DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mct1 and CG8051

DIOPT Version :9

Sequence 1:	NP_001284810.1	Gene:	Mct1 / 31198	FlyBaseID:	FBgn0023549	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_001285434.1	Gene:	CG8051 / 32925	FlyBaseID:	FBgn0031012	Length:	616	Species:	Drosophila melanogaster

Alignment Length:	645	Identity:	143/645 - (22%)
Similarity:	246/645 - (38%)	Gaps:	134/645 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PARRKSQQQHEACEMDMERQPTPPDGGWGWVVVFGSFMIHIVTDGMTYSFGIFYNEFLDYFNEGK 70
            ||::|..:.      |:......|||||||:|...|.:..:||..:...|||.:.:.:.......
  Fly    63 PAKKKRDKS------DLGEDFVAPDGGWGWLVSVASGVNILVTFALAQQFGILFRDRMAGLGISS 121

  Fly    71 GYTAWIASIMVGVTFSSGPISSSFVNRYGCRAVTIAGSILAASCIIVSMFAQNVLTLIITIGFGT 135
            .....|.:..:.|:..:|.::.....||..|.|.:.||:|....:...:||......|::.....
  Fly   122 SELTTIINTQIAVSAFTGLLNGPLFRRYTYRVVALVGSVLTFLGLFWMVFADTFAVYIMSFSILY 186

  Fly   136 GLGFGLIYLPAIVSVTQYFEAKRSLATGIAVCGSGFGTFVFAPLTEFLIGNYGWRGAMLIIGGIV 200
            |.|.||....:.::|..||:.||..||......:|.|..|......:::..:|.:|..|:..|..
  Fly   187 GFGRGLTVSASSLAVNTYFKVKRRTATAFQFGVAGLGPIVCPYFATYMLYEFGVQGTTLLFAGAS 251

  Fly   201 LNCIIFGAMFRPL---------ELEAPPQTPPNTPSTPKLAKKSAIIDQNTTAAE--LEP-LKVL 253
            |:.|....:::|:         :.||..|..|       ||::.   ||:....:  :|| ..||
  Fly   252 LHTIACSLIYQPVKWHVVKRDRDAEALQQVQP-------LAERE---DQDEDIIKNVVEPETPVL 306

  Fly   254 PKDQYLQLPQRTDTAVSG--GALCRSNSVGHNLKPNL--NNNSNGAVNGQGPTLVTPPQAVVKST 314
            |:            |..|  |:....||||...:.|.  .::|||.|.             :|..
  Fly   307 PR------------ANDGWFGSRASLNSVGTRNRLNTWEKSDSNGHVE-------------LKRL 346

  Fly   315 SNDDIARKCHSQLQLTPLRDAHRERSASGTMYRPDALYQGSLHNLPDYVSSRNDLSRSMSGSGVI 379
            |:.|    .:...||..:..:|..:....|.|..|       |.:
  Fly   347 SSKD----SNPGRQLRSISVSHSIKEEEATGYNSD-------HEV-------------------- 380

  Fly   380 KRYGSLRQSNNVSQSQEEAKCCGCITCSKETRDTFAEMM------NFSLLKDMVFVIFSVS---- 434
             ::..|.:..  .|..|:.|       .::.|......|      :..||:|:.:|..:|.
  Fly   381 -QHTELTEKE--KQELEDEK-------ERQRRKKLPFYMKVVIFFDMDLLRDITYVNLAVGITLI 435

  Fly   435 NFCTSIGFNVPYLYVVAYAETLKLTKTDASYLISTIGVANTVGRIILGYISDKPWVNRLLVYNVC 499
            || ..|.|.:...::::   .|...|...:..:||:|..:.|.|.::..|:.|..::....:.|.
  Fly   436 NF-VEINFAILTPFILS---DLGFNKDQIALAMSTLGFFDLVVRFLIPLITAKINLSNRTFFVVG 496

  Fly   500 LTACGVSTAMVPLCHDFQSLAFYCCVFGFTIGAYVGLT--------SVILVDLLGLDKLTNAFGL 556
            :....:....:.:..:|..:        ..|..::||.        |:|:...:.|.:|..|.||
  Fly   497 ILGMCIGRMFLSMTSNFYVM--------MAIFLWLGLNKAFRTVFWSLIIPSYVPLKRLPAAAGL 553

  Fly   557 LLLFQGIASFIGPPIGGWMYDLTDSYAPA--FLMAGLMIAISGLVMFAIPPLQRLQVRKS 614
            .||..|..|.|..|:.|.:.|.| |||..  .|.|..::|.:|   :.:....|.:.|||
  Fly   554 QLLMSGTFSMIFGPLIGLIRDHT-SYAVTLNLLNALCVMAFAG---WYLEDFIRARSRKS 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mct1	NP_001284810.1	MFS	35..>213	CDD:119392	41/177 (23%)
Mct1	NP_001284810.1	MFS	<426..604	CDD:119392	43/191 (23%)
CG8051	NP_001285434.1	MFS	86..>266	CDD:119392	42/179 (23%)
		MFS	<428..598	CDD:119392	42/185 (23%)
		MFS_1	440..>572	CDD:284993	30/142 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446227
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
	6	5.850