DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pcx and Pcnx2

DIOPT Version :9

Sequence 1:NP_001259183.2 Gene:pcx / 31204 FlyBaseID:FBgn0003048 Length:3417 Species:Drosophila melanogaster
Sequence 2:XP_006255883.1 Gene:Pcnx2 / 307949 RGDID:1305883 Length:2122 Species:Rattus norvegicus


Alignment Length:3160 Identity:866/3160 - (27%)
Similarity:1210/3160 - (38%) Gaps:1162/3160 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGSQTLEILRQGVWASLTGGYFYDPHQGVFCNVVHLYLWLYLLCSPFVAYLIFLQYFPSTWLTWC 65
            |.||.|::|||||||:||||:::||....|.|..||||||:||..|...:|.    ||...||..
  Rat     1 MASQVLQLLRQGVWAALTGGWYHDPEHSKFTNSCHLYLWLFLLLLPLALHLA----FPPNLLTAL 61

  Fly    66 LYCVITSLTILMVKLANLALHRLYDRAQTMSEGNLKGQFVKVTKETEPRHDDEGGIEMKVIRPGG 130
            .||...::...::||.:..||.::|:.:.:       |.....|.::.|.:.|...:    .|..
  Rat    62 FYCGSVTIFFTVIKLISYRLHLMFDKGEVI-------QHRSPRKRSKRRPEGEASSQ----HPPR 115

  Fly   131 SRI-SGEQAINEASEENSIMSIDNVNSIIDLKVDVHRKNSSESIELMFYAPSMLSGGSQQDQQSL 194
            .:| |..:.|:...:|.|................||.::||..:||          .:|:..:.|
  Rat   116 HKIPSNNRQIHSTKKEESRSLTTPPLCCSSRGQSVHSQHSSGPLEL----------PAQETVEDL 170

  Fly   195 AG--------SASVSKSIRSTGPGGNSSTSAAAQADMFNKYLTVYPEVVEAAGSSAGSADGGSSG 251
            .|        .|.||    ||.||..|.:..|:|                               
  Rat   171 KGVVLSEDQPEALVS----STSPGMKSESLPASQ------------------------------- 200

  Fly   252 GDSRSGAAVSTLGHTGAGT----APAQHVRTGHLSRKCSEVFSRRHRRR----LERQSSLDTAAA 308
                        |.|...|    .|.:.|.|        |:|..|..:.    .:|.:...:.:.
  Rat   201 ------------GRTPEPTPRPPCPVKPVTT--------EIFPARRVKESGGTAQRPARHRSESG 245

  Fly   309 AANSNAENKLMR---NQSDTIATAAPSFLHSQPTNKARGQTNPRQHFITSAPSTGIGGGDAPTSS 370
            ..|:.|..||..   :|.|.:.|.. ||   ||......                          
  Rat   246 LVNTEALKKLPHLSLSQYDLLETDI-SF---QPWGSEHS-------------------------- 280

  Fly   371 TAVVVIAPASNSLVNPGRSSRLQRHRSSETHDERLKHQSRGGLFQPILQLPHHSAASSIGALAVL 435
                |:.|..|....|.|:                         ||..:.|..|.:||....   
  Rat   281 ----VLIPQPNCPHAPTRA-------------------------QPQSRSPQDSQSSSFCQC--- 313

  Fly   436 GGGGNVAANDVEDMEL----GLVRNAGSGGVADACSRALQSWILDPFPDGYLEDDSYTKSDLGIE 496
               ..|.|...|: ||    |.|....:..|.|:              ||.:|   .|..|  ..
  Rat   314 ---NTVIAKPTEE-ELTRTSGQVELPSNPEVVDS--------------DGEVE---VTLID--TS 355

  Fly   497 QPHQPTFRTQHRHHHHHHHLHHHLGGAIIRKDPTSTM----SALQLAAVTQPGTGGSVTGGGGAA 557
            ||.:|.            .||..:...|......:::    |:|.|...:...||  |......|
  Rat   356 QPGEPL------------SLHEPIRIVITMSSTPNSISDPESSLHLRVTSSDRTG--VRPNAENA 406

