||||||||||.|||.
Human 891 AQPFPPVSLYGLTLFSASFFFCARDVATVFTLCFPFVFLLGLLPQVNTCLMYLLEQIDMHGFGGT 955
Fly 1474 AASSLLGSFLCVVRSVLAVMLLYGPLYGALDEQRGTQY--ILFSIFCAMLVPLGYHLSRCASDFS 1536
||:|.|.:...:.||:||..||||...||:......|: :|||:||.:||.|.|||||.:||.:
Human 956 AATSPLTAVFSLSRSLLAAALLYGFCLGAIKTPWPEQHVPVLFSVFCGLLVALSYHLSRQSSDPT 1020
Fly 1537 HLWRLIKTCIVSTYRDDEDEDLSQMQHIATGTVTGSGTANSTALQLTTSTPKQHRQTDVKTEHEQ 1601
.||.||::.: ..:
Human 1021 VLWSLIRSKL----------------------------------------------------FPE 1033
Fly 1602 IELSSLEKLTVNEEHHEKDHGADDQLETDQDLPLQQKHSKSKTSSLGSSQQTLGKTISSSKRAIT 1666
:|..|||
Human 1034 LEERSLE---------------------------------------------------------- 1040
Fly 1667 ASSSCTSIGTGEPAVEAGALTEEAVEGEEQRRNTLAGEVGSKHELAENYDQAAKIDECEDKISSS 1731
Human 1041 ----------------------------------------------------------------- 1040
Fly 1732 SATNPGDMSTLTAGAGTATTDATPACLEADPDAEAEAPADEKQHQGILGTGTGTGTGTTEASENG 1796
|..|.|
Human 1041 ------------------TARAEP----------------------------------------- 1046
Fly 1797 SGGGANGNTNSNGTGNDLPDPLPRKLQATVTTRLKNDLVVMTLLAVSVLGLHCSTVFTALQPDLN 1861
|||||.|::.:|...|.:|||:..::||....:..||||.||:..|.
Human 1047 ------------------PDPLPDKMRQSVREVLHSDLVMCVVIAVLTFAISASTVFIALKSVLG 1093
Fly 1862 VVLYSFIGVLGLLLHYIVPQMRKHMPWLCFSRPLLRQREFGQFEVLNAPKIMWFEKLYIYLSVLE 1926
.|||:..|.:|...||::||:||.:||.|.|:|:|:..|:.|:||..|.::|||||||..|..:|
Human 1094 FVLYALAGAVGFFTHYLLPQLRKQLPWFCLSQPVLKPLEYSQYEVRGAAQVMWFEKLYAGLQCVE 1158
Fly 1927 RNVLFPLLAISSLTADSQLIVA---KFGLPWGTLIVAICALKFVRNAYSDPTNQYLIIIFTVLLF 1988
:.:::|.:.:::||.|:..:|: |:......|::.:..||.:|:|:..|..|||.:.||||||
Human 1159 KYLIYPAVVLNALTVDAHTVVSHPDKYCFYCRALLMTVAGLKLLRSAFCCPPQQYLTLAFTVLLF 1223
Fly 1989 RIDFAMATETFIIDYFFVSLAFRKCCDFLLKLQFIVTYIAPWQITWGSAFHAFAQPFSVPHSAML 2053
..|:...::.|::|||.:||...|..|.|.||:|::|||||||||||||||||||||:|||||||
Human 1224 HFDYPRLSQGFLLDYFLMSLLCSKLWDLLYKLRFVLTYIAPWQITWGSAFHAFAQPFAVPHSAML 1288
Fly 2054 FLQAAISAVLSTPLNPFLGSAIFLTSYVRPIKFWERDYNTRRIDHSNTRLSSQLERDLGADDNNL 2118
|:||.:|.:.||||||.||||:|:.||.||:|||||||||:|:|||||||.:||:|:.|||||||
Human 1289 FVQALLSGLFSTPLNPLLGSAVFIMSYARPLKFWERDYNTKRVDHSNTRLVTQLDRNPGADDNNL 1353
Fly 2119 NSIFYEHLTRSLQHSLCGDLLMGRWGNVNQGDCFVLASDDLNCLVHIIELGNGLCTFQMRGLEFR 2183
||||||||||||||:|||||::|||||...|||||||||.||.|||:||:||||.|||:||||||
Human 1354 NSIFYEHLTRSLQHTLCGDLVLGRWGNYGPGDCFVLASDYLNALVHLIEVGNGLVTFQLRGLEFR 1418
Fly 2184 GTYCQQREVEAITEDVEDNDGCCCCDPGHLPQLLSANAMFSTRWLAWQVVAAQYVIEGYSISDNL 2248
||||||||||||||.||:::|||||:|||||::||.||.|..|||||:|.|::||:||||||||.
