|
Fly 1 MGSQTLEILRQGVWASLTGGYFYDPHQGVFCNVVHLYLWLYLLCSPFVAYLIFLQYFPSTWLTWC 65
|.||.|::|||||||:||||:::||....|.|..||||||:||..|...:|. ||...||..
Mouse 1 MASQVLQLLRQGVWAALTGGWYHDPEHSKFTNSCHLYLWLFLLLLPLALHLA----FPPNVLTAL 61
Fly 66 LYCVITSLTILMVKLANLALHRLYDRAQTMS------------EGNLKGQF------------VK 106
.||...::...::||.:..||.::|:.:.:. ||....|. :.
Mouse 62 FYCGSVTIFFAVIKLISYRLHLMFDKGEAIQHRSPRKRSKRKPEGEASSQHTARHKNPSNNRQIH 126
Fly 107 VTKETEPRHDDEGGIEMKVIRPGGSRISGEQAINEASEENSIMSIDNVNSIIDLKVDVHRKNSSE 171
.||:.||| ||..:.....:...: .||.::||.
Mouse 127 STKKEEPR---------------GSLTTPPLCCSSRGQ------------------SVHSQHSSG 158
Fly 172 SIELMFYAPSM-----LSGG--SQQDQQSLAGSASVSKSIRSTGPGGNSSTSAAAQA----DMFN 225
.:|| |:. |.|. |:...::||. ||.||..|.:..|:|. ....
Mouse 159 PLEL----PAQETVEDLKGVVLSEDQPEALAS---------STSPGMKSESLPASQGRTPEPTPR 210
Fly 226 KYLTVYPEVVEAAGSSAGSADGGSSGGDSRSGAAVSTLGHTGAGTAPAQHVRTGHLSRKCSEVFS 290
....:.|...|...:..|...||:: ..||
Mouse 211 PACPLKPVTTELFTARKGKESGGTA-------------------QRPA----------------- 239
Fly 291 RRHRRRLERQSSLDTAAAAANSNAENKLMR---NQSDTIATAAPSFLHSQPTNKARGQTNPRQHF 352
||| :.:...|..|..||.: :|.|.:.|.. || ||......
Mouse 240 -RHR----------SESGLVNPGALKKLPQLSLSQYDLLETDI-SF---QPWGSEHS-------- 281
Fly 353 ITSAPSTGIGGGDAPTSSTAVVVIAPASNSLVNPGRSSRLQRHRSSETHDERLKHQSRGGLFQPI 417
|:.|..|......|: ||.
Mouse 282 ----------------------VLLPQPNCTQGATRA-------------------------QPQ 299
Fly 418 LQLPHHSAASSIGALAVLGGGGNVAANDVEDMELGLVRNAGSGGVADACSRALQSWILDPFPDGY 482
.:.|..|.:||.... ..|.|...|: .|.|.:|. ....|...::|
Mouse 300 NRSPQDSLSSSCCQC------NTVLAKPTEE---ELTRTSGQ------VELPLNQEVVD------ 343
Fly 483 LEDDSYTKSDLGIEQPHQPTFRTQHRHHHHHHHLHHHLGGAIIRKDPTSTMSALQLAAVTQPGTG 547
.|.....:.:...||.:|. .||..:...| |||:.|
Mouse 344 -SDGEVAVTLIDTSQPGEPL------------SLHEPIKIVI-------TMSSTQ---------- 378
Fly 548 GSVTGGGGAAGGGGSAAGMKRRRHSNATSYKHGSSQSNKSSLVGGGGSRGPSG------------ 600
.|.:.::...|...||....|.:|:..| .|.|..||:.
Mouse 379 -------------NSISDLESSLHLRVTSSDRTSVRSSAES--AGSGGAGPADPEQVRIPLITLE 428
Fly 601 --EAGTSGGAG-----GTGGVRRIKSAALEVLCPQPSVSNLSPHPNSVEAISGQQQMRNPLPPPS 658
|.| ||.| |.||.| ....:||:.| :..||
Mouse 429 LTEDG--GGRGVSCSEGNGGER--TPERMEVMSP--------------DRCSG------------ 463
Fly 659 KSLVRNQHLNLYPTQGYGDGTPSAGGGGPGNSSTCSSLFFGSSSACGSTTALIEPPVYPIVEHSD 723
.|.|||:|:. |||.|.:.|.|.|..|.|.
