|
Fly 1 MGSQTLEILRQGVWASLTGGYFYDPHQGVFCNVVHLYLWLYLLCSPFVAYLIFLQYFPSTWLTWC 65
||||||:||||||||:|:||::|||||..|.|.:||||||:||..||..|:. .|||.:...
Human 1 MGSQTLQILRQGVWAALSGGWYYDPHQATFVNALHLYLWLFLLGLPFTLYMA----LPSTMIIVA 61
Fly 66 LYCVITSLTILMVKLANLALHRLYDRAQTMSEGNLKGQFVKVTKETEPRHDDEGGIEMKVIRPGG 130
:||.:.:...:::|:.|..|||..|..:.:
Human 62 VYCPVIAAVFIVLKMVNYRLHRALDAGEVV----------------------------------- 91
Fly 131 SRISGEQAINEASEENSIMSIDNVNSIIDLKVDVHRKNSSESIELMFYAPSMLSGGSQQDQQSLA 195
::..||.:::.:.....|.:: .||:|: .||...||.:
Human 92 -----DRTANEFTDQRTKAEQGNCST--------RRKDSN--------GPSDPGGGIE------- 128
Fly 196 GSASVSKSIR-STGPGGNSSTSAAAQADMFNKYLTVYPEVVEAAGSSAGSADGGSSGGDSRSGAA 259
:|:.|| :|.|.|.||.::.|..|..|:. || |.||.|.|
Human 129 ----MSEFIREATPPVGCSSRNSYAGLDPSNQI--------------------GS--GSSRLGTA 167
Fly 260 VSTLGHTG-AGTAPAQHVRTGHLSRKCSEVFSRRHRRRLERQSSLDTAAAAANSNAENKLMRNQS 323
.:..|.|. |.|:....:..|..|..|.| ..|.| |.| |:.||.|..|
Human 168 ATIKGDTDTAKTSDDISLSLGQSSSLCKE--------GSEEQ---DLA-------ADRKLFRLVS 214
Fly 324 DTIATAAPSFLHSQPTNKARGQTNPR-------------QHFITSAPSTGIGGGDAPTSSTAVVV 375
: .||:..||:..:.||..|| .|.:..:.|: ...|.|..
Human 215 N------DSFISIQPSLSSCGQDLPRDFSDKVNLPSHNHHHHVDQSLSS--------ACDTEVAS 265
Fly 376 IAPA-SNSLVNPGRSSRLQRHRSS-------ETHDERLKHQSRGGLFQPILQLPHHSAASSIGAL 432
:.|. |:|.....|...:.|..|| ..:|..|..|.|| ..|:.:|.
Human 266 LVPLHSHSYRKDHRPRGVPRTSSSAVAFPDTSLNDFPLYQQRRG--LDPVSELE----------- 317
Fly 433 AVLGGGGNVAANDVEDMELGLVRNAGSGGVADACSRALQSWILDPFPDGYLEDDSYTKSDLGIEQ 497
::..:...:..||.|:|..| :.....||.|..
Human 318 ---------SSKPLSGSKESLVENSGLSG------------------------EFQLAGDLKINT 349
Fly 498 PHQPTFRTQHRHHHHHHHLHHHLGGAIIRKDPTSTMSALQLAAVTQPGTGGSVTGGGGAAGGGGS 562
...|| ..|.........:|.:|:..:....|:..|.
Human 350 SQPPT-----------------KSGKSKPLKAEKSMDSLRSLSTRSSGSTESY------------ 385
Fly 563 AAGMKRRRHSNATSYKHGSSQSNKSSLVGGGGSRGPSGEAGTSGGAGGTGGVRRIKSAALEVLCP 627
.:|..|..:|..:||| |.|::.:.:.........|.:||| ||...:..|.
Human 386 CSGTDRDTNSTVSSYK--SEQTSSTHIESILSEHEESPKAGT-------------KSGRKKECCA 435
Fly 628 QPSVSN--LSPHPNSVEAI-------SGQQQMRNPLP------------PPSKSLVRNQHLNLYP 671
.|...| .|....|.|.| ||..:.::|.| ..|:...:|.|.|.:.