  Fly   558 G-GGGSAAGMKRRRHSNATSYKHGSSQSNKSSLVGGGGSRGPSGEAGTSGGAGGTGGVRRIKSAA 621
            | ||...|..::.|....|.......:       ||||...|.          |.||.|..:.  
  Rat   407 GPGGADPADPEQARIPLITLELTEDGR-------GGGGPSCPE----------GNGGERTPEK-- 452

  Fly   622 LEVLCPQPSVSNLSPHPNSVEAISGQQQMRNPLPPPSKSLVRNQHLNLYPTQGYGDGTPSAGGGG 686
            :||         :||...|...: |:...::..|.|..:.|        |.....|........|
  Rat   453 MEV---------MSPDRRSSSGV-GECSTKDESPTPGPTFV--------PLTPRADPESEGSREG 499

  Fly   687 PGNSSTCSSLFFGSSSACGSTTALIEPPVYPIVEHSDEKTAHEEHGDDCLGIGQGNADDDDEVDD 751
            |.|....|         |                    |::||:.....|.:..|.        |
  Rat   500 PANLDPAS---------C--------------------KSSHEKRHARVLSVDSGT--------D 527

  Fly   752 VPIRRRTRALGCSQTHYSVESDVGGFLADEVGADEDVFKDFDDNLEHILSELQQTHNQLDDVLKT 816
            |.:.|.|:         .|.||           .|........:||....::....|.|:.|...
  Rat   528 VFLSRSTK---------EVVSD-----------SEKPIPTSKSDLEAKEGQIPNESNFLEFVSLL 572

  Fly   817 HDLHHHSHLHHHKAASVEGA--GPSGGSVAVGVSAGNDDEDEETEDNN---------------TG 864
            ..:.....:....||..:|.  ||.|.:     |.|..:|..|.|.:|               ..
  Rat   573 ESISTSKAVAPDSAAEQKGVNQGPEGHA-----SPGIKEEAVENEKSNGRDPKPGKPDLPSQDPA 632

  Fly   865 SRSPLLNDRNRQPATLREIQADKQ---LRQELSHQSGAVIPAPNPPVPIRSEADSGCPSSDCEQV 926
            |.||:|   .:.|.|....|..:|   :.:..|.|..:|:                         
  Rat   633 SASPVL---TQPPKTTALFQGSRQRHIIYRVTSQQDSSVL------------------------- 669

  Fly   927 SASSKDQLLSGIELELQQYQILQRCQLDEEQPCTSKMAAKSLGAIPKVVKYREVDELRRRRRGGS 991
                  |::||.|..:|           ||.         ||.|:...:                
  Rat   670 ------QVISGPETSVQ-----------EEM---------SLDAMHIFI---------------- 692

  Fly   992 PADAAEAGNEFALVKQTKQASRNSSSSNSTHSISLTDSLTADIHKMLWLMHGGAVDDRGRPITGT 1056
                    :|...|:.....|.|....:|.|.....|.::   |....|:..          :.|
  Rat   693 --------DEHGEVRSCYLKSGNQKEGSSQHPPLNPDCVS---HAREILLSS----------SST 736

  Fly  1057 SADGTPIPASSSLVPPNMSNAHFQFYQDAIQALQGTHPTSGSSVEHMTNIELARDKLRLDAKLMC 1121
            :..|:|.|:|.               ..|:.|||                               
  Rat   737 TTTGSPDPSSG---------------DPAVSALQ------------------------------- 755

  Fly  1122 EQLVAAAEANSGVRGNTLATQQMTQQQVGMLMRGGSSSRHPSSAPFSVQGLINVIRSERPAARSQ 1186
            :||:             |...:.||.:         :.||.|                       
  Rat   756 QQLL-------------LMVARRTQSE---------TPRHVS----------------------- 775

  Fly  1187 LDALQQLSDAAAALAANASEAASVSASGAGGGASSGGGGVLSALGLANHPSNQISQISQLSQMSQ 1251
                |.|.|::.:                            ||.|..|.                
  Rat   776 ----QDLEDSSRS----------------------------SAQGKFNR---------------- 792