Mouse 464 --------------SGPGDGSPTP----------------------GSTLATLTPRVDPESEGSK 492
Fly 724 EKTAHEEHGDDCLGIGQGNADDDDEVDDVPIRRRTRALGCSQTH-------YSVESDVGGFLADE 781
| ||.|.| ...|..:| .||:|....||:
Mouse 493 E--------------GQANLD---------------PASCKSSHEKRHARVLSVDSGTDVFLS-- 526
Fly 782 VGADEDVFKDFDDNLEHILSELQQTHNQLDDVLKTHDLHHHSHLHHHKAASV---------EGA- 836
.:.::|..|.:..:....|:|:....|:.: :::.|...|.|.....:.| :||
Mouse 527 -RSTKEVVSDGEKPIPTSKSDLEAKEGQIPN--ESNFLEFVSLLESISTSKVVAPDSPAEQKGAS 588
Fly 837 -GPSGGSVAVGVSAGNDDEDEETEDNNTGSRSPLLNDRNRQPATLREIQADKQLRQELSHQSGAV 900
||.|.: |.|..:|..|.|..| .|.| |..:.:|..|.
Mouse 589 QGPEGHA-----SPGTKEEAVENEKPN-----------GRDP---------KPGKPDLPSQD--- 625
Fly 901 IPAPNPPV---PIRSEADSGCPSSDCEQVSASSKDQLLSGIELELQQYQILQRCQLDEEQ----- 957
||...|| |.:|.| |..| .:|..|:.|....::.
Mouse 626 -PANGSPVFTQPAKSAA-------------------LFQG----SRQRHIIYRVTSQQDSSVLQV 666
Fly 958 ---PCTSKMAAKSLGAIPKVVKYREVDELRRRRRGGSPADAAEAGNEFALVKQTKQASRNSSSSN 1019
|.||.....||.|:...: :|...|:.....|.|....:
Mouse 667 ISGPETSVQEEMSLDAMHVFI------------------------DEHGEVRSCYLKSGNQKEGS 707
Fly 1020 STHSISLTDSLTADIHKMLWLMHGGAVDD--RGRPITGTS--ADGTPIPASSSLVPPNMSNAHFQ 1080
|.|.....|.:: |..|:.. ||..::.:| |.|:|.|:|.
Mouse 708 SQHPPLNPDCVS----------HARAIFPVLRGILLSSSSSTATGSPDPSSG------------- 749
Fly 1081 FYQDAIQALQGTHPTSGSSVEHMTNIELARDKLRLDAKLMCEQLVAAAEANSGVRGNTLATQQMT 1145
..|:.||| :||: |...:.|
Mouse 750 --DPAVSALQ-------------------------------QQLL-------------LMVARRT 768
Fly 1146 QQQVGMLMRGGSSSRHPSSAPFSVQGLINVIRSERPAARSQLDALQQLSDAAAALAANASEAASV 1210
|.: :.||.| |.|.|::.:
Mouse 769 QSE---------TPRHVS---------------------------QDLEDSSRS----------- 786
Fly 1211 SASGAGGGASSGGGGVLSALGLANHPSNQISQISQLSQMSQPMLNVDGHFAPYCDYWRPACLLSA 1275
||.|..|.
Mouse 787 -----------------SAQGKFNR---------------------------------------- 794
Fly 1276 TEKPAAPKSFYKYRF---KWCGQEHEFKIAMDRLELLALFDRDLHWMHVLLASLLCTLVACLGAA 1337
:.|||:.. || .|:..|||.||||.||.......::|.||..||:.||..
Mouse 795 -------EQFYKFIVFPGKW------IKVWYDRLTLLALLDRTEDVKENMVAVLLSVLVSLLGFL 846
Fly 1338 ILQHDHYKDLCALLFCAVIAGAQYSLVKSVQPDAASPVHGFNKTVAYSRAIYFCLAGGMLLLLKR 1402
.|.....:||..||||.|:|..||||:||||||.|||:||.|:.:||||.||||:...::||
Mouse 847 TLNRGFCRDLWVLLFCLVMASCQYSLLKSVQPDPASPIHGHNQIIAYSRPIYFCMLCSLILL--- 908
Fly 1403 LDTDYGERTPDPVVFFGMRYSPADVVALLLQALYILLLCFPIIFSVGLCPQINTFLMYLLEQIDM 1467
||.....:.|...|.:|::....:.:..:...|.:.|.|||.|..:||.||||||..||||||||
Mouse 909 LDAGAKAKHPPSYVVYGLKLFTPETLQAVRDHLIVFLCCFPAISLLGLFPQINTFCTYLLEQIDM 973
Fly 1468 HVFGGNAASSLLGSFLCVVRSVLAVMLLYGPLYGALDEQRGTQYI--LFSIFCAMLVPLGYHLSR 1530
