DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mct1 and ATG22

DIOPT Version :9

Sequence 1:	NP_001284810.1	Gene:	Mct1 / 31198	FlyBaseID:	FBgn0023549	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_009892.1	Gene:	ATG22 / 850319	SGDID:	S000000543	Length:	528	Species:	Saccharomyces cerevisiae

Alignment Length:	536	Identity:	109/536 - (20%)
Similarity:	187/536 - (34%)	Gaps:	194/536 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 IAVCGSGFGTFVFAPLTEF-------------LIGNYGWRGAMLIIGGIVLNCIIFGAMFRPLEL 215
            |.|..|.|..:||:....|             |.|:..::|.:|:..|||      ||:
Yeast    89 IFVDTSSFALYVFSLSVLFQTIIVISVSGIVDLWGSVKFKGRILVWFGIV------GAL------ 141

  Fly   216 EAPPQTPPNTPSTPKLAKKSAIIDQNTTAAELEPLKVLPKDQYLQLPQRTDTAVSGGALCRSNSV 280
                       ||..::|.:     :|....|..|.:                |:.|.....|.|
Yeast   142 -----------STVAISKLN-----DTQIYSLAGLYI----------------VANGCFGVINVV 174

  Fly   281 GHNLKP-----NLNNNSNGA------------VNGQGPTLVTPPQAVVKSTSNDDIARKCHS--- 325
            |::|.|     :|...|.||            ::|:|.:|......:|:..|...:|.|..|
Yeast   175 GNSLLPIFVKDSLKCQSQGAYEPDKVDSLTTVISGRGASLGYSSALIVQIVSMFLVASKKGSKQD 239

  Fly   326 ---------------QLQL--------TPLRDAHRERSASGTMY--RPDALYQGSLHNLPDYVSS 365
                           ||.:        .|:|......:::.:.|  ..|||  |.| |..:|:|
Yeast   240 VQVAVLFVGIWWFVWQLPMIWLIDDVTIPIRVDDSTLASARSPYPGEQDAL--GQL-NWKNYLS- 300

  Fly   366 RNDLSRSMSGSGVIKRYGSLRQSNNVSQSQEEAKCCGCITCSKETRDTFAEMMNFSLLKD-MVFV 429
                            ||.:                          ..|....:..|||| |:|:
Yeast   301 ----------------YGWV--------------------------SLFESFKHARLLKDVMIFL 323

  Fly   430 I--FSVSNFCTSIGFNVPYLYVVA--YAETLKLTKTDASYLISTIGVANTV--GRIILGYISDK- 487
            |  |.:|:..|:|. :...|:..|  :..||.|      .:||.:.|.|.:  ..:|..:::.|
Yeast   324 IAWFIISDSITTIN-STAVLFSKAELHMSTLNL------IMISVLTVVNAMLGAFMIPQFLATKF 381

  Fly   488 PWV-NRLLVYNVCLTACGVSTAMVPLCHDFQSLAFYCCVFG-------FTIGAYVGLT----SVI 540
            .|. ::.|:|.:      :..:.:|.   :..|.|:...||       |.:..:.||:    |.:
Yeast   382 RWTSSQTLMYII------IWASFIPF---YGILGFFFNAFGLKHKFEMFLLAIWYGLSLGGLSAV 437

  Fly   541 LVDLLGL----DKLTNAFGLLLLFQGIASFIGPPIGGWMYDLTDSYAPAFLMAGLMIAISGLVMF 601
            ...:..|    .|.:..|.:..:....:|.:||.:.|.:.|.|.:...:|....|      |:|.
Yeast   438 SRSVFSLIVPPGKESTFFSMFSITDKGSSILGPFLVGLLTDKTHNIRYSFYFFFL------LLML 496

  Fly   602 AIPPLQRLQVRKSERK 617
            ::|.|..|.|::..|:
Yeast   497 SLPVLNCLDVKRGRRE 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mct1	NP_001284810.1	MFS	35..>213	CDD:119392	16/61 (26%)
Mct1	NP_001284810.1	MFS	<426..604	CDD:119392	43/200 (22%)
ATG22	NP_009892.1	MFS_Atg22_like	28..484	CDD:341036	100/500 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100