Protein Alignment pcx and PCNX1

DIOPT Version :9

• Sequence 1: NP_001259183.2
• Gene: pcx / 31204
• FlyBaseID: FBgn0003048
• Length: 3417
• Species: Drosophila melanogaster
• Sequence 2: XP_005267477.1
• Gene: PCNX1 / 22990
• HGNCID: 19740
• Length: 2349
• Species: Homo sapiens
• Alignment Length: 3312
• Identity: 1011/3312 - (30%)
• Similarity: 1403/3312 - (42%)
• Gaps: 1121/3312 - (33%)

  Fly     1 MGSQTLEILRQGVWASLTGGYFYDPHQGVFCNVVHLYLWLYLLCSPFVAYLIFLQYFPSTWLTWC 65
            ||||||:||||||||:|:||::|||||..|.|.:||||||:||..||..|:.    .|||.:...
Human     1 MGSQTLQILRQGVWAALSGGWYYDPHQATFVNALHLYLWLFLLGLPFTLYMA----LPSTMIIVA 61

  Fly    66 LYCVITSLTILMVKLANLALHRLYDRAQTMSEGNLKGQFVKVTKETEPRHDDEGGIEMKVIRPGG 130
            :||.:.:...:::|:.|..|||..|..:.:
Human    62 VYCPVIAAVFIVLKMVNYRLHRALDAGEVV----------------------------------- 91

  Fly   131 SRISGEQAINEASEENSIMSIDNVNSIIDLKVDVHRKNSSESIELMFYAPSMLSGGSQQDQQSLA 195
                 ::..||.:::.:.....|.::        .||:|:        .||...||.:
Human    92 -----DRTANEFTDQRTKAEQGNCST--------RRKDSN--------GPSDPGGGIE------- 128

  Fly   196 GSASVSKSIR-STGPGGNSSTSAAAQADMFNKYLTVYPEVVEAAGSSAGSADGGSSGGDSRSGAA 259
                :|:.|| :|.|.|.||.::.|..|..|:.                    ||  |.||.|.|
Human   129 ----MSEFIREATPPVGCSSRNSYAGLDPSNQI--------------------GS--GSSRLGTA 167

  Fly   260 VSTLGHTG-AGTAPAQHVRTGHLSRKCSEVFSRRHRRRLERQSSLDTAAAAANSNAENKLMRNQS 323
            .:..|.|. |.|:....:..|..|..|.|        ..|.|   |.|       |:.||.|..|
Human   168 ATIKGDTDTAKTSDDISLSLGQSSSLCKE--------GSEEQ---DLA-------ADRKLFRLVS 214

  Fly   324 DTIATAAPSFLHSQPTNKARGQTNPR-------------QHFITSAPSTGIGGGDAPTSSTAVVV 375
            :      .||:..||:..:.||..||             .|.:..:.|:        ...|.|..
Human   215 N------DSFISIQPSLSSCGQDLPRDFSDKVNLPSHNHHHHVDQSLSS--------ACDTEVAS 265

  Fly   376 IAPA-SNSLVNPGRSSRLQRHRSS-------ETHDERLKHQSRGGLFQPILQLPHHSAASSIGAL 432
            :.|. |:|.....|...:.|..||       ..:|..|..|.||  ..|:.:|.
Human   266 LVPLHSHSYRKDHRPRGVPRTSSSAVAFPDTSLNDFPLYQQRRG--LDPVSELE----------- 317

  Fly   433 AVLGGGGNVAANDVEDMELGLVRNAGSGGVADACSRALQSWILDPFPDGYLEDDSYTKSDLGIEQ 497
                     ::..:...:..||.|:|..|                        :.....||.|..
Human   318 ---------SSKPLSGSKESLVENSGLSG------------------------EFQLAGDLKINT 349

  Fly   498 PHQPTFRTQHRHHHHHHHLHHHLGGAIIRKDPTSTMSALQLAAVTQPGTGGSVTGGGGAAGGGGS 562
            ...||                 ..|.........:|.:|:..:....|:..|.
Human   350 SQPPT-----------------KSGKSKPLKAEKSMDSLRSLSTRSSGSTESY------------ 385

  Fly   563 AAGMKRRRHSNATSYKHGSSQSNKSSLVGGGGSRGPSGEAGTSGGAGGTGGVRRIKSAALEVLCP 627
            .:|..|..:|..:|||  |.|::.:.:.........|.:|||             ||...:..|.
Human   386 CSGTDRDTNSTVSSYK--SEQTSSTHIESILSEHEESPKAGT-------------KSGRKKECCA 435