Human 436 GPEEKNSCASDKRTSSEKIAMEASTNSGVHEAKDPTPSDEMHNQRGLSTSASEEANKNPHANEFT 500
Fly 672 TQGYGDGTPSAGGGGPGNSSTCSSLFFGSSSACGSTTALIEPPVYPIVEHSDEKTAHEEHGDDCL 736
:|| ..| |||:: |:.:||:
Human 501 SQG---DRP------PGNTA----------------------------ENKEEKS---------- 518
Fly 737 GIGQGNADDDDEVD-DVPIRRRTRALGCSQTHYSVESDVGGFLADEVGADEDVFKDFDDNLEHIL 800
|...|. |..:|: ||||
Human 519 --------DKSAVSVDSKVRK----------------DVGG------------------------ 535
Fly 801 SELQQTHNQLDDVLKTHDLHHHSHLHHHKAASVEGAGPSGGSVAVGVSAGNDDEDEETEDNNTGS 865
:| |..|:...|....|:.||...:| ...||.
Human 536 ---KQ---------KEGDVRPKSSSVIHRTASAHKSG----------------------RRRTGK 566
Fly 866 R--SPLLNDRNRQPATLREIQADKQLRQELSHQSGAVIPAPNPPVPIRSEADSGCPSSDCEQVSA 928
: |...:.|:|.....|.:...| |:..:....| .|||...:|.
Human 567 KRASSFDSSRHRDYVCFRGVSGTK----------------PHSAIFCHDE-----DSSDQSDLSR 610
Fly 929 SSKDQLLSGIELELQQYQILQRCQLDEEQPCTSKMAAKSLGAIPKVVKYREVDELRRRRRGGSPA 993
:|..|.......:.........||..|. :|..:......:..|:.:
Human 611 ASSVQSAHQFSSDSSSSTTSHSCQSPEG-------------------RYSALKTKHTHKERGTDS 656
Fly 994 DAAEAGNEFALVKQTKQASRNSSSSNSTHS----ISLTDSLTADIHKMLWLMHGGAVDDRGRPIT 1054
:.....:........|:|:|.:||:||..: :||.....|.::....||...:: :|:|
Human 657 EHTHKAHLVPEGTSKKRATRRTSSTNSAKTRARVLSLDSGTVACLNDSNRLMAPESI----KPLT 717
Fly 1055 GTSADGTPIPASSSLVPPNMSNAHFQFYQDAIQALQGTHPTSGSSVEHMTNIE-LARDKLRLDAK 1118
.:.:| ::|.:|......|.:...:.:| :.|.:..|..:
Human 718 TSKSD--------------------------LEAKEGEVLDELSLLGRASQLETVTRSRNSLPNQ 756
Fly 1119 LMCEQLVAAAEANSGVRGNTLATQQ----------MTQQQVGMLMRGGSSSRHPS---SAPFSV- 1169
:...: .|....|.|...|::: ..:|.|......||:...|: .:|.|:
Human 757 VAFPE----GEEQDAVSGAAQASEEAVSFRRERSTFRRQAVRRRHNAGSNPTPPTLLIGSPLSLQ 817
Fly 1170 ------QGLINVIRSERPAARSQLDALQQLSDAAAALAANAS---EAASVSASGAGGGA------ 1219
|....|....||.:::.: ||.:|:.|..|.| ||:..:||..||.:
Human 818 DGQQGQQSTAQVKVQSRPPSQAAV-----LSASASLLVRNGSVHLEASHDNASAVGGSSLHDELG 877
Fly 1220 --SS----GGGGVLSALGL---ANHPSNQISQISQLSQ-----------MSQPMLNVDGHFAPYC 1264
|| .||..:|.:.. |...||.....|.:|. :|.|.:.::.......
Human 878 KFSSTLYETGGCDMSLVNFEPAARRASNICDTDSHVSSSTSVRFYPHDVLSLPQIRLNRLLTIDT 942
Fly 1265 DYWRPACL-----LSATEKP---AAPKSFYKYRF-----KWCGQEHEFKIAMDRLELLALFDRDL 1316
|......: |:||..| ||.|..:.||| .|.| |..|||.|||||||:.
