|
Fly 1 MGSQTLEILRQGVWASLTGGYFYDPHQGVFCNVVHLYLWLYLLCSPFVAYLIFLQYFPSTWLTWC 65
|.||.|::|||||||:||||:::||....|.|..||||||:||..|...:|. ||...||..
Rat 1 MASQVLQLLRQGVWAALTGGWYHDPEHSKFTNSCHLYLWLFLLLLPLALHLA----FPPNLLTAL 61
Fly 66 LYCVITSLTILMVKLANLALHRLYDRAQTMSEGNLKGQFVKVTKETEPRHDDEGGIEMKVIRPGG 130
.||...::...::||.:..||.::|:.:.: |.....|.::.|.:.|...: .|..
Rat 62 FYCGSVTIFFTVIKLISYRLHLMFDKGEVI-------QHRSPRKRSKRRPEGEASSQ----HPPR 115
Fly 131 SRI-SGEQAINEASEENSIMSIDNVNSIIDLKVDVHRKNSSESIELMFYAPSMLSGGSQQDQQSL 194
.:| |..:.|:...:|.|................||.::||..:|| .:|:..:.|
Rat 116 HKIPSNNRQIHSTKKEESRSLTTPPLCCSSRGQSVHSQHSSGPLEL----------PAQETVEDL 170
Fly 195 AG--------SASVSKSIRSTGPGGNSSTSAAAQADMFNKYLTVYPEVVEAAGSSAGSADGGSSG 251
.| .|.|| ||.||..|.:..|:|
Rat 171 KGVVLSEDQPEALVS----STSPGMKSESLPASQ------------------------------- 200
Fly 252 GDSRSGAAVSTLGHTGAGT----APAQHVRTGHLSRKCSEVFSRRHRRR----LERQSSLDTAAA 308
|.|...| .|.:.|.| |:|..|..:. .:|.:...:.:.
Rat 201 ------------GRTPEPTPRPPCPVKPVTT--------EIFPARRVKESGGTAQRPARHRSESG 245
Fly 309 AANSNAENKLMR---NQSDTIATAAPSFLHSQPTNKARGQTNPRQHFITSAPSTGIGGGDAPTSS 370
..|:.|..||.. :|.|.:.|.. || ||......
Rat 246 LVNTEALKKLPHLSLSQYDLLETDI-SF---QPWGSEHS-------------------------- 280
Fly 371 TAVVVIAPASNSLVNPGRSSRLQRHRSSETHDERLKHQSRGGLFQPILQLPHHSAASSIGALAVL 435
|:.|..|....|.|: ||..:.|..|.:||....
Rat 281 ----VLIPQPNCPHAPTRA-------------------------QPQSRSPQDSQSSSFCQC--- 313
Fly 436 GGGGNVAANDVEDMEL----GLVRNAGSGGVADACSRALQSWILDPFPDGYLEDDSYTKSDLGIE 496
..|.|...|: || |.|....:..|.|: ||.:| .|..| ..
Rat 314 ---NTVIAKPTEE-ELTRTSGQVELPSNPEVVDS--------------DGEVE---VTLID--TS 355
Fly 497 QPHQPTFRTQHRHHHHHHHLHHHLGGAIIRKDPTSTM----SALQLAAVTQPGTGGSVTGGGGAA 557
||.:|. .||..:...|......::: |:|.|...:...|| |......|
Rat 356 QPGEPL------------SLHEPIRIVITMSSTPNSISDPESSLHLRVTSSDRTG--VRPNAENA 406
Fly 558 G-GGGSAAGMKRRRHSNATSYKHGSSQSNKSSLVGGGGSRGPSGEAGTSGGAGGTGGVRRIKSAA 621
| ||...|..::.|....|.......: ||||...|. |.||.|..:.
Rat 407 GPGGADPADPEQARIPLITLELTEDGR-------GGGGPSCPE----------GNGGERTPEK-- 452
Fly 622 LEVLCPQPSVSNLSPHPNSVEAISGQQQMRNPLPPPSKSLVRNQHLNLYPTQGYGDGTPSAGGGG 686
:|| :||...|...: |:...::..|.|..:.| |.....|........|
Rat 453 MEV---------MSPDRRSSSGV-GECSTKDESPTPGPTFV--------PLTPRADPESEGSREG 499
Fly 687 PGNSSTCSSLFFGSSSACGSTTALIEPPVYPIVEHSDEKTAHEEHGDDCLGIGQGNADDDDEVDD 751
|.|....| | |::||:.....|.:..|. |
Rat 500 PANLDPAS---------C--------------------KSSHEKRHARVLSVDSGT--------D 527
Fly 752 VPIRRRTRALGCSQTHYSVESDVGGFLADEVGADEDVFKDFDDNLEHILSELQQTHNQLDDVLKT 816
|.:.|.|: .|.|| .|........:||....::....|.|:.|...