.:|||:|.|.:..:...|.|||||..||:...:.|:.|...||:| |||.||.:||.|.|||||
Mouse 974 LLFGGSAVSGITSAVYSVGRSVLAAALLHAFCFSAVKEPWSTQHIPALFSAFCGLLVALSYHLSR 1038
Fly 1531 CASDFSHLWRLIKTCIVSTYRDDEDEDLSQMQHIATGTVTGSGTANSTALQLTTSTPKQHRQTDV 1595
.:||.|.|...|
Mouse 1039 QSSDPSVLLSFI----------------------------------------------------- 1050
Fly 1596 KTEHEQIELSSLEKLTVNEEHHEKDHGADDQLETDQDLPLQQKHSKSKTSSLGSSQQTLGKTISS 1660
Mouse 1051 ----------------------------------------------------------------- 1050
Fly 1661 SKRAITASSSCTSIGTGEPAVEAGALTEEAVEGEEQRRNTLAGEVGSKHELAENYDQAAKIDECE 1725
:|:
Mouse 1051 --------------------------------------------------------------QCK 1053
Fly 1726 DKISSSSATNPGDMSTLTAGAGTATTDATPACLEADPDAEAEAPADEKQHQGILGTGTGTGTGTT 1790
..|.|| ||.:..:.|
Mouse 1054 ---------------------------LLPKCL----------------HQNLEESAT------- 1068
Fly 1791 EASENGSGGGANGNTNSNGTGNDLPDPLPRKLQATVTTRLKNDLVVMTLLAVSVLGLHCSTVFTA 1855
||||::::.:|...|::|||:.:..||....:..||||.:
Mouse 1069 -------------------------DPLPQRMKDSVKDVLRSDLVICSAAAVLSFAVSASTVFLS 1108
Fly 1856 LQPDLNVVLYSFIGVLGLLLHYIVPQMRKHMPWLCFSRPLLRQREFGQFEVLNAPKIMWFEKLYI 1920
|:|.|::||::..|.:||:.|:::||:|||.||:..|.|:||.:|:.|.|..:...:||||:||:
Mouse 1109 LRPFLSIVLFALAGTVGLITHHLLPQLRKHHPWMWISHPVLRSKEYQQREARDIAHLMWFERLYV 1173
Fly 1921 YLSVLERNVLFPLLAISSLTADSQLI--VAKFGLPWGTLIVAICALKFVRNAYSDPTNQYLIIIF 1983
:|...|:.:|:|.:.:::||.|:..| ..:.|..|...::....:|.:|.::.:|.:|:..:.|
Mouse 1174 WLQCFEKYLLYPAIVLNALTLDAFSISNYRRLGTHWDIFLMITAGMKLLRTSFCNPVHQFANLGF 1238
Fly 1984 TVLLFRIDFAMATETFIIDYFFVSLAFRKCCDFLLKLQFIVTYIAPWQITWGSAFHAFAQPFSVP 2048
||:.|..|:...:|:|::|:|.||:.|.|..|.|.||||::.|:||||:.|||:||.|||.|::|
Mouse 1239 TVIFFHFDYKDISESFLLDFFMVSIVFTKLGDLLQKLQFVLAYVAPWQMAWGSSFHVFAQLFAIP 1303
Fly 2049 HSAMLFLQAAISAVLSTPLNPFLGSAIFLTSYVRPIKFWERDYNTRRIDHSNTRLSSQLERDLGA 2113
||||||.|...:::.||||:|||||.||:||||||:|||||.|||||:|:|||||:.|:|||.|:
Mouse 1304 HSAMLFFQTFATSIFSTPLSPFLGSVIFITSYVRPVKFWERSYNTRRMDNSNTRLAVQMERDPGS 1368
Fly 2114 DDNNLNSIFYEHLTRSLQHSLCGDLLMGRWGNVNQGDCFVLASDDLNCLVHIIELGNGLCTFQMR 2178
|||||||||||||||:||.||||||::|||||.:.||||:|||||||..||:||:||||.|||:|
Mouse 1369 DDNNLNSIFYEHLTRTLQESLCGDLVLGRWGNYSSGDCFILASDDLNAFVHLIEIGNGLVTFQLR 1433
Fly 2179 GLEFRGTYCQQREVEAITEDVEDNDGCCCCDPGHLPQLLSANAMFSTRWLAWQVVAAQYVIEGYS 2243
|||||||||||||||||.|..||:.|||||.|||||.|||.||.|..|||.|::...||::||||
Mouse 1434 GLEFRGTYCQQREVEAIMEGDEDDRGCCCCKPGHLPHLLSCNAAFHLRWLTWEITRTQYILEGYS 1498
Fly 2244 ISDNLASATLQVFEYRKVLITYYIKSIIYYVVKNPKLEQWLASGPIQDALQ-----HTLSRQFVD 2303
|.||.|:..|||::.|:|||.||:||||||:|.:|||..|:.:..:..:|| |.:.|...
