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Protein Alignment SmydA-8 and SMYD4

DIOPT Version :9

Sequence 1:	NP_001014717.1	Gene:	SmydA-8 / 31200	FlyBaseID:	FBgn0053548	Length:	462	Species:	Drosophila melanogaster
Sequence 2:	NP_443160.2	Gene:	SMYD4 / 114826	HGNCID:	21067	Length:	804	Species:	Homo sapiens

Alignment Length:	571	Identity:	111/571 - (19%)
Similarity:	175/571 - (30%)	Gaps:	217/571 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 DTTPEQLAQLIDVHLGDLRQEQPNWTISSSTVA-------GRGVFATRDIAAGELIFQERALVTG 90
            ::.|..||:.::.  ..||:|....:.:||::.       ||.:.||:||..|||:.||.|.|:.
Human   206 ESFPAALAKTLED--AALREENEQLSNASSSIGLCVDPLKGRCLVATKDILPGELLVQEDAFVSV 268

  Fly    91 ------PTARKGQLSSCICCHETLPQTGFLCRHRC------TLPVCETCS----DSEE------- 132
                  |....|..|.    .:|....|.|..|||      |:| |:.||    .|:|
Human   269 LNPGELPPPHHGLDSK----WDTRVTNGDLYCHRCLKHTLATVP-CDGCSYAKYCSQECLQQAWE 328

  Fly   133 --HQAEC-------------------------EHFRRWQPKDVD----------AEQEQVNPMSL 160
              |:.||                         |..|:...|..|          ....||..::
Human   329 LYHRTECPLGGLLLTLGVFCHIALRLTLLVGFEDVRKIITKLCDKISNKDICLPESNNQVKTLN- 392

  Fly   161 RILTAVRVFHLGKEQRH---------------------------LVDAMQANAERAYRREIIQAA 198
                    :.||:.:::                           |......:.|..:...:..:|
Human   393 --------YGLGESEKNGNIVETPIPGCDINGKYENNYNAVFNLLPHTENHSPEHKFLCALCVSA 449

  Fly   199 QC-------FRNFPTTDRVFMDQL-----------FRIVGV-LNTNAFEAPCRSGGHET------ 238
            .|       .:..||...|...||           ..|.|| :..:..:..|.:....|
Human   450 LCRQLEAASLQAIPTERIVNSSQLKAAVTPELCPDVTIWGVAMLRHMLQLQCNAQAMTTIQHTGP 514

  Fly   239 ------------LLRGLFPLTAIMNHECTPNASHYFENGRLAVVRAARDIPKGGEITTTY--TKI 289
                        |..|:||:.:::||.|:||.|..|.: .:|.:||::.|.||.||...|  .|.
Human   515 KGSIVTDSRQVRLATGIFPVISLLNHSCSPNTSVSFIS-TVATIRASQRIRKGQEILHCYGPHKS 578

  Fly   290 LWGNLTRNIFLKMTKHFACDCVRCHDNTENGTYLSALFCREQGCRGLVIPVQTRTLQPDWRCITC 354
            ..|...|...|:....|.|.|..|  .||                     .......|.|....|
Human   579 RMGVAERQQKLRSQYFFDCACPAC--QTE---------------------AHRMAAGPRWEAFCC 620

  Fly   355 ENVFPHAKMAKYQDFALNTINNRINSCSV----QDMIHFINELCPRFCPSSNYVL-----IEAKL 410
                                    |||..    .|::...:..|.....|.::::     ::.::
Human   621 ------------------------NSCGAPMQGDDVLRCGSRSCAESAVSRDHLVSRLQDLQQQV 661

  Fly   411 NVIWRMTRFDHEEYTPEEMGHMDRYREEVLAILHKLGAGECTLKKLITGEI 461
            .|..::.|....|...:.:....|..|..|...|           .:.|||
Human   662 RVAQKLLRDGELERAVQRLSGCQRDAESFLWAEH-----------AVVGEI 701

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.