  Fly   628 QPSVSN--LSPHPNSVEAI-------SGQQQMRNPLP------------PPSKSLVRNQHLNLYP 671
            .|...|  .|....|.|.|       ||..:.::|.|            ..|:...:|.|.|.:.
Human   436 GPEEKNSCASDKRTSSEKIAMEASTNSGVHEAKDPTPSDEMHNQRGLSTSASEEANKNPHANEFT 500

  Fly   672 TQGYGDGTPSAGGGGPGNSSTCSSLFFGSSSACGSTTALIEPPVYPIVEHSDEKTAHEEHGDDCL 736
            :||   ..|      |||::                            |:.:||:
Human   501 SQG---DRP------PGNTA----------------------------ENKEEKS---------- 518

  Fly   737 GIGQGNADDDDEVD-DVPIRRRTRALGCSQTHYSVESDVGGFLADEVGADEDVFKDFDDNLEHIL 800
                    |...|. |..:|:                ||||
Human   519 --------DKSAVSVDSKVRK----------------DVGG------------------------ 535

  Fly   801 SELQQTHNQLDDVLKTHDLHHHSHLHHHKAASVEGAGPSGGSVAVGVSAGNDDEDEETEDNNTGS 865
               :|         |..|:...|....|:.||...:|                      ...||.
Human   536 ---KQ---------KEGDVRPKSSSVIHRTASAHKSG----------------------RRRTGK 566

  Fly   866 R--SPLLNDRNRQPATLREIQADKQLRQELSHQSGAVIPAPNPPVPIRSEADSGCPSSDCEQVSA 928
            :  |...:.|:|.....|.:...|                |:..:....|     .|||...:|.
Human   567 KRASSFDSSRHRDYVCFRGVSGTK----------------PHSAIFCHDE-----DSSDQSDLSR 610

  Fly   929 SSKDQLLSGIELELQQYQILQRCQLDEEQPCTSKMAAKSLGAIPKVVKYREVDELRRRRRGGSPA 993
            :|..|.......:.........||..|.                   :|..:......:..|:.:
Human   611 ASSVQSAHQFSSDSSSSTTSHSCQSPEG-------------------RYSALKTKHTHKERGTDS 656

  Fly   994 DAAEAGNEFALVKQTKQASRNSSSSNSTHS----ISLTDSLTADIHKMLWLMHGGAVDDRGRPIT 1054
            :.....:........|:|:|.:||:||..:    :||.....|.::....||...::    :|:|
Human   657 EHTHKAHLVPEGTSKKRATRRTSSTNSAKTRARVLSLDSGTVACLNDSNRLMAPESI----KPLT 717

  Fly  1055 GTSADGTPIPASSSLVPPNMSNAHFQFYQDAIQALQGTHPTSGSSVEHMTNIE-LARDKLRLDAK 1118
            .:.:|                          ::|.:|......|.:...:.:| :.|.:..|..:
Human   718 TSKSD--------------------------LEAKEGEVLDELSLLGRASQLETVTRSRNSLPNQ 756

  Fly  1119 LMCEQLVAAAEANSGVRGNTLATQQ----------MTQQQVGMLMRGGSSSRHPS---SAPFSV- 1169
            :...:    .|....|.|...|:::          ..:|.|......||:...|:   .:|.|:
Human   757 VAFPE----GEEQDAVSGAAQASEEAVSFRRERSTFRRQAVRRRHNAGSNPTPPTLLIGSPLSLQ 817

  Fly  1170 ------QGLINVIRSERPAARSQLDALQQLSDAAAALAANAS---EAASVSASGAGGGA------ 1219
                  |....|....||.:::.:     ||.:|:.|..|.|   ||:..:||..||.:
Human   818 DGQQGQQSTAQVKVQSRPPSQAAV-----LSASASLLVRNGSVHLEASHDNASAVGGSSLHDELG 877

  Fly  1220 --SS----GGGGVLSALGL---ANHPSNQISQISQLSQ-----------MSQP------MLNVDG 1258
              ||    .||..:|.:..   |...||.....|.:|.           :|.|      :|.:|.
Human   878 KFSSTLYETGGCDMSLVNFEPAARRASNICDTDSHVSSSTSVRFYPHDVLSLPQIRLNRLLTIDT 942

