Protein Alignment Mct1 and SLC16A7

DIOPT Version :9

• Sequence 1: NP_001284810.1
• Gene: Mct1 / 31198
• FlyBaseID: FBgn0023549
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: XP_011537291.1
• Gene: SLC16A7 / 9194
• HGNCID: 10928
• Length: 504
• Species: Homo sapiens
• Alignment Length: 638
• Identity: 135/638 - (21%)
• Similarity: 235/638 - (36%)
• Gaps: 209/638 - (32%)

  Fly    28 PPDGGWGWVVVFGSFMIHIVTDGMTYSF----GIFYNEFLDYFNEGKGYTAWIASIMVGVTFSS- 87
            ||||||||:||..:|    ::.|.:|:|    .:|:.|....|:......|||:|||:.|.::.
Human    13 PPDGGWGWIVVGAAF----ISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGG 73

  Fly    88 -------------------------GPISSSFVNRYGCRAVTIAGSILAASCIIVSMFAQNVLTL 127
                                     ||:||..||:||.|.|.|||.:|....::::.|:.:|:.|
Human    74 RIFESFLIFTSLRIQCSFTQSGSCLGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQL 138

  Fly   128 IITIGFGTGLGFGLIYLPAIVSVTQYFEAKRSLATGIAVCGSGFGTFVFAPLTEFLIGNYGWRGA 192
            .:|:||.||||......||:..:.:||..||.:|.|:|:.||.......||..::|...:||:|:
Human   139 YLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGS 203

  Fly   193 MLIIGGIVLNCIIFGAMFRPLELEAPPQTPPNTPSTPKLAKKSAIIDQNTTAAELEPLKVLPKDQ 257
            .||:|.::||..:.|::.|||
Human   204 FLILGSLLLNACVAGSLMRPL-------------------------------------------- 224

  Fly   258 YLQLPQRTDTAVSGGALCRSNSVGHNLKPNLNNNSNGAVNGQGPTLVTPPQAVVKSTSNDDIARK 322
                                   |.|...:.:.|..|                  .|.:|...:|
Human   225 -----------------------GPNQTTSKSKNKTG------------------KTEDDSSPKK 248

  Fly   323 CHSQLQLTPLRDAHRERSASGTMYRPDALYQGSLHNLPDYVSSRNDLSRSMSGSGVIKRYGSLRQ 387
                                                                             
Human   249 ----------------------------------------------------------------- 248

  Fly   388 SNNVSQSQEEAKCCGCITCSKETRDTFAEMMNFSLLKDMVFVIFSVSNFCTSIGFNVPYLYVVAY 452
                            |...|.|.:...:.::|||.|...|:|:...|....:||..|.:::..|
Human   249 ----------------IKTKKSTWEKVNKYLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPY 297

  Fly   453 AETLKLTKTDASYLISTIGVANTVGRIILGYISDKPWVNRLLVY--NVCLTACGVSTAMVPLCHD 515
            |:...:.:..|::|:|.:...:...|..:|.|::..::...:.|  :..:...||...:.||..|
Human   298 AKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQD 362

  Fly   516 FQSLAFYCCVFGFTIGAYVGLTSVILVDLLGLDKLTNAFGLLLLFQGIASFIGPPIGGWMYDLTD 580
            :.||..|...||...|:...:....|:||:|..:.::|.||:.:.:.....:|||:.|.:.|||.
Human   363 YTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTG 427

  Fly   581 SYAPAFLMAGLMIA-------ISGLVMFAIPPLQRLQVRKSERKPHTEHLALS 626
            .|...::..|.::.       |...:.:.:...:|.:....::...:|.|:.|
Human   428 EYKYMYMSCGAIVVAASVWLLIGNAINYRLLAKERKEENARQKTRESEPLSKS 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mct1	NP_001284810.1	MFS	35..>213	CDD:119392	65/207 (31%)
		MFS	<426..604	CDD:119392	43/186 (23%)
SLC16A7	XP_011537291.1	2A0113	15..484	CDD:273325	133/636 (21%)
		MFS	20..449	CDD:119392	123/598 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145483
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		mtm9818
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.850