DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pcx and B0511.12

DIOPT Version :9

Sequence 1:	NP_001259183.2	Gene:	pcx / 31204	FlyBaseID:	FBgn0003048	Length:	3417	Species:	Drosophila melanogaster
Sequence 2:	NP_001251456.1	Gene:	B0511.12 / 172961	WormBaseID:	WBGene00015237	Length:	2245	Species:	Caenorhabditis elegans

Alignment Length:	3400	Identity:	869/3400 - (25%)
Similarity:	1237/3400 - (36%)	Gaps:	1308/3400 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSQTLEILRQGVWASLTGGYFYDPHQGVFCNVVHLYLWLYLLCSP----FVA-----------Y 50
            :|:..:|::|||:|||||||::|:|...:|||.:|||:|..|:..|    |||           |
Worm     3 VGTHIIEVIRQGIWASLTGGWYYEPGFSIFCNTMHLYVWFILIILPLILGFVASQGVSLVFAASY 67

  Fly    51 LIFLQYFPSTWLTWCLYCVITSLTILMVKLANLALHRLYDRAQ-TMSEGNLKGQFVKVTKETE-P 113
            ..|:.:|         :.||.|:...        ||.::|... .:....:.....::.:|:| |
Worm    68 TGFIVFF---------FTVIKSVVAY--------LHMIFDTTDPVVVTRTINDSVDELYRESEQP 115

  Fly   114 RHDDEGGIEMKVIRPGGSRISGEQAINEASEENSIMSIDNVNSIIDLKVDVHRKNSSESIELMFY 178
            ..|    :||..:|..|..:.|.:...:...|.|:..          ::..:...:...:|...:
Worm   116 PLD----VEMIELRDMGYNLRGSERALDGRREPSVRE----------EIAANMARARRHLEAERH 166

  Fly   179 APSMLSGGSQQDQQSLAGSASVSK------SIRSTGPGGNSSTSAAAQADMFNKYLTVYPEVVEA 237
            |      .|.::.||.......||      |..||     :|.:|.|.|::.....|:..|..|.
Worm   167 A------DSARESQSTPIPQITSKFWDFVISNSST-----TSVNATALAEVRKVLNTIEDESTET 220

  Fly   238 AGSSAGSADGGSSGGDSRSGAAVSTLGHTGAGTAPAQHVRTGHLSRKCSEVFSRRHRRRLERQSS 302
            ......|.                                                  |.:|.|.
Worm   221 ESEPTSST--------------------------------------------------RRQRSSP 235

  Fly   303 LDTAAAAANSNAENKLMRNQSDTIATAAPSFLHSQPTNKARGQTNPRQHFITSAPSTGIGGGDAP 367
            :.........|..::  .....||.|  |....|.|:|..|...|..        |||      |
Worm   236 MKVVYEDEQPNIRSR--STSPPTIVT--PKRKRSVPSNLRRQLENQE--------STG------P 282

  Fly   368 TSSTAVVVIAPASNSLVNPGRSSRLQRHRSSETHDERLKHQSRGGLFQPILQLPHHSAASSIGAL 432
            ::|              :..|||.....:..:| ||:|.|              :|.....
Worm   283 STS--------------SERRSSDPTIRKKGKT-DEQLDH--------------YHEKIRE---- 314

  Fly   433 AVLGGGGNVAANDVEDMELGLVRNAGSGGVADACSRALQSWILDPFPDGYLEDDSYTKSDLGIEQ 497
                                ..||                  :....:|..|:|...:.|
Worm   315 --------------------KYRN------------------IQKIQEGVEEEDEDEEDD----- 336

  Fly   498 PHQPTFRTQHRHHHHHHHLHHHLGGAIIRKDPTSTMSALQLAAVTQPGTGGSVTGGGG------- 555
                                          |..||.|||..::..|.....| ||...
Worm   337 ------------------------------DMPSTSSALPSSSRRQSRRRSS-TGATNRKRKYTR 370

  Fly   556 AAGGGGSAAGMKRRRHSNATSYKHGSSQSNKSS------LVGGGGSRGPSGEAGTSGGAGGTGGV 614
            .||.....||...::.|      |.||:|..||      :|..|....|:....::..|.....:
Worm   371 RAGSPAVFAGNLMKKDS------HESSRSMPSSVGWTPVVVSLGDVDRPTTSRYSADDADNGADI 429