Human 943 DLLEQQDIDLSPDLAATYGPTEEAAQKVKHYYRFWILPQLWIG------INFDRLTLLALFDRNR 1001
Fly 1317 HWMHVLLASLLCTLVACLGAAILQHDHYKDLCALLFCAVIAGAQYSLVKSVQPDAASPVHGFNKT 1381
..:..:||.:|..|||.||:.:|....::|:....||.|||..||||:||||||::||.||.|:.
Human 1002 EILENVLAVILAILVAFLGSILLIQGFFRDIWVFQFCLVIASCQYSLLKSVQPDSSSPRHGHNRI 1066
Fly 1382 VAYSRAIYFCLAGGMLLLLKRLDTDYGERT-------------PDPVVFFGMRYSPADVVALLLQ 1433
:||||.:|||:..|::.|| |||.|. .:|:||...| |:|
Human 1067 IAYSRPVYFCICCGLIWLL-----DYGSRNLTATKFKLYGITFTNPLVFISAR----DLV----- 1117
Fly 1434 ALYILLLCFPIIFSVGLCPQINTFLMYLLEQIDMHVFGGNAASSLLG---SFLCVVRSVLAVMLL 1495
.:..|||||:|.:||.||:|||:|||.||:|:|:|||||.:|||. ||:| |::||.||
Human 1118 --IVFTLCFPIVFFIGLLPQVNTFVMYLCEQLDIHIFGGNATTSLLAALYSFIC---SIVAVALL 1177
Fly 1496 YGPLYGALDEQRGTQYI--LFSIFCAMLVPLGYHLSRCASDFSHLWRLIKTCIVSTYRDDEDEDL 1558
||..||||.:....|:| ||||||.:||.:.|||||.:||.|.|:.|:::.|.
Human 1178 YGLCYGALKDSWDGQHIPVLFSIFCGLLVAVSYHLSRQSSDPSVLFSLVQSKIF----------- 1231
Fly 1559 SQMQHIATGTVTGSGTANSTALQLTTSTPKQHRQTDVKTEHEQIELSSLEKLTVNEEHHEKDHGA 1623
||
Human 1232 ----------------------------PK----------------------------------- 1233
Fly 1624 DDQLETDQDLPLQQKHSKSKTSSLGSSQQTLGKTISSSKRAITASSSCTSIGTGEPAVEAGALTE 1688
||
Human 1234 ---------------------------------------------------------------TE 1235
Fly 1689 EAVEGEEQRRNTLAGEVGSKHELAENYDQAAKIDECEDKISSSSATNPGDMSTLTAGAGTATTDA 1753
| .||.|
Human 1236 E--------------------------------------------KNPED--------------- 1241
Fly 1754 TPACLEADPDAEAEAPADEKQHQGILGTGTGTGTGTTEASENGSGGGANGNTNSNGTGNDLPDPL 1818
|..| :.|||
Human 1242 ---------------PLSE-----------------------------------------VKDPL 1250
Fly 1819 PRKLQATVTTRLKNDLVVMTLLAVSVLGLHCSTVFTALQPDLNVVLYSFIGVLGLLLHYIVPQMR 1883
|.||:.:|:.||::||||..::.|....:|.|||||.|||.|..|||:.:|.:|.:.||::||:|
Human 1251 PEKLRNSVSERLQSDLVVCIVIGVLYFAIHVSTVFTVLQPALKYVLYTLVGFVGFVTHYVLPQVR 1315
Fly 1884 KHMPWLCFSRPLLRQREFGQFEV--------LNAPKIMWFEKLYIYLSVLERNVLFPLLAISSLT 1940
|.:||.|||.|||:..|:.|:|| |:|..:||||||:::|..:|:|:::||:.::.|:
Human 1316 KQLPWHCFSHPLLKTLEYNQYEVRILIYTALLDAATMMWFEKLHVWLLFVEKNIIYPLIVLNELS 1380
Fly 1941 ADSQLIVA--KFGLPWGTLIVAICALKFVRNAYSDPTNQYLIIIFTVLLFRIDFAMATETFIIDY 2003
:.::.|.: |.....|.|::.:..||.:|:::|.||.||:.:|||||.|:.|:...:||.::|.
