DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mct1 and Slc16a12

DIOPT Version :9

Sequence 1:	NP_001284810.1	Gene:	Mct1 / 31198	FlyBaseID:	FBgn0023549	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_766426.1	Gene:	Slc16a12 / 240638	MGIID:	2147716	Length:	486	Species:	Mus musculus

Alignment Length:	600	Identity:	157/600 - (26%)
Similarity:	258/600 - (43%)	Gaps:	168/600 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 TPPDGGWGWVVVFGSFMIHIVTDGMTYSFGIFYNEFLDYFNEGKGYTAWIASIMVGVTFSSGPIS 91
            :||||||||::|.|.|::.|.|..:|....||:.||..||.:....||||.||:..:|....|:.
Mouse    11 SPPDGGWGWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFAQDYSQTAWIHSIVDCMTMLCAPLG 75

  Fly    92 SSFVNRYGCRAVTIAGSILAASCIIVSMFAQNVLTLIITIGFGTGLGFGLIYLPAIVSVTQYFEA 156
            |...|:..|:|..:.|.:||::..|:..||.::..|.:::|..|||||.|.|.|||..|.:||..
Mouse    76 SVVSNQLSCQAGIMLGGLLASTGFILGSFATSLKHLYLSLGVLTGLGFALCYSPAIAMVGKYFSR 140

  Fly   157 KRSLATGIAVCGSGFGTFVFAPLTEFLIGNYGWRGAMLIIGGIVLNCIIFGAMFRPLELEAPPQT 221
            :::||.|||:.|||.|||:.||:.:.||..:.||||:||:||.|||..:.||:.||:.|
Mouse   141 RKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPITL------ 199

  Fly   222 PPNTPSTPKLAKKSAIIDQNTTAAELEPLKVLPKDQYLQLPQRTDTAVSGGALCRSNSVGHNLKP 286
                                                      :.|.:|                |
Mouse   200 ------------------------------------------KEDRSV----------------P 206

  Fly   287 NLNNNSNGAVNGQGPTLVTPPQAVVKSTSNDDIARKCHSQLQLTPLRDAHRERSASGTMYRPDAL 351
            ..|:|                                         |::.||.....:.|.|
Mouse   207 EKNHN-----------------------------------------RESQREDCKQASPYSP--- 227

  Fly   352 YQGSLHNLPDYVSSRNDLSRSMSGSGVIKRYGSLRQSNNVSQSQEEAKCCGCITCSKETRDTFAE 416
                                                   :::...|.:.|    ||.:      :
Mouse   228 ---------------------------------------LTKECTETRLC----CSLQ------Q 243

  Fly   417 MMNFSLLKDMVFVIFSVSNFCTSIGFNVPYLYVVAYAETLKLTKTDASYLISTIGVANTVGRIIL 481
            ...|.|:.|  ||:.:||....:.|.:..::|:|.||.::.::...|::|:|.:||.:.||.|..
Mouse   244 EYGFLLMSD--FVVLAVSVLFMAYGCSPLFVYLVPYALSVGVSHHQAAFLMSILGVIDIVGNITF 306

  Fly   482 GYISDKPWVN--RLLVYNVCLTACGVSTAMVPLCHDFQSLAFYCCVFGFTIGAYVGLTSVILVDL 544
            |:::|:..:.  |.:.|...:...|:....:|:...|..|..:.|.||:..||||.|..|:..::
Mouse   307 GWLTDRRCLKNYRYVCYLFAVALDGLCYLCLPMLQTFPLLVPFSCTFGYFDGAYVTLIPVVTAEI 371

  Fly   545 LGLDKLTNAFGLLLLFQGIASFIGPPIGGWMYDLTDSYAPAFLMAGLMIAISGLVMFAIPPLQRL 609
            :|...|::|.|::.....:...:.|||.||:.|.|.||..|||:.|..:..|.:::..:..::|:
Mouse   372 VGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSILLGFVRIVKRM 436

  Fly   610 Q-------VRKSERK 617
            :       |:.|:.|
Mouse   437 KRTQVPFPVKDSDPK 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mct1	NP_001284810.1	MFS	35..>213	CDD:119392	75/177 (42%)
Mct1	NP_001284810.1	MFS	<426..604	CDD:119392	52/179 (29%)
Slc16a12	NP_766426.1	MFS_MCT12	18..431	CDD:340982	147/571 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835631
Domainoid	1	1.000	145	1.000	Domainoid score	I4552
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H130007
Inparanoid	1	1.050	285	1.000	Inparanoid score	I2828
Isobase	1	0.950	-	0	Normalized mean entropy	S4363
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		mtm8713
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2106
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.780