Protein Alignment Vinc and CTNNA2

DIOPT Version :9

• Sequence 1: NP_001284813.1
• Gene: Vinc / 31201
• FlyBaseID: FBgn0004397
• Length: 961
• Species: Drosophila melanogaster
• Sequence 2: NP_001269526.1
• Gene: CTNNA2 / 1496
• HGNCID: 2510
• Length: 953
• Species: Homo sapiens
• Alignment Length: 1052
• Identity: 218/1052 - (20%)
• Similarity: 394/1052 - (37%)
• Gaps: 261/1052 - (24%)

  Fly     6 TKTIESILDPVAQQVSRLVILHEEAEDGNAMPDLSRPVQVVSAAV----ANLVKVGRDTINSSDD 66
            |.|:|.:|:|:..||:.||....:...|. ....|:...|::|:|    .|.::.|......|.|
Human    21 TLTVERLLEPLVTQVTTLVNTSNKGPSGK-KKGRSKKAHVLAASVEQATQNFLEKGEQIAKESQD 84

  Fly    67 KILRQDMPSALHRVEGASQLLEEASDMLRSDPYSGPARKKLIEGSRGILQGTSSLLLCFDESEVR 131
              |::::.:|:..|....:.:..||.....||.|...|..::..:|.:|...:.||:..|.::|.
Human    85 --LKEELVAAVEDVRKQGETMRIASSEFADDPCSSVKRGTMVRAARALLSAVTRLLILADMADVM 147

  Fly   132 KIIQECKRVLDYLAVAEVINTMEQLVQFLKDLSPCLSKVHREVGAREKELTHQVHSEILVRCLEQ 196
            :::...|.|.:.|...:.....:.|....|:....:.|::.....|::||......:.:......
Human   148 RLLSHLKIVEEALEAVKNATNEQDLANRFKEFGKEMVKLNYVAARRQQELKDPHCRDEMAAARGA 212

  Fly   197 VKTLAPILICSMKVYIHIVEQQGRGAEEAA--ENRNYLAARMSDELQEIIRVLQLTTYDEDTSEL 259
            :|..|.:|..:.:.::       |..:.||  .||:|:..::.:.:..|....|.|:..::....
Human   213 LKKNATMLYTASQAFL-------RHPDVAATRANRDYVFKQVQEAIAGISNAAQATSPTDEAKGH 270

  Fly   260 DNLTVLKKLSNAISNKMEQANEWLSNPYALRGGVGEKALRQVIDNATEISERCLPQDSYPIRKLA 324
            ..:..|....|...||:                        ::|..|....|..|.....:..:.
Human   271 TGIGELAAALNEFDNKI------------------------ILDPMTFSEARFRPSLEERLESII 311

  Fly   325 DEVTAMANTLCELRQEGKGQSPQAESLVRGIRDRMGELKSLVHQAVLGVDKAGVQQTAHTIQGRL 389
            .....||::.|                   .||...|  .:|.:.                 ..:
Human   312 SGAALMADSSC-------------------TRDDRRE--RIVAEC-----------------NAV 338

  Fly   390 EQAVKWLQHPEINDGGLGERA--INLIVEEGRKVAEGCPGHQKAEIQQLCDEVERLKRQAAGSGP 452
            .||::.|....:|:.|..|:.  :|:.::
Human   339 RQALQDLLSEYMNNTGRKEKGDPLNIAID------------------------------------ 367

  Fly   453 AAKQAAKQLTQKLYELKAAIQNALVNRIVQDFMDVSTPLKQFTEAVLQPEGTPGREQNFNQKSNN 517
                   ::|:|..:|:..::.|:::.|...|::.:.||....||     ...|.|:...:.:
Human   368 -------KMTKKTRDLRRQLRKAVMDHISDSFLETNVPLLVLIEA-----AKSGNEKEVKEYA-- 418

  Fly   518 LQAFSDRASKTSRMVAAGGAC---GNKKIAEILLSSAAQVDSLTPQLISAGRIRMNYPGSKAADE 579
             |.|.:.|:|.  :..|..||   .|::..:::..:|.|:|||.||:|:|.......|.||.|.:
Human   419 -QVFREHANKL--VEVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQD 480

  Fly   580 HLQNLKQQYADTVLRMRTLCDQATDPADFIKTSEEHMQVYAKLCEDAIHARQPQKMVDNTSNIAR 644
            ::...|.|:...|..:....|..|...||:..||.|:......|..|:.    :..||.....|.
Human   481 NMDVFKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQ----EGDVDTLDRTAG 541

  Fly   645 LIN----RVLLVAKQEADNSEDPVFTERLNAAANRL-ERSLPAMVGDAKL----VATNIADPAAA 700
            .|.    ||:.:...|.:|.|..|:||::..|...| |..:|......::    ::.|:..|..
Human   542 AIRGRAARVIHIINAEMENYEAGVYTEKVLEATKLLSETVMPRFAEQVEVAIEALSANVPQPFE- 605

  Fly   701 AAWKNSF---QRLLGD-VREVRDAIAPPQPPP----------------LPTSLPPPIPELSALHL 745
               :|.|   .||:.| ||::|.|:...:.|.                ..||:.....:|    :
Human   606 ---ENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQL----I 663

  Fly   746 SNQNAERAPPRPPLPREGLAPVRPPPPETDDEDEGVFRTMPHANQPILIAARGLHQEVRQWSSKD 810
            :.|:|.....:  ||:|..|.:.        |...:|    |..:..|.|      ||.:|....
Human   664 AGQSARAIMAQ--LPQEEKAKIA--------EQVEIF----HQEKSKLDA------EVAKWDDSG 708

  Fly   811 NEIIAAAKRMAILMARLSELVLSDSRG-----SKRELIATAKKIAEASEDVTRLAKELARQCTDR 870
            |:||..||:|.::|..:::.    :||     :..::|..|||||||...:.:||:.:|.||.|.
Human   709 NDIIVLAKQMCMIMMEMTDF----TRGKGPLKNTSDVINAAKKIAEAGSRMDKLARAVADQCPDS 769

  Fly   871 RIRTNLLQVCERIPTIGTQLKILSTVKATM----------------------------------- 900
            ..:.:||...:||.....||.|.|.|||.:
Human   770 ACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGTGVQSTFTTFYEVDCDVIDGGRAS 834

  Fly   901 --------------LGAQGSDEDR-EATEMLVGNAQNLMQSVKETVRAAEGASIKIR-----SDQ 945
                          :|:..||... ::...|:..|:|||.:|..||:|:..||.|.:     :..
Human   835 QLSTHLPTCAEGAPIGSGSSDSSMLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQKVYGTAAV 899

  Fly   946 TSNRLQWVRRQP 957
            .|..:.|..:.|
Human   900 NSPVVSWKMKAP 911

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vinc	NP_001284813.1	Vinculin	63..960	CDD:279395	202/991 (20%)
CTNNA2	NP_001269526.1	Vinculin	81..914	CDD:395830	202/991 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	912..939		218/1052 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3681
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810