Rat 528 VFLSRSTK---------EVVSD-----------SEKPIPTSKSDLEAKEGQIPNESNFLEFVSLL 572
Fly 817 HDLHHHSHLHHHKAASVEGA--GPSGGSVAVGVSAGNDDEDEETEDNN---------------TG 864
..:.....:....||..:|. ||.|.: |.|..:|..|.|.:| ..
Rat 573 ESISTSKAVAPDSAAEQKGVNQGPEGHA-----SPGIKEEAVENEKSNGRDPKPGKPDLPSQDPA 632
Fly 865 SRSPLLNDRNRQPATLREIQADKQ---LRQELSHQSGAVIPAPNPPVPIRSEADSGCPSSDCEQV 926
|.||:| .:.|.|....|..:| :.:..|.|..:|:
Rat 633 SASPVL---TQPPKTTALFQGSRQRHIIYRVTSQQDSSVL------------------------- 669
Fly 927 SASSKDQLLSGIELELQQYQILQRCQLDEEQPCTSKMAAKSLGAIPKVVKYREVDELRRRRRGGS 991
|::||.|..:| ||. ||.|:...:
Rat 670 ------QVISGPETSVQ-----------EEM---------SLDAMHIFI---------------- 692
Fly 992 PADAAEAGNEFALVKQTKQASRNSSSSNSTHSISLTDSLTADIHKMLWLMHGGAVDDRGRPITGT 1056
:|...|:.....|.|....:|.|.....|.:: |....|:.. :.|
Rat 693 --------DEHGEVRSCYLKSGNQKEGSSQHPPLNPDCVS---HAREILLSS----------SST 736
Fly 1057 SADGTPIPASSSLVPPNMSNAHFQFYQDAIQALQGTHPTSGSSVEHMTNIELARDKLRLDAKLMC 1121
:..|:|.|:|. ..|:.|||
Rat 737 TTTGSPDPSSG---------------DPAVSALQ------------------------------- 755
Fly 1122 EQLVAAAEANSGVRGNTLATQQMTQQQVGMLMRGGSSSRHPSSAPFSVQGLINVIRSERPAARSQ 1186
:||: |...:.||.: :.||.|
Rat 756 QQLL-------------LMVARRTQSE---------TPRHVS----------------------- 775
Fly 1187 LDALQQLSDAAAALAANASEAASVSASGAGGGASSGGGGVLSALGLANHPSNQISQISQLSQMSQ 1251
|.|.|::.: ||.|..|.
Rat 776 ----QDLEDSSRS----------------------------SAQGKFNR---------------- 792
Fly 1252 PMLNVDGHFAPYCDYWRPACLLSATEKPAAPKSFYKYRF---KWCGQEHEFKIAMDRLELLALFD 1313
:.|||:.. || .|:..|||.||||.|
Rat 793 -------------------------------EQFYKFIIFPGKW------IKVWYDRLTLLALLD 820
Fly 1314 RDLHWMHVLLASLLCTLVACLGAAILQHDHYKDLCALLFCAVIAGAQYSLVKSVQPDAASPVHGF 1378
|.......::|.||..||:.||...|.....:||..||||.|:|..||||:||||||.|||:||.
Rat 821 RTEDVKENMVAVLLSVLVSLLGFLTLNRGFCRDLWVLLFCLVMASCQYSLLKSVQPDPASPIHGH 885
Fly 1379 NKTVAYSRAIYFCLAGGMLLLLKRLDTDYGERTPDPVVFFGMRYSPADVVALLLQALYILLLCFP 1443
|:.:||||.||||:..|::|| ||.....|.|...|.:|::....:.:..:...|.:.|.|||
Rat 886 NQIIAYSRPIYFCMLCGLILL---LDAGAKARHPPSYVVYGLKLFTPETLQSVRDHLIVFLCCFP 947
Fly 1444 IIFSVGLCPQINTFLMYLLEQIDMHVFGGNAASSLLGSFLCVVRSVLAVMLLYGPLYGALDEQRG 1508
.|..:||.||||||..||||||||.:|||:|.|.:..:...|.|||||..||:...:.|:.|...
