DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mct1 and Slc16a5

DIOPT Version :9

Sequence 1:	NP_001284810.1	Gene:	Mct1 / 31198	FlyBaseID:	FBgn0023549	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_001103038.1	Gene:	Slc16a5 / 690212	RGDID:	1582896	Length:	466	Species:	Rattus norvegicus

Alignment Length:	601	Identity:	133/601 - (22%)
Similarity:	228/601 - (37%)	Gaps:	178/601 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 DGGWGWVVVFGSFMIHIVTDGMTYSFGIFYNEFLDYFNEGKGYTAWIASIMVGVTFSSGPISSSF 94
            ||.|.|||:..|.:...:|.|.....|:|:.:....|......|:|..|||..:....||:.|..
  Rat     9 DGRWAWVVLLASLVTQALTVGFPSCIGVFFTDLQRDFQASNSETSWFPSIMGAMLHCGGPLCSIL 73

  Fly    95 VNRYGCRAVTIAGSILAASCIIVSMFAQNVLTLIITIGFGTGLGFGLIYLPAIVSVTQYFEAKRS 159
            :.|:|||...:.|.:||:..::.|.|:.:::.|.:|.|..||||....:..:|..|..||..:|.
  Rat    74 IKRFGCRVTMMLGGVLASLGMVASTFSDSLIHLFLTAGLITGLGMCFSFQSSITVVGLYFVRQRP 138

  Fly   160 LATGIAVCGSGFGTFVFAPLTEFLIGNYGWRGAMLIIGGIVLNCIIFGAMFRPLELEAPPQTPPN 224
            ||..:|..|...|..::..|..:|:...|||||.||.|||.|:|.:.|||.||:.....|:
  Rat   139 LANALASIGISMGVTLWPLLARYLLETLGWRGAFLIFGGIFLHCCVCGAMLRPVATNVDPE---- 199

  Fly   225 TPSTPKLAKKSAIIDQNTTAAELEPLKVLPKDQYLQLPQRTDTAVSGGALCRSNSVGHNLKPNLN 289
                                         ||:..| ||.:|.|
  Rat   200 -----------------------------PKEDLL-LPPKTPT---------------------- 212

  Fly   290 NNSNGAVNGQGPTLVTPPQAVVKSTSNDDIARKCHSQLQLTPLRDAHRERSASGTMYRPDALYQG 354
                                                             ||...|
  Rat   213 -------------------------------------------------RSCLAT---------- 218

  Fly   355 SLHNLPDYVSSRNDLSRSMSGSGVIKRYGSLRQSNNVSQSQEEAKCCGCITCSKETRDTFAEMMN 419
                                                            |::       |....:.
  Rat   219 ------------------------------------------------CVS-------TIQYYLA 228

  Fly   420 FSLLK-DMVFVIFSVSNFCTSIGFNVPYLYVVAYAETLKLTKTDASYLISTIGVANTVGRIILGY 483
            |.:|: :|||.|:.......::||::|::::|.||....:.:..|:.|:|.:|..|...|.:.|.
  Rat   229 FDILRHNMVFCIYVTGATWMTLGFSLPHIFLVPYAMHHGMEEYWAAMLMSIVGFCNIFLRPVAGM 293

  Fly   484 ISDKPWV--NRLLVYNVCLTACGVSTAMVPLCHDFQSLAFYCCVFGFTIGAYVGLTSVILVDLLG 546
            ::.:..:  .|..::.|.:...|::..:..:..||:.|..||.|:..::.....|...:|:|::.
  Rat   294 LAGRKSLAAYRKYLFAVAILINGLTNLICTVSADFRVLLGYCLVYSLSMCGTGILVFQVLMDIVP 358

  Fly   547 LDKLTNAFGLLLLFQGIASFIGPPIGGWMYDLTDSYAPAFLM-AGLMIAISGLVM---FAIPPLQ 607
            :|:..:|.||..:..|:.|.|.||:.|.:.|.|:::...|.| :||:|:.| |.|   |.:...:
  Rat   359 MDRFPSALGLFTILCGMGSLISPPLAGLLLDTTNNFNYVFYMSSGLLISAS-LFMGVGFYVAEKK 422

  Fly   608 RLQVRKSERKPHTEHL 623
            ..|.|:::.:..|..:
  Rat   423 LKQDRQAKMEDATSEI 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mct1	NP_001284810.1	MFS	35..>213	CDD:119392	61/177 (34%)
Mct1	NP_001284810.1	MFS	<426..604	CDD:119392	50/183 (27%)
Slc16a5	NP_001103038.1	2A0113	1..432	CDD:273325	132/593 (22%)
Slc16a5	NP_001103038.1	MFS	32..412	CDD:119392	119/550 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339230
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		mtm12325
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.750