Protein Alignment Mct1 and SLC16A12

DIOPT Version :10

• Sequence 1: NP_477334.2
• Gene: Mct1 / 31198
• FlyBaseID: FBgn0023549
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_998771.3
• Gene: SLC16A12 / 387700
• HGNCID: 23094
• Length: 516
• Species: Homo sapiens
• Alignment Length: 618
• Identity: 166/618 - (26%)
• Similarity: 265/618 - (42%)
• Gaps: 169/618 - (27%)

  Fly    10 KSQQQHEACEMDMERQPTPPDGGWGWVVVFGSFMIHIVTDGMTYSFGIFYNEFLDYFNEGKGYTA 74
            |.:::....:::..|..:||||||||::|.|.|::.|.|..:|....||:.||..||.:....||
Human    24 KEEKRKTMAKVNRARSTSPPDGGWGWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFTQDYAQTA 88

  Fly    75 WIASIMVGVTFSSGPISSSFVNRYGCRAVTIAGSILAASCIIVSMFAQNVLTLIITIGFGTGLGF 139
            ||.||:..||....|:.|...|...|:...:.|.:||::.:|:|.||.::..|.:|:|..|||||
Human    89 WIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLASTGLILSSFATSLKHLYLTLGVLTGLGF 153

  Fly   140 GLIYLPAIVSVTQYFEAKRSLATGIAVCGSGFGTFVFAPLTEFLIGNYGWRGAMLIIGGIVLNCI 204
            .|.|.|||..|.:||..:::||.|||:.|||.|||:.||:.:.||..:.||||:||:||.|||..
Human   154 ALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLC 218

  Fly   205 IFGAMFRPLELEAPPQTPPNTPSTPKLAKKSAIIDQNTTAAELEPLKVLPKDQYLQLPQRTDTAV 269
            :.||:.||:.|:....||                :||
Human   219 VCGALMRPITLKEDHTTP----------------EQN---------------------------- 239

  Fly   270 SGGALCRSNSVGHNLKPNLNNNSNGAVNGQGPTLVTPPQAVVKSTSNDDIARKCHSQLQLTPLRD 334
               .:||                                     |..:||.|
Human   240 ---HVCR-------------------------------------TQKEDIKR------------- 251

  Fly   335 AHRERSASGTMYRPDALYQGSLHNLPDYVSSRNDLSRSMSGSGVIKRYGSLRQSNNVSQSQEEAK 399
                                                        :..|.||        ::|.|:
Human   252 --------------------------------------------VSPYSSL--------TKEWAQ 264

  Fly   400 CCGCITCSKETRDTFAEMMNFSLLKDMVFVIFSVSNFCTSIGFNVPYLYVVAYAETLKLTKTDAS 464
            .|.|....:|        .:|.|:.|  ||:.:||....:.|.:..::|:|.||.::.::...|:
Human   265 TCLCCCLQQE--------YSFLLMSD--FVVLAVSVLFMAYGCSPLFVYLVPYALSVGVSHQQAA 319

  Fly   465 YLISTIGVANTVGRIILGYISDKPWVN--RLLVYNVCLTACGVSTAMVPLCHDFQSLAFYCCVFG 527
            :|:|.:||.:.:|.|..|:::|:..:.  :.:.|...:...|:....:|:......|..:.|.||
Human   320 FLMSILGVIDIIGNITFGWLTDRRCLKNYQYVCYLFAVGMDGLCYLCLPMLQSLPLLVPFSCTFG 384

  Fly   528 FTIGAYVGLTSVILVDLLGLDKLTNAFGLLLLFQGIASFIGPPIGGWMYDLTDSYAPAFLMAGL- 591
            :..||||.|..|:..:::|...|::|.|::.....:...:.|||.|.:.|.|.||..|||:.|.
Human   385 YFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYTAAFLLCGFS 449

  Fly   592 MIAISGLVMFAIPPLQRLQVRKSERKPHTEHLA 624
            ||..|.|:.||       ::.|..||...:.:|
Human   450 MIFSSVLLGFA-------RLIKRMRKTQLQFIA 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mct1	NP_477334.2	MFS_MCT_SLC16	34..604	CDD:340910	154/572 (27%)
SLC16A12	NP_998771.3	MFS_MCT12	48..461	CDD:340982	154/578 (27%)