DRSC/TRiP Functional Genomics Resources

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Protein Alignment Vinc and VCL

DIOPT Version :9

Sequence 1:NP_001284813.1 Gene:Vinc / 31201 FlyBaseID:FBgn0004397 Length:961 Species:Drosophila melanogaster
Sequence 2:NP_054706.1 Gene:VCL / 7414 HGNCID:12665 Length:1134 Species:Homo sapiens


Alignment Length:1148 Identity:469/1148 - (40%)
Similarity:647/1148 - (56%) Gaps:202/1148 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MPVFHTKTIESILDPVAQQVSRLVILHEEAE-DGNAMPDLSRPVQVVSAAVANLVKVGRDTINSS 64
            ||||||:||||||:|||||:|.|||:|||.| ||.|:|||:.||..|.|||:|||:||::|:.::
Human     1 MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKETVQTT 65

  Fly    65 DDKILRQDMPSALHRVEGASQLLEEASDMLRSDPYSGPARKKLIEGSRGILQGTSSLLLCFDESE 129
            :|:||::|||.|..:||.|...|.:|:.||:|||||.|||..||:||||||.|||.|||.|||:|
Human    66 EDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTSDLLLTFDEAE 130

  Fly   130 VRKIIQECKRVLDYLAVAEVINTMEQLVQFLKDLSPCLSKVHREVGAREKELTHQVHSEILVRCL 194
            |||||:.||.:|:||.||||:.|||.||.:.|:|.|.::|:.:.:..|::|||||.|..:||..:
Human   131 VRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLVNSM 195

  Fly   195 EQVKTLAPILICSMKVYIHIVEQQGRGAEEAAENRNYLAARMSDELQEIIRVLQLTTYDEDTSEL 259
            ..||.|.|:||.:||:::.....:.:|.|||.:|||:...:||.|:.|||||||||::|||....
Human   196 NTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEIIRVLQLTSWDEDAWAS 260

  Fly   260 DNLTVLKKLSNAISNKMEQANEWLSNPYALRGGVGEKALRQVIDNATEISERCL----------- 313
            .:...:|:...:|.:|:.||..||.:|.|..|..||:|:||::|.|.::.|.|.           
Human   261 KDTEAMKRALASIDSKLNQAKGWLRDPSASPGDAGEQAIRQILDEAGKVGELCAGKERREILGTC 325

  Fly   314 ----------------PQDSYPI------------------------------------------ 320
                            .|.|.|:                                          
Human   326 KMLGQMTDQVADLRARGQGSSPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDA 390

  Fly   321 -------------------------RKLAD----------------EVTAMANTLCELRQEGKGQ 344
                                     ||:|:                |::|:.:.|.:||::|||.
Human   391 AQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEISALTSKLADLRRQGKGD 455

  Fly   345 SPQAESLVRGIRDRMGELKSLVHQAVLGVDKAGVQQTAHTIQGRLEQAVKWLQHPEINDGGLGER 409
            ||:|.:|.:.:...:..|::..::||.....|   :.|..::|::|||.:|:.:|.::|.|:|:.
Human   456 SPEARALAKQVATALQNLQTKTNRAVANSRPA---KAAVHLEGKIEQAQRWIDNPTVDDRGVGQA 517

  Fly   410 AINLIVEEGRKVAEGCPGHQKAEIQQLCDEVERLKRQAA-------GSGPAAKQAAKQLTQKLYE 467
            ||..:|.||.::|....|..:.::...||.|::|..|.|       |..|.|:..|.||...|.:
Human   518 AIRGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKD 582

  Fly   468 LKAAIQNALVNRIVQDFMDVSTPLKQFTEAVLQPEGTPGREQNFNQKSNNLQAFSDRASKTSRMV 532
            |||.:|.|:...:...|.|.:||:|....|...|...|.||:.|::::.|.:..|.:...|:...
Human   583 LKARMQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGKLGATAEKA 647

  Fly   533 AAGGACGNKKIAEILLSSAAQVDSLTPQLISAGRIRMNYPGSKAADEHLQNLKQQYADTVLRMRT 597
            ||.|. .||...|.:.:|......||||::||.||.:..||::||.||.:.:|.|:.|.|.:|..
Human   648 AAVGT-ANKSTVEGIQASVKTARELTPQVVSAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTG 711