  Fly   615 RRIKSAALEVLCPQPSVSNLSPHPNSVEAISGQQQMRNPLPPPSKSLVRNQHLNLYPTQGYGDGT 679
            |...:..||.|        :..||.:::||...:..|.....||.....:..:.|.|       .
Worm   430 RGEITKFLEDL--------IDKHPETLDAIENVRMSRLGRGRPSSESHDSAPVELAP-------L 479

  Fly   680 PSAGGGGPGNSSTCSSLFFGSSSACGSTTALIEPPVYPIVEHSDEKTAHEEHGDDCLGIGQGNAD 744
            |.:...||..|                                   |||:
Worm   480 PPSTSAGPSTS-----------------------------------TAHQ--------------- 494

  Fly   745 DDDEVDDVPIRRRTRALGCSQTHYSVESDVGGFLADEVGADEDVFKDFDDNLEHILSELQQTHNQ 809
            :.|.|                .|        |..|                :.|:|....::::.
Worm   495 NSDRV----------------AH--------GIFA----------------VPHVLRSAARSNSF 519

  Fly   810 LDDVLKTHDLHHHSHL----HHHKAASVEGAGPSGGSVAVGVSAGNDDEDEE------TEDNNTG 864
            :       |.|.||.:    .||.|...|..  |.|:|..     ..|||..      .|::..|
Worm   520 I-------DWHSHSQVVSSSQHHIAQGHEDT--SQGAVHT-----FQDEDGNWWTYTFDENSGVG 570

  Fly   865 SRSPLLNDRNRQPATLREIQADKQLRQELSHQSGAVIPAPNPPVPIRSEADSGCPSSDCEQVSAS 929
            :..||.:.|    |.|..|..:::...|.:.:.       .||..:....:|...|::.|:...:
Worm   571 TAQPLGSGR----AVLELIHREREKNPESARKL-------FPPAELEVLPESMYDSTEDEKGEKT 624

  Fly   930 SKDQLLSGIELELQQYQILQRCQLDEEQPCTS-KMAAKSLGAIPKVVKYREVDELRRRRRGGSPA 993
            |.:.                    |.:||.|| ..||.|:..:|
Worm   625 SDED--------------------DGKQPSTSAAAAASSVTVLP--------------------- 648

  Fly   994 DAAEAGNEFALVKQTKQASRNSSSSNSTHSISLTDSLTADIHKMLWLMHGGAVDDRGRPITGTSA 1058
                                 |:|::.|.::.|  .||.                |.|.::.:|
Worm   649 ---------------------STSNSQTQTVQL--PLTR----------------RERALSSSS- 673

  Fly  1059 DGTPIPASSSLVPPNMSNAHFQFYQDAIQALQGTHPTSGSSVEHMTNIELARDKLRLDAKLMCEQ 1123
                          |.|:.:.              ||..|||.|
Worm   674 --------------NESSTYM--------------PTLPSSVFH--------------------- 689

  Fly  1124 LVAAAEANSGVRGNTLATQQMTQQQVGMLMRGGSSSRHPSSAPFSVQG--LINVIR--SERPAAR 1184
                  |.||    |.||:             .||:|......||..|  |.|.:|  .:|.|
Worm   690 ------APSG----TGATR-------------ASSARGSQMVCFSSNGSRLRNTVRDGDDRSA-- 729

  Fly  1185 SQLDALQQLSDAAAALAANASEAASVSASGAGGGASSGGGGVLSALGLANHPSNQISQISQLSQM 1249
               |::.|:                                               .||.:|.:.
Worm   730 ---DSMWQM-----------------------------------------------EQIMELIEN 744

  Fly  1250 SQPMLNVDGHFAPYCDYWRPACLLSATEKPAAP-------------KSFYKYRFKWCGQ-EHEFK 1300
            :....|    |.|              |.|:.|             ||:| |..|...: :..|.
Worm   745 THSRRN----FGP--------------EMPSLPITNLDRRASSNVRKSYY-YPMKMFPKAQKNFN 790

  Fly  1301 IAMDRLELLALFDRDLHWMHVLLASLLCTLVACLGAAILQHDHYKDLCALLFCAVIAGAQYSLVK 1365
            :.:||:.:..||||:.....:|...:|.|:||.|...::....:.|...:.||.|:|.||:||:|
Worm   791 LKVDRMSVDRLFDRNHTIWSLLFDIVLATIVALLAVLLIDARIFYDYSLVAFCFVVASAQFSLLK 855