  Fly  1252 PMLNVDGHFAPYCDYWRPACLLSATEKPAAPKSFYKYRF---KWCGQEHEFKIAMDRLELLALFD 1313
                                           :.|||:..   ||      .|:..|||.||||.|
  Rat   793 -------------------------------EQFYKFIIFPGKW------IKVWYDRLTLLALLD 820

  Fly  1314 RDLHWMHVLLASLLCTLVACLGAAILQHDHYKDLCALLFCAVIAGAQYSLVKSVQPDAASPVHGF 1378
            |.......::|.||..||:.||...|.....:||..||||.|:|..||||:||||||.|||:||.
  Rat   821 RTEDVKENMVAVLLSVLVSLLGFLTLNRGFCRDLWVLLFCLVMASCQYSLLKSVQPDPASPIHGH 885

  Fly  1379 NKTVAYSRAIYFCLAGGMLLLLKRLDTDYGERTPDPVVFFGMRYSPADVVALLLQALYILLLCFP 1443
            |:.:||||.||||:..|::||   ||.....|.|...|.:|::....:.:..:...|.:.|.|||
  Rat   886 NQIIAYSRPIYFCMLCGLILL---LDAGAKARHPPSYVVYGLKLFTPETLQSVRDHLIVFLCCFP 947

  Fly  1444 IIFSVGLCPQINTFLMYLLEQIDMHVFGGNAASSLLGSFLCVVRSVLAVMLLYGPLYGALDEQRG 1508
            .|..:||.||||||..||||||||.:|||:|.|.:..:...|.|||||..||:...:.|:.|...
  Rat   948 AISLLGLFPQINTFCTYLLEQIDMLLFGGSAVSGITSAVYSVGRSVLAAALLHVFCFSAVKEPWS 1012

  Fly  1509 TQYI--LFSIFCAMLVPLGYHLSRCASDFSHLWRLIKTCIVSTYRDDEDEDLSQMQHIATGTVTG 1571
            ||:|  |||.||.:||.|.|||||.:||.|.|...|                             
  Rat  1013 TQHIPALFSAFCGLLVALSYHLSRQSSDPSVLLSFI----------------------------- 1048

  Fly  1572 SGTANSTALQLTTSTPKQHRQTDVKTEHEQIELSSLEKLTVNEEHHEKDHGADDQLETDQDLPLQ 1636
                                                                             
  Rat  1049 ----------------------------------------------------------------- 1048

  Fly  1637 QKHSKSKTSSLGSSQQTLGKTISSSKRAITASSSCTSIGTGEPAVEAGALTEEAVEGEEQRRNTL 1701
                                                                             
  Rat  1049 ----------------------------------------------------------------- 1048

  Fly  1702 AGEVGSKHELAENYDQAAKIDECEDKISSSSATNPGDMSTLTAGAGTATTDATPACLEADPDAEA 1766
                                 :|:                           ..|.||..:.|..|
  Rat  1049 ---------------------QCK---------------------------LLPKCLHQNLDESA 1065

  Fly  1767 EAPADEKQHQGILGTGTGTGTGTTEASENGSGGGANGNTNSNGTGNDLPDPLPRKLQATVTTRLK 1831
                                                            .||||::::.:|...|:
  Rat  1066 ------------------------------------------------ADPLPQRMKDSVKDVLR 1082

  Fly  1832 NDLVVMTLLAVSVLGLHCSTVFTALQPDLNVVLYSFIGVLGLLLHYIVPQMRKHMPWLCFSRPLL 1896
            :||::.:..||....:..||||.:|:|.|::||::..|.:||:.|:::||:|||.||:..|.|:|
  Rat  1083 SDLIICSAAAVLSFAVSASTVFLSLRPFLSIVLFALAGTVGLITHHLLPQLRKHHPWMWISHPVL 1147

  Fly  1897 RQREFGQFEVLNAPKIMWFEKLYIYLSVLERNVLFPLLAISSLTADSQLI--VAKFGLPWGTLIV 1959
            :.:|:.|.|..:...:||||:||::|...|:.:|:|.:.::::|.|:..|  ..:.|..|...::
  Rat  1148 KSKEYQQREARDIAHLMWFERLYVWLQCFEKYLLYPAIVLNAVTLDAFSISNYRRLGTHWDIFLM 1212