  Fly  1259 HFAPYCDY-WRPACLLSATEKP---AAPKSFYKYRF-----KWCGQEHEFKIAMDRLELLALFDR 1314
            ......|. ..|.  |:||..|   ||.|..:.|||     .|.|      |..|||.|||||||
Human   943 DLLEQQDIDLSPD--LAATYGPTEEAAQKVKHYYRFWILPQLWIG------INFDRLTLLALFDR 999

  Fly  1315 DLHWMHVLLASLLCTLVACLGAAILQHDHYKDLCALLFCAVIAGAQYSLVKSVQPDAASPVHGFN 1379
            :...:..:||.:|..|||.||:.:|....::|:....||.|||..||||:||||||::||.||.|
Human  1000 NREILENVLAVILAILVAFLGSILLIQGFFRDIWVFQFCLVIASCQYSLLKSVQPDSSSPRHGHN 1064

  Fly  1380 KTVAYSRAIYFCLAGGMLLLLKRLDTDYGERT-------------PDPVVFFGMRYSPADVVALL 1431
            :.:||||.:|||:..|::.||     |||.|.             .:|:||...|    |:|
Human  1065 RIIAYSRPVYFCICCGLIWLL-----DYGSRNLTATKFKLYGITFTNPLVFISAR----DLV--- 1117

  Fly  1432 LQALYILLLCFPIIFSVGLCPQINTFLMYLLEQIDMHVFGGNAASSLLG---SFLCVVRSVLAVM 1493
                .:..|||||:|.:||.||:|||:|||.||:|:|:|||||.:|||.   ||:|   |::||.
Human  1118 ----IVFTLCFPIVFFIGLLPQVNTFVMYLCEQLDIHIFGGNATTSLLAALYSFIC---SIVAVA 1175

  Fly  1494 LLYGPLYGALDEQRGTQYI--LFSIFCAMLVPLGYHLSRCASDFSHLWRLIKTCIVSTYRDDEDE 1556
            ||||..||||.:....|:|  ||||||.:||.:.|||||.:||.|.|:.|:::.|.
Human  1176 LLYGLCYGALKDSWDGQHIPVLFSIFCGLLVAVSYHLSRQSSDPSVLFSLVQSKIF--------- 1231

  Fly  1557 DLSQMQHIATGTVTGSGTANSTALQLTTSTPKQHRQTDVKTEHEQIELSSLEKLTVNEEHHEKDH 1621
                                          ||
Human  1232 ------------------------------PK--------------------------------- 1233

  Fly  1622 GADDQLETDQDLPLQQKHSKSKTSSLGSSQQTLGKTISSSKRAITASSSCTSIGTGEPAVEAGAL 1686
                                                                             
Human  1234 ----------------------------------------------------------------- 1233

  Fly  1687 TEEAVEGEEQRRNTLAGEVGSKHELAENYDQAAKIDECEDKISSSSATNPGDMSTLTAGAGTATT 1751
            |||                                            .||.|
Human  1234 TEE--------------------------------------------KNPED------------- 1241

  Fly  1752 DATPACLEADPDAEAEAPADEKQHQGILGTGTGTGTGTTEASENGSGGGANGNTNSNGTGNDLPD 1816
                             |..|                                         :.|
Human  1242 -----------------PLSE-----------------------------------------VKD 1248

  Fly  1817 PLPRKLQATVTTRLKNDLVVMTLLAVSVLGLHCSTVFTALQPDLNVVLYSFIGVLGLLLHYIVPQ 1881
            |||.||:.:|:.||::||||..::.|....:|.|||||.|||.|..|||:.:|.:|.:.||::||
Human  1249 PLPEKLRNSVSERLQSDLVVCIVIGVLYFAIHVSTVFTVLQPALKYVLYTLVGFVGFVTHYVLPQ 1313

  Fly  1882 MRKHMPWLCFSRPLLRQREFGQFEV--------LNAPKIMWFEKLYIYLSVLERNVLFPLLAISS 1938
            :||.:||.|||.|||:..|:.|:||        |:|..:||||||:::|..:|:|:::||:.::.
Human  1314 VRKQLPWHCFSHPLLKTLEYNQYEVRILIYTALLDAATMMWFEKLHVWLLFVEKNIIYPLIVLNE 1378

  Fly  1939 LTADSQLIVA--KFGLPWGTLIVAICALKFVRNAYSDPTNQYLIIIFTVLLFRIDFAMATETFII 2001
            |::.::.|.:  |.....|.|::.:..||.:|:::|.||.||:.:|||||.|:.|:...:||.::
Human  1379 LSSSAETIASPKKLNTELGALMITVAGLKLLRSSFSSPTYQYVTVIFTVLFFKFDYEAFSETMLL 1443