  Fly  1366 SVQPDAASPVHGFNKTVAYSRAIYFCLAGGMLLLL------KRLDTDYGERTPDPVVF------F 1418
            ||||||:||:||||...:|:|.||||:....||.:      |.:|     ..|:.:.:      .
Worm   856 SVQPDASSPIHGFNWVASYNRPIYFCIMAMGLLYIHQVAGGKEID-----ENPEELAWNWNPFRL 915

  Fly  1419 GMRYSPADVVALLLQALYILLLCFPIIFSVGLCPQINTFLMYLLEQIDMHVFGGNAASSLLGSFL 1483
            .|..|.|.::| :...|.||:|..|:.|::|..||.||...::.|||:||:|||.|:.|:..:.:
Worm   916 HMMTSSAILIA-VRDLLSILILLLPVAFTLGWLPQFNTLAHHVAEQIEMHIFGGTASFSVFSACV 979

  Fly  1484 CVVRS---VLAVMLLYGPLYGALDEQRGTQYILFSIFCAMLVPLGYHLSRCASDFSHLWRLIKTC 1545
            .:::|   .:|:.:|....|  ......||..|||.|.|..|.:.|.|||.:|: .:|..::...
Worm   980 QLIKSSVFYVALCVLCRVAY--TFSPTSTQNPLFSTFVATSVAVSYLLSRMSSN-QNLMVILFDI 1041

  Fly  1546 IVSTYRDDEDEDLSQMQHIATGTVTGSGTANSTALQLTTSTPKQHRQTDVKTEHEQIELSSLEKL 1610
            |.|.:|
Worm  1042 ITSPFR----------------------------------------------------------- 1047

  Fly  1611 TVNEEHHEKDHGADDQLETDQDLPLQQKHSKSKTSSLGSSQQTLGKTISSSKRAITASSSCTSIG 1675
                                       ||       |.|.|:
Worm  1048 ---------------------------KH-------LDSEQE----------------------- 1055

  Fly  1676 TGEPAVEAGALTEEAVEGEEQRRNTLAGEVGSKHELAENYDQAAKIDECEDKISSSSATNPGDMS 1740

Worm  1056 ----------------------------------------------------------------- 1055

  Fly  1741 TLTAGAGTATTDATPACLEADPDAEAEAPADEKQHQGILGTGTGTGTGTTEASENGSGGGANGNT 1805
                                |.|| |.||:        :.|..
Worm  1056 --------------------DEDA-ANAPS--------ISTAR---------------------- 1069

  Fly  1806 NSNGTGNDLPDPLPRKLQATVTTRLKNDLVVMTLLAVSVLGLHCSTVFTALQPDLNVVLYSFIGV 1870
                      |.:|:.::.||..|.:.||:....|.....|||.:::|||.:|.....:......
Worm  1070 ----------DEMPKMVRKTVGERARYDLIFSIFLVAFFFGLHSTSLFTATEPYFTRAISGVCVC 1124

  Fly  1871 LGLLLHYIVPQMRKHMPWLCFSRPLLRQREFGQFEVLNAPKIMWFEKLYIYLSVLERNVLFPLLA 1935
            ||:|.||:.||.|.|.||...|.|||:..|..|||..:|.|:|:||.:::::..:|||:::|||.
Worm  1125 LGVLNHYLYPQFRSHTPWRTVSSPLLKSAEHRQFESPDAAKLMYFEAIHLWMVAIERNIVYPLLI 1189

  Fly  1936 ISSLTADSQLIVAKFGLPWGTLIVAICALKFVRNAYSDPTNQYLIIIFTVLLFRIDFAMATETF- 1999
            ||.:|.::..:.|    ||  :|:.:..|:.:|..:|.|...|:.:....|....|.....:..
Worm  1190 ISMVTENNWAVPA----PW--IIIPLICLRLLRGGFSQPQLMYIPVAVACLAAAFDLKKVIDIEY 1248

  Fly  2000 ------------IIDYFFVSLAFRKCCDFLLKLQFIVTYIAPWQITWGSAFHAFAQPFSVPHSAM 2052
                        ||.|..||: |.|..:..||:.||:.|:|||||:||||||||||||||||||:
Worm  1249 NGKSLTSWNLLPIIMYICVSV-FPKVVELYLKIAFILAYVAPWQISWGSAFHAFAQPFSVPHSAL 1312