Rat 948 AISLLGLFPQINTFCTYLLEQIDMLLFGGSAVSGITSAVYSVGRSVLAAALLHVFCFSAVKEPWS 1012
Fly 1509 TQYI--LFSIFCAMLVPLGYHLSRCASDFSHLWRLIKTCIVSTYRDDEDEDLSQMQHIATGTVTG 1571
||:| |||.||.:||.|.|||||.:||.|.|...|
Rat 1013 TQHIPALFSAFCGLLVALSYHLSRQSSDPSVLLSFI----------------------------- 1048
Fly 1572 SGTANSTALQLTTSTPKQHRQTDVKTEHEQIELSSLEKLTVNEEHHEKDHGADDQLETDQDLPLQ 1636
Rat 1049 ----------------------------------------------------------------- 1048
Fly 1637 QKHSKSKTSSLGSSQQTLGKTISSSKRAITASSSCTSIGTGEPAVEAGALTEEAVEGEEQRRNTL 1701
Rat 1049 ----------------------------------------------------------------- 1048
Fly 1702 AGEVGSKHELAENYDQAAKIDECEDKISSSSATNPGDMSTLTAGAGTATTDATPACLEADPDAEA 1766
:|: ..|.||..:.|..|
Rat 1049 ---------------------QCK---------------------------LLPKCLHQNLDESA 1065
Fly 1767 EAPADEKQHQGILGTGTGTGTGTTEASENGSGGGANGNTNSNGTGNDLPDPLPRKLQATVTTRLK 1831
.||||::::.:|...|:
Rat 1066 ------------------------------------------------ADPLPQRMKDSVKDVLR 1082
Fly 1832 NDLVVMTLLAVSVLGLHCSTVFTALQPDLNVVLYSFIGVLGLLLHYIVPQMRKHMPWLCFSRPLL 1896
:||::.:..||....:..||||.:|:|.|::||::..|.:||:.|:::||:|||.||:..|.|:|
Rat 1083 SDLIICSAAAVLSFAVSASTVFLSLRPFLSIVLFALAGTVGLITHHLLPQLRKHHPWMWISHPVL 1147
Fly 1897 RQREFGQFEVLNAPKIMWFEKLYIYLSVLERNVLFPLLAISSLTADSQLI--VAKFGLPWGTLIV 1959
:.:|:.|.|..:...:||||:||::|...|:.:|:|.:.::::|.|:..| ..:.|..|...::
Rat 1148 KSKEYQQREARDIAHLMWFERLYVWLQCFEKYLLYPAIVLNAVTLDAFSISNYRRLGTHWDIFLM 1212
Fly 1960 AICALKFVRNAYSDPTNQYLIIIFTVLLFRIDFAMATETFIIDYFFVSLAFRKCCDFLLKLQFIV 2024
....:|.:|.::.:|.:|:..:.|||:.|..|:...:|:|::|:|.||:.|.|..|.|.||||::
Rat 1213 ITAGMKLLRTSFCNPVHQFANLGFTVVFFHFDYKDVSESFLLDFFMVSIVFTKLGDLLQKLQFVL 1277
Fly 2025 TYIAPWQITWGSAFHAFAQPFSVPHSAMLFLQAAISAVLSTPLNPFLGSAIFLTSYVRPIKFWER 2089
.|:||||:.|||:||.|||.|::|||||||.|...:::.||||:|||||.||:||||||:|||||
Rat 1278 AYVAPWQMAWGSSFHVFAQLFAIPHSAMLFFQTFATSIFSTPLSPFLGSVIFITSYVRPVKFWER 1342
Fly 2090 DYNTRRIDHSNTRLSSQLERDLGADDNNLNSIFYEHLTRSLQHSLCGDLLMGRWGNVNQGDCFVL 2154
.|||:|:|:|||||:.|:|||.|:||.:|||||||||||:||.||||||.:|||||.:.||||:|
Rat 1343 SYNTQRVDNSNTRLAVQMERDPGSDDGSLNSIFYEHLTRTLQDSLCGDLALGRWGNYSSGDCFIL 1407
Fly 2155 ASDDLNCLVHIIELGNGLCTFQMRGLEFRGTYCQQREVEAITEDVEDNDGCCCCDPGHLPQLLSA 2219
||||||..||:||:||||.|||:||||||||||||||||||.|..||:.|||||.|||||.|||.
