Protein Alignment SmydA-8 and SMYD1

DIOPT Version :10

• Sequence 1: NP_001014717.1
• Gene: SmydA-8 / 31200
• FlyBaseID: FBgn0053548
• Length: 462
• Species: Drosophila melanogaster
• Sequence 2: NP_938015.1
• Gene: SMYD1 / 150572
• HGNCID: 20986
• Length: 490
• Species: Homo sapiens
• Alignment Length: 417
• Identity: 93/417 - (22%)
• Similarity: 156/417 - (37%)
• Gaps: 96/417 - (23%)

  Fly    66 GRGVFATRDIAAGELIFQERA--------LVTGPTARKGQLSSCICCHETLPQTGFLCRHRC--- 119
            |||:.||::..|.::||.|||        ||.            ..||....:...|  |||
Human    18 GRGLKATKEFWAADIIFAERAYSAVVFDSLVN------------FVCHTCFKRQEKL--HRCGQC 68

  Fly   120 -TLPVCE-TCSDSE--EHQAECEHFRRWQPKDVDAEQEQVNPMSLRILTAVRVFHLGKEQRHL-- 178
             ....|: ||....  .|:.||...:|:.    ....|.:. ::.||:..|.....|..:..|
Human    69 KFAHYCDRTCQKDAWLNHKNECSAIKRYG----KVPNENIR-LAARIMWRVEREGTGLTEGCLVS 128

  Fly   179 VDAMQANAE---RAYRREIIQAAQCFRNF--PTTDRVFMDQLFRIVGVLNTNAFEAPCRSGGHET 238
            ||.:|.:.|   ...::::......|..:  |.:.:..|..:..|.||:|.|.|....:. |.:.
Human   129 VDDLQNHVEHFGEEEQKDLRVDVDTFLQYWPPQSQQFSMQYISHIFGVINCNGFTLSDQR-GLQA 192

  Fly   239 LLRGLFPLTAIMNHECTPNASHYFENGRLAVV------------RAARDIPKGGEITTTYTKILW 291
            :..|:||...::||:|.||.:..|.||....|            ||...|.:|.|:|.:|...|.
Human   193 VGVGIFPNLGLVNHDCWPNCTVIFNNGNHEAVKSMFHTQMRIELRALGKISEGEELTVSYIDFLN 257

  Fly   292 GNLTRNIFLKMTKHFACDCVRCHDNTENGTYLSALFCREQGCRGLVIPVQTRTLQPDWRCITCEN 356
            .:..|...||...:|.|.|..|....::..:|...                            :|
Human   258 VSEERKRQLKKQYYFDCTCEHCQKKLKDDLFLGVK----------------------------DN 294

  Fly   357 VFPHAKMAKYQ-DFALNTINNRINSCSVQDMIHFINELC--------PRFCPSSNYVL--IEAKL 410
            ..|..::.|.. .|:.:|: .:|:....:.:.|.:.:||        |.|..::.|:|  :....
Human   295 PKPSQEVVKEMIQFSKDTL-EKIDKARSEGLYHEVVKLCRECLEKQEPVFADTNIYMLRMLSIVS 358

  Fly   411 NVIWRMTRFDHEEYTPEEM--GHMDRY 435
            .|:..:..|:...:....|  |:|..|
Human   359 EVLSYLQAFEEASFYARRMVDGYMKLY 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SmydA-8	NP_001014717.1	SET	58..>88	CDD:394802	11/29 (38%)
		SET_SMYD	<224..313	CDD:380997	29/100 (29%)
SMYD1	NP_938015.1	SET_SMYD1	7..281	CDD:380924	73/282 (26%)
		zf-MYND	52..90	CDD:460312	10/39 (26%)