Protein Alignment SmydA-8 and Smyd4

DIOPT Version :10

• Sequence 1: NP_001014717.1
• Gene: SmydA-8 / 31200
• FlyBaseID: FBgn0053548
• Length: 462
• Species: Drosophila melanogaster
• Sequence 2: NP_001096081.1
• Gene: Smyd4 / 319822
• MGIID: 2442796
• Length: 799
• Species: Mus musculus
• Alignment Length: 578
• Identity: 120/578 - (20%)
• Similarity: 193/578 - (33%)
• Gaps: 205/578 - (35%)

  Fly    32 RDTTPEQLAQLIDVHLGDLRQEQPNWTISSSTVA---------GRGVFATRDIAAGELIFQERAL 87
            ::|.||.:...:.....|:...:.|..||.::::         ||.:.||:||..|||:.:|.|.
Mouse   201 KETLPEPIPAALTNAFEDIALGEENTQISGASLSVSLCTHPLKGRHLVATKDILPGELLVKEDAF 265

  Fly    88 VTGPTARKGQLSSCICCHE----TLPQTGFLCRHRC------TLPVCETCS----DSEE------ 132
            |:  ....|::.....|.|    |...:|.|..|||      |:| |.:||    .|:|
Mouse   266 VS--VLIPGEMPRPHHCLENKWDTRVTSGDLYCHRCLKHTLATVP-CGSCSYAKYCSQECMQQAW 327

  Fly   133 ---HQAECE------------H-------FRRWQPKDVD-------------------------- 149
               |..||.            |       ..|::  |||
Mouse   328 DLYHSTECSLGGLLLTLGVFCHVALRMTLLARFE--DVDRVVRMLCDEVGSTDTCLPESKNLVKA 390

  Fly   150 ------AEQEQVNPM----------------------SL-----------RILTAVRVFHLGKEQ 175
                  .|.|:.:.:                      ||           |.:.|:.|..|.::.
Mouse   391 FDYTSQGESEEKSKIGEPPIPGCNVNGKYGSNYNAIFSLLPHTEKHSPEHRFICAISVSALCRQL 455

  Fly   176 RHLVDAMQANAERAYRREIIQAAQCFRNFPTTDRVFMDQLFRIVGVLNTNAFEAPCRSGGHETLL 240
            :  .|::||...::.:.:.:....| .:........:..:.::  ..|..|..:.|.:|.:|:::
Mouse   456 K--ADSVQAQTLKSPKLKAVTPGLC-ADLTVWGAAMLRHMLQL--QCNAQAITSICHTGSNESII 515

  Fly   241 ---------RGLFPLTAIMNHECTPNASHYFENGRLAVVRAARDIPKGGEITTTY--TKILWGNL 294
                     .|:||:.:::||.|.||.|..| .|.:|.||||:.|.||.||...|  .:...|..
Mouse   516 TNSRQIRLATGIFPVVSLLNHSCRPNTSVSF-TGTVATVRAAQRIAKGQEILHCYGPHESRMGVA 579

  Fly   295 TRNIFLKMTKHFACDCVRCHDNTENGTYL------------------SALFCREQGCRG------ 335
            .|...|.....|.|.|..||..|......                  ..|.|..:.|..
Mouse   580 ERQQRLSSQYFFDCRCGACHAETLRAAAAPRWEAFCCKTCRALMQGNDVLSCSNESCTNSVSRDQ 644

  Fly   336 LVIPVQ------------TRTLQPD------WRCITCENVF---PHAKMAKYQD---FALNTINN 376
            ||..:|            .||.:|:      .||......|   .|..:.:.:|   .|..|:.|
Mouse   645 LVSRLQDLQQQVCMAQKLLRTGKPEQAIQQLLRCREAAESFLSAEHTVLGEIEDGLAQAHATLGN 709

  Fly   377 RINSCS-VQDMIHFINELCPRFCPSS---------------NYVLIEAKLNVIWRMTR 418
            .:.|.: ||..:..:.   .|..|||               |.:.:...|:.||:..|
Mouse   710 WLKSAAHVQKSLQVVE---TRHGPSSVEIGHELFKLAQVLFNGLAVPEALSAIWKAER 764

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-8	NP_001014717.1	SET	58..>88	CDD:394802	13/38 (34%)
		SET_SMYD	<224..313	CDD:380997	32/99 (32%)
Smyd4	NP_001096081.1	3a0801s09	39..>211	CDD:273380	3/9 (33%)
		TPR repeat	68..96	CDD:276809
		TPR repeat	101..136	CDD:276809
		SET	243..>299	CDD:394802	19/57 (33%)
		zf-MYND	296..335	CDD:460312	11/39 (28%)
		SET_SMYD4	418..598	CDD:380934	43/185 (23%)
		TPR_12	655..725	CDD:315987	14/69 (20%)