  Fly  1960 AICALKFVRNAYSDPTNQYLIIIFTVLLFRIDFAMATETFIIDYFFVSLAFRKCCDFLLKLQFIV 2024
            ....:|.:|.::.:|.:|:..:.|||:.|..|:...:|:|::|:|.||:.|.|..|.|.||||::
  Rat  1213 ITAGMKLLRTSFCNPVHQFANLGFTVVFFHFDYKDVSESFLLDFFMVSIVFTKLGDLLQKLQFVL 1277

  Fly  2025 TYIAPWQITWGSAFHAFAQPFSVPHSAMLFLQAAISAVLSTPLNPFLGSAIFLTSYVRPIKFWER 2089
            .|:||||:.|||:||.|||.|::|||||||.|...:::.||||:|||||.||:||||||:|||||
  Rat  1278 AYVAPWQMAWGSSFHVFAQLFAIPHSAMLFFQTFATSIFSTPLSPFLGSVIFITSYVRPVKFWER 1342

  Fly  2090 DYNTRRIDHSNTRLSSQLERDLGADDNNLNSIFYEHLTRSLQHSLCGDLLMGRWGNVNQGDCFVL 2154
            .|||:|:|:|||||:.|:|||.|:||.:|||||||||||:||.||||||.:|||||.:.||||:|
  Rat  1343 SYNTQRVDNSNTRLAVQMERDPGSDDGSLNSIFYEHLTRTLQDSLCGDLALGRWGNYSSGDCFIL 1407

  Fly  2155 ASDDLNCLVHIIELGNGLCTFQMRGLEFRGTYCQQREVEAITEDVEDNDGCCCCDPGHLPQLLSA 2219
            ||||||..||:||:||||.|||:||||||||||||||||||.|..||:.|||||.|||||.|||.
  Rat  1408 ASDDLNAFVHLIEIGNGLVTFQLRGLEFRGTYCQQREVEAIMEGDEDDRGCCCCKPGHLPHLLSC 1472

  Fly  2220 NAMFSTRWLAWQVVAAQYVIEGYSISDNLASATLQVFEYRKVLITYYIKSIIYYVVKNPKLEQWL 2284
            ||.|..|||.|::...||::|||||.||.|:..|.||:.|:|||.|||||||||:|.:|||..|:
  Rat  1473 NAAFHLRWLTWEITRTQYILEGYSIIDNNAATMLHVFDLRRVLIRYYIKSIIYYMVTSPKLASWV 1537

  Fly  2285 ASGPIQDALQ-----HTLSRQFVDLDPIFNFNLDEDFDFRAVGITRSSFCYVYLKWINYCVDMRR 2344
            .:..:..:|:     |.:.|...    :||.|:|:|:.....||||:|:|.|:|:||.||...|:
  Rat  1538 KNESLLKSLEPFAKWHHIERDLA----MFNINIDDDYVPCLQGITRASYCSVFLEWIQYCAGKRQ 1598

  Fly  2345 DANSMGGAPPAQAPAAAGGASSAPATAGVAPPAPVTPAHNDSKSTPNLSAHGGQAGPSSGQSKSQ 2409
            :.:.                               |..|.||                       
  Rat  1599 ELSK-------------------------------TLDHVDS----------------------- 1609

  Fly  2410 SQQQLRRPQKSVAQETSVGGGGVVVGGTTVPGTGGVTGGGGDPQLSSSHSFANISRQTSESAPGL 2474
                                                                             
  Rat  1610 ----------------------------------------------------------------- 1609

  Fly  2475 GGYVAYMDQNVFVKLAKSSTTTGAGAGAPTSRKESQEKPALRLKLASVGKDAPLVSLCLALGLLA 2539
                                                            .:|:.||:|..||.:|.
  Rat  1610 ------------------------------------------------DEDSALVTLSFALCILG 1626

  Fly  2540 RRSLATASHSALTGVEFFLHGLHALFKGDFRITSPRDEWVFADMELLHSVVAPAVKMALKLQQDH 2604
            ||:|.||:|:....::.||:|||||||||||:|: |||||||||:|||.||.||::|:|||.||.
  Rat  1627 RRALGTAAHNMAMSLDSFLYGLHALFKGDFRVTA-RDEWVFADMDLLHKVVVPAIRMSLKLHQDQ 1690

