Protein Alignment Mct1 and SLC16A6

DIOPT Version :9

• Sequence 1: NP_001284810.1
• Gene: Mct1 / 31198
• FlyBaseID: FBgn0023549
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: XP_005257846.2
• Gene: SLC16A6 / 9120
• HGNCID: 10927
• Length: 527
• Species: Homo sapiens
• Alignment Length: 580
• Identity: 147/580 - (25%)
• Similarity: 260/580 - (44%)
• Gaps: 128/580 - (22%)

  Fly    29 PDGGWGWVVVFGSFMIHIVTDGMTYSFGIFYNEFLDYFNEGKGYTAWIASIMVGVTFSSGPISSS 93
            |||||||.|....|.:.:.|.|:..:||:|:|:.:|.|||.....:||.||.|.|...|.|:::.
Human    23 PDGGWGWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATV 87

  Fly    94 FVNRYGCRAVTIAGSILAASCIIVSMFAQNVLTLIITIGFGTGLGFGLIYLPAIVSVTQYFEAKR 158
            ..||:|.|.|.:.|.:|.::.::.:.|:|.|..:.:.||..:|||:...:||.:..::|||..:|
Human    88 LSNRFGHRLVVMLGGLLVSTGMVAASFSQEVSHMYVAIGIISGLGYCFSFLPTVTILSQYFGKRR 152

  Fly   159 SLATGIAVCGSGFGTFVFAPLTEFLIGNYGWRGAMLIIGGIVLNCIIFGAMFRPLELEAPPQTPP 223
            |:.|.:|..|..|..|.|||....|....|||.::|.:|.:.||.:||||:.||:.:..
Human   153 SIVTAVASTGECFAVFAFAPAIMALKERIGWRYSLLFVGLLQLNIVIFGALLRPIFIRG------ 211

  Fly   224 NTPSTPKLAKKSAIIDQNTTAAELEPLKVLPKDQYLQLPQRTDTAVSGGALCRSNSVGHNLKPNL 288
              |::||:     :|.:|...|           ||:...::|.|::        :|:
Human   212 --PASPKI-----VIQENRKEA-----------QYMLENEKTRTSI--------DSI-------- 242

  Fly   289 NNNSNGAVNGQGPTLVTPPQAVVKSTSNDDIARKCHSQLQLTPLRDAHRERSASGTMYRPDALYQ 353
                     ..|..|.|.|:.|           ..|:.|:|.|..|..:.
Human   243 ---------DSGVELTTSPKNV-----------PTHTNLELEPKADMQQV--------------- 272

  Fly   354 GSLHNLPDYVSSRNDLSRSMSGSGVIKRYGSLRQSNNVSQSQEEAKCCGCITCSKETRDTFAEMM 418
                                    ::|          .|....|.|               |.::
Human   273 ------------------------LVK----------TSPRPSEKK---------------APLL 288

  Fly   419 NFSLLKDMVFVIFSVSNFCTSIGFNVPYLYVVAYAETLKLTKTDASYLISTIGVANTVGRIILGY 483
            :||:||:..|:.:::.....::||..|.||::....:|.:.:..|::|:||:.:|...|||..|:
Human   289 DFSILKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDQDRAAFLLSTMAIAEVFGRIGAGF 353

  Fly   484 ISDKPWVNRLLVYNVCLTACGVSTAMVPLCHDFQSLAFYCCVFGFTIGAYVGLTSVILV---DLL 545
            :.::..:.::.:..:|:....||........:|..|......|||.:|. :|.|.:.|:   |::
Human   354 VLNREPIRKIYIELICVILLTVSLFAFTFATEFWGLMSCSIFFGFMVGT-IGGTHIPLLAEDDVV 417

  Fly   546 GLDKLTNAFGLLLLFQGIASFIGPPIGGWMYDLTDSYAPAFLMAGLMIAISGLVMFAIPP 605
            |::|:::|.|:.:..|.||...|||:.|.:.|.:..|:.||......:|::.:.:..:.|
Human   418 GIEKMSSAAGVYIFIQSIAGLAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLALVRP 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mct1	NP_001284810.1	MFS	35..>213	CDD:119392	64/177 (36%)
		MFS	<426..604	CDD:119392	45/180 (25%)
SLC16A6	XP_005257846.2	2A0113	23..512	CDD:273325	147/580 (25%)
		MFS	33..476	CDD:119392	138/567 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145563
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		mtm8478
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.840