Protein Alignment Mct1 and SLC16A1

DIOPT Version :10

• Sequence 1: NP_477334.2
• Gene: Mct1 / 31198
• FlyBaseID: FBgn0023549
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_003042.3
• Gene: SLC16A1 / 6566
• HGNCID: 10922
• Length: 500
• Species: Homo sapiens
• Alignment Length: 608
• Identity: 142/608 - (23%)
• Similarity: 236/608 - (38%)
• Gaps: 174/608 - (28%)

  Fly    27 TPPDGGWGWVVVFGSFMIHIVTDGMTYSF----GIFYNEFLDYFNEGKGYTAWIASIMVGVTFSS 87
            |||||||||.||.|:|    ::.|.:|:|    .:|:.|....|:......:||:|||:.|.:..
Human    12 TPPDGGWGWAVVIGAF----ISIGFSYAFPKSITVFFKEIEGIFHATTSEVSWISSIMLAVMYGG 72

  Fly    88 GPISSSFVNRYGCRAVTIAGSILAASCIIVSMFAQNVLTLIITIGFGTGLGFGLIYLPAIVSVTQ 152
            |||||..||:||.|.|.|.|..|:...:|.:.|...|..|.:.||...|||......||:..:.:
Human    73 GPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIGGLGLAFNLNPALTMIGK 137

  Fly   153 YFEAKRSLATGIAVCGSGFGTFVFAPLTEFLIGNYGWRGAMLIIGGIVLNCIIFGAMFRPLELEA 217
            ||..:|.||.|:|:.||.......|||.:...|.:||||:.||:||::|||.:.||:.||:
Human   138 YFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLILGGLLLNCCVAGALMRPI---- 198

  Fly   218 PPQTPPNTPSTPKLAKKSAIIDQNTTAAELEPLKVLPKDQYLQLPQRTDTAVSGGALCRSNSVGH 282
                   .|...|..|     |::..:.|......:.||
Human   199 -------GPKPTKAGK-----DKSKASLEKAGKSGVKKD-------------------------- 225

  Fly   283 NLKPNLNNNSNGAVNGQGPTLVTPPQAVVKSTSNDDIARKCHSQLQLTPLRDAHRERSASGTMYR 347
                                                             |.||:.:
Human   226 -------------------------------------------------LHDANTD--------- 232

  Fly   348 PDALYQGSLHNLPDYVSSRNDLSRSMSGSGVIKRYGSLRQSNNVSQSQEEAKCCGCITCSKETRD 412
                                          :|.|:          ..||:          :....
Human   233 ------------------------------LIGRH----------PKQEK----------RSVFQ 247

  Fly   413 TFAEMMNFSLLKDMVFVIFSVSNFCTSIGFNVPYLYVVAYAETLKLTKTDASYLISTIGVANTVG 477
            |..:.::.:|.....|:::...|.....|...|.:::.:|.::...:...:::|:|.:...:.|.
Human   248 TINQFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAFLLSILAFVDMVA 312

  Fly   478 RIILGYISD-KPWVNRL-LVYNVCLTACGVSTAMVPLCHDFQSLAFYCCVFGFTIGAYVGLTSVI 540
            |..:|.::: ||...|: ..:...:.|.||...:.||...:.....|...|||..|   .|:||:
Human   313 RPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYAGFFGFAFG---WLSSVL 374

  Fly   541 ---LVDLLGLDKLTNAFGLLLLFQGIASFIGPPIGGWMYDLTDSYAPAFLMAGLMIAISGLVMF- 601
               |:||:|..:.::|.||:.:.:.....:|||:.|.:.|:...|...:...|:::.|||:.:|
Human   375 FETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVVLIISGIYLFI 439

  Fly   602 -------AIPPLQRLQVRKSERK 617
                   .:...|:...:|.|.|
Human   440 GMGINYRLLAKEQKANEQKKESK 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mct1	NP_477334.2	MFS_MCT_SLC16	34..604	CDD:340910	131/586 (22%)
SLC16A1	NP_003042.3	2A0113	1..455	CDD:273325	139/599 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	454..500		3/9 (33%)