Human 1419 GTYCQQREVEAITEGVEEDEGCCCCEPGHLPRVLSFNAAFGQRWLAWEVTASKYVLEGYSISDNN 1483
Fly 2249 ASATLQVFEYRKVLITYYIKSIIYYVVKNPKLEQWLASGPIQDALQHTLSRQFVDLDPIFNFNLD 2313
|::.||||:.||:|||||:|||||||.::||||.||:...|..||:......:.|.||.|:.::|
Human 1484 AASMLQVFDLRKILITYYVKSIIYYVSRSPKLEVWLSHEGITAALRPVRVPGYADSDPTFSLSVD 1548
Fly 2314 EDFDFRAVGITRSSFCYVYLKWINYCVDMRRDANSMGGAPPAQAPAAAGGASSAPATAGVAPPAP 2378
||:|.|..|::..|||.|:|:||.||...|
Human 1549 EDYDLRLSGLSLPSFCAVHLEWIQYCASRR----------------------------------- 1578
Fly 2379 VTPAHNDSKSTPNLSAHGGQAGPSSGQSKSQSQQQLRRPQKSVAQETSVGGGGVVVGGTTVPGTG 2443
Human 1579 ----------------------------------------------------------------- 1578
Fly 2444 GVTGGGGDPQLSSSHSFANISRQTSESAPGLGGYVAYMDQNVFVKLAKSSTTTGAGAGAPTSRKE 2508
|.| :||:
Human 1579 --------------------------SQP--------VDQD------------------------ 1585
Fly 2509 SQEKPALRLKLASVGKDAPLVSLCLALGLLARRSLATASHSALTGVEFFLHGLHALFKGDFRITS 2573
.::|||:||..|.:|.||:|.|||||....:|.||:||||||||||||||
Human 1586 ---------------WNSPLVTLCFGLCVLGRRALGTASHSMSASLEPFLYGLHALFKGDFRITS 1635
Fly 2574 PRDEWVFADMELLHSVVAPAVKMALKLQQDHITNPDEFLDPHALYDAIDNCSNELVISHEADPVW 2638
||||||||||:|||.||||.|:|||||.|||.|:|||:.:|.||||||......||||||.||.|
Human 1636 PRDEWVFADMDLLHRVVAPGVRMALKLHQDHFTSPDEYEEPAALYDAIAANEERLVISHEGDPAW 1700
Fly 2639 RSAVLRGAPNLLALRHVMEDGSDEYRIIRLTKRCLSFRVIKLNRECVRGLWAGQQQELIYLRNRN 2703
|||:|...|:|||||||::|.||||:||.|.:|.|||||||:||||||||||||||||::|||||
Human 1701 RSAILSNTPSLLALRHVLDDASDEYKIIMLNRRHLSFRVIKVNRECVRGLWAGQQQELVFLRNRN 1765
Fly 2704 PERGSIQNAKQALRNIINSSCDQPIGYPIYVSPLTTSYADTNAQLCEVIGGAITLDTIRHTVLGW 2768
|||||||||||||||:||||||||:||||||||||||.|.::.||..:.||.|:|..|.|.:|..
Human 1766 PERGSIQNAKQALRNMINSSCDQPLGYPIYVSPLTTSLAGSHPQLRALWGGPISLGAIAHWLLRT 1830
Fly 2769 WHRIRERCRQGCSSGSALEPHPGSGPVQLGACNFGSGGSVVGAASTATGVGAST-----GSGLGV 2828
|.|:.:.|..||:|| |.|....| |||..:.:.|....|...| |:|...
Human 1831 WERLHKGCGAGCNSG---------GNVDDSDC---SGGGGLTSLSNNPPVAHPTPENTAGNGDQP 1883
Fly 2829 AAPGTA----GSTGGESGDLAPVFISAPLYNTLTVNSYYSVRPGNVPGGPIPGNLGGNYVSDSLA 2889
..||.. .|..|......|..:..| |..:||.|
Human 1884 LPPGPGWGPRSSLSGSGDGRPPPLLQWP--------------PPRLPGPP--------------- 1919
Fly 2890 VVRGGLAVMPVKPTSTTLIAGLLNRERDETS---GSGIMGAGASGPTRATSSGGVRSRRPEVGSS 2951
|..|..| |...|| |.|:: .:.||:...|.||.:
Human 1920 ---------PASPIPT---------EGPRTSRPPGPGLL--SSEGPSGKWSLGGRK--------- 1955
Fly 2952 RGRDHERRATLPIASGGAGGEPGKDLTAPQTQVEHEPSPR-STKLSSSSGSLGLGMGVGLGNIIT 3015
..||:.|||... ||: .|..|.:...|.|.:.:.|...::
Human 1956 -------------GLGGSDGEPASG------------SPKGGTPKSQAPLDLSLSLSLSLSPDVS 1995
Fly 3016 TPGDYPRKTKGPICL--TAVDTGTSSSAAEGKPA 3047
|....||.::...|| :|.::||...|....||
Human 1996 TEASPPRASQDIPCLDSSAPESGTPMGALGDWPA 2029
| 