  Fly  2605 ITNPDEFLDPHALYDAIDNCSNELVISHEADPVWRSAVLRGAPNLLALRHVMEDGSDEYRIIRLT 2669
            .|.|||:.||..||:||.:...::||.||.||.||.|||.....||.||||:::|::||::|.|.
  Rat  1691 FTCPDEYEDPEILYEAIQSFEKKVVICHEGDPAWRGAVLSNKEELLTLRHVVDEGANEYKVIMLH 1755

  Fly  2670 KRCLSFRVIKLNRECVRGLWAGQQQELIYLRNRNPERGSIQNAKQALRNIINSSCDQPIGYPIYV 2734
            :..|||:|||:|:|||||||||||||||:|||||||||||||.||.|||:||||||||:|||:||
  Rat  1756 RGFLSFKVIKVNKECVRGLWAGQQQELIFLRNRNPERGSIQNNKQVLRNLINSSCDQPLGYPMYV 1820

  Fly  2735 SPLTTSYADTNAQLCEVIGGAITLDTIRHTVLGWWHRIRERCRQGCSSGSALEPHPGSGPVQLGA 2799
            |||||||..|:.||..|.||.|||:.:|......|.|:|:.|..|..||..:|  .|.|.|..|.
  Rat  1821 SPLTTSYLGTHKQLQSVWGGPITLNRVRTWFQTRWLRMRKDCSVGQRSGGNIE--DGEGAVPPGG 1883

  Fly  2800 CNFGSGGSVVGAASTATGVGASTGSGLGVAAPGTAGSTGGESGDLAPVFISAPLYNTLTVNSYYS 2864
             |..||.|    ..::|......|:....:..|.|...|...|            .:.:|.::.:
  Rat  1884 -NAPSGES----RDSSTEQPRKGGTQQWASPRGEAPRAGRRKG------------RSQSVQAHSA 1931

  Fly  2865 V---RPGNVPGGPIPGNLGGNYVSDSLAVVRGGLAVMPVKPTSTTLIAGLLNRERDETSGSGIMG 2926
            :   ||.....|||        :....|.::          |||:     ::......||     
  Rat  1932 ISQRRPTLSSSGPI--------LESHQAFLQ----------TSTS-----VHELAQRPSG----- 1968

  Fly  2927 AGASGPTRATSSGGVRSRRPEV---GSSRGRDHERRATLP------------------------I 2964
               |.|:..||:|.:.|:.|.|   |...|..|:..|.:.                        :
  Rat  1969 ---SRPSLNTSAGSLHSQPPPVLTTGPYLGIQHQAEALIQSSLGSSTSSTLSFLFGKRSFSSALV 2030

  Fly  2965 ASGGAGGEPGKDLTAPQTQVEHEPSPRSTKLSSSSGSLGLGMGVGL------------------- 3010
            .||.:..|.|                 :|..:.||.|:.:.||...                   
  Rat  2031 ISGLSAAEGG-----------------NTSDTQSSSSVNIVMGPSARAAARHFSEPCEPIDSPEQ 2078

  Fly  3011 -----GNIITTPGDYPRKTKGPICLTA--VDTGTSSSAAE 3043
                 |.:....|:.||   |.:|..|  .|.|...:|::
  Rat  2079 GQLQDGRLAEAAGENPR---GVLCRRASQEDMGLDDTASQ 2115

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pcxNP_001259183.2 Pecanex_C 2523..2746 CDD:282845 142/222 (64%)
Loricrin <2779..>2842 CDD:292475 17/62 (27%)
Pcnx2XP_006255883.1 DUF4045 354..644 CDD:289995 79/405 (20%)
Pecanex_C 1608..1831 CDD:282845 143/359 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166337043
Domainoid 1 1.000 338 1.000 Domainoid score I1073
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D41206at33208
OrthoFinder 1 1.000 - - FOG0002108
OrthoInspector 1 1.000 - - otm44448
orthoMCL 1 0.900 - - OOG6_104101
Panther 1 1.100 - - O PTHR12372
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1397
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1110.850

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