Rat 1408 ASDDLNAFVHLIEIGNGLVTFQLRGLEFRGTYCQQREVEAIMEGDEDDRGCCCCKPGHLPHLLSC 1472
Fly 2220 NAMFSTRWLAWQVVAAQYVIEGYSISDNLASATLQVFEYRKVLITYYIKSIIYYVVKNPKLEQWL 2284
||.|..|||.|::...||::|||||.||.|:..|.||:.|:|||.|||||||||:|.:|||..|:
Rat 1473 NAAFHLRWLTWEITRTQYILEGYSIIDNNAATMLHVFDLRRVLIRYYIKSIIYYMVTSPKLASWV 1537
Fly 2285 ASGPIQDALQ-----HTLSRQFVDLDPIFNFNLDEDFDFRAVGITRSSFCYVYLKWINYCVDMRR 2344
.:..:..:|: |.:.|... :||.|:|:|:.....||||:|:|.|:|:||.||...|:
Rat 1538 KNESLLKSLEPFAKWHHIERDLA----MFNINIDDDYVPCLQGITRASYCSVFLEWIQYCAGKRQ 1598
Fly 2345 DANSMGGAPPAQAPAAAGGASSAPATAGVAPPAPVTPAHNDSKSTPNLSAHGGQAGPSSGQSKSQ 2409
:.:. |..|.||
Rat 1599 ELSK-------------------------------TLDHVDS----------------------- 1609
Fly 2410 SQQQLRRPQKSVAQETSVGGGGVVVGGTTVPGTGGVTGGGGDPQLSSSHSFANISRQTSESAPGL 2474
Rat 1610 ----------------------------------------------------------------- 1609
Fly 2475 GGYVAYMDQNVFVKLAKSSTTTGAGAGAPTSRKESQEKPALRLKLASVGKDAPLVSLCLALGLLA 2539
.:|:.||:|..||.:|.
Rat 1610 ------------------------------------------------DEDSALVTLSFALCILG 1626
Fly 2540 RRSLATASHSALTGVEFFLHGLHALFKGDFRITSPRDEWVFADMELLHSVVAPAVKMALKLQQDH 2604
||:|.||:|:....::.||:|||||||||||:|: |||||||||:|||.||.||::|:|||.||.
Rat 1627 RRALGTAAHNMAMSLDSFLYGLHALFKGDFRVTA-RDEWVFADMDLLHKVVVPAIRMSLKLHQDQ 1690
Fly 2605 ITNPDEFLDPHALYDAIDNCSNELVISHEADPVWRSAVLRGAPNLLALRHVMEDGSDEYRIIRLT 2669
.|.|||:.||..||:||.:...::||.||.||.||.|||.....||.||||:::|::||::|.|.
Rat 1691 FTCPDEYEDPEILYEAIQSFEKKVVICHEGDPAWRGAVLSNKEELLTLRHVVDEGANEYKVIMLH 1755
Fly 2670 KRCLSFRVIKLNRECVRGLWAGQQQELIYLRNRNPERGSIQNAKQALRNIINSSCDQPIGYPIYV 2734
:..|||:|||:|:|||||||||||||||:|||||||||||||.||.|||:||||||||:|||:||
Rat 1756 RGFLSFKVIKVNKECVRGLWAGQQQELIFLRNRNPERGSIQNNKQVLRNLINSSCDQPLGYPMYV 1820
Fly 2735 SPLTTSYADTNAQLCEVIGGAITLDTIRHTVLGWWHRIRERCRQGCSSGSALEPHPGSGPVQLGA 2799
|||||||..|:.||..|.||.|||:.:|......|.|:|:.|..|..||..:| .|.|.|..|.
Rat 1821 SPLTTSYLGTHKQLQSVWGGPITLNRVRTWFQTRWLRMRKDCSVGQRSGGNIE--DGEGAVPPGG 1883
Fly 2800 CNFGSGGSVVGAASTATGVGASTGSGLGVAAPGTAGSTGGESGDLAPVFISAPLYNTLTVNSYYS 2864
|..||.| ..::|......|:....:..|.|...|...| .:.:|.::.:
Rat 1884 -NAPSGES----RDSSTEQPRKGGTQQWASPRGEAPRAGRRKG------------RSQSVQAHSA 1931
Fly 2865 V---RPGNVPGGPIPGNLGGNYVSDSLAVVRGGLAVMPVKPTSTTLIAGLLNRERDETSGSGIMG 2926
: ||.....||| :....|.:: |||: ::......||
Rat 1932 ISQRRPTLSSSGPI--------LESHQAFLQ----------TSTS-----VHELAQRPSG----- 1968
Fly 2927 AGASGPTRATSSGGVRSRRPEV---GSSRGRDHERRATLP------------------------I 2964
|.|:..||:|.:.|:.|.| |...|..|:..|.:. :
Rat 1969 ---SRPSLNTSAGSLHSQPPPVLTTGPYLGIQHQAEALIQSSLGSSTSSTLSFLFGKRSFSSALV 2030
Fly 2965 ASGGAGGEPGKDLTAPQTQVEHEPSPRSTKLSSSSGSLGLGMGVGL------------------- 3010
.||.:..|.| :|..:.||.|:.:.||...
Rat 2031 ISGLSAAEGG-----------------NTSDTQSSSSVNIVMGPSARAAARHFSEPCEPIDSPEQ 2078
Fly 3011 -----GNIITTPGDYPRKTKGPICLTA--VDTGTSSSAAE 3043
|.:....|:.|| |.:|..| .|.|...:|::
Rat 2079 GQLQDGRLAEAAGENPR---GVLCRRASQEDMGLDDTASQ 2115
| 