  Fly  2053 LFLQAAISAVLSTPLNPFLGSAIFLTSYVRPIKFWERDYNTRRIDHSNTRLSSQLERDLGADDNN 2117
            :.:|..||:::|.||||||||:.|.:|||||:||||:||||:|.|.|..|||||::|....||:|
Worm  1313 IAIQTVISSIISAPLNPFLGSSFFTSSYVRPVKFWEKDYNTKRTDASTMRLSSQIDRGPMLDDSN 1377

  Fly  2118 LNSIFYEHLTRSLQHSLCGDLLMGRWG-NVNQGDCFVLASDDLNCLVHIIELGNGLCTFQMRGLE 2181
            ||::||||||||||.||.|||.||||. :|..||||||||..||.||||||:|||..|||:||||
Worm  1378 LNAVFYEHLTRSLQKSLAGDLAMGRWATSVQPGDCFVLASFYLNSLVHIIEVGNGFVTFQLRGLE 1442

  Fly  2182 FRGTYCQQREVEAITEDVEDNDGCCCCDPGHLPQLLSANAMFSTRWLAWQVVAAQYVIEGYSISD 2246
            ||||||.||||||||||:.|..|.|||.||.||..||.|..::.|||||:||:.:|:|:||||||
Worm  1443 FRGTYCHQREVEAITEDIRDGSGFCCCSPGSLPGFLSFNTAWNLRWLAWEVVSGKYIIDGYSISD 1507

  Fly  2247 NLASATLQVFEYRKVLITYYIKSIIYYVVKNPKLEQWLASGPIQDALQHTLSR-QFVDLDPIFNF 2310
            |.|...|||.|.|::|:|.|||.||||...:.|..|||....:|.|::..:.. ::.|:|.||..
Worm  1508 NSAVNLLQVHELRRLLVTLYIKCIIYYTFTSTKFRQWLRDDTVQTAIRSVIENPRYTDVDSIFCS 1572

  Fly  2311 NLDEDFDFRAVGITRSSFCYVYLKWINYCVDMRRDANSMGGAPPAQAPAAAGGASSAPATAGVAP 2375
            ..|||:|....||:||||..:||.||.||::.|.:.
Worm  1573 TNDEDYDTVESGISRSSFKSMYLPWIMYCIEKRGEC----------------------------- 1608

  Fly  2376 PAPVTPAHNDSKSTPNLSAHGGQAGPSSGQSKSQSQQQLRRPQKSVAQETSVGGGGVVVGGTTVP 2440
                                                          .||
Worm  1609 ----------------------------------------------VQE---------------- 1611

  Fly  2441 GTGGVTGGGGDPQLSSSHSFANISRQTSESAPGLGGYVAYMDQNVFVKLAKSSTTTGAGAGAPTS 2505
                                   .:...|.|
Worm  1612 -----------------------DKYDHEEA---------------------------------- 1619

  Fly  2506 RKESQEKPALRLKLASVGKDAPLVSLCLALGLLARRSLATAS---HSALTGVEFFLHGLHALFKG 2567
                                   |:||..|.|:|||||.|||   ||  :..|.||:|||:||||
Worm  1620 -----------------------VTLCFLLSLVARRSLGTASFNRHS--SAAESFLYGLHSLFKG 1659

  Fly  2568 DFRITSPRDEWVFADMELLHSVVAPAVKMALKLQQDHITNPDEFLDPHALYDAIDNCSNELVISH 2632
            |||||..||||||.||::|..||:|||||||||.|||....:||.:...||..|.....::.|||
Worm  1660 DFRITCQRDEWVFTDMDMLRCVVSPAVKMALKLHQDHFAQFEEFDENDGLYTVIGEYQTKMFISH 1724

  Fly  2633 EADPVWRSAVLRGAPNLLALRHVMEDGSDEYRIIRLTKRCLSFRVIKLNRECVRGLWAGQQQELI 2697
            |.||.||.|:|...|:||||||:.:||.|:|:||.|.:..|:.|||||||||||..|||||||||
Worm  1725 EQDPGWRQAILANTPSLLALRHIYDDGQDDYKIIMLNQMHLNMRVIKLNRECVRAFWAGQQQELI 1789

  Fly  2698 YLRNRNPERGSIQNAKQALRNIINSSCDQPIGYPIYVSPLTTSYADTNAQLCEVIGGAITLDTIR 2762
            :||||||||||||||:|.|||:||||.|.|:||||||||||||:.::::|:.:|.|...|.:..|
Worm  1790 FLRNRNPERGSIQNARQVLRNMINSSADLPVGYPIYVSPLTTSHIESHSQIHKVFGPTFTFEGFR 1854

