Protein Alignment Vinc and Ctnna3

DIOPT Version :9

• Sequence 1: NP_001284813.1
• Gene: Vinc / 31201
• FlyBaseID: FBgn0004397
• Length: 961
• Species: Drosophila melanogaster
• Sequence 2: NP_001157848.1
• Gene: Ctnna3 / 216033
• MGIID: 2661445
• Length: 895
• Species: Mus musculus
• Alignment Length: 1014
• Identity: 201/1014 - (19%)
• Similarity: 385/1014 - (37%)
• Gaps: 267/1014 - (26%)

  Fly     6 TKTIESILDPVAQQVSRLVILHEEAEDGNAMPDLSRPVQVVSAAVA----NLVKVGRDTINSSDD 66
            |.|:|.:|:|:..||:.||...:  ...|.....|:..:|:.|:|.    ||:..|.  :.:.:.
Mouse    20 TFTVEKLLEPLIIQVTTLVNCPQ--NPSNRKKGRSKRARVLLASVEEATWNLLDKGE--MIAKEA 80

  Fly    67 KILRQDMPSALHRVEGASQLLEEASDMLRSDPYSGPARKKLIEGSRGILQGTSSLLLCFDESEVR 131
            .:|::::.:||..|...|:.|:.:::....||...|.|:.:::.:|.:|...:.||:..|
Mouse    81 TVLKEELAAALQEVRKESKALKVSAERFTDDPCYLPKREAVVQAARALLAAVTRLLVLAD----- 140

  Fly   132 KIIQECKRVLDYLAVAEVINTMEQLVQFLKDLS--PCLSKVHREVG-----------AREKELTH 183
                    ::|.:.:.:.:::.::..:.||::|  ..|.:.::::|           .|:::|..
Mouse   141 --------MIDVMCLLQHVSSFQRTFESLKNVSNKSDLQRTYQKLGKELESLDYLAFKRQQDLKS 197

  Fly   184 QVHSEILVRCLEQVKTLAPIL--ICSMKVYIHIVEQQGRGAEEAAENRNYLAARMSDELQEIIRV 246
            ....:.:......:|..:|:|  |||.     .:|.....:.:|:::      .:.:|:|..:.|
Mouse   198 PSQRDEIAGARATLKENSPLLHSICSA-----CLEHSDVASLKASKD------TVCEEIQNALDV 251

  Fly   247 L----------------QLTTYDEDTSELDNLTVLKKLSNAISNKMEQANEWLSNPYALRGGVGE 295
            :                |..|......||:||.||    |.::...|.....|           |
Mouse   252 ISNASQGIQNAPAPPEPQAATLGSAFDELENLIVL----NPLTVTEEDVRPSL-----------E 301

  Fly   296 KALRQVIDNATEISERCLPQDSYPIRKLADEVTAMANTLCELRQEGKGQSPQAESLVRGIRDRMG 360
            |.|..:|..|..:::....:|.:..|.:|:         |
Mouse   302 KRLEAIISGAALLADSSCTRDLHRERIIAE---------C------------------------- 332

  Fly   361 ELKSLVHQAVLGVDKAGVQQTAHTIQGRLEQAVKWLQHPEINDGGLGERAINLIVEEGRKVAEGC 425
                                      ..:.||::.|....:::.|..||:..|
Mouse   333 --------------------------NAIRQALQDLLTEYMSNTGKTERSNTL------------ 359

  Fly   426 PGHQKAEIQQLCDEVERLKRQAAGSGPAAKQAAKQLTQKLYELKAAIQNALVNRIVQDFMDVSTP 490
                                         ..|...:::|..:|:..::.|:::.|...|:|.:.|
Mouse   360 -----------------------------NTAIVNMSKKTRDLRRQLRKAIIDHISDSFLDTTVP 395

  Fly   491 LKQFTEAVLQPEGTPGREQNFNQKSNNLQAFSDRAS----KTSRMV-AAGGACG---NKKIAEIL 547
            |....||.               |:..::...|.|:    .|.|:| .|..||.   |:...:|:
Mouse   396 LLVLIEAA---------------KNGRVKEIKDYAAIFHEHTGRLVEVANLACSMSTNEDGIKIV 445

  Fly   548 LSSAAQVDSLTPQLISAGRIRMNYPGSKAADEHLQNLKQQYADTVLRMRTLCDQATDPADFIKTS 612
            ..:|..:::|.||:|:|.....:.|.|:.....::..|:.:...:..:....|..|...||:..|
Mouse   446 RIAANHLETLCPQIINAALALASRPKSQVVKNTMEMYKRTWEHYIHVLTEAVDDITSIDDFLAVS 510

  Fly   613 EEHMQVYAKLCEDAIHARQPQKMVDNTSNIARLIN----RVLLVAKQEADNSEDPVFTERLNAAA 673
            |.|:......|..|:..:.    .||....|..|.    ||..:...|.|:.|...:||.:....
Mouse   511 ESHILEDVNKCIIALRDQD----ADNLDRAAGAIRGRAARVAHIVAGEMDSYEPGAYTEGVMRNV 571

  Fly   674 NRLERS-LPAMVGDAKLVATNIADPAAAAAWKNSF----QRLLGDVREVRDAIAPPQPPPLPTSL 733
            |.|..: :|..|....:....::..:..|...|.|    :::...:.::|.::       :....
Mouse   572 NFLTSTVIPEFVTQVNVALDALSKNSLTALDDNQFVDISKKIYDTIHDIRCSV-------MMIRT 629

  Fly   734 PPPIPELSAL--------HLSNQ---NAERA--PPRPPLPREGLAPVRPPPPETDDEDEGVFRTM 785
            |..:.::|.|        |.|.|   ..:||  ...|...:|.:|           |....|:.:
Mouse   630 PEELEDVSDLEDDHEVRSHTSIQTEGKTDRAKMTQLPEAEKEKIA-----------EQVADFKKV 683

  Fly   786 PHANQPILIAARGLHQEVRQWSSKDNEIIAAAKRMAILMARLSELVLSDSRGS-----KRELIAT 845
            ...          |..|:..|....|:||..||:|.::|..:::.    :||.     ..::|..
Mouse   684 KSK----------LDAEIEIWDDTSNDIIVLAKKMCMIMMEMTDF----TRGKGPLKHTTDVIYA 734

  Fly   846 AKKIAEASEDVTRLAKELARQCTDRRIRTNLLQVCERIPTIGTQLKILSTVKATM--LGAQGSDE 908
            ||.|:|:...:..||:::|.||.|...:.:||...|:|.....||||.|.|||.:  ||.:....
Mouse   735 AKMISESGSRMDVLARQIANQCPDPPCKQDLLAYLEQIKFYSHQLKICSQVKAEIQNLGGELIVS 799

  Fly   909 DREATEMLVGNAQNLMQSVKETVRAAEGASIKIRSDQTS 947
            ..::...|:..|:|||.:|.:||:.:..||.||...|:|
Mouse   800 ALDSVTSLIQAAKNLMNAVVQTVKMSYIASTKIIRIQSS 838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vinc	NP_001284813.1	Vinculin	63..960	CDD:279395	184/953 (19%)
Ctnna3	NP_001157848.1	Vinculin	18..856	CDD:366435	201/1014 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	635..660		5/24 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3681
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810