DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vinc and CTNNA1

DIOPT Version :9

Sequence 1:	NP_001284813.1	Gene:	Vinc / 31201	FlyBaseID:	FBgn0004397	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	NP_001310911.1	Gene:	CTNNA1 / 1495	HGNCID:	2509	Length:	906	Species:	Homo sapiens

Alignment Length:	1008	Identity:	229/1008 - (22%)
Similarity:	399/1008 - (39%)	Gaps:	221/1008 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TKTIESILDPVAQQVSRLVILHEEAEDGNAMPDLSRPVQVVSAAV----ANLVKVGRDTINSSDD 66
            |..:|.:|:|:..||:.||..:.:. ..|.....|:...|::|:|    .|.::.| |.| :.:.
Human    22 TLAVERLLEPLVTQVTTLVNTNSKG-PSNKKRGRSKKAHVLAASVEQATENFLEKG-DKI-AKES 83

  Fly    67 KILRQDMPSALHRVEGASQLLEEASDMLRSDPYSGPARKKLIEGSRGILQGTSSLLLCFDESEVR 131
            :.|::::.:|:..|.....|::.|:.....||.|...|..::..:|.:|...:.||:..|.::|.
Human    84 QFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVKRGNMVRAARALLSAVTRLLILADMADVY 148

  Fly   132 KIIQECKRVLD-YLAVAEVINTMEQLVQFLKDLSPCLSKVHREVGAREKELTHQVHSEILVRCLE 195
            |::.:.|.|.| .|.:....|..:..:|: |.|.|.:.|::.....|::||....|.:.:.....
Human   149 KLLVQLKVVEDGILKLRNAGNEQDLGIQY-KALKPEVDKLNIMAAKRQQELKDVGHRDQMAAARG 212

  Fly   196 QVKTLAPILICSMKVYIHIVEQQGRGAEEAAENRNYLAARMSDELQEIIRVLQLTTYDEDTSELD 260
            .::...|||..:.:.   .::.....|.:|  ||:.:..::...:..|....|.|..| |.|:..
Human   213 ILQKNVPILYTASQA---CLQHPDVAAYKA--NRDLIYKQLQQAVTGISNAAQATASD-DASQHQ 271

  Fly   261 NLTVLKKLSNAISNKMEQANEWLSNPYALRGGVGEKAL------RQVIDNATEISERCLPQDSYP 319
            .                             ||.||.|.      :|:|.:....||
Human   272 G-----------------------------GGGGELAYALNNFDKQIIVDPLSFSE--------- 298

  Fly   320 IRKLADEVTAMANTLCELRQEGKGQSPQAESLVRGIRDRMGELKSLVHQAVLGVDKAGVQQTAHT 384
                                         |.....:.:|   |:|::..|.|..|      ::.|
Human   299 -----------------------------ERFRPSLEER---LESIISGAALMAD------SSCT 325

  Fly   385 IQGRLEQAVKWLQHPEINDGGLGERAINLIVEEGRKVAEGCPGHQKAEIQQLCDE----VERLKR 445
            ...|.|                            |.||| |...::| :|.|..|    ..|.:|
Human   326 RDDRRE----------------------------RIVAE-CNAVRQA-LQDLLSEYMGNAGRKER 360

  Fly   446 QAAGSGPAAKQAAKQLTQKLYELKAAIQNALVNRIVQDFMDVSTPLKQFTEAVLQPEGTPGREQN 510
                 ..|...|..::|:|..:|:..::.|:::.:...|::.:.||....||.          :|
Human   361 -----SDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAA----------KN 410

  Fly   511 FNQK--SNNLQAFSDRASKTSRMVAAGGAC---GNKKIAEILLSSAAQVDSLTPQLISAGRIRMN 570
            .|:|  ....|.|.:.|:|.  :..|..||   .|::..:::..||:|:::|.||:|:|......
Human   411 GNEKEVKEYAQVFREHANKL--IEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAA 473

  Fly   571 YPGSKAADEHLQNLKQQYADTVLRMRTLCDQATDPADFIKTSEEHMQVYAKLCEDAIHARQPQKM 635
            .|.||.|.|::...|:|:...|..:....|..|...||:..||.|:......|..|:.    :|.
Human   474 KPQSKLAQENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQ----EKD 534

  Fly   636 VDNTSNIARLIN----RVLLVAKQEADNSEDPVFTERLNAAANRLERS-LPAMVGDAKLVATNIA 695
            ||.....|..|.    ||:.|...|.||.|..|:||::..|...|..: :|......:.....::
Human   535 VDGLDRTAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALS 599

  Fly   696 DPAAAAAWKNSF---QRLLGD-VREVRDAIAPPQPPP---------------LPTSLPPPIPELS 741
            ...|....:|.|   .||:.| :|::|.|:...:.|.               ..||:.....:|
Human   600 SDPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTEDDQL- 663

  Fly   742 ALHLSNQNAERAPPRPPLPREGLAPVRPPPPETDDEDEGVFRTMPHANQPILIAARGLHQEVRQW 806
               ::.|:|.....:  ||:|..|.:........:|..                  .|..||.:|
Human   664 ---IAGQSARAIMAQ--LPQEQKAKIAEQVASFQEEKS------------------KLDAEVSKW 705

  Fly   807 SSKDNEIIAAAKRMAILMARLSELVLSDSRG-----SKRELIATAKKIAEASEDVTRLAKELARQ 866
            ....|:||..||:|.::|..:::.    :||     :..::|:.|||||||...:.:|.:.:|..
Human   706 DDSGNDIIVLAKQMCMIMMEMTDF----TRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADH 766

  Fly   867 CTDRRIRTNLLQVCERIPTIGTQLKILSTVKATM--LGAQGSDEDREATEMLVGNAQNLMQSVKE 929
            |.|...:.:||...:||.....||.|.|.|||.:  ||.:......::...|:..|:|||.:|.:
Human   767 CPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQ 831

  Fly   930 TVRAAEGASIKIRSDQTSNRL-----QWVRRQP 957
            ||:|:..||.|.:..|....|     .|..:.|
Human   832 TVKASYVASTKYQKSQGMASLNLPAVSWKMKAP 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vinc	NP_001284813.1	Vinculin	63..960	CDD:279395	212/947 (22%)
CTNNA1	NP_001310911.1	Involved in homodimerization	2..228		50/212 (24%)
		Vinculin	82..867	CDD:395830	212/945 (22%)
		Interaction with JUP and CTNNB1. /evidence=ECO:0000269\|PubMed:9152027	97..148		12/50 (24%)
		Interaction with alpha-actinin	325..394		20/103 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	864..894		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3681
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810