Mouse 1499 IIDNNAATMLQVYDLRRVLIRYYVKSIIYYMVTSPKLVSWVKNESLLKSLQPFAKWHHIERDLA- 1562
Fly 2304 LDPIFNFNLDEDFDFRAVGITRSSFCYVYLKWINYCVDMRRDANSMGGAPPAQAPAAAGGASSAP 2368
:||.|:|:|:.....||||:|:|.|:|:||.||...|::.:.
Mouse 1563 ---MFNINIDDDYVPCLQGITRASYCNVFLEWIQYCAGKRQELSK-------------------- 1604
Fly 2369 ATAGVAPPAPVTPAHNDSKSTPNLSAHGGQAGPSSGQSKSQSQQQLRRPQKSVAQETSVGGGGVV 2433
|..|.||
Mouse 1605 -----------TLEHVDS----------------------------------------------- 1611
Fly 2434 VGGTTVPGTGGVTGGGGDPQLSSSHSFANISRQTSESAPGLGGYVAYMDQNVFVKLAKSSTTTGA 2498
Mouse 1612 ----------------------------------------------------------------- 1611
Fly 2499 GAGAPTSRKESQEKPALRLKLASVGKDAPLVSLCLALGLLARRSLATASHSALTGVEFFLHGLHA 2563
.:|:.||:|..||.:|.||:|.||:|:....::.||:||||
Mouse 1612 ------------------------DEDSALVTLAFALCILGRRALGTAAHNMAMSLDSFLYGLHA 1652
Fly 2564 LFKGDFRITSPRDEWVFADMELLHSVVAPAVKMALKLQQDHITNPDEFLDPHALYDAIDNCSNEL 2628
|||||||:|: |||||||||:|||.||.||::|:|||.||..|.|||:.||..||:||.:.:.::
Mouse 1653 LFKGDFRVTA-RDEWVFADMDLLHKVVVPAIRMSLKLHQDQFTCPDEYEDPAVLYEAIRSFAKKV 1716
Fly 2629 VISHEADPVWRSAVLRGAPNLLALRHVMEDGSDEYRIIRLTKRCLSFRVIKLNRECVRGLWAGQQ 2693
||.||.||.||.|:|.....||.||||:::|:|||::|.|.:..|||:|||:|:|||||||||||
Mouse 1717 VICHEGDPAWRGAMLSNKEELLTLRHVVDEGADEYKVIMLHRGFLSFKVIKVNKECVRGLWAGQQ 1781
Fly 2694 QELIYLRNRNPERGSIQNAKQALRNIINSSCDQPIGYPIYVSPLTTSYADTNAQLCEVIGGAITL 2758
||||:|||||||||||||.||.|||:||||||||:|||:|||||||||..|:.||..|.||.:||
Mouse 1782 QELIFLRNRNPERGSIQNNKQVLRNLINSSCDQPLGYPMYVSPLTTSYLGTHKQLQSVWGGPVTL 1846
Fly 2759 DTIRHTVLGWWHRIRERCRQGCSSGSA-LE-------PHPGSGPVQLGACNFGS------GG--- 2806
:.:|......|.|:|:.|..|..||.. :| |..|.|....|....|| ||
Mouse 1847 NRVRTWFQTRWLRMRKDCSVGQRSGGGNIEDGEGGAVPSAGGGSAPNGESRDGSTEQPRKGGTQQ 1911
Fly 2807 --SVVGAASTATGVGASTGSGLGVAA-------PGTAGSTGGESGDLAPVFISAPLY-NTLTVNS 2861
|..|.|..| |...|....|.| |.|..|:| |:..|...: .|.|...
Mouse 1912 WSSPRGEAQRA---GRRKGRSQSVQAHSAISQRPPTLSSSG-------PILESHQAFLQTSTSVH 1966
Fly 2862 YYSVRPGNVPGGPIPGNLGGNYVSDSLAVVRGGLAVMPVKPTSTTLIAGLLNRERDETSGSGIMG 2926
..:.|| |.|...:....|.:..:|...|....|..|||.|......:|
Mouse 1967 ELAQRP-----------------SGSRLSLHTSAASLHSQPPPVTTTGHLSVRERAEALIRSSLG 2014
Fly 2927 AGASGP------TRATSSGGVRSRRPEVGSSRGRDHERRATLPIASG---GAGGEPGKDLTAPQT 2982
:..|.. .|:.||..|.|...........|.:..:::.|..| .|.|...:..:.|
Mouse 2015 SSTSSTLSFLFGKRSFSSALVISGLSAAEGGNTSDTQSSSSVNIVMGPSARAAGHAARHFSEP-- 2077
Fly 2983 QVEHEPSPRSTKLSSSSGSLGLGMGVGLG 3011
.|...||...:| ..|.|...|...||
Mouse 2078 -CEPTDSPEQGQL--QDGRLAEAMEENLG 2103
| 