  Fly  2002 DYFFVSLAFRKCCDFLLKLQFIVTYIAPWQITWGSAFHAFAQPFSVPHSAMLFLQAAISAVLSTP 2066
            |.||:|:.|.|..:.|.||||:.|||||||||||||||||||||:||||||||:|||:||..|||
Human  1444 DLFFMSILFNKLWELLYKLQFVYTYIAPWQITWGSAFHAFAQPFAVPHSAMLFIQAAVSAFFSTP 1508

  Fly  2067 LNPFLGSAIFLTSYVRPIKFWERDYNTRRIDHSNTRLSSQLERDLGADDNNLNSIFYEHLTRSLQ 2131
            ||||||||||:||||||:|||||||||:|:|||||||:|||:|:.|:||||||||||||||||||
Human  1509 LNPFLGSAIFITSYVRPVKFWERDYNTKRVDHSNTRLASQLDRNPGSDDNNLNSIFYEHLTRSLQ 1573

  Fly  2132 HSLCGDLLMGRWGNVNQGDCFVLASDDLNCLVHIIELGNGLCTFQMRGLEFRGTYCQQREVEAIT 2196
            ||||||||:|||||.:.||||:||||.||.|||:||:||||.|||:|||||||||||||||||||
Human  1574 HSLCGDLLLGRWGNYSTGDCFILASDYLNALVHLIEIGNGLVTFQLRGLEFRGTYCQQREVEAIT 1638

  Fly  2197 EDVEDNDGCCCCDPGHLPQLLSANAMFSTRWLAWQVVAAQYVIEGYSISDNLASATLQVFEYRKV 2261
            |.||:::|.|||:|||:|.:||.||.||.|||||:|:..:|::|||||:||.|::.||||:.|||
Human  1639 EGVEEDEGFCCCEPGHIPHMLSFNAAFSQRWLAWEVIVTKYILEGYSITDNSAASMLQVFDLRKV 1703

  Fly  2262 LITYYIKSIIYYVVKNPKLEQWLASGPIQDALQHTLSRQFVDLDPIFNFNLDEDFDFRAVGITRS 2326
            |.|||:|.|||||..:.|||:|||:..:|:.|:....|.:||:||.||.|:|||:|.|..||:|.
Human  1704 LTTYYVKGIIYYVTTSSKLEEWLANETMQEGLRLCADRNYVDVDPTFNPNIDEDYDHRLAGISRE 1768

  Fly  2327 SFCYVYLKWINYCVDMRRDANSMGGAPPAQAPAAAGGASSAPATAGVAPPAPVTPAHNDSKSTPN 2391
            |||.:||.||.||
Human  1769 SFCVIYLNWIEYC---------------------------------------------------- 1781

  Fly  2392 LSAHGGQAGPSSGQSKSQSQQQLRRPQKSVAQETSVGGGGVVVGGTTVPGTGGVTGGGGDPQLSS 2456
                                                                             
Human  1782 ----------------------------------------------------------------- 1781

  Fly  2457 SHSFANISRQTSESAPGLGGYVAYMDQNVFVKLAKSSTTTGAGAGAPTSRKESQEKPALRLKLAS 2521
                                                           :||         |.|...
Human  1782 -----------------------------------------------SSR---------RAKPVD 1790

  Fly  2522 VGKDAPLVSLCLALGLLARRSLATASHSALTGVEFFLHGLHALFKGDFRITSPRDEWVFADMELL 2586
            |.||:.||:||..|.:|.||:|.||||...:.:|.||:||||||||||||:|.||||:|||||||
Human  1791 VDKDSSLVTLCYGLCVLGRRALGTASHHMSSNLESFLYGLHALFKGDFRISSIRDEWIFADMELL 1855

  Fly  2587 HSVVAPAVKMALKLQQDHITNPDEFLDPHALYDAIDNCSNELVISHEADPVWRSAVLRGAPNLLA 2651
            ..||.|.::|::||.|||.|:|||:.||..||:||.:....|||:||.||.||||||..:|:|||
Human  1856 RKVVVPGIRMSIKLHQDHFTSPDEYDDPTVLYEAIVSHEKNLVIAHEGDPAWRSAVLANSPSLLA 1920

