Protein Alignment Mct1 and SLC16A8

DIOPT Version :9

• Sequence 1: NP_001284810.1
• Gene: Mct1 / 31198
• FlyBaseID: FBgn0023549
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_037488.2
• Gene: SLC16A8 / 23539
• HGNCID: 16270
• Length: 504
• Species: Homo sapiens
• Alignment Length: 581
• Identity: 147/581 - (25%)
• Similarity: 241/581 - (41%)
• Gaps: 173/581 - (29%)

  Fly    28 PPDGGWGWVVVFGSFMIHIVTDGMTYSF----GIFYNEFLDYFNEGKGYTAWIASIMVGVTFSSG 88
            ||||||||||:...|    |..|..|.|    .:|:...:..|:.|...|||::|||:.:.:.:|
Human    12 PPDGGWGWVVLGACF----VVTGFAYGFPKAVSVFFRALMRDFDAGYSDTAWVSSIMLAMLYGTG 72

  Fly    89 PISSSFVNRYGCRAVTIAGSILAASCIIVSMFAQNVLTLIITIGFGTGLGFGLIYLPAIVSVTQY 153
            |:||..|.|:|||.|.:||.:||::.:|::.||..:|.|.:|.|..||||..|.:.|:::.:..|
Human    73 PVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTGLGLALNFQPSLIMLGLY 137

  Fly   154 FEAKRSLATGIAVCGSGFGTFVFAPLTEFLIGNYGWRGAMLIIGGIVLNCIIFGAMFRPLELEAP 218
            ||.:|.||.|:|..||.......:||.:.|:..:||||..|::||::|:|...||:.||
Human   138 FERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLLGGLLLHCCACGAVMRP------ 196

  Fly   219 PQTPPNTPSTPKLAKKSAIIDQNTTAAELEPLKVLPKDQYLQLPQRTDTAVSGGALCRSNSVGHN 283
               ||
Human   197 ---PP------------------------------------------------------------ 198

  Fly   284 LKPNLNNNSNGAVNGQGPTLVTPPQAVVKSTSNDDIARKCHSQLQLTPLRDAHRERSASGTMYRP 348
                          |.||                            .|.||:..:|:.
Human   199 --------------GPGP----------------------------RPRRDSAGDRAG------- 214

  Fly   349 DALYQGSLHNLPDYVSSRNDLSRSMSGSGVIKRYGSLRQSNNVSQSQEEAKCCGCITCSKETRDT 413
            ||         |....:        .|:|:     .||::                  |...|..
Human   215 DA---------PGEAEA--------DGAGL-----QLREA------------------SPRVRPR 239

  Fly   414 FAEMMNFSLLKDMVFVIFSVSNFCTSIGFNVPYLYVVAYAETLKLTKTDASYLISTIGVANTVGR 478
             ..:::.::..|..|.:::|:.|..::|..||.:.:|.||:...:..|||::|:|.:|..:.|.|
Human   240 -RRLLDLAVCTDRAFAVYAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAFLLSIVGFVDIVAR 303

  Fly   479 IILGYISD----KPWVNRLLVYNVCLTACGVSTAMVPLCHDFQSLAFYCCVFGFTIGAYVGLTSV 539
            ...|.::.    :|.|..|  :::.|.|.|::.........:.:|..:|..||.:.|....|...
Human   304 PACGALAGLARLRPHVPYL--FSLALLANGLTDLSSARARSYGALVAFCVAFGLSYGMVGALQFE 366

  Fly   540 ILVDLLGLDKLTNAFGLLLLFQGIASFIGPPIGGWMYDLTDSYAPAFLMAGLMIAISGLVM 600
            :|:..:|..:..:|.||:||.:..|..||||..|.:.|:..:|...|.:||..:|::|:.|
Human   367 VLMAAVGAPRFPSALGLVLLVEAAAVLIGPPSAGRLVDVLKNYEIIFYLAGSEVALAGVFM 427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mct1	NP_001284810.1	MFS	35..>213	CDD:119392	69/181 (38%)
		MFS	<426..604	CDD:119392	51/179 (28%)
SLC16A8	NP_037488.2	2A0113	1..460	CDD:273325	147/581 (25%)
		MFS	19..429	CDD:119392	140/574 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	196..224		13/162 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	441..504

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145571
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		mtm9818
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.950