Protein Alignment Mct1 and mct-6

DIOPT Version :9

• Sequence 1: NP_001284810.1
• Gene: Mct1 / 31198
• FlyBaseID: FBgn0023549
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_510705.1
• Gene: mct-6 / 181724
• WormBaseID: WBGene00015676
• Length: 594
• Species: Caenorhabditis elegans
• Alignment Length: 642
• Identity: 225/642 - (35%)
• Similarity: 321/642 - (50%)
• Gaps: 116/642 - (18%)

  Fly    26 PTPPDGGWGWVVVFGSFMIHIVTDGMTYSFGIFYNEFLDYFNEGKGYTAWIASIMVGVTFSSGPI 90
            |.|||||||||||.|||.:|:..||..||||:.....::.|:......|.|.|::.|:|..|||:
 Worm    15 PLPPDGGWGWVVVLGSFFVHVFADGFVYSFGVLVETLMEEFHASNTMAALIISLLTGLTLGSGPL 79

  Fly    91 SSSFVNRYGCRAVTIAGSILAASCIIVSMFAQNVLTLIITIGFGTGLGFGLIYLPAIVSVTQYFE 155
            :|:..|:||||..||.|:.:|.....:|.||..:..::||:|...|.||||:|.||||.||.|||
 Worm    80 ASAVCNKYGCRITTITGAGVAFVGCALSYFATAMWHIVITVGVIMGTGFGLMYCPAIVIVTMYFE 144

  Fly   156 AKRSLATGIAVCGSGFGTFVFAPLTEFLIGNYGWRGAMLIIGGIVLNCIIFGAMFRPLELEAPPQ 220
            .||||||||||.|:|.||.:|||:..|.|.|||||...|....|::.|.:.||.|.|||....|.
 Worm   145 NKRSLATGIAVAGAGVGTVLFAPINAFFINNYGWRSVFLAFLFILVLCALCGATFAPLEFALVPD 209

  Fly   221 TPPNTPSTPKLAKKSAIIDQNT--TAAELEPLKVLPKDQYLQLPQRTDTAVSGGALCRSNSVGHN 283
            .....        ...::|::.  |||..|
 Worm   210 EEEEV--------NDEVLDEDVKKTAANEE----------------------------------- 231

  Fly   284 LKPNLNNNSNGAVNGQGPTLVTPPQAVVKSTSNDDIARKC------HSQLQLTPLRDAHRERSA- 341
                         :|:..||::||..:.:|.|.....:|.      .|.:....:....|.|..
 Worm   232 -------------HGEKATLLSPPSLLERSMSQSSGVQKAGEKIRPASSMGAVDVESQPRSRRGT 283

  Fly   342 -----SGTMYRPDALYQGSLHNL------PDYVSSRNDLSRSMSGSGVIKRYGSLRQSNNVSQSQ 395
                 ||.:.|.|..|.||:.|:      ||...|...|....:..|.|..:.:.|..:....|:
 Worm   284 VGERDSGYLNRKDVFYTGSISNVAEFREDPDKYRSTGSLHGRHTTVGSIPAHSTGRLDDVREGSE 348

  Fly   396 EEAKCCGCITCSKETR--------------DTFAEMMNFSLLKDMVFVIFSVSNFCTSIGFNVPY 446
            |::|   .:..|::|.              .|.:.|::..||.:..|::|::||..||:|||.|.
 Worm   349 EDSK---AMDISEKTNGTDNTDNVEGKNMFKTISNMLSLELLLEPTFLLFAISNLLTSVGFNSPL 410

  Fly   447 LYVVAYAETLKLTKTDASYLISTIGVANTVGRIILGYISDKPWV-----------NRLLVYNVCL 500
            .::..:|..:.|.....|.::|..||:|||||||.|.::|....           |||.:||:.|
 Worm   411 YFLPLHATKIGLEPIQGSKVLSAFGVSNTVGRIIFGVVADHKLPLPGGIGNDTARNRLWMYNISL 475

  Fly   501 TACGVSTAMVPLCHDFQS---LAFYCCVFGFTIGAYVGLTSVILVDLLGLDKLTNAFGLLLLFQG 562
            |.||:.|.   .|:.|..   ||.|..:|||:|.:|:.||||||||||||||||||||||||:||
 Worm   476 TICGLLTV---FCYQFNGFIPLATYSALFGFSIASYICLTSVILVDLLGLDKLTNAFGLLLLWQG 537

  Fly   563 IASFIGPPIGGWMYDLTDSYAPAFLMAGLMIAISGLVMFAIPPLQR------LQVRK 613
            :.:..|||:.|::.|:|.:|..:|:..|:.:..|||::|.||..|:      |.::|
 Worm   538 VGTVFGPPVSGYLADMTGNYTLSFVFCGVNLLASGLMLFGIPFFQKKAKAKALAIKK 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mct1	NP_001284810.1	MFS	35..>213	CDD:119392	84/177 (47%)
		MFS	<426..604	CDD:119392	84/191 (44%)
mct-6	NP_510705.1	MFS_MCT_SLC16	23..579	CDD:340910	213/617 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159667
Domainoid	1	1.000	158	1.000	Domainoid score	I2508
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H130007
Inparanoid	1	1.050	364	1.000	Inparanoid score	I1263
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28635
OrthoDB	1	1.010	-	-		D352338at33208
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	1	1.000	-	-		otm14164
orthoMCL	1	0.900	-	-		OOG6_109218
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2106
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.840