  Fly  2763 HTVLGWWHRIRERCRQGCSSGSALEPHPGSGPVQLGACNFGSGGSVVGAASTATGVGASTGSGLG 2827
            ......|:|:|...
Worm  1855 QLGQNVWNRLRNHF--------------------------------------------------- 1868

  Fly  2828 VAAPGTAGSTGGE--------SGDLAPVFISAPLYNTLTVNSYYSVRPGNVPGGPIP--GNLGGN 2882
                |.:|||...        |..:.|.....|....:|:.|.......:.||||.|  |..||
Worm  1869 ----GPSGSTSAHQQQQQQQASQSIVPTPTPVPPVMQITIPSATPSGISSAPGGPNPSSGAPGG- 1928

  Fly  2883 YVSDSLAVVRGGLAVMPVKPTSTTLIAGLLNRERDETSGSGIMGAGASGPTRATSSGGVRSRRPE 2947
                    :|....|.|| |:|     |..:.|:|......::....:.|
Worm  1929 --------LRAHFHVGPV-PSS-----GRSDGEKDTDEEQEMIVLTMTTP--------------- 1964

  Fly  2948 VGSSRGRDHERRATLPIASGGAGGEPGKDLTAPQTQVEHEPSPRSTKLSSSSGSLGLGMGVGLGN 3012
               .:||..|....          |..||.|| :..|.| |..|.....|.:..:.|
Worm  1965 ---RQGRRLENSIV----------EMTKDGTA-RVSVLH-PKTRPPLDDSIAAPVTL-------- 2006

  Fly  3013 IITTPGDYPRK---TKGPICLTAVDTGTSSSAAEGKPAGSGTVAGTGVGGVIRKPRIEIFKKVII 3074
              |||....|:   ...|...|.:.:|...:..:....||.                     .:|
Worm  2007 --TTPPQTERERAIMNRPNFQTLLKSGQVINGNQEMGIGSW---------------------ALI 2048

  Fly  3075 VDDTGIY-----------DCLDIIDAVVWPTERMRNNGGRLSWKDWEPSAGMVGHVVHCWTPNHK 3128
            :|...|:           :||     ||||.|.:::..||.||. ::||.||.|.:|:.|.|:|.
Worm  2049 IDSEQIFKYLNEPLKSSGECL-----VVWPDELVQHMSGRGSWL-FQPSRGMAGKIVYTWYPSHP 2107

  Fly  3129 DIRFRSHVNRYVYLVEI---GDHYVPVEELGLR-----EYNQ--IMGSTEEMANSRRSSIQRDFH 3183
            ....||||..:::|:.:   .:..|||.|.|||     :.|.  :.|.|.:.        |::|.
Worm  2108 LRNRRSHVGDHIHLISLPLMPNGLVPVAEKGLRLLAPHDINTLGLSGCTTQE--------QQEFQ 2164

  Fly  3184 EYNIQLKLAGLAPIIGGGESSTATTSDASK--------SHKAKIRAVSSSSS-----------ED 3229
            ...|.:.:  |:.|:.|  :.:|.||...|        ..:.:.|...:|||           |.
Worm  2165 TRYIDVLI--LSKIVTG--TVSARTSFPKKPPIPPPNIRDRERDRETGTSSSALPTTTASNPLET 2225

  Fly  3230 EDTSSTRSIPLPQGDDGDLT 3249
            ...|||.|:||...:...||
Worm  2226 TGNSSTDSVPLETSELPALT 2245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pcx	NP_001259183.2	Pecanex_C	2523..2746	CDD:282845	139/225 (62%)
pcx	NP_001259183.2	Loricrin	<2779..>2842	CDD:292475	4/70 (6%)
B0511.12	NP_001251456.1	Pecanex_C	1612..1839	CDD:368258	141/285 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162198
Domainoid	1	1.000	736	1.000	Domainoid score	I38
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1087	1.000	Inparanoid score	I124
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002108
OrthoInspector	1	1.000	-	-		oto19909
orthoMCL	1	0.900	-	-		OOG6_104101
Panther	1	1.100	-	-	LDO	PTHR12372
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3574
SonicParanoid	1	1.000	-	-		X1397
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.010