  Fly   598 LCDQATDPADFIKTSEEHMQVYAKLCEDAIHARQPQKMVDNTSNIARLINRVLLVAKQEADNSED 662
            |.|:|.|....:..|||.::.....|:.|:...|||.:|...::|||..||:|||||:|.:||||
Human   712 LVDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSED 776

  Fly   663 PVFTERLNAAANRLERSLPAMVGDAKLVATNIADPAAAAAWKNSFQRLLGDVREVRDAIAPPQPP 727
            |.|.|.:.||::.|.:::..||.|||.||.||:||....::.:|..|:||.|.:||:|..|.:| 
Human   777 PKFREAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEP- 840

  Fly   728 PLPTSLPPPIPELSALHLSNQNAERAPPRPPLPREGLAPVRPPPPETDDED-------------- 778
                ..|||.|:|..|.|::   |.|||:||||...:.|.||||||..||:              
Human   841 ----DFPPPPPDLEQLRLTD---ELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPM 898

  Fly   779 ---------------------------------------------------EGVFRTMPH---AN 789
                                                               |.....||.   .|
Human   899 MMAARQLHDEARKWSSKPGIPAAEVGIGVVAEADAADAAGFPVPPDMEDDYEPELLLMPSNQPVN 963

  Fly   790 QPILIAARGLHQEVRQWSSKDNEIIAAAKRMAILMARLSELVLSDSRGSKRELIATAKKIAEASE 854
            ||||.||:.||:|..:||||.|:|||||||||:|||.:|.||...| |:||.||..||.||:||:
Human   964 QPILAAAQSLHREATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGS-GTKRALIQCAKDIAKASD 1027

  Fly   855 DVTRLAKELARQCTDRRIRTNLLQVCERIPTIGTQLKILSTVKATMLGAQG-SDEDRE-ATEMLV 917
            :|||||||:|:||||:||||||||||||||||.|||||||||||||||... |||:.| ||||||
Human  1028 EVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLV 1092

  Fly   918 GNAQNLMQSVKETVRAAEGASIKIRSDQTSNRLQWVRRQPWYQ 960
            .||||||||||||||.||.||||||:| ....|:|||:.||||
Human  1093 HNAQNLMQSVKETVREAEAASIKIRTD-AGFTLRWVRKTPWYQ 1134

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VincNP_001284813.1 Vinculin 63..960 CDD:279395 424/1083 (39%)
VCLNP_054706.1 N-terminal globular head. /evidence=ECO:0000269|PubMed:20484056 1..835 313/837 (37%)
Vinculin 66..1134 CDD:395830 424/1081 (39%)
Talin-interaction. /evidence=ECO:0000250|UniProtKB:P12003 168..208 16/39 (41%)
3 X 112 AA tandem repeats. /evidence=ECO:0000255 259..589 74/332 (22%)
Interaction with ACTN4. /evidence=ECO:0000269|PubMed:15988023, ECO:0007744|PDB:1YDI 741..764 9/22 (41%)
Linker (Pro-rich). /evidence=ECO:0000269|PubMed:20484056 836..878 21/49 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 857..887 17/29 (59%)
C-terminal tail. /evidence=ECO:0000269|PubMed:20484056 879..1134 130/256 (51%)
Facilitates phospholipid membrane insertion. /evidence=ECO:0000250|UniProtKB:Q64727 1003..1046 27/43 (63%)
Facilitates phospholipid membrane insertion. /evidence=ECO:0000250|UniProtKB:Q64727 1120..1134 6/13 (46%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165157782
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3681
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 501 1.000 Inparanoid score I1367
Isobase 1 0.950 - 0 Normalized mean entropy S4383
OMA 1 1.010 - - QHG51903
OrthoDB 1 1.010 - - D141915at33208
OrthoFinder 1 1.000 - - FOG0005827
OrthoInspector 1 1.000 - - oto89294
orthoMCL 1 0.900 - - OOG6_106307
Panther 1 1.100 - - LDO PTHR46180
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X4806
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.720

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