Human 1381 SSAETIASPKKLNTELGALMITVAGLKLLRSSFSSPTYQYVTVIFTVLFFKFDYEAFSETMLLDL 1445
Fly 2004 FFVSLAFRKCCDFLLKLQFIVTYIAPWQITWGSAFHAFAQPFSVPHSAMLFLQAAISAVLSTPLN 2068
||:|:.|.|..:.|.||||:.|||||||||||||||||||||:||||||||:|||:||..|||||
Human 1446 FFMSILFNKLWELLYKLQFVYTYIAPWQITWGSAFHAFAQPFAVPHSAMLFIQAAVSAFFSTPLN 1510
Fly 2069 PFLGSAIFLTSYVRPIKFWERDYNTRRIDHSNTRLSSQLERDLGADDNNLNSIFYEHLTRSLQHS 2133
||||||||:||||||:|||||||||:|:|||||||:|||:|:.|:||||||||||||||||||||
Human 1511 PFLGSAIFITSYVRPVKFWERDYNTKRVDHSNTRLASQLDRNPGSDDNNLNSIFYEHLTRSLQHS 1575
Fly 2134 LCGDLLMGRWGNVNQGDCFVLASDDLNCLVHIIELGNGLCTFQMRGLEFRGTYCQQREVEAITED 2198
||||||:|||||.:.||||:||||.||.|||:||:||||.|||:||||||||||||||||||||.
Human 1576 LCGDLLLGRWGNYSTGDCFILASDYLNALVHLIEIGNGLVTFQLRGLEFRGTYCQQREVEAITEG 1640
Fly 2199 VEDNDGCCCCDPGHLPQLLSANAMFSTRWLAWQVVAAQYVIEGYSISDNLASATLQVFEYRKVLI 2263
||:::|.|||:|||:|.:||.||.||.|||||:|:..:|::|||||:||.|::.||||:.||||.
Human 1641 VEEDEGFCCCEPGHIPHMLSFNAAFSQRWLAWEVIVTKYILEGYSITDNSAASMLQVFDLRKVLT 1705
Fly 2264 TYYIKSIIYYVVKNPKLEQWLASGPIQDALQHTLSRQFVDLDPIFNFNLDEDFDFRAVGITRSSF 2328
|||:|.|||||..:.|||:|||:..:|:.|:....|.:||:||.||.|:|||:|.|..||:|.||
Human 1706 TYYVKGIIYYVTTSSKLEEWLANETMQEGLRLCADRNYVDVDPTFNPNIDEDYDHRLAGISRESF 1770
Fly 2329 CYVYLKWINYCVDMRRDANSMGGAPPAQAPAAAGGASSAPATAGVAPPAPVTPAHNDSKSTPNLS 2393
|.:||.||.||
Human 1771 CVIYLNWIEYC------------------------------------------------------ 1781
Fly 2394 AHGGQAGPSSGQSKSQSQQQLRRPQKSVAQETSVGGGGVVVGGTTVPGTGGVTGGGGDPQLSSSH 2458
Human 1782 ----------------------------------------------------------------- 1781
Fly 2459 SFANISRQTSESAPGLGGYVAYMDQNVFVKLAKSSTTTGAGAGAPTSRKESQEKPALRLKLASVG 2523
:|| |.|...|.
Human 1782 ---------------------------------------------SSR---------RAKPVDVD 1792
Fly 2524 KDAPLVSLCLALGLLARRSLATASHSALTGVEFFLHGLHALFKGDFRITSPRDEWVFADMELLHS 2588
||:.||:||..|.:|.||:|.||||...:.:|.||:||||||||||||:|.||||:|||||||..