  Fly  2652 LRHVMEDGSDEYRIIRLTKRCLSFRVIKLNRECVRGLWAGQQQELIYLRNRNPERGSIQNAKQAL 2716
            |||||:||::||:||.|.:|.|||||||:|:||||||||||||||::||||||||||||||||||
Human  1921 LRHVMDDGTNEYKIIMLNRRYLSFRVIKVNKECVRGLWAGQQQELVFLRNRNPERGSIQNAKQAL 1985

  Fly  2717 RNIINSSCDQPIGYPIYVSPLTTSYADTNAQLCEVIGGAITLDTIRHTVLGWWHRIRERCRQGCS 2781
            ||:|||||||||||||:||||||||:|::.||.:::||.|:|..||:.::..|||:|:.|..||:
Human  1986 RNMINSSCDQPIGYPIFVSPLTTSYSDSHEQLKDILGGPISLGNIRNFIVSTWHRLRKGCGAGCN 2050

  Fly  2782 SGSALEPHPGSGPVQLGACNFGSGGSVVG-AASTATGVGASTGSGLGVAAPGTAGSTGGESGDLA 2845
            ||..:|.           .:.|.|.|..| .|:||....::...| .:..||....||     |.
Human  2051 SGGNIED-----------SDTGGGTSCTGNNATTANNPHSNVTQG-SIGNPGQGSGTG-----LH 2098

  Fly  2846 PVFISAPLYNTLTVNSYYSVRPGNVPGGPIPGNLGGNYVSDSLAVVRGGLAVMPVKPTSTTLIAG 2910
            |           .|.||             |..||.::.|.|   |:.||.
Human  2099 P-----------PVTSY-------------PPTLGTSHSSHS---VQSGLV-------------- 2122

  Fly  2911 LLNRERDETSGSGIMGAGASGPTRATSSGGVRSRRPEVGSSRGRDHERRATLPIASGGAGGEPGK 2975
                              ...|.||:    |.|:.....||      |.::|.:::  .|..|.:
Human  2123 ------------------RQSPARAS----VASQSSYCYSS------RHSSLRMST--TGFVPCR 2157

  Fly  2976 DLTAPQTQVEHEPSPRSTKLS-----SSSGSLGLG-MGVGLGNIITTPGDYPRKTKGPICLTAVD 3034
            ..:..|..:.:.||...::||     ..||..||. :..||.:..::....|......:......
Human  2158 RSSTSQISLRNLPSSIQSRLSMVNQMEPSGQSGLACVQHGLPSSSSSSQSIPACKHHTLVGFLAT 2222

  Fly  3035 TGTSSSAAEGKPAGSGTVAGTGVGGVIRKPRIEIFKKVIIVDDTGIYDCLDII--DAVVWPTERM 3097
            .|..|||.:.:|..:.:.|...     ...:.|:..:|.|||.:.|.:.:::.  ..:.||.|.:
Human  2223 EGGQSSATDAQPGNTLSPANNS-----HSRKAEVIYRVQIVDPSQILEGINLSKRKELQWPDEGI 2282

  Fly  3098 RNNGGRLSWKDWEPSAGMVGHVVHCWTPNHKDIRFRSHVNRYVYLVEIGDHYVPVEELGLRE 3159
            |...||.|||||.|..||.|||:|.|.|..:|...|||:::.|.||:|.|.||.|.|.|:.|
Human  2283 RLKAGRNSWKDWSPQEGMEGHVIHRWVPCSRDPGTRSHIDKAVLLVQIDDKYVTVIETGVLE 2344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pcx	NP_001259183.2	Pecanex_C	2523..2746	CDD:282845	155/222 (70%)
		Loricrin	<2779..>2842	CDD:292475	17/63 (27%)
PCNX1	XP_005267477.1	ABC2_membrane_4	1032..1279	CDD:289500	127/517 (25%)
		EcsB	<1407..>1532	CDD:299768	84/124 (68%)
		Pecanex_C	1790..2015	CDD:282845	156/224 (70%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143312
Domainoid	1	1.000	1059	1.000	Domainoid score	I25
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1473	1.000	Inparanoid score	I107
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41206at33208
OrthoFinder	1	1.000	-	-		FOG0002108
OrthoInspector	1	1.000	-	-		otm40320
orthoMCL	1	0.900	-	-		OOG6_104101
Panther	1	1.100	-	-	O	PTHR12372
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3574
SonicParanoid	1	1.000	-	-		X1397
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	11.020