DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SmydA-8 and ZMYND15

DIOPT Version :9

Sequence 1:	NP_001014717.1	Gene:	SmydA-8 / 31200	FlyBaseID:	FBgn0053548	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_001254751.1	Gene:	ZMYND15 / 84225	HGNCID:	20997	Length:	750	Species:	Homo sapiens

Alignment Length:	322	Identity:	70/322 - (21%)
Similarity:	102/322 - (31%)	Gaps:	90/322 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RPGGGGGDTTLAALSAHMAPCRDTTPEQLAQLIDVHLGDLRQEQPNWTISSSTVAGRGVFATRDI 75
            |..||.|.|            ....||:     |..|....:|.|..|    ...|....|.|:.
Human   128 REDGGAGST------------EKVEPEE-----DRELAPTSRESPQET----NPPGESEEAAREA 171

  Fly    76 AAGELIFQERAL--VTGPTARKGQLSSCICCHETLPQTGFLCRHRCTLPVCETCSDSEEHQA--- 135
            ..|:...:|..:  .|.|..||||.|.....|.:           |.|.|      ::||..
Human   172 GGGKDGCREDRVENETRPQKRKGQRSEAAPLHVS-----------CLLLV------TDEHGTILG 219

  Fly   136 ------ECEHFRRWQPKDVDAEQEQVNPMSLRILTAVRVFHLG----KEQRHLV--DA-MQANAE 187
                  ..:....|     .:..:.:.|.:..:|.......:|    ::.|.|.  || :....|
Human   220 IDLLVDGAQGTASW-----GSGTKDLAPWAYALLCHSMACPMGSGDPRKPRQLTVGDARLHRELE 279

  Fly   188 RAYRREIIQAAQC-FRNF-PTTDRVFMDQLFRIVGVLNTNAFEA---PCRSGG-----HETLLRG 242
            ....|..::.|:. .|.: |.....|.....|...|.:.::|||   ||....     .|..||.
Human   280 SLVPRLGVKLAKTPMRTWGPRPGFTFASLRARTCHVCHRHSFEAKLTPCPQCSAVLYCGEACLRA 344

  Fly   243 LFPLTAIMNHECTPNASHYFENGRLAVVRAARDIPKGGEITT---TYTKILWGNLTRNIFLK 301
            .:       ..|..:.||.|...|||..     :.:.||:.|   |||    ..:|...|.|
Human   345 DW-------QRCPDDVSHRFWCPRLAAF-----MERAGELATLPFTYT----AEVTSETFNK 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-8	NP_001014717.1	SET	<189..293	CDD:214614	28/116 (24%)
ZMYND15	NP_001254751.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..199		24/91 (26%)
		zf-MYND	313..359	CDD:280009	13/52 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	565..590
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	709..750
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148801
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.830