Human 1793 KDSSLVTLCYGLCVLGRRALGTASHHMSSNLESFLYGLHALFKGDFRISSIRDEWIFADMELLRK 1857
Fly 2589 VVAPAVKMALKLQQDHITNPDEFLDPHALYDAIDNCSNELVISHEADPVWRSAVLRGAPNLLALR 2653
||.|.::|::||.|||.|:|||:.||..||:||.:....|||:||.||.||||||..:|:|||||
Human 1858 VVVPGIRMSIKLHQDHFTSPDEYDDPTVLYEAIVSHEKNLVIAHEGDPAWRSAVLANSPSLLALR 1922
Fly 2654 HVMEDGSDEYRIIRLTKRCLSFRVIKLNRECVRGLWAGQQQELIYLRNRNPERGSIQNAKQALRN 2718
|||:||::||:||.|.:|.|||||||:|:||||||||||||||::||||||||||||||||||||
Human 1923 HVMDDGTNEYKIIMLNRRYLSFRVIKVNKECVRGLWAGQQQELVFLRNRNPERGSIQNAKQALRN 1987
Fly 2719 IINSSCDQPIGYPIYVSPLTTSYADTNAQLCEVIGGAITLDTIRHTVLGWWHRIRERCRQGCSSG 2783
:|||||||||||||:||||||||:|::.||.:::||.|:|..||:.::..|||:|:.|..||:||
Human 1988 MINSSCDQPIGYPIFVSPLTTSYSDSHEQLKDILGGPISLGNIRNFIVSTWHRLRKGCGAGCNSG 2052
Fly 2784 SALEPHPGSGPVQLGACNFGSGGSVVG-AASTATGVGASTGSGLGVAAPGTAGSTGGESGDLAPV 2847
..:|. .:.|.|.|..| .|:||....::...| .:..||....|| |.|
Human 2053 GNIED-----------SDTGGGTSCTGNNATTANNPHSNVTQG-SIGNPGQGSGTG-----LHP- 2099
Fly 2848 FISAPLYNTLTVNSYYSVRPGNVPGGPIPGNLGGNYVSDSLAVVRGGLAVMPVKPTSTTLIAGLL 2912
.|.|| |..||.::.|.| |:.||.
Human 2100 ----------PVTSY-------------PPTLGTSHSSHS---VQSGLV---------------- 2122
Fly 2913 NRERDETSGSGIMGAGASGPTRATSSGGVRSRRPEVGSSRGRDHERRATLPIASGGAGGEPGKDL 2977
...|.||: |.|:.....|| |.::|.::: .|..|.:..
Human 2123 ----------------RQSPARAS----VASQSSYCYSS------RHSSLRMST--TGFVPCRRS 2159
Fly 2978 TAPQTQVEHEPSPRSTKLS-----SSSGSLGLG-MGVGLGNIITTPGDYPRKTKGPICLTAVDTG 3036
:..|..:.:.||...::|| ..||..||. :..||.:..::....|......:.......|
Human 2160 STSQISLRNLPSSIQSRLSMVNQMEPSGQSGLACVQHGLPSSSSSSQSIPACKHHTLVGFLATEG 2224
Fly 3037 TSSSAAEGKPAGSGTVAGTGVGGVIRKPRIEIFKKVIIVDDTGIYDCLDII--DAVVWPTERMRN 3099
..|||.:.:|..:.:.|... ...:.|:..:|.|||.:.|.:.:::. ..:.||.|.:|.
Human 2225 GQSSATDAQPGNTLSPANNS-----HSRKAEVIYRVQIVDPSQILEGINLSKRKELQWPDEGIRL 2284
Fly 3100 NGGRLSWKDWEPSAGMVGHVVHCWTPNHKDIRFRSHVNRYVYLVEIGDHYVPVEELGLRE 3159
..||.|||||.|..||.|||:|.|.|..:|...|||:::.|.||:|.|.||.|.|.|:.|
Human 2285 KAGRNSWKDWSPQEGMEGHVIHRWVPCSRDPGTRSHIDKAVLLVQIDDKYVTVIETGVLE 2344
| 
